Article
Chemistry, Physical
Sidi Cheng, Yu Luo, Ting Yu, Jing Li, Chunfang Gan, Shuang Luo, Qiang Zhu
Summary: An unactivated alkene was successfully subjected to 1,2-difunctionalization through a palladium-catalyzed four-component cascade reaction, leading to the convenient synthesis of acetamides with various substituents and pyrrolo-fused heterocycles.
Article
Chemistry, Physical
Zhi-Peng Bao, Youcan Zhang, Xiao-Feng Wu
Summary: In this study, a palladium-catalyzed four-component difluoroalkylative carbonylation reaction was developed, leading to the synthesis of a variety of β-difluoromethylene substituted amide derivatives with high yields. Ethylene gas can also be transformed into the corresponding products, and this reaction can be applied to the synthesis of various natural products or bioactive molecules.
JOURNAL OF CATALYSIS
(2022)
Article
Chemistry, Physical
Fabien J. T. Talbot, Shibo Zhang, Bishnupada Satpathi, Gareth P. Howell, Gregory J. P. Perry, Giacomo E. M. Crisenza, David J. Procter
Summary: A new synthetic method has been developed in this study to efficiently and selectively synthesize densely functionalized BCBs compounds, which can also be extended to the synthesis of other organic derivatives. The results provide new ideas and technical support for the synthesis of BCB compounds with specific functions.
Article
Chemistry, Organic
Xuelun Duan, Nan Zheng, Gongbo Liu, Ming Li, Qiming Wu, Xinhao Sun, Wangze Song
Summary: A novel four-component reaction has been developed for the efficient synthesis of polyfunctionalized triazoles. This reaction involves the formation of four C-N bonds in one step under mild conditions, using alkynes, amines, azides, and 2H-azirines as reactants.
Article
Chemistry, Organic
Zhenli Xu, Zongxue Zhang, Chenxiang Meng, Xiaoya Zhang, Kai Xu, Lantao Liu, Tao Wang, Haiyun Xu, Guoliang Mao
Summary: A ligand-free Pd-catalyzed hydrophosphorylation of internal alkynes with diphenyl H-phosphonate in various alcohols was reported for the synthesis of E-vinylphosphonates. This practical three-component reaction showed high stereoselectivity, broad substrate scope, and no need for additional ligands.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Dipak B. Deokar, Soumi Laha, B. Sridhar, Dharmendra Kumar Tiwari, Pravin R. Likhar
Summary: A palladium-catalyzed coupling reaction followed by dual annulation has been developed for the synthesis of various triazolo/pyrrolo fused benzofuro-quinolines from readily available starting materials. This method involves palladium-catalyzed Sonogashira coupling, benzan-nulation, and C-H activation triggered second annulation reaction cascades in a single pot. The polycyclic compound formed by this method consists of three different heterocyclic structures: benzofuran, quinoline, and triazole/pyrrole. The method provides a simple access to obtain a range of fused benzofurotriazalo/pyrroloquinolines in good to moderate yields.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Jakub Vaith, Dasha Rodina, Gregory C. Spaulding, Shauna M. Paradine
Summary: We developed ureas as sterically undemanding pro-ligands for Pd catalysis. N-Arylureas showed better performance than phosphine ligands in Pd-catalyzed reactions, enabling the heteroannulation of N-tosyl-o-bromoanilines and 1,3-dienes to prepare 2-substituted indolines, even with sterically demanding substrates. Experimental and computational studies confirmed the monodentate binding through the nonsubstituted nitrogen in Pd-urea complexes, which is uncommon for metal-ureate complexes.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Chemistry, Multidisciplinary
Bing Xu, Quanpu Wang, Chao Fang, Zhan-Ming Zhang, Junliang Zhang
Summary: This review summarizes the latest advancements in enantioselective palladium-catalyzed cyclization reactions over the past eleven years. The review is organized into thirteen sections based on the different types of transformations involved. Chiral palladium catalysts have shown outstanding features in promoting a plethora of enantioselective cyclization reactions, providing convenient access to structurally diverse chiral carbo- and hetero-cycles.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Yang Yuan, Jian-Xing Xu, Xiao-Feng Wu
Summary: A cooperative Cu/Pd-catalyzed multi-component borocarbonylation of ethylene with aryl iodides was reported, providing a variety of synthetically useful beta-boryl ketones in good yields.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Physical
Nikita Kvasovs, Valeriia Iziumchenko, Vitalii Palchykov, Vladimir Gevorgyan
Summary: This method utilizes visible light-induced generation of nucleophilic hybrid alkyl Pd radical intermediates to achieve efficient atom economical C-C bond construction of alkyl-substituted oximes, allowing a broad range of primary, secondary, and tertiary alkyl bromides and iodides, as well as a range of different formaldoximes, to efficiently undergo this transformation.
