Article
Psychology, Multidisciplinary
Akshay Shanker, John H. Abel, Gabriel Schamberg, Emery N. Brown
Summary: The burst-suppression EEG patterns, characterized by intermittent high-power broad-spectrum oscillations alternating with isoelectricity, have been observed in the human brain during general anesthesia, hypothermia, coma and early infantile encephalopathy. Recent research suggests that these patterns may have effects on the brain and could be used as a therapeutic tool. Monitoring and controlling burst suppression remains a technical challenge.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Joel Frohlich, Micah A. Johnson, David L. McArthur, Evan S. Lutkenhoff, John Dell'Italia, Courtney Real, Vikesh Shrestha, Norman M. Spivak, Jesus E. Ruiz Tejeda, Paul M. Vespa, Martin M. Monti
Summary: The study found that sedation-induced burst-suppression (SIBS) was positively associated with outcomes at 6 months in patients with moderate-to-severe traumatic brain injury (TBI), but did not predict outcomes at discharge. These results suggest that burst suppression may have neuroprotective effects in acute patients with TBI etiologies.
FRONTIERS IN NEUROLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Carla Murillo, Hsin-Yi Weng, Ann B. Weil, Matthias Kreuzer, Jeff C. Ko
Summary: This study investigated the use of EEG for detecting brain activity changes perioperatively in anesthetized horses undergoing surgery. EEG data were collected at different stages, and the processed EEG indices showed significant changes between the stages of anesthesia. The presence of slow EEG wave activities and burst suppression indicated that the horses were profoundly unconscious during anesthesia. EEG provided clinically relevant information about perioperative brain state changes in anesthetized horses.
Article
Neurosciences
Simon Ruch, Flavio Jean Schmidig, Leona Knuesel, Katharina Henke
Summary: Slow-wave sleep is a crucial stage for the body's recovery, characterized by slow oscillations in the scalp EEG. Studies have shown that closed-loop sensory stimulation targeting the UP-states of slow oscillations can enhance sleep depth and promote sleep's recuperative functions. However, conventional closed-loop stimulation algorithms may overlook the individual differences in slow oscillations on the scalp. Researchers have proposed a novel EEG-based algorithm, TOPOSO, that can accurately detect and target specific cerebral origins of local slow oscillations.
Article
Clinical Neurology
G. Narula, M. Haeberlin, J. Balsiger, C. Strassle, L. L. Imbach, E. Keller
Summary: The study introduces a novel unsupervised learning algorithm for detecting bursts in EEG and generating burst estimates for monitoring sedation levels in the ICU. Results show competitive performance compared to neural networks learned through supervised learning, with a small mean absolute error in bursts per minute.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Engineering, Biomedical
Scott Bressler, Ryan Neely, Ryan M. Yost, David Wang, Heather L. Read
Summary: This study examines the feasibility of using a headband wearable device with an endpoint-corrected version of the Hilbert transform algorithm to measure alpha phase and deliver phase-locked auditory stimulation during the transition from wakefulness to sleep. The results show that the wearable system is capable of measuring sleep-related neural activity with high fidelity and delivering auditory stimuli at the intended phases of neural oscillations. This study demonstrates the potential for closed-loop real-time tracking and neuromodulation of sleep-related oscillations using a wearable EEG device.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Automation & Control Systems
Dominika Machowska, Andrzej Nowakowski, Agnieszka Wiszniewska-Matyszkiel
Summary: This paper focuses on an N-person partial differential game with a hyperbolic differential equation describing the dynamics of the state variable. Each player aims to maximize their accumulated payoff within a finite time horizon, considering discounting. The concept of closed-loop Nash equilibrium is extended to this game setting, and a dual closed-loop Nash equilibrium is proposed along with its sufficient conditions. The relationship between Nash equilibria, the dual closed-loop Nash equilibrium, and the classical closed-loop information structure is presented. The proposed results are applied to a goodwill dynamics model influenced by personalized advertising and consumers' recommendations, and the economic properties of the dual closed-loop Nash equilibrium are examined.
