Journal
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
Volume 29, Issue 5, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1361-6439/ab093d
Keywords
MEMS; piezoresistive cantilever; iPS-cell derived cardiomyocytes; contractile force; force-length relationship
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Funding
- Mitsubishi Foundation
- Hattori Hokokai Foundation
- JSPS KAKENHI [JP18H03759]
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This paper reports on a method for evaluating the force-length relationship of adhering human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) on the substrate using a measurement system comprising of a micromachined movable plate and a piezoresistive force probe. The cells on the plate are stretched by pushing the movable plate with the piezoresistive cantilever, which is actuated by a piezo stage. The twitch forces and the applied stretch are measured quantitatively with the piezoresistive cantilever. The results demonstrated that the twitch forces of the hiPSC-CMs increased when a stretch was applied. This evaluation method improves the understanding of the intrinsic force-length relationship of hiPSC-CMs at the cellular scale.
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