Article
Chemistry, Multidisciplinary
Yong Shen, Minjie Xiang, Song Wu, Zibin Zhang, Shijun Li, Chunsong Xie
Summary: The innovation of versatile multi-component reaction modes for one-pot assembly of polyfunctional arenes is achieved by orchestrating mechanistically sequential and compatible palladium-catalyzed domino carbopalladation of arynes and norbornene (NBE)-mediated Catellani processes. Balancing the reaction parameters, especially the loading amount of NBE, is crucial for the success of the reaction. The method can tolerate a wide selection of functional groups and conveniently obtain polyfunctional arenes with diverse substitutions.
CELL REPORTS PHYSICAL SCIENCE
(2021)
Article
Chemistry, Organic
Peter G. N. Neate, Bufan Zhang, Jessica Conforti, William W. Brennessel, Michael L. Neidig
Summary: Dilithium amides have been developed as a bespoke and general ligand for iron-catalyzed Kumada-Tamao-Corriu cross-coupling reactions, allowing for diverse coupling reactions without significant modification of the catalytic protocol. This represents a rare example of a single iron-catalyzed system effective across various coupling reactions while remaining operationally simple.
Article
Chemistry, Multidisciplinary
Srividhya Sundaram, Christoph Diehl, Nina Socorro Cortina, Jan Bamberger, Nicole Paczia, Tobias J. Erb
Summary: The study introduced a modular in vitro platform for the continuous conversion of CO2 into complex multi-carbon compounds, paving the way for future synthesis of CO2-based chemicals.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Guangkuo Zeng, Lingyun Shen, Qingshu Zheng, Tao Tu
Summary: In this study, a palladium-catalyzed dehydrogenation-coupling-aromatization protocol was developed to access ortho-substituted phenols from cyclohexanols with primary alcohols. The method demonstrated broad substrate scope and resulted in clean byproducts of water and hydrogen gas. The ortho-mono- and ortho-disubstitutions could be readily controlled by N-heterocyclic carbene (NHC) ligands and the amount of base.
Article
Chemistry, Physical
Mario Prejano, Raffaella Mancuso, Tiziana Marino, Bartolo Gabriele
Summary: In this study, a detailed computational investigation was conducted on the conversion of 1-(methylthio)-3-yn-2-ols to thiophene-3-carboxylate esters using PdI2/KI catalyst. The study provides insights into the role of each species involved in the reaction mechanism and confirms the experimental data.
JOURNAL OF CATALYSIS
(2023)
Article
Chemistry, Inorganic & Nuclear
Nisha Kamboj, Atanu Betal, Moumita Majumder, Satyajit Sahu, Ramesh K. Metre
Summary: We report a new square-planar complex [CoIIL] synthesized from the phenalenyl-derived ligand LH2. The structure of the [CoIIL] complex was confirmed using single-crystal X-ray diffraction. The complex exhibited stable and reproducible resistive switching behavior in a memory device, which was attributed to the role of the CoII metal center and π-conjugated phenalenyl backbone.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Pritam Maity, Joydeep Chatterjee, Kiran T. Patil, Sahil Arora, Madhurendra K. Katiyar, Manvendra Kumar, Amirreza Samarbakhsh, Gaurav Joshi, Priyadeep Bhutani, Manoj Chugh, Navnath S. Gavande, Raj Kumar
Summary: Epidermal growth factor receptor (EGFR) is a critical oncogenic drug target involved in multiple cellular functions. Despite the approval of small-molecule tyrosine kinase inhibitors (TKIs) and monoclonal antibodies (mAbs), limitations such as cancer heterogeneity and drug resistance persist. To overcome these limitations, novel modalities like molecular degraders have gained attention. This article provides an overview of traditional and existing anti-EGFR therapies and discusses the design, synthesis, applications, and future opportunities of each modality.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Organic
Vivek Sharma, Kailas Arjun Chavan, Ghanshyam Mali, Dipanjana Sarkar, Prem Lama, Moumita Majumder, Rohan D. Erande, Ramesh K. Metre
Summary: A nickel(II) complex [Ni(HL)2] 1 was synthesized through the reaction of a new catecholaldimine-based ligand with NiCl2 center dot 6H2O in methanol at room temperature. The complex displayed excellent catalytic activity, enabling the rapid conversion of aromatic and heterocyclic alcohols into trans-cinnamonitrile via oxidative olefination in the presence of KOH. DFT studies provided further support for the potential and results of the catalyst in the direct conversion of alcohols to two different functionalities (trans-cinnamonitrile and aldehydes).
