Article
Medicine, General & Internal
Yoo Jin Lee, Eunjae Yoon, Sihyung Park, Yang Wook Kim, Si Eun Kim, Junghae Ko, Jin Han Park, Kang Min Park, Il Hwan Kim, Bong Soo Park
Summary: The study focused on the alterations of structural and functional brain connectivity in neurologically asymptomatic patients with early-stage chronic kidney disease (CKD), finding significant differences in all measures of structural connectivity but not in global functional connectivity. The efficiency of the structural brain network was decreased in CKD patients, with significant differences in certain regions like the right insular cortex, right occipital pole, and right thalamus.
Review
Clinical Neurology
Marion Pepin, Aleksandra Klimkowicz-Mrowiec, Olivier Godefroy, Pilar Delgado, Sol Carriazo, Ana Carina Ferreira, Aleksandra Golenia, Jolanta Malyszko, Tomasz Grodzicki, Konstantinos Giannakou, Giuseppe Paolisso, Michelangela Barbieri, Liliana Garneata, Carmen Antonia Mocanu, Sophie Liabeuf, Goce Spasovski, Carmine Zoccali, Annette Bruchfeld, Ana Farinha, Mustafa Arici, Giovambattista Capasso, Andrzej A. Wiecek, Ziad Massy
Summary: Cognitive impairment is common in patients with chronic kidney disease (CKD). This article reviews interventions for the complications of CKD and prevention of vascular events, which may potentially also be protective against cognitive impairment. Nonpharmacological and pharmacological methods to prevent cognitive impairment and/or minimize its impact on CKD patients' daily lives are discussed. It is necessary to conduct studies assessing the effect of interventions on the cognitive function of patients with CKD.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Hongling Wang, Daquan Liu
Summary: This study aims to identify risk factors for patients with CKD to develop AAE.
Review
Urology & Nephrology
Mehmet Sukru Sever, Kitty J. Jager, Raymond Vanholder, Benedicte Stengel, Jerome Harambat, Patrik Finne, Vladimir Tesar, Myftar Barbullushi, Inga A. Bumblyte, Elena Zakharova, Goce Spasovski, Halima Resic, Andrzej Wiecek, Peter J. Blankestijn, Annette Bruchfeld, Mario Cozzolino, Dimitris Goumenos, Maria Jose Soler, Ivan Rychlik, Kate Stevens, Christoph Wanner, Carmine Zoccali, Ziad A. Massy
Summary: Chronic kidney disease is a significant health problem in Eastern Europe, with differences in prevalence and risk factors compared to Western Europe. Interventions such as raising awareness, early detection, prevention, promoting transplantation and home dialysis, implementing guidelines, and encouraging country-specific research are important for minimizing the impact of CKD in the region. Collaboration with non-nephrology European societies and patient involvement in research are also crucial for addressing CKD-related issues effectively.
CLINICAL KIDNEY JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Victor M. Baiao, Vinicius A. Cunha, Marvery P. Duarte, Francini P. Andrade, Aparecido P. Ferreira, Otavio T. Nobrega, Joao L. Viana, Heitor S. Ribeiro
Summary: Individuals with chronic kidney disease (CKD) show systemic inflammation. Exercise interventions significantly reduce levels of inflammatory markers and increase levels of IL-10 in individuals with CKD. Resistance interventions have greater anti-inflammatory effects compared to aerobic interventions. Combined exercise interventions do not lead to significant changes in inflammatory markers.
Article
Endocrinology & Metabolism
Joao Victor Salgado, Miguel Angelo Goes, Natalino Salgado Filho
Summary: The global nephrology community acknowledges the increasing burden of kidney disease and emphasizes on early diagnosis, understanding of disease progression, and development of new therapeutic interventions. FGF21 is considered a key regulator of lipid, glucose, and energy metabolism, as well as stress responses. While promising results have been shown with FGF21 analogs in metabolic disease, its exact role in kidney function remains poorly understood.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Nutrition & Dietetics
Heitor S. Ribeiro, Silvia G. R. Neri, Juliana S. Oliveira, Paul N. Bennett, Joao L. Viana, Ricardo M. Lima
Summary: Sarcopenia is associated with adverse outcomes in CKD patients, including mortality, hospitalization, and ESKD progression. Low muscle strength, low muscle mass, and low physical performance are specifically related to increased mortality risk in CKD patients.
