Article
Dermatology
Howyda M. Ebrahim, Reham Elkot, Waleed Albalate
Summary: The results of the study suggest that the combination of microneedling with tacrolimus is significantly more effective in treating vitiligo, with a higher percentage of patients achieving over 75% repigmentation compared to tacrolimus alone. Additionally, the combination therapy showed faster response and more significant improvement in the legs and extremities.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2021)
Article
Dermatology
A. Salava, M. Perala, A. Pelkonen, M. Makela, A. Remitz
Summary: Topical tacrolimus (0.03% and 0.1%) and topical corticosteroids (mild and moderate potency) are safe and effective in treating moderate to severe atopic dermatitis in young children.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Manon Paul-Traversaz, Kaoru Umehara, Kenji Watanabe, Walid Rachidi, Michel Seve, Florence Souard
Summary: Managing skin wound healing problems is a public health issue that can be addressed by traditional herbal medicines, such as Kampo medicine. Three traditionally used ointments, Shiunko, Chuoko, and Shinsen taitsuko, have a lipophilic base and incorporate herbal crude drugs extracted from botanical genera such as Angelica, Lithospermum, Curcuma, etc. The content of metabolites in these ointments is influenced by various factors, and further research is needed to explore their therapeutic potential for wound healing in Kampo medicine.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Dermatology
Deepak Kumar, Vishal Thakur, Kiruthika Subburaj, Anuradha Bishnoi, Keshavamurthy Vinay, Muthu Sendhil Kumaran, Davinder Parsad
Summary: This study found that the application of 0.1% tacrolimus ointment can effectively prevent the appearance of new lesions and promote repigmentation in unstable acral vitiligo. Moreover, using the ointment on both affected and unaffected skin yields better results.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Yujie Dong, Qi Yang, Baofeng Guo, Jiajing Zhu, Xiaojie Sun
Summary: Combination treatment with tacrolimus and phototherapy was more effective than phototherapy alone for patients with vitiligo, especially in lesions located in the face and proximal limbs. Children had a higher excellent response rate, and other demographic and clinical variables such as gender and disease duration did not significantly impact treatment effectiveness. Further large-scale, well-executed trials are needed to confirm these findings.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2021)
Article
Dermatology
Julien Seneschal, Alexandra Duplaine, Herve Maillard, Thierry Passeron, Nicolas Andreu, Regis Lassalle, Clelia Favary, Catherine Droitcourt, Alain Taieb, Khaled Ezzedine
Summary: In adult patients with facial vitiligo, twice-daily use of tacrolimus 0.1% ointment showed superior efficacy compared to the vehicle over 24 weeks of intervention and 24 weeks of follow-up. Therapeutic success rate was 65%, with only a 40% relapse rate at week 48.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dermatology
Samia M. Esmat, Heba Ismail Gawdat, Rehab A. Hegazy, Farah Sayed Ahmed, Eman Raafat Said
Summary: The study aimed to evaluate different methods of enhancing the absorption of topical tacrolimus in extra-facial vitiligo sites using microneedling and occlusion. Results showed that the combination of microneedling and topical tacrolimus had an edge over monotherapy in vitiligo treatment, but there was no statistically significant difference in repigmentation percentage between the four treatment areas.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Review
Immunology
Erica L. Katz, John E. Harris
Summary: Vitiligo is a skin disease characterized by white spots, and significant progress has been made in understanding its pathogenesis over the past 30 years through perseverance, collaboration, and open-minded discussion. Researchers have explored various possible mechanisms through innervation, microvascular anomalies, oxidative stress, defects in melanocyte adhesion, autoimmunity, somatic mosaicism, and genetics, with animal models and improved patient sample collection methods playing important roles in translational studies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Dermatology
Ramadan Saleh, Aml Abd-Elaziz Ahmed, Wafaa Abd-Elmagid
Summary: Topical tacrolimus is increasingly used in the treatment of vitiligo. This study showed that 45% of NSV patients achieved repigmentation after 24 weeks of treatment with tacrolimus 0.03% monotherapy. Tacrolimus-induced repigmentation is more likely in patients with vitiligo vulgaris, head and neck lesions, skin phototype III, and young age.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Dermatology
Diala M. Alshiyab, Firas A. Al-qarqaz, Jihan M. Muhaidat, Yousef S. Alkhader, Ruba F. Al-sheyab, Sala I. Jafaar
Summary: This study aimed to assess the synergic effect of pseudocatalase/superoxide dismutase (PSD) gel when combined with Tacrolimus 0.1% ointment versus Tacrolimus 0.1% alone for the treatment of vitiligo. The results showed that adding PSD to Tacrolimus ointment did not provide any additional therapeutic benefit in children with limited vitiligo.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Engineering, Chemical
Sylwester Mazurek, Kamil Pichlak, Roman Szostak
Summary: This study conducted a quantitative analysis of vitamins A and E in commercial ointments using partial least squares models based on FT Raman spectra. The composition of samples was controlled through principal component analysis, and the Raman technique was found to allow for accurate analysis of semisolid formulations.