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Sandhya Chahal, Payal Rani, Gaurav Kiran, Jayant Sindhu, Gaurav Joshi, Aravindhan Ganesan, Subha Kalyaanamoorthy, Rajvir Mayank, Parvin Kumar, Rajvir Singh, Arvind Negi
Summary: COX-II is an important therapeutic target, but the use of COX-II inhibitors may cause cardiovascular side effects, so there is a need to develop inhibitors that have both inhibitory potency and no side effects.
Article
Chemistry, Physical
Sunita Birara, Atanu Betal, Prem Lama, Satyajit Sahu, Ramesh K. Metre
Summary: This article presents the synthesis, structure, and write once read many (WORM) type memory behavior of an ionic organotin complex containing a 2-pyridine substituted formazan ligand. The complex exhibited unique WORM switching memory characteristics with a high switching on-off ratio of 10^4, low switching voltage, and good reading capability when used in a MIM type memory device. This work provides a new direction for the rational design and fabrication of high-performance WORM type memory devices based on ionic organotin complexes.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Vishal Kathuria, Kiran, Payal Rani, Mayank, Gaurav Joshi, Roshan Kumar, Jayant Sindhu, Parvin Kumar, Arvind Negi, Sudhir Kumar
Summary: This article presents two new turn-off fluorescent sensors (V3 and V4) that have the potential application for precise detection of Fe3+ and diethylchlorophosphate (DCP). The sensors are designed with oxazolonaphthoimidazo [1,2-a]pyridine scaffold integrated with anthracene and pyrene-based framework, enabling twisted intramolecular charge transfer (TICT) and planarised intramolecular charge transfer (PLICT) mechanisms. The V3 and V4 probes exhibit high sensitivity and selectivity for Fe3+ and DCP detection. The detection limits for Fe3+ are 14.1 and 4.5 nM for V3 and V4, respectively. Intracellular detection of Fe3+ using confocal live cell imaging is also demonstrated, highlighting the potential application of V3 and V4 for on-spot monitoring of Fe3+ and DCP, even in the presence of interfering analytes.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Neurosciences
Abhilash Ludhiadch, Sandeep Sulena, Sandeep Singh, Sudip Chakraborty, Dixit Sharma, Mahesh Kulharia, Paramdeep Singh, Anjana Munshi
Summary: This study evaluates the association between MPV and PLT count with genetic variation and its impact on the development of ischemic stroke and its subtypes. The results suggest that THPO and ARHGEF3 genes play a significant role in determining MPV values and are associated with platelet activation, aggregation, and cytoskeleton rearrangements. These findings highlight the potential of MPV as a biomarker and therapeutic target for ischemic stroke.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Kapil Kumar Goel, Somesh Thapliyal, Rajeev Kharb, Gaurav Joshi, Arvind Negi, Bhupinder Kumar
Summary: This article discusses the structure-activity relationship and development overview of imidazole derivatives as antidepressant drugs, as well as their role in modulating the serotonergic system.
Article
Chemistry, Multidisciplinary
Bara Singh, Arshad J. Ansari, Nirmal Malik, S. S. V. Ramasastry
Summary: In this study, a structured remodeling of designed pyridinium salts was achieved through an interrupted Corey-Chaykovsky reaction, leading to the synthesis of unprecedented multi-ring compounds such as vicinal bis-spirocyclic indanones and spirannulated benzocycloheptanones. By rationally combining nucleophilic sulfur ylides with electrophilic pyridinium salts, a regio- and stereoselective synthesis of new classes of cyclopropanoids was achieved. Plausible mechanistic pathways were proposed based on experimental results and control experiments.
