Article
Clinical Neurology
Andrea Morotti, Gregoire Boulouis, Andreas Charidimou, Qi Li, Loris Poli, Paolo Costa, Valeria De Giuli, Eleonora Leuci, Federico Mazzacane, Giorgio Busto, Francesco Arba, Laura Brancaleoni, Sebastiano Giacomozzi, Luigi Simonetti, Michele Laudisi, Giuseppe Micieli, Anna Cavallini, Elisa Candeloro, Massimo Gamba, Mauro Magoni, Andrew D. Warren, Christopher D. Anderson, M. Edip Gurol, Alessandro Biffi, Anand Viswanathan, Ilaria Casetta, Enrico Fainardi, Andrea Zini, Alessandro Pezzini, Alessandro Padovani, Steven M. Greenberg, Jonathan Rosand, Joshua N. Goldstein
Summary: The study found that hematoma expansion is common in patients with unclear symptom onset of intracerebral hemorrhage and independently associated with worse outcome. These findings suggest that patients with unclear symptom onset may benefit from clinical trials of medical treatments targeting hematoma expansion.
Article
Clinical Neurology
Vignan Yogendrakumar, Tim Ramsay, Bijoy K. Menon, Adnan Qureshi, Jeffrey L. Saver, Dar Dowlatshahi
Summary: This proof-of-concept study introduced an HE shift analysis model to enhance the evaluation of ICH therapies using data from the ATACH-2 trial. Results from analyzing 863 patients indicated that intensive blood pressure lowering treatment may reduce hematoma growth in high-risk patients, suggesting the potential benefits of the shift analysis model in assessing hemostatic agents for future studies.
Article
Medicine, General & Internal
Peng Wang, Fa Wu, Yang Wang, Feizhou Du, Xiaokun Yang, Jianhao Li, Jinping Sheng, Hongmei Yu, Rui Jiang
Summary: This study evaluated the association between imaging signs and clinical parameters and established a predictive model for hematoma expansion. The model combined radiological characteristics with clinical indicators and showed considerable predictive performance.
Review
Critical Care Medicine
Andrea Loggini, Faten El Ammar, Ali Mansour, Christopher L. Kramer, Fernando D. Goldenberg, Christos Lazaridis
Summary: This study suggests a significant association between hypocalcemia and hyponatremia with hematoma expansion and worse outcome in intracerebral hemorrhage patients, while the association with hypomagnesemia is weaker.
JOURNAL OF CRITICAL CARE
(2021)
Article
Medicine, General & Internal
Aristeidis H. Katsanos, Himanshu Gupta, Andrea Morotti, Simon Beshara, Tushar Patil, Saeed Al-Zahrani, Georgios Tsivgoulis, Dariush Dowlatshahi, Joshua N. Goldstein, Andreas Charidimou, Ashkan Shoamanesh
Summary: Combined assessment of NCCT markers seems to increase the prognostic accuracy for hematoma expansion in antithrombotic-related spontaneous ICH patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Lei Song, Xiao-Ming Qiu, Ting-Ting Guo, Hang Zhou, Dong-Fang Tang, Long-Sheng Wang, Yu-Fei Fu, Hui Chen, Hua-Qing Mao, Hai-Bao Wang, Yong-Qiang Yu
Summary: The involvement of the posterior limb of the internal capsule in deep intracerebral hemorrhage is associated with hematoma expansion and may serve as a promising predictor.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Wen-Song Yang, Yi-Qing Shen, Xiao Wei, Li-Bo Zhao, Qing-Jun Liu, Xiong-Fei Xie, Zhi-Wei Zhang, Lan Deng, Xin-Ni Lv, Shu-Qiang Zhang, Xin-Hui Li, Qi Li, Peng Xie
Summary: The study developed the dynamic ICH (dICH) score and ultra-early ICH (uICH) score to improve the prediction of functional outcomes in patients with ICH by incorporating hematoma expansion, IVH growth, and independent non-contrast CT markers. Compared to the original ICH score, these new scores exhibited better performance in predicting poor functional outcomes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Yejin Kim, Jong-Hee Sohn, Chulho Kim, So Young Park, Sang-Hwa Lee
Summary: This study evaluated the impact of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) on hematoma expansion (HE) and worse outcomes in patients with intracranial hemorrhage (ICH). The results showed that NLR and PLR were associated with HE and could reliably predict its occurrence.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Sanjula D. Singh, Marco Pasi, Floris H. B. M. Schreuder, Andrea Morotti, Jasper R. Senff, Andrew D. Warren, Brenna N. McKaig, Kristin Schwab, M. Edip Gurol, Jonathan Rosand, Steven M. Greenberg, Anand Viswanathan, Catharina J. M. Klijn, Gabriel J. E. Rinkel, Joshua N. Goldstein, H. Bart Brouwers
Summary: In patients with spontaneous cerebellar ICH treated conservatively, the spot sign is associated with speed of hematoma expansion, case fatality, and poor functional outcome. In surgically treated patients, the spot sign is associated with 90-day case fatality.
