Article
Hematology
Inge A. Gimbel, Frits I. Mulder, Floris T. M. Bosch, Jan Erik Freund, Noori Guman, Nick van Es, Pieter W. Kamphuisen, Harry R. Buller, Saskia Middeldorp
Summary: The study found that 12.4% of cancer patients had pulmonary embolism at autopsy, with 90.2% being thrombotic embolism. Venous thromboembolism occurred in 12.8% of the patients.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Cardiac & Cardiovascular Systems
Ella Grilz, Florian Posch, Stephan Nopp, Oliver Koenigsbruegge, Irene M. Lang, Peter Klimek, Stefan Thurner, Ingrid Pabinger, Cihan Ay
Summary: Patients with cancer have a significantly higher risk of both arterial thromboembolism (ATE) and venous thromboembolism (VTE) compared to those without cancer. Different types of cancer show variations in the incidence of ATE and VTE.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Ella Grilz, Florian Posch, Stephan Nopp, Oliver Konigsbrugge, Irene M. Lang, Peter Klimek, Stefan Thurner, Ingrid Pabinger, Cihan Ay
Summary: This study in Austria found a significantly higher risk of arterial and venous thrombosis in cancer patients using International Classification of Disease 10th Revision (ICD-10) diagnosis codes, indicating a strong association between cancer, ATE, and VTE.
EUROPEAN HEART JOURNAL
(2021)
Review
Hematology
Gina Perrella, Magdolna Nagy, Steve P. Watson, Johan W. M. Heemskerk
Summary: GPVI is a receptor expressed on megakaryocytes and platelets that plays a role in both arterial and venous thrombus formation, as well as in the formation of platelet-leukocyte complexes. It is emerging as a potential therapeutic target for venous thrombosis, pulmonary thromboembolism, and cancer metastasis due to its involvement in venous thrombus formation and thromboinflammation. Circulating soluble GPVI is also being explored as a biomarker for thrombosis-related complications.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Hematology
Arafat Ul Alam, Mohammad Karkhaneh, Haowei (Linda) Sun, Cynthia Wu
Summary: The study identified the prevalence of VTE in hematologic malignancy patients and compared survival outcomes with or without VTE. The results showed that VTE adversely affects survival among patients with hematologic malignancies, especially in those with specific conditions like MDS, MPN, and plasma cell dyscrasia.
THROMBOSIS RESEARCH
(2021)
Article
Hematology
Charles Orione, Cecile Tromeur, Raphael Le Mao, Pierre-Yves Le Floch, Philippe Robin, Clement Hoffmann, Luc Bressollette, Michel Nonent, Pierre-Yves Le Roux, Pierre-Yves Salaun, Marie Guegan, Elise Poulhazan, Karine Lacut, Christophe Leroyer, Catherine A. Lemarie, Francis Couturaud
Summary: This study aimed to assess the association between high PVOI at PE diagnosis and the risk of recurrent VTE. The results showed that PVOI >= 40% was an independent risk factor for VTE recurrence in PE patients, even six months after stopping anticoagulation therapy. Further prospective validation studies are needed to confirm these findings.
THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Hematology
Megan Purdy, Andrea Obi, Daniel Myers, Thomas Wakefield
Summary: Venous thromboembolism (VTE) is a common and costly health problem worldwide. Current anticoagulant treatments have limitations in terms of bleeding risks and prevention of post-thrombotic syndrome or chronic thromboembolic pulmonary hypertension. Inhibition of selectins, a family of glycoproteins that modulate thrombosis, has shown promise as a potential therapy for VTE, with the ability to decrease thrombosis and vein wall fibrosis without increasing bleeding risks.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Peder Wiklund, Koshiar Medson, Johan Elf
Summary: This study assessed the risk of recurrent venous thromboembolism (VTE) and death in patients with unreported cancer-associated incidental pulmonary embolism (iPE). The results showed that the extent of iPE burden was associated with the risk of recurrent VTE, but a single subsegmental iPE was not associated with the risk of recurrent VTE. There were no significant associations between iPE burden and risk of death.