CLINICAL NUTRITION
(2022)
Article
Transplantation
Debasish Banerjee, Angela Yee-Moon Wang
Summary: Chronic kidney disease is common in heart failure patients and is associated with higher mortality and multiple hospital admissions. Managing heart failure in CKD patients can be challenging due to various factors, but specific therapies have shown improvements in mortality and hospitalizations in certain CKD stages. Personalized, multidisciplinary care is associated with better outcomes and patient satisfaction.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Endocrinology & Metabolism
Huan Yu, Chaoyang Zhang, Yan Cai, Ning Wu, Xiuqin Jia, Jiaojiao Wu, Feng Shi, Rui Hua, Qi Yang
Summary: This study investigated the morphological brain-tissue changes in patients with dialysis- and non-dialysis-dependent chronic kidney disease (CKD), and analyzed the effects of CKD on brain cortical thickness, volume, surface area, and curvature. The results showed that CKD patients exhibited significant and widespread decrease in cortical thickness and volume compared to normal controls. The extent of brain atrophy was further increased in dialysis-dependent CKD patients. The findings suggest that blood urea nitrogen and dialysis may play a role in brain morphological changes in CKD patients.
METABOLIC BRAIN DISEASE
(2023)
Review
Urology & Nephrology
Piyumi Wijewickrama, Jennifer Williams, Steve Bain, Indranil Dasgupta, Tahseen A. Chowdhury, Mona Wahba, Andrew H. Frankel, Mark Lambie, Janaka Karalliedde
Summary: There is a lack of guidelines for managing glucose control in people with diabetes on peritoneal dialysis (PD). Therefore, a summarized review of relevant literature was conducted, focusing on individualized care, burden of hypo-glycemia, glycemic variability, and treatment choices for optimizing glucose control in this population. The lack of sufficient and suitable clinical studies limited the ability to conduct a formal systematic review, but available evidence was reviewed to provide guidance.
KIDNEY INTERNATIONAL REPORTS
(2023)
Review
Nutrition & Dietetics
Aleksandra Beata Juszczak, Maciej Kupczak, Tomasz Konecki
Summary: This narrative review summarizes 98 studies of chronic kidney disease (CKD) and the effects of vitamin supplementation on patients on dialysis. The findings suggest potential effectiveness of certain vitamins, such as B, D, or C, but recommendations for vitamins A and K are still unclear due to potential toxicity. Further research is needed to evaluate the effectiveness and risks of vitamin supplementation for CKD patients.
Review
Urology & Nephrology
Hayet Baouche, Jean-Philippe Jais, Samy Meriem, Mimi Kareche, Olivier Moranne, Cecile Vigneau, Cecile Couchoud
Summary: This systematic review examines the recent data on maternal and foetal outcomes in pregnant women with end-stage renal failure on chronic dialysis over the last decade. The study found that the prognosis of their pregnancies has improved with advances in dialysis treatments and maternal and neonatal care. However, there are significant differences in the practice of treating pregnant women on dialysis among countries.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Surgery
Dharmenaan Palamuthusingam, Carmel M. Hawley, Elaine M. Pascoe, David W. Johnson, Palvannan Sivalingam, Stephen McDonald, Neil Boudville, Matthew D. Jose, Girish Talaulikar, Magid Fahim
Summary: This study found that patients receiving chronic kidney replacement therapy have high rates of surgery and morbidity, with older age, diabetes, dialysis modality, and time all influencing these rates.
