Article
Multidisciplinary Sciences
Weidong Yan, Bingyang Ji
Summary: This study successfully established a rat model for DHCA and evaluated its impact on vital signs and hippocampal autophagosomes.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Multidisciplinary Sciences
Parag N. Jain, Matthew Robertson, Javier J. Lasa, Lara Shekerdemian, Danielle Guffey, Yuhao Zhang, Krithika Lingappan, Paul Checchia, Cristian Coarfa
Summary: The study explored differential gene expression profiles in neonates with HLHS who develop LCOS after CPB, revealing significant changes in inflammatory and metabolic pathways. This opens up new possibilities for identifying potential therapeutic targets in this high-risk population.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Marten Larsson, Igor Zindovic, Johan Sjogren, Peter J. Svensson, Karin Strandberg, Shahab Nozohoor
Summary: This study evaluated the hemostatic system in patients with acute type aortic dissection (ATAAD) undergoing surgery using ROTEM. The results showed that ATAAD patients had activated coagulation before surgery and experienced further damage to the hemostatic system during surgery. However, ROTEM was not able to fully detect the coagulopathy in ATAAD, highlighting the need for a specific transfusion protocol and routine laboratory tests.
SCIENTIFIC REPORTS
(2022)
Review
Medical Laboratory Technology
Giuseppe Lapergola, Alessandro Graziosi, Ebe D'Adamo, Patrizia Brindisino, Mariangela Ferrari, Anna Romanelli, Mariachiara Strozzi, Roberta Libener, Danilo A. W. Gavilanes, Antonio Maconi, Angela Satriano, Alessandro Varrica, Diego Gazzolo
Summary: Recent advances in perioperative management have significantly reduced mortality rate in open heart surgery and cardiopulmonary bypass for heart disease repair. However, the morbidity rate remains unchanged. The measurement of neuro-biomarkers, particularly S100B protein, can be useful in detecting early stage brain damage during the perioperative period. This review provides an updated overview of the pros and cons of using S100B protein for perioperative monitoring in both adult and pediatric patients.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Neurosciences
Julien Aguet, Nikan Fakhari, Minh Nguyen, Luc Mertens, Elod Szabo, Birgit Ertl-Wagner, Lynn Crawford, Christoph Haller, David Barron, Jerome Baranger, Olivier Villemain
Summary: Newborns with congenital heart disease undergoing cardiac surgery are at risk of neurodevelopmental impairment. This study used ultrafast power Doppler to assess cerebral blood volume (CBV) variations in neonates with hypoplastic left heart syndrome during surgery. The results showed that global CBV did not differ significantly before and after surgery. However, regional differences in CBV were observed during hypothermia, and CBV was correlated with cardiopulmonary bypass (CPB) flow rate. Patients with higher CBV variation had brain injury on post-operative imaging. This suggests that the measurement of CBV using ultrafast power Doppler can optimize cerebral perfusion during neonatal cardiac surgery.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Cardiac & Cardiovascular Systems
Chang Shu, Liang Hong, Xiao Shen, Wenhao Zhang, Yongsheng Niu, Xiaochun Song, Jie Kong, Cui Zhang
Summary: This study evaluated the efficacy of Del Nido cardioplegia in preventing ventricular arrhythmias in adult patients undergoing cardiovascular surgery. The results showed that the incidence of postoperative ventricular arrhythmias was lower and the ICU stay was shorter in the DNC group compared to the STH group. Multivariate logistic regression demonstrated that the use of DNC helped to reduce the incidence of postoperative ventricular arrhythmias, and propensity score-based analysis confirmed its protective effects on myocardial function in various cardiopulmonary bypass surgeries.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cell Biology
Rishabh C. C. Choudhary, Muhammad Shoaib, Kei Hayashida, Tai Yin, Santiago J. J. Miyara, Cristina d'Abramo, William G. G. Heuser, Koichiro Shinozaki, Nancy Kim, Ryosuke Takegawa, Mitsuaki Nishikimi, Timmy Li, Casey Owens, Ernesto P. P. Molmenti, Mingzhu He, Sonya Vanpatten, Yousef Al-Abed, Junhwan Kim, Lance B. B. Becker
Summary: In this study, a therapeutic cocktail consisting of ten drugs targeting multiple pathways after cardiac arrest was developed and evaluated in rats. The results showed that the survival rate of rats treated with the cocktail was significantly higher than the control group, and neurological deficits were improved. These findings suggest that the multi-drug cocktail may be a promising post-cardiac arrest therapy.
