Novel stilbene analogues containing thiazole moiety: Synthesis, biological evaluation and docking study

Fifteen novel stilbene analogues containing thiazole moiety were designed and synthesized. The structure of the synthesized compounds was confirmed by H-1 NMR, C-13 NMR and ESI-HRMS. These compounds were screened for their topoisomerase I inhibitory activity using Topl-mediated relaxation assay, and compound 6n displayed promising Top1 inhibitory activity. Molecular docking was established to study the structure-activity relationship of the title compounds and a good correlation was observed between Topl inhibitory activity and molecular docking study. Furthermore, in vitro antifungal activities of these compounds were evaluated against FusaHum graminearum, Mycosphaerella melonis and Thanatephorus cucumeris respectively. Some compounds possessed moderate antifungal activity at 50 mg/L, while compound 6i displayed 70.1% inhibition against E graminearum and 6o showed 61.6% inhibition against M. melonis. (C) 2018 Elsevier B.V. All rights reserved.