Review
Biochemistry & Molecular Biology
Nika Hlaca, Tina Zagar, Marija Kastelan, Ines Brajac, Larisa Prpic-Massari
Summary: Vitiligo is an acquired immune-mediated disorder of pigmentation characterized by depigmented or chalk-white macules and patches on the skin. It has a significant impact on patients' social and emotional aspects of life. Genetic predisposition and environmental triggers are involved in the development of vitiligo. Immune cells and their mediators play a critical role in the immunopathogenesis, leading to apoptosis of melanocytes.
Article
Dermatology
J. Shourick, J. Seneschal, N. Andreu, J-M Meurant, I Pane, P. Ravaud, V-T Tran, K. Ezzedine
Summary: This study developed and validated a patient reported measurement of the burden of treatment in vitiligo, with results suggesting four domains ('Finding a doctor', 'Phototherapy', 'Topical treatment', and 'Impact on outdoor activities and photoprotection'). The total score of the measurement was well correlated with DLQI, VIP, and TBQ scores, and the agreement between test and retest was good.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
N. van Geel, L. Depaepe, V. Vandaele, L. Mertens, J. Van Causenbroeck, S. De Schepper, L. Van Coile, A. Van Reempts, A-S De Vos, J. Papeleu, I Hoorens, D. Mertens, A. Wolkerstorfer, J. E. Lommerts, R. Speeckaert
Summary: The study aimed to develop and validate the Vitiligo Disease Activity Score (VDAS) and Vitiligo Disease Improvement Score (VDIS) to assess the evolution of vitiligo lesions over time. The results demonstrate that VDAS and VDIS are valid, reliable, and feasible instruments for evaluating vitiligo activity and improvement. These scores meet the urgent need for a simple, standardized, and practical assessment of vitiligo.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Review
Immunology
Chen Lyu, Yonghu Sun
Summary: Vitiligo is a skin disorder characterized by the loss of melanocytes. The pathogenesis of vitiligo involves immunometabolism, including mitochondrial dysfunction, oxidative stress, and defects in metabolic pathways. These abnormalities are influenced by genetic and epigenetic factors and are associated with glucose and lipid metabolism. Melanocytes, keratinocytes, and tissue-resident memory T cells play important roles in the dysregulation of metabolic pathways in vitiligo.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Surgery
Carlo M. Oranges, Vendela Grufman, Pietro G. di Summa, Elmar Fritsche, Daniel F. Kalbermatten
Summary: This study conducted a systematic literature review to analyze the outcomes and complications associated with different chin augmentation techniques. All techniques achieved satisfactory cosmetic outcomes, but caution is needed to avoid nerve injuries and overcorrection or undercorrection.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Orthopedics
William Watfa, Gianluca Sapino, Francesco Teatini, Carlo M. M. Oranges, Mario Cherubino, David Guiller, Wassim Raffoul, Pietro G. G. di Summa
Summary: This study aimed to evaluate which flap or patient-related factors may predict flap reinnervation by comparing and analyzing a standardized reconstructive procedure. The results showed that flaps of smaller surface area had a significantly better recovery in sensory discrimination and sensory cutaneous pressure perception.
JOURNAL OF PLASTIC SURGERY AND HAND SURGERY
(2023)
Article
Medicine, General & Internal
Nora Holopainen, Carlo M. M. Oranges, Pietro G. G. di Summa, Francesca Toia, Salvatore Giordano
Summary: The aim of this study was to assess the return to work for women with breast hypertrophy after reduction mammaplasty. The occurrence of postoperative complications increased the patients' return to work time, while comorbidities and preoperative parameters did not affect the length of sick leave. Based on individual variations, a recovery period of approximately 3 weeks is suggested.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Oskari Repo, Carlo M. Oranges, Pietro G. di Summa, Panu Uusalo, Mikael Anttinen, Salvatore Giordano
Summary: Preserving Scarpa fascia can reduce the occurrence of seroma and shorten the duration of drainage in MWL patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Juan A. Viscardi, Ebai A. Eseme, Andreas Gohritz, Mathias Tremp, Rastine Merat, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: This article presents a multistaged procedure using a keystone flap and a temporary synthetic skin substitute to reconstruct a large arm defect. The procedure is complex but resulted in a satisfactory outcome after an 8-month follow-up.
PLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN
(2023)
Article
Orthopedics
Nimatullah Idris, Matthieu Zingg, Morgan Gauthier, Carlo M. M. Oranges, Daniel F. F. Kalbermatten, Didier Hannouche
Summary: This case report describes a complication of extensive skin necrosis after total hip arthroplasty, but without joint infection. The patient underwent debridement and tissue reconstruction, and achieved satisfactory outcomes with pain-free hip and restored motion after 1 year.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Review
Obstetrics & Gynecology
Giovanni Sisti, Cecilia Fochesato, Deena Elkafrawi, Brooke Marcus, Antonio Schiattarella
Summary: Hypertensive disorders of pregnancy affect a significant number of pregnant women globally and has serious implications for fetal and maternal health. This study found evidence of poor pregnancy outcomes in patients with blood pressure below the accepted cut-off of 140/90 mmHg, indicating the need for interventions to reduce the risk of hypertensive disorders in pregnancies with blood pressures ranging from 120-139/80-89 mmHg.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Review
Obstetrics & Gynecology
Giovanni Sisti, Gal Rubin, Chi Zhou, Teresa Orth, Antonio Schiattarella
Summary: Several studies have found that protein neutrophil gelatinase-associated lipocalin (NGAL) in maternal blood is associated with the development of pre-eclampsia, suggesting that it could be used as a potential predictor.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Letter
Dermatology
Andre S. Alves, Matteo Scampa, Jerome Martineau, Daniel F. Kalbermatten, Carlo M. Oranges
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Editorial Material
Surgery
Carlo M. Oranges, Juan A. Viscardi, Ebai A. Eseme, Daniel F. Kalbermatten
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Medicine, General & Internal
Matteo Scampa, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: Merkel cell carcinoma is an aggressive malignant skin tumor with high recurrence and low survival. Lymph nodal metastases are associated with a worse overall prognosis. Factors such as increasing age, tumor size, and truncal location are associated with higher positive lymph node rates.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jerome Martineau, Solange N. Walz, Matteo Scampa, Salvatore Giordano, Daniel F. Kalbermatten, Carlo M. Oranges
Summary: This study analyzed the demographic and pathological characteristics, treatment patterns, and survival outcomes of patients with spiradenocarcinoma. The results showed that spiradenocarcinoma affects males and females equally, with low rates of regional and distant invasion. Surgical excision is the main treatment modality, and the overall and disease-specific survival rates are high for patients with spiradenocarcinoma.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Jarna Heikkinen, Christian Bonde, Carlo M. Oranges, Francesca Toia, Pietro G. di Summa, Salvatore Giordano
Summary: This study demonstrates that microsurgical breast reconstruction using DIEP is safe in elderly patients, achieving outcomes and complication rates comparable to those observed in a younger population.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2023)
Review
Pediatrics
Megan A. Sylvester, Gabrielle Mintz, Giovanni Sisti
Summary: The diagnosis of previable preterm pre-labor rupture of membranes (PROM) is associated with poor outcomes for both the mother and the fetus. A meta-analysis was conducted to compare the effects of active management and expectant management on maternal risks. The results showed no significant differences in maternal risks between active management and expectant management for previable preterm PROM at <24 weeks.
Article
Obstetrics & Gynecology
Giovanni Sisti, Debra Guinn, Melissa Magenta, Jessica Silva, Julie T. Joseph, Ruchi Upadhyay, Antonio Schiattarella
Summary: This study explored the association between neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) measured during pregnancy, and the occurrence of stillbirth (SB). The study found that a PLR higher than 156.4 in the first trimester can reliably exclude the possibility of SB later during pregnancy. Lower platelet and higher lymphocyte levels may be related to an early inflammatory process. Larger studies are needed to confirm the results.
MINERVA OBSTETRICS AND GYNECOLOGY
(2023)