THROMBOSIS RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Annie Brink, Johan Elf, Peter J. J. Svensson, Gunnar Engstrom, Olle Melander, Bengt Zoller
Summary: This study aimed to investigate whether there are sex-specific differences in risk factors for noncancer-related DVT and PE in middle-aged and older individuals. The results showed that anthropometric obesity measures were more strongly associated with DVT and PE in women than in men.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Oncology
Monika Wojcik-Giertuga, Anna Malczewska-Herman, Beata Kos-Kudla
Summary: Neuroendocrine neoplasms (NENs) exhibit significant differences from other malignancies in terms of biology and clinical management. However, there is limited data on the incidence of thromboembolic events in NENs and no specific recommendations on the use of antithrombotic prophylaxis in this group. Accurate assessment of the thromboembolic risk in NENs is important to reduce morbidity and mortality.
Article
Medicine, General & Internal
Chiara Di Blasi, Matteo Renzi, Paola Michelozzi, Francesca De' Donato, Matteo Scortichini, Marina Davoli, Francesco Forastiere, Pier Mannuccio Mannucci, Massimo Stafoggia
Summary: This study investigated the association between air temperature, particulate matter air pollution, and hospital admissions for pulmonary embolism (PE) and venous thrombosis (VT) in Italy. The results showed a significant effect of air temperature on PE hospitalizations in the cold seasons and summer, with no effect of particulate matter.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Hematology
Laura Girardi, Tzu-Fei Wang, Walter Ageno, Marc Carrier
Summary: Patients with cancer have a higher risk of developing venous thromboembolism (VTE) due to specific risk factors and thrombotic and hemostatic pathophysiological pathways. Managing cancer-associated VTE can be challenging due to increased risk of recurrent events and bleeding complications. Direct oral anticoagulants have shown effectiveness, safety, and convenience compared to low-molecular-weight heparin in managing cancer-associated VTE. However, there are still unmet needs and potential solutions, such as factor XI inhibitors, to address bleeding risk, drug interactions, and liver dysfunction.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Hematology
Nicolas Wenger, Tim Sebastian, Jurg H. Beer, Lucia Mazzolai, Drahomir Aujesky, Daniel Hayoz, Rolf P. Engelberger, Wolfgang Korte, Davide Voci, Nils Kucher, Stefano Barco, David Spirk
Summary: The study found differences in demographics, risk factors, and clinical outcomes between PE and DVT alone. Management of anticoagulation duration differs between the two manifestations of VTE in routine clinical practice, contrary to recommendations in the current consensus guidelines.
THROMBOSIS RESEARCH
(2022)
Article
Oncology
Yukari Tsubata, Takamasa Hotta, Kosuke Hamai, Naoki Furuya, Toshihide Yokoyama, Ryota Saito, Atsushi Nakamura, Takeshi Masuda, Megumi Hamaguchi, Shoichi Kuyama, Ryoichi Honda, Tadashi Senoo, Masamoto Nakanishi, Masahiro Yamasaki, Nobuhisa Ishikawa, Kazunori Fujitaka, Tetsuya Kubota, Hiroshi Ohtsu, Kunihiko Kobayashi, Takeshi Isobe
Summary: This study aimed to assess the incidence of VTE associated with lung cancer and the effectiveness of edoxaban. The results showed the importance of monitoring VTE occurrence during lung cancer treatment and the cautious consideration of edoxaban administration due to its high bleeding rate.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2022)
Article
Medicine, General & Internal
Jonathan Yugo Maesaka, Yedda Nunes Reis, Livia Menezes Elias, Denise Akerman, Edmund Chada Baracat, Jose Roberto Filassi
Summary: The aim of this study was to determine the frequency of VTE in breast cancer patients undergoing surgery and identify the related risk factors. The study found that 0.9% of patients experienced VTE events, with 0.2% being deep vein thrombosis and 0.7% being pulmonary thromboembolism. Immediate reconstruction, especially with abdominal-based flaps, and longer surgical time were associated with increased risk of VTE. Postoperative prophylaxis with LMWH reduced this risk.
