Article
Microbiology
Seyedesomaye Jasemi, Mohammad Emaneini, Zahra Ahmadinejad, Mohammad Sadegh Fazeli, Leonardo A. Sechi, Fatemah Sadeghpour Heravi, Mohammad Mehdi Feizabadi
Summary: Bacteroides fragilis showed high resistance to antibiotics but remained sensitive to metronidazole. tetQ, cepA, and ermF were the most common antibiotic resistance genes identified. Isolates with cepA, cfxA, and ermF genes had significantly different MIC values for cefoxitin, penicillin, and clindamycin.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2021)
Article
Microbiology
Melissa C. Kordahi, Ian B. Stanaway, Marion Avril, Denise Chac, Marie-Pierre Blanc, Benjamin Ross, Christian Diener, Sumita Jain, Paul McCleary, Ana Parker, Vincent Friedman, Jennifer Huang, Wynn Burke, Sean M. Gibbons, Amy D. Willis, Richard P. Darveau, William M. Grady, Cynthia W. Ko, R. William DePaolo
Summary: This study provides fundamental insight into the microbial microenvironment of the pre-neoplastic polyp by highlighting strain-specific genomic and proteomic differences, as well as more broad compositional differences in the microbiome.
CELL HOST & MICROBE
(2021)
Article
Multidisciplinary Sciences
Alan Aitchison, John F. Pearson, Rachel Purcell, Frank A. Frizelle, Jacqueline Keenan
Summary: This study investigated the presence of F. nucleatum DNA in colorectal cancer (CRC) patients and primary care patients. The findings showed that F. nucleatum was present at similar rates in stool samples from both groups, indicating that it may be a biomarker for increased risk of disease. However, molecular evidence of F. nucleatum did not predict the progression of colonic lesions.
Article
Biochemistry & Molecular Biology
Ana Jimenez-Alesanco, Ulrich Eckhard, Marta Asencio del Rio, Sonia Vega, Tibisay Guevara, Adrian Velazquez-Campoy, Francesc Xavier Gomis-Ruth, Olga Abian
Summary: Bacteroides fragilis is a commensal component of the human colon, but under dysbiotic conditions, enterotoxigenic B. fragilis (ETBF) can cause various diseases. ETBF is resistant to many antibiotics and its virulence is mainly related to a zinc-dependent metallopeptidase called B. fragilis toxin (BFT). Researchers have focused on a specific isoform of BFT, BFT-3, and found that certain approved drugs can be repurposed as BFT-3 inhibitors. These inhibitors bind to an allosteric site in the proBFT-3 zymogen structure, preventing the activation of the toxin and reducing its hydrolytic activity. This discovery provides a new approach for developing specific inhibitors for ETBF-mediated enteropathogenic conditions.
Article
Gastroenterology & Hepatology
Manon Oliero, Roy Hajjar, Thibault Cuisiniere, Gabriela Fragoso, Annie Calve, Francois Dagbert, Rasmy Loungnarath, Herawaty Sebajang, Frank Schwenter, Ramses Wassef, Richard Ratelle, Eric De Broux, Carole S. Richard, Manuela M. Santos
Summary: Both healthy controls and CRC patients showed similar levels of colonization by pks + bacteria and ETBF, potentially increasing the risk of developing CRC for both groups. Early-onset CRC patients had significantly lower colonization rates of pks + bacteria compared to late-onset CRC patients.
Article
Oncology
Nasibeh Khodaverdi, Habib Zeighami, Ahmad Jalilvand, Fakhri Haghi, Negar Hesami
Summary: The study revealed a higher concentration of E. faecalis and ETBF in FFPE samples of CRC patients compared to controls. Frequency of ETBF and E. faecalis was significantly higher in late stages of cancer. Additional investigations on fecal and fresh colorectal cancer tissue samples are needed to confirm this correlation.
Article
Oncology
Nancy Scott, Emma Whittle, Patricio Jeraldo, Nicholas Chia
Summary: Studies have shown that there is a potential association or causal role between ETBF and CRC, but the high heterogeneity in study design and reporting makes it difficult to draw a definitive conclusion. More comprehensive studies are needed to confirm the direct involvement of ETBF in the etiology of CRC.