Article
Medicine, General & Internal
Sarah E. Drennan, Kathryn Y. Burge, Edgardo G. Szyld, Jeffrey V. Eckert, Arshid M. Mir, Andrew K. Gormley, Randall M. Schwartz, Suanne M. Daves, Jess L. Thompson, Harold M. Burkhart, Hala Chaaban
Summary: The study evaluated the utility of clinical and laboratory variables in predicting low cardiac output syndrome following cardiac surgery in infants. Patients on cardiopulmonary bypass had higher levels of specific cytokines upon ICU admission compared to non-bypass patients. Aortic cross-clamp duration was the most predictive surgical metric for low cardiac output syndrome in the patient population studied.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Anesthesiology
J. G. Reves
Summary: The article recounts the experience of William A. Lell becoming the first cardiac anesthesia fellow at Harvard's Massachusetts General Hospital fifty years ago, emphasizing the importance of seizing new opportunities and establishing meaningful working relationships for successful career development and research in a new medical subspecialty.
ANESTHESIA AND ANALGESIA
(2021)
Article
Engineering, Biomedical
Mousa Kharnaf, Spencer Hogue, Zachariah Wilkes, James A. A. Reagor, Daniel G. G. Leino, Benjamin Gourley, Leah Rosenfeldt, Qing Ma, Prasad Devarajan, Joseph S. S. Palumbo, James S. S. Tweddell, Farhan Zafar
Summary: This study developed a novel blood-primed murine model of veno-arterial ECMO and demonstrated its good functionality in maintaining oxygenation and perfusion. The model showed stable hemodynamic parameters and adequate blood oxygenation during ECMO. The study also revealed a significant increase in plasma-free hemoglobin and proinflammatory cytokines, as well as early signs of kidney and liver dysfunction during ECMO.
Article
Cardiac & Cardiovascular Systems
Marta Macarena Rodriguez-Lima, Antonio Gonzalez-Calle, Alejandro Adsuar-Gomez, Maria Jose Sanchez-Martin, Alvaro Sepulveda Iturzaeta, Elia Sanchez-Valderrabanos, Juan Antonio Garcia-Hernandez, Maria Angeles Murillo-Pozo, Antonio Ordonez-Fernandez, Amir-Reza Hosseinpour
Summary: Mechanical ventilation during cardiopulmonary bypass in neonates improves postoperative outcome.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Mahmoud Diab, Thomas Lehmann, Wolfgang Bothe, Payam Akhyari, Stephanie Platzer, Daniel Wendt, Antje-Christin Deppe, Justus Strauch, Stefan Hagel, Albrecht Guenther, Gloria Faerber, Christoph Sponholz, Marcus Franz, Andre Scherag, Ilia Velichkov, Miriam Silaschi, Jens Fassl, Britt Hofmann, Sven Lehmann, Rene Schramm, Georg Fritz, Gabor Szabo, Thorsten Wahlers, Klaus Matschke, Artur Lichtenberg, Mathias W. Pletz, Jan F. Gummert, Friedhelm Beyersdorf, Christian Hagl, Michael A. Borger, Michael Bauer, Frank M. Brunkhorst, Torsten Doenst
Summary: This study investigated the effect of hemoadsorption during cardiac surgery for infective endocarditis (IE) on postoperative organ dysfunction and found that hemoadsorption did not reduce the occurrence of organ dysfunction. Although hemoadsorption reduced cytokine levels during surgery, it did not have an impact on clinically relevant outcome measures.
Article
Multidisciplinary Sciences
Na Wang, Ting Zhao, Jiabei Li, Sisi Zeng, Jixiang Wan, Xuechao Li, Fangjun Wang
Summary: The objective of our study was to observe the effects of extracorporeal circulation (ECC) with different time on platelet count in patients undergoing cardiac surgery. A total of 427 patients who underwent elective cardiac surgery were divided into three groups based on ECC time. The results showed that thrombocytopenia was common after ECC, with the maximum drop in platelet counts usually occurring on the second day after ECC. Furthermore, platelet counts started to recover on the fifth day after ECC. As the duration of ECC increased, the drop in platelet counts became more pronounced, accompanied by increased perioperative blood loss and blood product transfusion, as well as lower levels and slower recovery of platelet counts.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Emanuele Pilato, Giovanni Battista Pinna, Loredana Grande, Vera Cirillo, Raffaele Izzo, Antonella Tufano, Maurizio Guida, Laura Sarno, Rosie Browning, Giuseppe Comentale
Summary: In this case, a young woman in her 16th week of gestation with a history of multiple abortions and autoimmune thrombophilia successfully underwent cardiac surgery to remove a large right endoventricular mass, leading to a healthy birth. This case demonstrates the feasibility of cardiac surgery during pregnancy with a multidisciplinary approach.