Article
Audiology & Speech-Language Pathology
Stephanie Youssef, Semirra Bayan, Dale Ekbom, Christine Lohse, Terence Zimmermann, Rebecca Pittelko, Diana M. Orbelo
Summary: In patients with unilateral vocal fold paralysis, those who underwent medialization laryngoplasty with arytenoid adduction had significantly higher preoperative breathiness perception compared to those who had only medialization laryngoplasty. Postoperatively, the former group showed improvements in breathiness, loudness, strain, and pitch, while the latter group showed greater improvement in roughness. Surgeons may consider auditory perceptual evaluation of voice when deciding on arytenoid adduction surgery for UVFP patients.
Article
Clinical Neurology
Mohammed Ali Alvi, Desmond Brown, Yagiz Yolcu, Jad Zreik, Saad Javeed, Mohamad Bydon, Jeremy K. Cutsforth-Gregory, Jonathan Graff-Radford, David T. Jones, Neill R. Graff-Radford, Petrice M. Cogswell, Benjamin D. Elder
Summary: This study summarized the national prevalence of iNPH, trends in its management over the previous decade, and variations in procedure utilization by region and hospital type in the United States.
WORLD NEUROSURGERY
(2021)
Article
Clinical Neurology
Dileep D. Monie, Archis R. Bhandarkar, Ian F. Parney, Cristina Correia, Jann N. Sarkaria, Richard G. Vile, Hu Li
Summary: The review discusses the use of synthetic and systems biology concepts to develop programmable, logic-based oncolytic viruses for treating GBMs. Synthetic biology focuses on developing synthetic DNA constructs, while systems biology enables the analysis of complex interactions between host pathways and synthetic genetic circuits.
NEUROSURGICAL FOCUS
(2021)
Article
Cell & Tissue Engineering
Saranya P. Wyles, Dileep D. Monie, Christopher R. Paradise, Fredric B. Meyer, Richard E. Hayden, Andre Terzic
Summary: The field of regenerative medicine has matured, but there is a lack of trained healthcare providers for the next generation. This report discusses the development of a regenerative medicine curriculum as a reference for scholars and institutions aiming to establish formalized regenerative medicine courses.
REGENERATIVE MEDICINE
(2021)
Review
Neurosciences
Jaclyn J. Renfrow, Desmond A. Brown, Michael J. Link, Nadia N. Laack, David M. Routman, Bruce E. Pollock, Ian F. Parney
Summary: This study retrospectively reviewed 8 patients treated with SRS for recurrent supratentorial PNET from 1999 to 2014. The results showed that SRS could be effective in these patients, but the overall survival time remains limited.
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2021)
Article
Oncology
Cesar A. Garcia, Adip G. Bhargav, Mieu Brooks, Paola Suarez-Meade, Sujan K. Mondal, Natanael Zarco, Karim ReFaey, Mark Jentoft, Erik H. Middlebrooks, Matija Snuderl, Anna Carrano, Hugo Guerrero-Cazares, Paula Schiapparelli, Rachel Sarabia-Estrada, Alfredo Quinones-Hinojosa
Summary: The study functionally characterized six patient-derived GBM cell lines and established sex-specific preclinical models, showing that GBM cell lines of different sexes exhibited differential growth rates and survival times in mice.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Dileep D. Monie, Cristina Correia, Cheng Zhang, Choong Yong Ung, Richard G. Vile, Hu Li
Summary: The study suggests that Cellular communication network factor 1 (CCN1) may influence antiviral therapy resistance in Glioblastomas (GBMs) by regulating multiple innate immune pathways, affecting virus response programs and cytokine-mediated signaling pathways.