Article
Clinical Neurology
Christopher P. Kellner, Rui Song, Muhammad Ali, Dominic A. Nistal, Milan Samarage, Neha S. Dangayach, John Liang, Ian McNeill, Xiangnan Zhang, Joshua B. Bederson, J. Mocco
Summary: This retrospective analysis of 90 patients undergoing minimally invasive endoscopic intracerebral hemorrhage evacuation found that younger age, absence of intraventricular hemorrhage, lobar location, and early time to evacuation were independently associated with good long-term functional outcomes. The odds ratio for time to evacuation suggests a 5% reduction in the odds of achieving a favorable outcome for each additional hour.
Article
Clinical Neurology
Andrea Morotti, Gregoire Boulouis, Jawed Nawabi, Qi Li, Andreas Charidimou, Marco Pasi, Frieder Schlunk, Ashkan Shoamanesh, Aristeidis H. Katsanos, Federico Mazzacane, Giorgio Busto, Francesco Arba, Laura Brancaleoni, Sebastiano Giacomozzi, Luigi Simonetti, Andrew D. Warren, Michele Laudisi, Anna Cavallini, Edip M. Gurol, Anand Viswanathan, Andrea Zini, Ilaria Casetta, Enrico Fainardi, Steven M. Greenberg, Alessandro Padovani, Jonathan Rosand, Joshua N. Goldstein
Summary: Noncontrast computed tomography hypodensities are a valuable alternative to the computed tomography angiography spot sign and provide significant added value in the prediction of hematoma expansion in intracerebral hemorrhage.
Article
Surgery
Heling Chu, Chuyi Huang, Zaiying Zhou, Yuping Tang, Qiang Dong, Qihao Guo
Summary: This study aimed to develop an inflammatory score that can predict hematoma expansion and poor outcomes in patients with intracerebral hemorrhage (ICH). The inflammatory score was developed by integrating several inflammatory markers and was found to be significantly associated with hematoma expansion and poor outcomes. The inflammatory score showed good diagnostic accuracy in predicting these outcomes compared to individual markers.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Clinical Neurology
Stefan P. Haider, Adnan I. Qureshi, Abhi Jain, Hishan Tharmaseelan, Elisa R. Berson, Tal Zeevi, Shahram Majidi, Christopher G. Filippi, Simon Iseke, Moritz Gross, Julian N. Acosta, Ajay Malhotra, Jennifer A. Kim, Lauren H. Sansing, Guido J. Falcone, Kevin N. Sheth, Seyedmehdi Payabvash
Summary: This study aimed to determine radiomics signature correlates of clinical severity and medium-term outcome in patients with intracerebral hemorrhage (ICH) using the ATACH-2 trial dataset. The radiomics signatures were found to have a stronger association with admission clinical scores and 3-month outcome compared to hematoma volume, suggesting potential for improving prognostication and treatment triage of ICH patients using imaging biomarkers.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Emergency Medicine
Yuchao Jia, Xiaodong Ye, Guini Song, Xianxian Li, Jiahe Ye, Yuyan Yang, Kai Lu, Shanshan Huang, Suiqiang Zhu
Summary: This study aimed to explore laboratory biomarkers associated with hematoma expansion (HE) after intracerebral hemorrhage (ICH) that were readily available in clinical practice. The results showed that higher levels of direct bilirubin (DBil) were associated with HE and poor 3-month outcomes, and this association was partially mediated by HE. This suggests that interventions targeting DBil may improve post-ICH prognosis.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Review
Clinical Neurology
Yujie Wu, Donghang Zhang, Hongyang Chen, Bin Liu, Cheng Zhou
Summary: This study found that prior use of antiplatelet therapy in patients with intracerebral hemorrhage is associated with a slightly increased mortality rate, but does not affect poor functional outcomes or hematoma expansion.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Negar Morovatdar, Abolfazl Avan, M. Reza Azarpazhooh, Mario Di Napoli, Saverio Stranges, Moira K. Kapral, Arash Akhavan Rezayat, Aidin Shariatzadeh, Shahram Abootalebi, Naghmeh Mokhber, J. David Spence, Vladimir Hachinski
Summary: From 1990 to 2017, the age-standardized burden of IHD, stroke, and dementia decreased, more prominently in OECD countries than the world. However, their rising crude numbers mainly due to population growth and ageing require urgent identification of reversible risk and protective factors.