Article
Pediatrics
Liang Zou, Di Yu, Ruonan Wang, Yueshuang Cun, Yaping Li, Qingfeng Wang, Yaqin Shu, Xuming Mo
Summary: This study found that the incidence of LCOS after cardiopulmonary bypass in infants with congenital heart disease was 28.11%. It was demonstrated that preoperative FT3 levels, ACC time, and body weight were independent predictors of LCOS.
FRONTIERS IN PEDIATRICS
(2022)
Article
Medicine, Research & Experimental
Stefan F. Lange, Naomi Kremer, Teus van Laar, Fiete Lange, T. Elien Steendam-Oldekamp, D. L. Marinus Oterdoom, Anthony R. Absalom, J. Marc C. van Dijk, Gea Drost
Summary: This study aimed to determine the correlation between the intraoperative microlesion effect (MLE) and the clinical effect of deep brain stimulation (DBS) in Parkinson's disease (PD) patients. The results showed that MLE had a clinically relevant correlation with the effect of DBS, suggesting it can be relied upon as evidence of a clinically effective DBS electrode placement.
Article
Critical Care Medicine
Frank A. Rasulo, Philip Hopkins, Francisco A. Lobo, Pierre Pandin, Basil Matta, Carla Carozzi, Stefano Romagnoli, Anthony Absalom, Rafael Badenes, Thomas Bleck, Anselmo Caricato, Jan Claassen, Andre Denault, Cristina Honorato, Saba Motta, Geert Meyfroidt, Finn Michael Radtke, Zaccaria Ricci, Chiara Robba, Fabio S. Taccone, Paul Vespa, Ida Nardiello, Massimo Lamperti
Summary: This study highlights the increasing use of processed electroencephalography (pEEG) for monitoring depth of sedation (DOS) in critically ill patients in the intensive care unit (ICU), but also points out the challenges and areas for improvement in patient selection and application of this monitoring method. The study provides specific recommendations and training programs to enhance the effectiveness of pEEG monitoring.
NEUROCRITICAL CARE
(2023)
Article
Anesthesiology
Jayant S. Jainandunsing, Dario Massari, Jaap Jan Vos, Inez J. Wijdh-den Hamer, Ad F. M. van den Heuvel, Massimo A. Mariani, Feroze Mahmood, Wobbe Bouma, Thomas W. L. Scheeren
Summary: The objective of this study was to develop a mathematical model for simulating mitral annular dilatation and assess its effects on the individualized mitral valve coaptation reserve index. The study retrospectively analyzed intraoperative transesophageal 3-dimensional echocardiographic datasets of the mitral valve and created a mathematical model to evaluate the coaptation reserve index for different leaflet segments. The results showed that the A2-to-P2 region had the lowest coaptation reserve in the majority of patients and was also the most susceptible to mitral regurgitation after simulation of progressive annular dilation.
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2023)
Letter
Clinical Neurology
S. E. Dulfer, M. C. Gadella, M. M. Sahinovic, F. Lange, A. R. Absalom, R. J. M. Groen, A. Szelenyi, G. Drost
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Anesthesiology
Ramon Pierik, Thomas W. L. Scheeren, Michiel E. Erasmus, Walter M. van den Bergh
Summary: This study aimed to assess the predictive value of intra-operative neuromonitoring and blood pressure monitoring for peri-operative stroke after cardiothoracic surgery. The study found that cumulative intra-operative BIS values below 25 and longer duration of MAP below 60 mmHg were associated with the occurrence of peri-operative stroke.
EUROPEAN JOURNAL OF ANAESTHESIOLOGY
(2023)
Article
Critical Care Medicine
Sebastiaan Bossers, Floor Mansvelder, Stephan Loer, Christa Boer, Frank Bloemers, Esther M. M. Van Lieshout, Dennis Den Hartog, Nico Hoogerwerf, Joukje van der Naalt, Anthony Absalom, Lothar A. Schwarte, Jos W. R. O. Twisk, Patrick Schober, RAIN PROTECT Collaborators
Summary: Severe traumatic brain injury is a leading cause of mortality and morbidity, and the arterial partial pressure of CO2 can influence cerebral perfusion and intracranial pressure. This study investigated the association between prehospital end-tidal CO2 levels and mortality in patients with severe traumatic brain injury. The results showed that end-tidal CO2 values below 35 mmHg were associated with increased mortality.