Article
Clinical Neurology
Chaoyang Zhang, Huan Yu, Yan Cai, Ning Wu, Shuang Liang, Chun Zhang, Zhiyu Duan, Zhou Zhang, Guangyan Cai
Summary: Neurological damage is commonly observed in individuals with chronic kidney disease (CKD), and this is associated with microstructural damage to the brain white matter and cognitive dysfunction. This study aimed to investigate the correlation between cognitive impairment and diffusion parameters obtained from diffusion tensor imaging (DTI) of abnormal white matter tracts in CKD patients. The results showed extensive white matter microstructural changes and impaired cognitive function in CKD patients, with worse cognitive function and more severe microstructural damage in dialysis-dependent CKD patients compared to non-dialysis-dependent CKD patients.
FRONTIERS IN NEUROLOGY
(2022)
Review
Medicine, General & Internal
Hanna Cholerzynska, Wiktoria Zasada, Hanna Michalak, Milosz Miedziaszczyk, Andrzej Oko, Ilona Idasiak-Piechocka
Summary: Acute kidney injury (AKI) and sudden exacerbation of chronic kidney disease (CKD) often require urgent kidney replacement therapy (UKRT). Peritoneal dialysis (PD) is seen as a viable option for managing these patients. This review examines recent literature on the clinical outcomes of urgent-start peritoneal dialysis (USPD) in CKD and AKI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chi-Lun Ko, Shau-Syuan Lin, Cheng-Wen Huang, Yu-Hui Chang, Kuan-Yin Ko, Mei-Fang Cheng, Shan-Ying Wang, Chung-Ming Chen, Yen-Wen Wu
Summary: This study proposes a polar map-free 3D deep learning algorithm for predicting obstructive coronary artery disease from myocardial perfusion imaging. The algorithm preprocesses the images accurately and demonstrates superior performance compared to previous methods.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Medicine, General & Internal
Kei-Ip Cheong, Hsin-Bang Leu, Chau-Chung Wu, Wei-Hsian Yin, Ji-Hung Wang, Tsung-Hsien Lin, Wei-Kung Tseng, Kuan-Cheng Chang, Shu-Hsun Chu, Hung- Yeh, Jaw-Wen Chen, Yen-Wen Wu
Summary: This study aimed to evaluate the association between osteopontin (OPN) levels and the prognosis of Taiwanese patients with chronic coronary syndrome (CCS). The results showed that higher OPN levels were associated with an increased risk of hospitalization for acute myocardial infarction (AMI). However, combining OPN with hs-CRP did not improve the prediction of cardiovascular outcomes.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Ching-Chi Chi, Yen-Wen Wu, Ting-Hsing Chao, Chih-Chiang Chen, Yi-Ju Chen, Hao-Min Cheng, Hsien-Yi Chiu, Yu-Wei Chiu, Wen-Hung Chung, Tsu-Yi Hsieh, Po-Hsun Huang, Yu-Huei Huang, Shang-Hung Lin, Tsung-Hsien Lin, Kwo-Chang Ueng, Chun-Chieh Wang, Yu-Chen Wang, Nan-Lin Wu, Charles Jia-Yin Hou, Tsen-Fang Tsai
Summary: Psoriatic disease, a chronic inflammatory disorder with skin and joint manifestations, is associated with an increased risk of cardiovascular diseases due to the shared pathogenic mechanisms between psoriatic and CV diseases. Therefore, attention to cardiovascular comorbidities is crucial in the management of psoriasis, particularly in screening, primary prevention, and treatment selection. The collaboration between dermatology, cardiology, and rheumatology experts has led to consensus expert recommendations for the management of patients with psoriatic disease with a focus on CV comorbidities.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Urology & Nephrology
Mei-Fen Pai, Kuei-Ting Tung, Shih-Ping Hsu, Yu-Sen Peng, Wan-Yu Lin, Ju-Yeh Yang, Hon-Yen Wu, Yen-Ling Chiu, Kai-Hsiang Shu, Wan-Chuan Tsai
Summary: This study aimed to identify adverse events following the first three doses of COVID-19 vaccines in hemodialysis (HD) patients. Risk factors associated with postvaccination adverse events were explored. Age, sex, dialysis vascular access and vaccine types were found to be associated with postvaccination adverse events.