Article
Geriatrics & Gerontology
Susanne Koch, Benjamin Blankertz, Victoria Windmann, Claudia Spies, Finn M. Radtke, Vera Roehr
Summary: This study aimed to determine whether the choice of anesthetic agent affects the risk of postoperative delirium (POD) and if this risk is correlated with the duration of intraoperative burst suppression activity. Through analysis of 1277 patients over 60 years old undergoing general anesthesia, it was found that the risk of POD was higher in patients receiving propofol anesthesia, despite shorter burst suppression duration compared to desflurane anesthesia.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Neurosciences
Fabrizio Grani, Cristina Soto-Sanchez, Antonio Fimia, Eduardo Fernandez
Summary: Current cortical visual prosthesis approaches need to consider the feedback circuits in the nervous system, and closed-loop strategies may improve the effectiveness and stability of visual cortex stimulation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Melody Reese, Soren Christensen, Harel Anolick, Kenneth C. Roberts, Megan K. Wong, Mary Cooter Wright, Leah Acker, Jeffrey N. Browndyke, Marty G. Woldorff, Miles Berger
Summary: Postoperative delirium (POD) is a common complication in older surgical patients. This study finds that pre-burst suppression (preBSup), a state of lowered EEG power before burst suppression (BSup), is associated with a higher risk of POD. PreBSup appears to be more sensitive in predicting POD compared to BSup.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Zhaohuan Ding, Longzhou Guan, Wenbo He, Heng Gu, Yong Wang, Xiaoli Li
Summary: The purpose of this study is to discuss the spatial characteristics of closed-loop TMS-EEG data with occipital alpha-phase synchronization. By collecting closed-loop TMS-EEG data from 30 healthy college students and calculating the frequency-band connectivity and brain network difference under different alpha phase conditions, we found that occipital alpha phase has a significant modulation effect on the gamma network. In addition, we also calculated the perturbational complexity index (PCI) of the closed-loop TMS-EEG data and found a smaller coefficient of intertrial PCI variation when stimulated at the phase 90 condition.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2023)
Article
Neurosciences
Thomas Wahl, Josephine Riedinger, Michel Duprez, Axel Hutt
Summary: Mental disorders pose a significant challenge to global health, as they exhibit pathological rhythms that can serve as biomarkers for diagnosis and treatment. This study introduces a fully-adaptive closed-loop neurostimulation setup that adjusts the brain's power spectral density according to user-defined values. By utilizing a non-parametric brain model and considering conduction delays, this algorithm demonstrates its effectiveness in simulating and explaining brain activity related to psychosis.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Michael W. K. Fong, Kelly Pu, Rakesh Jadav, Tasleema Khan, Lawrence J. Hirsch, Hitten P. Zaveri
Summary: This study aimed to determine whether quantitative EEG analysis of burst suppression can predict seizure recurrence in patients with refractory status epilepticus (RSE) being treated with anesthetic doses of continuous IV antiseizure medications (cIVASM). The results showed that occasions resulting in seizure recurrence had lower burst and interburst interval average amplitude, duration, and total power. Bursts and interburst intervals with epileptiform discharges and measures of evolution within bursts predicted seizure recurrence.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Engineering, Biomedical
Zhaohuan Ding, Yong Wang, Jiaxi Li, Xiaoli Li
Summary: This study investigates the characteristics of closed-loop TMS-EEG and reveals the improved repeatability compared to open-loop TMS-EEG. The study also reveals the dependence of closed-loop TMS-EEG on occipital alpha phase and the changes in TMS-evoked potentials. The findings provide support for the dependence of EEG reactivity on cortical oscillation phase under TMS stimulation.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Engineering, Electrical & Electronic
Xing Heng, Kai Wei, Tian Zhao, Zitong Xu, Qian Cao, Xiaofei Huang, Yueyang Zhai, Mao Ye, Wei Quan
Summary: In this study, a new model is established to analyze the noise mechanism caused by the fluctuations of probe light's polarization in a modulated optical rotation detection system (ORDS). It is discovered that residual probe photon spin polarization leads to transverse electron-spin polarization errors and extra coupling magnetic noise. A novel closed-loop system is proposed to reduce the electron-spin errors and suppress the noise. Experimental results show an improved angular sensitivity and measurement uncertainty with the closed-loop control.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Engineering, Biomedical
Parima Ahmadipour, Yuxiao Yang, Edward F. Chang, Maryam M. Shanechi
Summary: This study focuses on using an adaptive linear state-space model to analyze the dynamics of multi-site electrocorticogram (ECoG) network activity. The results show that adaptive modeling significantly improves the prediction of ECoG network dynamics compared to non-adaptive modeling, while also allowing for additional dimensionality reduction. The findings suggest that ECoG network dynamics exhibit non-stationarity, which can be effectively tracked using adaptive modeling techniques.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Anesthesiology
Ksenia Vlasov, JunZhu Pei, Christa J. Nehs, Jennifer A. Guidera, Edlyn R. Zhang, Jonathan D. Kenny, Timothy T. Houle, Gary J. Brenner, Norman E. Taylor, Ken Solt
Summary: This study suggests that GABAergic neurons in the RMTg and other brainstem regions promote sedation and facilitate sevoflurane-induced unconsciousness.