INTENSIVE CARE MEDICINE
(2023)
Article
Medicine, General & Internal
Sebastiaan E. Dulfer, Maria C. Gadella, Katalin Tamasi, Anthony R. Absalom, Fiete Lange, Carola H. M. Scholtens-Henzen, Christopher Faber, Frits H. Wapstra, Rob J. M. Groen, Marko M. Sahinovic, Sedat Ulkatan, Gea Drost
Summary: The NERFACE study compared the characteristics of muscle transcranial electrical stimulation motor evoked potentials (mTc-MEPs) recorded from the tibialis anterior muscles using surface and subcutaneous needle electrodes. The aim of this study (NERFACE part II) was to determine if surface electrodes were non-inferior to subcutaneous needle electrodes in detecting mTc-MEP warnings during spinal cord monitoring. The results showed that there was perfect agreement between both electrode types in detecting mTc-MEP warnings, and the use of surface electrodes was non-inferior to the use of subcutaneous needle electrodes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Maria C. Gadella, Sebastiaan E. Dulfer, Anthony R. Absalom, Fiete Lange, Carola H. M. Scholtens-Henzen, Rob J. M. Groen, Frits H. Wapstra, Christopher Faber, Katalin Tamasi, Marko M. Sahinovic, Gea Drost
Summary: This study compared the characteristics of muscle-recorded transcranial electrical stimulation motor-evoked potentials (mTc-MEPs) recorded with surface and subcutaneous needle electrodes. The results showed that although the amplitude and area under the curve (AUC) were significantly higher in subcutaneous needle recordings, the motor thresholds and elicitability were similar for both electrode types. Additionally, the signal-to-noise ratio (SNR) and variability between consecutive amplitudes were not significantly different. Therefore, surface electrodes can be considered a good alternative to needle electrodes for spinal cord monitoring.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Anesthesiology
Simon J. Howell, Anthony R. Absalom
Summary: The publication of consensus guidelines on the anaesthetic management of endoscopic retrograde cholangiopancreatography (ERCP) is a significant step forward. The synthesis of expert opinion is invaluable in the absence of sufficient data, and these guidelines not only provide guidance for clinical practice, but also identify important research questions.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Editorial Material
Anesthesiology
Keith J. Anderson, Anthony R. Absalom
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2023)
Article
Anesthesiology
Ilonka N. de Keijzer, Jaap Jan Vos, David Yates, Caroline Reynolds, Sally Moore, Rebecca J. Lawton, Thomas W. L. Scheeren, Simon J. Davies
Summary: Clinicians believed they had sufficient knowledge and skills, which could explain why no difference was found after the educational intervention. In the HPI cohort, IOH was significantly reduced compared to baseline, therefore HPI-software may help prevent IOH.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Anesthesiology
Johannes Enevoldsen, Birgitte Brandsborg, Peter Juhl-Olsen, Stephen Edward Rees, Henriette Vind Thaysen, Thomas W. L. Scheeren, Simon Tilma Vistisen
Summary: Pulse pressure variation (PPV) is a method for predicting fluid responsiveness in mechanically ventilated patients. The accuracy of this method is disputed when ventilation has low tidal volume (VT) or low heart-rate-to-respiratory-rate ratio (HR/RR). This study investigated the effects of VT and RR on PPV and its ability to predict fluid responsiveness.
JOURNAL OF CLINICAL MONITORING AND COMPUTING
(2023)
Article
Anesthesiology
Manon Stern, Gertrude J. Nieuwenhuijs-Moeke, Anthony Absalom, Barbara van Leeuwen, Hanneke van der Wal-huisman, Matthijs Plas, Dirk J. Bosch
Summary: Postoperative neurocognitive disorder (pNCD) is a common complication after surgery, and exposure to anaesthetic drugs is implicated as a potential cause. This study identified that longer duration of anesthesia and lower preoperative Mini-Mental State Examination scores are risk factors for pNCD at 3 months after surgery.
BMC ANESTHESIOLOGY
(2023)
Review
Clinical Neurology
Maura Marcucci, Matthew T. Chan, Eric E. Smith, Anthony R. Absalom, P. J. Devereaux
Summary: Although the incidence of perioperative stroke is low, its impact on patients can be substantial. Covert brain infarctions are more common than overt strokes and can lead to various complications. Traditional risk factors and perioperative events are associated with perioperative stroke. Clinicians should be aware of these factors and adopt effective prevention strategies.
Article
Medicine, General & Internal
Annemarie Smid, D. L. Marinus Oterdoom, Rik W. J. Pauwels, Katalin Tamasi, Jan Willem J. Elting, Anthony R. Absalom, Teus van Laar, J. Marc C. van Dijk, Gea Drost
Summary: The study quantified tremor status during and after thalamotomy and found that both the intraoperative insertion effect and the post-coagulation effect are good predictors for the outcomes of thalamotomy.
JOURNAL OF CLINICAL MEDICINE
(2023)
