Journal
ANALYST
Volume 141, Issue 16, Pages 4973-4981Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6an00659k
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Funding
- Ministry of Science and Technology, Taiwan [MOST 103-2221-E-008-027, MOST 104-2911-I-008-514]
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Nanoscale silicon surface-assisted laser desorption/ionization mass spectrometry (SALDI-MS) is an emerging matrix-free, highly sensitive MS analysis method. An important challenge in using nanoscale silicon SALDI-MS analysis is the aging and stability of silicon after storage in various environments. No proper nanoscale silicon SALDI-MS activation procedure has been reported to solve this issue. This study investigated the sensitivity, wettability, and surface oxidation behavior of nanoscale silicon surface SALDI-MS in a room, an inert gas atmosphere, and a vacuum environment. A simple vacuum oven desiccation was proposed to activate the SALDI-MS surface, and the limit of detection was further enhanced 1000 times to a 500 attomole level using this approach. The long-term stability and desorption/ionization mechanism were also investigated.
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