Article
Pharmacology & Pharmacy
Suhang Guo, Yi Peng, Yan Lou, Lijuan Cao, Junqing Liu, Nengming Lin, Sheng Cai, Yu Kang, Su Zeng, Lushan Yu
Summary: The downregulation of FXR in colorectal cancer results in dysregulation of bile acid metabolism, affecting the concentration of secretory immunoglobulin A and gut microbiome, thereby increasing the risk of colorectal tumor development.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Julia Butt, Mazda Jenab, Jill Werner, Veronika Fedirko, Elisabete Weiderpass, Christina C. Dahm, Anne Tjonneland, Anja Olsen, Marie-Christine Boutron-Ruault, Joseph A. Rothwell, Gianluca Severi, Rudolf Kaaks, Renee Turzanski-Fortner, Krasimira Aleksandrova, Matthias Schulze, Domenico Palli, Valeria Pala, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Bas Bueno-de-Mesquita, Carla H. Van Gils, Inger Torhild Gram, Marko Lukic, Nuria Sala, Maria Jose Sanchez Perez, Eva Ardanaz, Maria-Dolores Chirlaque, Richard Palmquist, Thyra Lowenmark, Ruth C. Travis, Alicia Heath, Amanda J. Cross, Heinz Freisling, Semi Zouiouich, Elom Aglago, Tim Waterboer, David J. Hughes
Summary: The study found that sero-positivity to E. coli and ETBF was associated with the development of CRC, with dual infection of these bacterial species potentially contributing to colorectal carcinogenesis. These findings call for further exploration in larger prospective studies and within different population groups.
Article
Gastroenterology & Hepatology
Rachel V. Purcell, Jessica Permain, Jacqueline I. Keenan
Summary: ETBF infection activates IL-8 gene and protein expression through Stat3, while the disruption of E-cadherin appears to be independent of Stat3 signaling.
Article
Oncology
Leila Dadgar-Zankbar, Aref Shariati, Narjess Bostanghadiri, Zahra Elahi, Shiva Mirkalantari, Shabnam Razavi, Fatemeh Kamali, Davood Darban-Sarokhalil
Summary: This study investigated the correlation between the gut microbiota B. fragilis and the expression of signaling pathway genes in colorectal cancer (CRC). The results showed that B. fragilis had a higher abundance in tumor samples and may contribute to CRC by altering cellular signaling pathways and gene expression. No correlation was found between this bacterium and the clinicopathological features of the tumor samples.
INFECTIOUS AGENTS AND CANCER
(2023)
Article
Oncology
Xiaonan Shen, Jialu Li, Jiaqi Li, Yao Zhang, Xiaobo Li, Yun Cui, Qinyan Gao, Xiaoyu Chen, Yingxuan Chen, Jing-Yuan Fang
Summary: This study identified a microbial signature (ETBF-P. stomatis-P. micra) that can accurately diagnose LSTs, with P. stomatis showing strong diagnostic value. P. stomatis was also associated with adenoma recurrence after LST resection, indicating its potential as a predictive biomarker.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, Research & Experimental
Slater L. Clay, Diogo Fonseca-Pereira, Wendy S. Garrett
Summary: The microbiota plays an important role in the development of colorectal cancer (CRC). Identifying specific microbial features that impact CRC initiation and progression is crucial. Bacterial factors, such as toxins, contribute to colorectal carcinogenesis. However, further research is needed to understand the host determinants of a toxin's cancer-promoting effects. For bacteria associated with CRC but lacking toxins, defining cancer-relevant virulence factors is challenging. Additionally, gut microbes can have beneficial effects on CRC antitumor immunity through the production of certain metabolites.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Multidisciplinary Sciences
Dengmei Gong, Amma G. Adomako-Bonsu, Maijian Wang, Jida Li
Summary: Colorectal cancer (CRC) develops from tubular adenomas and serrated polyps in the colon and rectum, and is associated with poor prognosis and high mortality rate. In addition to genetics, lifestyle, and chronic diseases, intestinal integrity and microbiota play important roles in promoting CRC development. This review focuses on the roles and mechanisms of enterotoxigenic Bacteroides fragilis, genotoxic Escherichia coli, and Fusobacterium nucleatum in CRC, and proposes their interaction during CRC initiation and progression. Understanding the relationship between gut microbiota and CRC development may provide valuable insights for therapeutic strategies and prevention strategies.
Review
Microbiology
Maxwell T. White, Cynthia L. Sears
Summary: This review discusses the significant role of the gut microbiota in the development of colorectal cancer (CRC) and the mechanisms by which specific microorganisms and complex microbial communities contribute to CRC pathogenesis. Despite advancements in understanding the microbiota-CRC relationship, there are substantial gaps in current research that need to be addressed.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Grace Gatenby, Tamara Glyn, John Pearson, Richard Gearry, Tim Eglinton
Summary: This study characterized the risk of colorectal cancer in a New Zealand population-based cohort of Crohn's disease patients with colonic inflammation, showing a significantly increased risk compared to the general population. The results suggest that colonic inflammation may increase the risk of neoplasia in this patient population.