Review
Oncology
Rhuthuparna Malayil, Yogita Chhichholiya, Kanika Vasudeva, Harsh Vikram Singh, Tashvinder Singh, Sandeep Singh, Anjana Munshi
Summary: Oncogenic metabolic reprogramming affects the abundance of key metabolites regulating signaling and epigenetics. The Warburg effect demonstrates the metabolic vulnerability of cancer cells. Research on metabolism in breast cancer is focused on. The mechanisms underlying metabolic reprogramming in breast cancer are complex and only partially understood.
Review
Oncology
Yogita Chhichholiya, Harsh Vikram Singh, Sandeep Singh, Anjana Munshi
Summary: MicroRNAs (miRNAs) can negatively regulate gene expression by binding to specific mRNAs, which can lead to mRNA degradation or translational repression. Abnormal expression of various miRNAs has been linked to human cancer, including breast cancer (BC), where oncogenic or tumor-suppressor miRNAs regulate important pathways involved in BC development. Genetic variations in miRNA-encoding genes and their target genes contribute to dysregulated gene expression and the progression of BC. Therapeutic approaches for BC include chemotherapy, radiation therapy, surgery, hormone therapy, and targeted biological therapy. This review examines the genetic variations in tumor-suppressor miRNA-encoding genes and their target genes in relation to BC development and prognosis, as well as discusses potential therapeutic interventions targeting these variants for improved disease outcomes.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sandhya Chahal, Jyoti Punia, Payal Rani, Rajvir Singh, Mayank, Parvin Kumar, Ramesh Kataria, Gaurav Joshi, Jayant Sindhu
Summary: This study developed a series of thiazole-clubbed hydrazones, which showed inhibitory activity against α-amylase and anticancer activity. The synthesized compounds 5a-5aa exhibited better α-amylase inhibitory activity compared to the reference drug acarbose. Compounds 5e, 5f, and 5y showed notable inhibition of cancer cell growth, which correlated with their α-amylase inhibitory activity.
RSC MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
T. P. Sri Laasya, Somesh Thapliyal, Kapil Kumar Goel, Bhupinder Kumar, Ramarao Poduri, Gaurav Joshi
Summary: This study analyzed the components of Boerhaavia diffusa and found that alkaloids, carbohydrates, saponins, phytosterols, flavonoids, and glycosides were present in the methanolic extract of roots, while they were absent in the petroleum ether extract. Phytosterols were found in the ethyl acetate extract, but other components were absent. Cell experiments showed that the ethyl acetate root extract (LEA) and petroleum ether root extract had higher cell survival rates and better safety profiles at a dose of 1 mg/mL.
SEPARATION SCIENCE PLUS
(2023)
Article
Chemistry, Inorganic & Nuclear
Sunita Birara, Shalu Saini, Moumita Majumder, Prem Lama, Shree Prakash Tiwari, Ramesh K. Metre
Summary: In this paper, the synthesis and characterization of a redox-active zinc complex and its application in resistive switching memory are reported. The complex exhibits high conductance switching, a large ON-OFF ratio, and long retention time. The resistive switching behavior is explained by a trap-controlled space charge limited current mechanism. This study provides important insights into the molecular design of transition metal complexes for memory applications and demonstrates the cost-effectiveness and sustainability of non-volatile resistive random access memory (RRAM) devices with inorganic/organic hybrid active layers.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Nisha Kamboj, Ayan Dey, Prem Lama, Moumita Majumder, Srijan Sengupta, Ramesh K. Metre
Summary: Closed-shell phenalenyl (PLY) systems are increasingly attractive as building blocks for catalysts and electrode materials due to their ability to accept electrons and participate in redox reactions. In this study, a PLY-based dinuclear [FeIII2(hmbh-PLY)3] complex was synthesized and used as a cathode material in a H2O2 fuel cell, exhibiting exceptional power density compared to previously reported Fe-based complexes. DFT studies were performed to gain insights into the catalytic reduction of H2O2 by the Fe-center of the complex.
DALTON TRANSACTIONS
(2023)