Editorial Material
Medicine, General & Internal
Ai-Hsien Li, Yen-Ling Chiu
Summary: Chen et al. compared the prognostic impact of an H2RA and a PPI in patients with chronic renal disease. They found a dose-response relationship between H2RA and reduced risk of ESRD and overall mortality, while PPI treatment was associated with increased overall mortality in CKD patients. However, further clarification of methodological and research concerns is needed before drawing a convincing conclusion.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Kuan-Yin Ko, Chi-Lun Ko, Chii-Ming Lee, Ju-Shin Cheng, Yen-Wen Wu, Ron-Bin Hsu, Yih-Sharng Chen, Shoei-Shen Wang, Ruoh-Fang Yen, Mei-Fang Cheng
Summary: This study investigated the diagnostic performance of Tc-99m and Tl-201 tracers in assessing cardiac allograft vasculopathy (CAV) in heart transplant patients using cadmium-zinc-telluride (CZT) single-photon emission computed tomography (SPECT) for myocardial blood flow (MBF) and myocardial flow reserve (MFR) quantification. The results showed that CZT SPECT using Tl-201 and Tc-99m tracers had comparable MBF and MFR, and correlated well with (13) N-NH3 PET.
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Review
Pathology
Yueh Lee, Siao-Muk Cheng, Daw-Yang Hwang, Yen-Ling Chiu, Yueh-Hung Chou
Summary: Secondary polycythemia is a paraneoplastic syndrome characterized by excessive erythropoietin (EPO) production in tumors. Renal cell carcinoma (RCC) and cerebellar hemangioblastoma are the most well-known tumors associated with secondary polycythemia. This case study presents a rare occurrence of renal hemangioblastoma causing erythrocytosis in a 19-year-old male. The diagnosis was established through immunohistochemistry to confirm intratumoural EPO production and whole-exome sequencing to identify potential genetic alterations.
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Li-Jen Liao, Wan-Lun Hsu, Chi-Ju Chen, Yen-Ling Chiu
Summary: Nasopharyngeal carcinoma is endemic in southern Asia and this article describes the molecular abnormalities in NPC and potential molecular mechanisms for future therapy. It provides an up-to-date review on the molecular pathways of NPC, improving our understanding of the disease and highlighting areas for further research.
Article
Multidisciplinary Sciences
Shan-Ying Wang, Kuan-Heng Lin, Yen-Wen Wu, Chih-Wei Yu, Shu-Ya Yang, Pei-Wei Shueng, Chen-Xiong Hsu, Tung-Hsin Wu
Summary: Adjuvant breast radiotherapy reduces local recurrence risk but increases the risk of cardiotoxicity. This study aimed to evaluate cardiac subvolume doses and corresponding perfusion defects after breast cancer radiotherapy. Results showed that radiation doses were higher in segments with new perfusion defects compared to those without, suggesting that even low radiation doses may cause cardiac perfusion decline.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Shan-Ying Wang, Wei-Ta Tsai, Kuan-Heng Lin, Chih-Wei Yu, Shu-Ya Yang, Pei-Wei Shueng, Yen-Wen Wu, Chen-Xiong Hsu, Tung-Hsin Wu
Summary: This study aimed to integrate the 20 subvolume dose of left ventricle and Tl-201 single photon emission computed tomography (SPECT) with myocardial perfusion imaging (MPI) parameters to evaluate the cardiac condition of breast cancer patients after radiation therapy. The results showed that left-sided breast cancer patients received higher radiation doses to the heart, left ventricular, and its territories and subvolumes compared to right-sided breast cancer patients. The study also found a significant decline in wall motion and wall thickening in the coronary artery territories of both sides.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mei-Fang Cheng, Yue Leon Guo, Ruoh-Fang Yen, Yen-Wen Wu, Hsiu-Po Wang
Summary: This study aimed to determine whether inflammation levels detected by 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) could predict disease relapse in immunoglobulin G4-related disease (IgG4-RD) patients receiving standard induction steroid therapy. The results showed that whole-body total lesion glycolysis (WTLG) > 600 on FDG-PET was an independent risk factor for disease relapse, and could be used for guiding the treatment and management of IgG-RD patients.
