Journal
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
Volume 164, Issue -, Pages 514-519Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jpba.2018.11.025
Keywords
Salazosulfapyridine; Carbon quantum dots; Ginkgo leaf; Fluorescence; Plasma
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Funding
- National Natural Science Foundation of China [21765004, 21365006]
- Guangxi Science Foundation of China [2014GXNSFDA118004, 1598025-4]
- Innovation Project of Guangxi Graduate Education [YCSZ2013039]
- State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University) [CMEMR2017-A5]
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A simple, economical hydrothermal strategy for synthesizing nitrogen-doped carbon quantum dots (N-CQDs) was developed using Ginko leaves as a carbon source. These N-CQDs have strong blue fluorescence, excitation-relevant emissions, high monodispersity, good stability, good water solubility, and a 22.8% fluorescence quantum yield. They average 3 nm in size, and have maximum excitation and emission wavelengths of 350 and 436 nm, respectively. They are used as an effective fluorescent sensing platform for the label-free sensitive detection of salazosulfapyridine (SASP) due to the strong quenching effect of SASP. When SASP concentration is 0.1-80 mu mol/L, there is a good linear relationship with a detection limit of 40 nmol/L. This method was successfully applied to detect SASP in mouse plasma. The results show that the SASP recovery range was 96%-101%. RSDs ranged from 2.6% to 3.1%. (C) 2018 Elsevier B.V. All rights reserved.
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