NEUROLOGICAL SCIENCES
(2022)
Article
Neurosciences
Payam Sasanejad, Leila Afshar Hezarkhani, Shahram Arsang-Jang, Georgios Tsivgoulis, Abdoreza Ghoreishi, Barlinn Kristian, Jan Rahmig, Mehdi Farhoudi, Elyar Sadeghi Hokmabadi, Afshin Borhani-Haghighi, Payam Sariaslani, Athena Sharifi-Razavi, Kavian Ghandehari, Alireza Khosravi, Craig Smith, Yongchai Nilanont, Yama Akbari, Thanh N. Nguyen, Anna Bersano, Nawaf Yassi, Takeshi Yoshimoto, Simona Lattanzi, Animesh Gupta, Ramin Zand, Shahram Rafie, Seyede Pourandokht Mousavian, Mohammad Reza Shahsavaripour, Shahram Amini, Saltanat U. Kamenova, Aida Kondybayeva, Murat Zhanuzakov, Elizabeth M. Macri, Christa O'Hana S. Nobleza, Sean Ruland, Anna M. Cervantes-Arslanian, Masoom J. Desai, Annemarei Ranta, Amir Moghadam Ahmadi, Mahtab Rostamihosseinkhani, Razieh Foroughi, Etrat Hooshmandi, Fahimeh H. Akhoundi, Ashfaq Shuaib, David S. Liebeskind, James Siegler, Jose G. Romano, Stephan A. Mayer, Reza Bavarsad Shahripour, Babak Zamani, Amadene Woolsey, Yasaman Fazli, Khazaei Mojtaba, Christian F. Isaac, Jose Biller, Mario Di Napoli, M. Reza Azarpazhooh
Summary: This multicenter study found that the use of IV-tPA for acute ischemic stroke in COVID-19 patients did not increase the risks of disability, mortality, and hemorrhagic transformation compared to those without COVID-19.
JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
(2021)
Article
Pathology
Gelsomina Mansueto, Mario Di Napoli, Carlo Pietro Campobasso, Mark Slevin
Summary: This study aimed to verify the morphological and histological criteria of fatal cases of PAH and evaluate the lymphocytic populations associated with lesions. The results showed that inflammatory infiltrate is essential for a correct diagnosis of PAH and may play a key role in the pathogenesis. This finding is crucial for ruling out secondary pulmonary hypertension and adding new insights to the immunologically related pathogenesis of PAH.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Neurosciences
Simona Lattanzi, Davide Norata, Afshin A. Divani, Mario Di Napoli, Serena Broggi, Chiara Rocchi, Santiago Ortega-Gutierrez, Gelsomina Mansueto, Mauro Silvestrini
Summary: This study aimed to evaluate the relationship between systemic inflammatory response index (SIRI) and futile recanalization in patients with AIS. The study found that older age, higher admission National Institutes of Health stroke scale score, and higher admission SIRI increased the risk of poor outcomes at 3 months despite complete or near-complete recanalization.
Review
Clinical Neurology
Gelsomina Mansueto, Giuseppe Lanza, Francesco Fisicaro, Danielle Alaouieh, Emily Hong, Sara Girolami, Marco Montella, Alessandro Feola, Mario Di Napoli
Summary: This review provides a comprehensive update on the clinical assessment, diagnosis, complications, and treatment of PCNSV. Recent developments and advances in technology have improved diagnostic accuracy and provided new insights for preventing misdiagnosis. However, treatment for PCNSV remains largely empirical.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2022)
Article
Genetics & Heredity
Nitin Kumar, Manminder Kaur, Gurjinderpal Singh, Srishti Valecha, Rubanpal Khinda, Mario DiNapoli, Monica Singh, Puneetpal Singh, Sarabjit Mastana
Summary: This study explores the genetic implications of NLRP3 inflammasome in ischemic stroke (IS) in Punjab. It finds that certain SNPs and haplotypes within the NLRP3 gene are associated with an increased risk of IS, and this risk is linked to higher levels of systolic blood pressure and pro-inflammatory markers.
INTERNATIONAL JOURNAL OF IMMUNOGENETICS
(2022)
Article
Biology
Simona Lattanzi, Davide Norata, Serena Broggi, Stefano Meletti, Milena Switonska, Artur Slomka, Mauro Silvestrini
Summary: The worsening of neurological status shortly after acute ischemic stroke (AIS) is a serious problem, and inflammation plays a key role in stroke pathology. A study found that the neutrophil-to-lymphocyte ratio (NLR) at admission in AIS patients undergoing endovascular treatment (EVT) is associated with early neurological deterioration (END). Higher NLR values predicted a higher risk of END.