ANESTHESIA AND ANALGESIA
(2021)
Editorial Material
Anesthesiology
Risako Kato, Ken Solt
ANESTHESIA AND ANALGESIA
(2021)
Review
Anesthesiology
Olivia A. Moody, Edlyn R. Zhang, Kathleen F. Vincent, Risako Kato, Eric D. Melonakos, Christa J. Nehs, Ken Solt
Summary: General anesthesia and natural sleep share common features of reversible unconsciousness, but the neural circuits underlying them are not fully understood. EEG is a common tool to measure cortical activity, with different anesthetic agents producing varying effects on EEG oscillations. Understanding the distinct effects of different anesthetic drugs on subcortical and cortical targets is essential for comprehending the mechanisms of reversible unconsciousness.
ANESTHESIA AND ANALGESIA
(2021)
Article
Pharmacology & Pharmacy
Risako Kato, Edlyn R. Zhang, Olivia G. Mallari, Olivia A. Moody, Kathleen F. Vincent, Eric D. Melonakos, Morgan J. Siegmann, Christa J. Nehs, Timothy T. Houle, Oluwaseun Akeju, Ken Solt
Summary: The study found that D-amphetamine can accelerate the recovery of consciousness from dexmedetomidine anesthesia, and this effect is influenced by dopamine receptor antagonists, while its effect on ketamine anesthesia is minimal. Gender has a significant impact on recovery time, suggesting the clinical potential of D-amphetamine as a reversal agent for dexmedetomidine.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Anesthesiology
Eric D. Melonakos, Morgan J. Siegmann, Charles Rey, Christopher O'Brien, Ksenia K. Nikolaeva, Ken Solt, Christa J. Nehs
Summary: The effectiveness of parabrachial nucleus excitation in altering the neurophysiological and behavioral effects of anesthesia appears to depend on the specific molecular target of the anesthetic.
Editorial Material
Anesthesiology
Olivia A. Moody, Kathleen F. Vincent, Ken Solt
Summary: The study highlights significant sex differences in sensitivity to a novel neurosteroid anesthetic, with female rats being more sensitive than male rats. This underscores the importance of sex differences in anesthesia research and the need for more efforts to understand these disparities.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Pharmacology & Pharmacy
Megan E. Barra, Brian L. Edlow, James T. Lund, Katherine S. DeSanctis, John Vetrano, Cherylann Reilly-Tremblay, Edlyn R. Zhang, Yelena G. Bodien, Emery N. Brown, Ken Solt
Summary: This study evaluated the long-term stability of an extemporaneously prepared preservative-free methylphenidate intravenous solution. The results showed that the solution remained physically and chemically stable for up to one year when stored in refrigerated temperatures.
AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
(2022)
Article
Anesthesiology
Takamitsu Ikeda, Edilberto Amorim, Yusuke Miyazaki, Risako Kato, Eizo Marutani, Michael G. G. Silverman, Rajeev Malhotra, Ken Solt, Fumito Ichinose
Summary: The study found that early administration of sedation with propofol or dexmedetomidine can improve survival and neurological outcomes in mice resuscitated from cardiac arrest. The beneficial effects of sedation may be achieved through attenuation of cerebral hyperemia and enhancement of electroencephalographic slow-wave activity.
Meeting Abstract
Cardiac & Cardiovascular Systems
Takamitsu Ikeda, Edilberto Amorim, Yusuke Miyazaki, Risako Kato, Eizo Marutani, Michael G. Silverman, Rajeev Malhotra, Ken Solt, Fumito Ichinose
Meeting Abstract
Anesthesiology
Risako Kato, Francisco Flores, Josefina Correa Menendez, Emery N. Brown, Ken Solt
ANESTHESIA AND ANALGESIA
(2022)
Meeting Abstract
Anesthesiology
Olivia Moody, Kathleen F. Vincent, Angel Cho, Risako Kato, Edlyn R. Zhang, Ken Solt
ANESTHESIA AND ANALGESIA
(2022)
Meeting Abstract
Anesthesiology
Kathleen F. Vincent, Angel Cho, Edlyn R. Zhang, Risako Kato, Olivia Moody, Ken Solt
ANESTHESIA AND ANALGESIA
(2022)
Meeting Abstract
Anesthesiology
Kathleen F. Vincent, Olivia Mallari, Emmaline Dillon, Victoria Stewart, Angel Cho, Yuanlin Dong, Olivia Moody, Edlyn R. Zhang, Risako Kato, Zhongcong Xie, Ken Solt
ANESTHESIA AND ANALGESIA
(2022)
Meeting Abstract
Anesthesiology
Kathleen Vincent, Edlyn R. Zhang, Risako Kato, Angel Cho, Olivia Moody, Ken Solt
ANESTHESIA AND ANALGESIA
(2021)