SCIENTIFIC REPORTS
(2021)
Review
Clinical Neurology
Cameron Zamanian, Archis R. Bhandarkar, Dileep D. Monie, F. M. Moinuddin, Richard G. Vile, Alfredo Quinones-Hinojosa, Mohamad Bydon
Summary: Neuroimmunology plays a critical role in neurosurgical diseases, and emerging multiomics methods provide new ways to study immune signaling pathways. This review summarizes methods for gathering and analyzing multiomics data and shares use cases that utilize machine learning and network analysis in clinical research.
NEUROSURGICAL FOCUS
(2022)
Article
Oncology
Ti Wen, Whitney Barham, Ying Li, Henan Zhang, Joanina K. Gicobi, Jacob B. Hirdler, Xin Liu, Hyoungjun Ham, Kodi E. Peterson Martinez, Fabrice Lucien, Roxane R. Lavoie, Hu Li, Cristina Correia, Dileep D. Monie, Zesheng An, Susan M. Harrington, Xiaosheng Wu, Ruifeng Guo, Roxana S. Dronca, Aaron S. Mansfield, Yiyi Yan, Svetomir N. Markovic, Sean S. Park, Jie Sun, Hong Qin, Minetta C. Liu, George Vasmatzis, Daniel D. Billadeau, Haidong Dong
CANCER IMMUNOLOGY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Edjah K. Nduom, John Glod, Desmond A. Brown, Margaret Fagan, Mahalia Dalmage, John Heiss, Seth M. Steinberg, Cody Peer, William D. Figg, Sadhana Jackson
Summary: Diffuse midline gliomas (DMG) are aggressive brain tumors with low survival rates. The function of the blood-brain barrier (BBB) contributes to treatment failure. This clinical trial aims to use intratumoral microdialysis sampling to understand drug permeability and its relationship to DMG treatment response. The findings of this study could improve drug delivery efficacy and influence prognostic and diagnostic decisions for this lethal disease with limited treatment options.
Article
Cell Biology
Aimee L. Dowling, Stuart Walbridge, Celine Ertekin, Sriya Namagiri, Krystal Camacho, Ashis Chowdhury, Jean-Paul Bryant, Eric Kohut, John D. Heiss, Desmond A. Brown, Sangamesh G. Kumbar, Yeshavanth Kumar Banasavadi-Siddegowda
Summary: FKBP38 expression is upregulated in glioblastoma and plays a crucial role in cell survival and self-renewal. It negatively regulates autophagy through the JNK/C-Jun-PTEN-AKT pathway. Targeting FKBP38 could be a potential therapeutic strategy for glioblastoma.
Article
Geriatrics & Gerontology
Grace T. Yu, Dileep D. Monie, Sundeep Khosla, Tamar Tchkonia, James L. Kirkland, Saranya P. Wyles
Summary: This study found that cellular senescence plays an important role in the pathogenesis of diabetic foot ulcers. Gene expression analysis showed upregulated cellular senescence markers and downregulated TP53 in diabetic foot ulcers compared to uninvolved skin. Protein-protein interaction network analysis revealed significant perturbations in diabetic foot ulcer tissues, suggesting the involvement of cellular senescence in this condition.
Article
Clinical Neurology
Karina A. Lenartowicz, Dileep D. Monie, Kimberly K. Amrami, Christopher J. Klein, Caterina Giannini, Robert J. Spinner
Summary: Hybrid peripheral nerve sheath tumors (HPNST) are a newly recognized class of peripheral nerve sheath tumors. They tend to occur in mid-adulthood, predominantly affect females, and commonly present as painless masses or swelling, mostly in the lower extremity. Their diagnostic challenge and association with neurofibromatosis and genetic profiles require further research.
ACTA NEUROCHIRURGICA
(2023)
Meeting Abstract
Oncology
Dileep D. Monie, Cristina Correia, Cheng Zhang, Choong Ung, Richard G. Vile, Hu Li
Review
Neurosciences
Jaclyn J. Renfrow, Desmond A. Brown, Gesina F. Keating, Nadia N. Laack, Ian F. Parney
STEREOTACTIC AND FUNCTIONAL NEUROSURGERY
(2021)