KOREAN JOURNAL OF RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Chun-Chieh Wang, Wei-Ting Chang, Yen-Hung Lin, Bing-Hsiean Tzeng, Ting-Hsing Chao, Chung-Lieh Hung, Yen-Wen Wu, Cheng-Hsuan Tsai, Wei-Wen Lin, Kuan-Cheng Chang, Hung-Yu Chang, Wen-Chung Yu, Wen-Hwa Wang, Cheng- Cheng, Tzung-Dau Wang, Charles Jia-Yin Hou, Wen-Jone Chen
Summary: Cardiac amyloidosis is a form of systemic amyloidosis characterized by abnormal amyloid fibril deposits in the myocardium, leading to heart failure and conduction disturbances. The incidence and prevalence of cardiac amyloidosis are higher than previously thought, especially in special populations. The diagnosis of cardiac amyloidosis is often delayed, highlighting gaps in knowledge and lack of multidisciplinary teamwork in clinical practice.
ACTA CARDIOLOGICA SINICA
(2023)
Article
Cardiac & Cardiovascular Systems
Chern-En Chiang, Chung-Lieh Hung, Yen-Wen Wu, Tsung-Hsien Lin, Kwo-Chang Ueng, Shih-Hsien Sung, Cho-Kai Wu, Ting-Hsing Chao, Hung-Ju Lin, Yen-Hung Lin, Jin-Long Huang, Michael Yu Chih Chen, Po-Lin Lin, Tze-Fan Chao, Hao-Min Cheng, Ming-En Liu, Tzung-Dau Wang, Hung- Yeh, Yi-Heng Li, Ping-Yen Liu, Wei-Hsian Yin, I-Chang Hsieh, Chun-Chieh Wang, Chen-Huan Chen, Pao-Hsien Chu, Shing-Jong Lin, San-Jou Yeh, Jiunn-Lee Lin, Juey-Jen Hwang, Huei-Fong Hung, Wen-Jone Chen, Charles Jia-Yin Hou
Summary: The prevalence of heart failure is increasing and has become a significant burden on healthcare systems worldwide. Despite the availability of effective treatments, mortality rates remain high. In order to prioritize and integrate these therapies for Asian patients, the Taiwan Society of Cardiology has formed a working group to create a consensus on pharmacological treatment for chronic heart failure.
ACTA CARDIOLOGICA SINICA
(2023)
Letter
Cardiac & Cardiovascular Systems
Pei-Lin Lee, Yen-Wen Wu
ACTA CARDIOLOGICA SINICA
(2023)
Article
Multidisciplinary Sciences
Hung-Chih Chen, Yen-Wen Liu, Kuan-Cheng Chang, Yen-Wen Wu, Yi-Ming Chen, Yu-Kai Chao, Min-Yi You, David J. Lundy, Chen-Ju Lin, Marvin L. Hsieh, Yu-Che Cheng, Ray P. Prajnamitra, Po-Ju Lin, Shu-Chian Ruan, David Hsin-Kuang Chen, Edward S. C. Shih, Ke-Wei Chen, Shih-Sheng Chang, Cindy M. C. Chang, Riley Puntney, Amy Wu Moy, Yuan-Yuan Cheng, Hsin-Yuan Chien, Jia-Jung Lee, Deng-Chyang Wu, Ming-Jing Hwang, Jennifer Coonen, Timothy A. Hacker, C-L. Eric Yen, Federico E. Rey, Timothy J. Kamp, Patrick C. H. Hsieh
Summary: The study reveals the role of butyrate-producing bacteria in the post-response to myocardial infarction (MI). Through analysis using animal models and machine learning, the researchers found that these bacteria can produce beta-hydroxybutyrate, which improves cardiac function. Further experiments confirmed this finding and highlighted the significance of butyrate-producing bacteria and beta-hydroxybutyrate in improving post-MI outcomes.
NATURE COMMUNICATIONS
(2023)
