Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 328, Issue -, Pages 1-4Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2018.11.012
Keywords
Neuromyelitis optica; Autoantibodies; Prognosis
Categories
Funding
- Ministry of Science and ICT, South Korea [NRF-2018R1C1B6008884, NRF-2018M3A9E8066249]
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In neuromyelitis optica spectrum disorders (NMOSD), the clinical and long-term prognostic value of antinuclear antibodies (ANAs) is unclear. We analyzed registry data of NMO-IgG seropositive NMOSD patients (n = 74) according to ANA presence. The ANA-positive group (n = 32) demonstrated more frequent other autoantibodies (anti-SSA/Ro, anti-SSB/La, antiphospholipid, and anti-double stranded DNA antibodies) than did the ANA-negative group (n = 42). Clinically, annual relapse rates, and average lesion extents on MRI during attacks were comparable between the two groups (median follow-up of 7 years). The development of a poor outcome (walking with unilateral aid) also did not differ. In conclusion, although common, ANAs were not associated with a benign/malignant disease course in our NMOSD cohort.
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