Article
Medicine, General & Internal
Giovanni Falcicchio, Simona Lattanzi, Francesco Negri, Marina de Tommaso, Angela La Neve, Nicola Specchio
Summary: This retrospective study examined the 12-month effectiveness and tolerability of Cenobamate (CNB) in patients with Lennox-Gastaut syndrome (LGS) in real-world practice. The results showed a reduction in seizure frequency and minimal side effects after CNB treatment. These findings suggest that CNB may be a promising therapeutic option for drug-resistant epilepsy associated with LGS.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Diana L. L. Alsbrook, Mario Di Napoli, Kunal Bhatia, Masoom Desai, Archana Hinduja, Clio A. A. Rubinos, Gelsomina Mansueto, Puneetpal Singh, Gustavo G. G. Domeniconi, Asad Ikram, Sara Y. Y. Sabbagh, Afshin A. A. Divani
Summary: This review article provides an up-to-date understanding of the pathophysiology of DCI and its association with EBI in aSAH patients. Recent studies have shown that EBI plays a crucial role in the development of DCI, and advanced monitoring and neuroimaging techniques can help detect EBI and improve clinical management.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Puneetpal Singh, Nitin Kumar, Monica Singh, Manminder Kaur, Gurjinderpal Singh, Amit Narang, Abhinav Kanwal, Kirti Sharma, Baani Singh, Mario Di Napoli, Sarabjit Mastana
Summary: Atherosclerosis is the formation of plaque within arteries, caused by the accumulation of fats, cholesterol, and fibrous material, leading to blockage of blood flow and ischemia. It has a significant impact on global health statistics, being the main cause of morbidity and mortality for diseases such as rheumatological, heart, and brain disorders. Inflammation and coagulatory mediators contribute to the development and worsening of atherosclerotic plaque, with neutrophil extracellular traps and NLRP3 playing a significant role in this process. This review focuses on the contribution of these two processes in atherosclerosis, inflammation, and atherothrombosis.
Review
Clinical Neurology
Ylenia Pastorello, Roxana O. Carare, Claudia Banescu, Lawrence Potempa, Mario Di Napoli, Mark Slevin
Summary: Circulating C-reactive protein (pCRP) concentrations significantly increase during acute and chronic infection and disease, playing a role in complement fixation. It is now known that pCRP dissociates into the monomeric form (mCRP) when exposed to activated immune cells or damaged tissue, becoming biologically active. Studies have shown that mCRP is distributed within the brain tissue of individuals with neuroinflammatory disease and has been linked to neurovascular dysfunction, blood brain barrier compromise, and increased risk of dementia. Future therapeutic options aim to inhibit pCRP-LPC mediated dissociation and prevent associated damage.
Review
Clinical Neurology
Gelsomina Mansueto, Giuseppe Lanza, Jessica Falleti, Pasquale Orabona, Danielle Alaouieh, Emily Hong, Sara Girolami, Marco Montella, Francesco Fisicaro, Anna Galdieri, Puneetpal Singh, Mario Di Napoli
Summary: This review provides a comprehensive update on the clinical assessment, diagnosis, complications, treatment, and follow-up of peripheral nervous system vasculitides (PNSV). Recent advancements in neuroimaging, molecular testing, and peripheral nerve biopsy have improved the clinical assessment and diagnostic accuracy of PNSV. The identification of specific morphological findings has improved the differentiation between systemic and non-systemic neuropathies, leading to more accurate diagnoses and proper management.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Iga Kwiatkowska, Ewa Zekanowska, Simona Lattanzi, Andrea M. Alexandre, Agata Kister-Kowalska, Artur Slomka
Summary: Factor VII activating protease (FSAP) was first isolated from human plasma less than 30 years ago, and its biological properties and role in hemostasis have been extensively studied. The structure of FSAP and its interactions with other proteins and compounds that modulate its activity have been elucidated. This review summarizes the current knowledge on FSAP, including its structure, the processes regulating its activity, and its role in hemostasis and cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Simona Lattanzi, Stefano Meletti, Eugen Trinka, Francesco Brigo, Gianni Turcato, Claudia Rinaldi, Claudia Cagnetti, Nicoletta Foschi, Serena Broggi, Davide Norata, Mauro Silvestrini
Summary: This study aimed to develop a model and nomogram to predict drug resistance in patients with post-stroke epilepsy (PSE). The study identified age, intracerebral hemorrhage, stroke severity, latency of PSE, and status epilepticus as independent predictors of drug resistance. The nomogram showed good predictive accuracy and may serve as a practical tool for personalized prediction of drug-resistant PSE.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Neurosciences
Payam Tabaee Damavandi, Francesco Pasini, Gaia Fanella, Giulia Sofia Cereda, Gabriele Mainini, Jacopo C. DiFrancesco, Eugen Trinka, Simona Lattanzi
Summary: Brain tumor-related epilepsy (BTRE) is a common comorbidity in patients with brain neoplasms. Glutamate receptors antagonist Perampanel (PER) may have therapeutic potential in reducing tumor growth and controlling epileptiform activity. Both pre-clinical and clinical studies suggest that PER can be an effective and well-tolerated option for patients with BTRE, but more research is needed for further understanding of its effects on tumor progression.