COLORECTAL DISEASE
(2021)
Article
Psychiatry
Hill F. Ip, Camiel M. van der Laan, Eva M. L. Krapohl, Isabell Brikell, Cristina Sanchez-Mora, Ilja M. Nolte, Beate St Pourcain, Koen Bolhuis, Teemu Palviainen, Hadi Zafarmand, Lucia Colodro-Conde, Scott Gordon, Tetyana Zayats, Fazil Aliev, Chang Jiang, Carol A. Wang, Gretchen Saunders, Ville Karhunen, Anke R. Hammerschlag, Daniel E. Adkins, Richard Border, Roseann E. Peterson, Joseph A. Prinz, Elisabeth Thiering, Ilkka Seppala, Natalia Vilor-Tejedor, Tarunveer S. Ahluwalia, Felix R. Day, Jouke-Jan Hottenga, Andrea G. Allegrini, Kaili Rimfeld, Qi Chen, Yi Lu, Joanna Martin, Maria Soler Artigas, Paula Rovira, Rosa Bosch, Gemma Espanol, Josep Antoni Ramos Quiroga, Alexander Neumann, Judith Ensink, Katrina Grasby, Jose J. Morosoli, Xiaoran Tong, Shelby Marrington, Christel Middeldorp, James G. Scott, Anna Vinkhuyzen, Andrey A. Shabalin, Robin Corley, Luke M. Evans, Karen Sugden, Silvia Alemany, Laerke Sass, Rebecca Vinding, Kate Ruth, Jess Tyrrell, Gareth E. Davies, Erik A. Ehli, Fiona A. Hagenbeek, Eveline De Zeeuw, Toos C. E. M. Van Beijsterveldt, Henrik Larsson, Harold Snieder, Frank C. Verhulst, Najaf Amin, Alyce M. Whipp, Tellervo Korhonen, Eero Vuoksimaa, Richard J. Rose, Andre G. Uitterlinden, Andrew C. Heath, Pamela Madden, Jan Haavik, Jennifer R. Harris, Oyvind Helgeland, Stefan Johansson, Gun Peggy S. Knudsen, Pal Rasmus Njolstad, Qing Lu, Alina Rodriguez, Anjali K. Henders, Abdullah Mamun, Jackob M. Najman, Sandy Brown, Christian Hopfer, Kenneth Krauter, Chandra Reynolds, Andrew Smolen, Michael Stallings, Sally Wadsworth, Tamara L. Wall, Judy L. Silberg, Allison Miller, Liisa Keltikangas-Jarvinen, Christian Hakulinen, Laura Pulkki-Raback, Alexandra Havdahl, Per Magnus, Olli T. Raitakari, John R. B. Perry, Sabrina Llop, Maria-Jose Lopez-Espinosa, Klaus Bonnelykke, Hans Bisgaard, Jordi Sunyer, Terho Lehtimaki, Louise Arseneault, Marie Standl, Joachim Heinrich, Joseph Boden, John Pearson, L. John Horwood, Martin Kennedy, Richie Poulton, Lindon J. Eaves, Hermine H. Maes, John Hewitt, William E. Copeland, Elizabeth J. Costello, Gail M. Williams, Naomi Wray, Marjo-Riitta Jarvelin, Matt McGue, William Iacono, Avshalom Caspi, Terrie E. Moffitt, Andrew Whitehouse, Craig E. Pennell, Kelly L. Klump, S. Alexandra Burt, Danielle M. Dick, Ted Reichborn-Kjennerud, Nicholas G. Martin, Sarah E. Medland, Tanja Vrijkotte, Jaakko Kaprio, Henning Tiemeier, George Davey Smith, Catharina A. Hartman, Albertine J. Oldehinkel, Miquel Casas, Marta Ribases, Paul Lichtenstein, Sebastian Lundstrom, Robert Plomin, Meike Bartels, Michel G. Nivard, Dorret I. Boomsma
Summary: Childhood aggressive behavior has a high heritability of around 50% and a genome-wide association metaanalysis was conducted in this study. Three significant genes associated with educational traits were identified and polygenic scores based on the analysis could predict aggression significantly. Aggression showed genetic correlations with various psychiatric and psychological traits, while having a negative correlation with cognitive traits and age at first birth. Genetic correlations were stronger for aggression with smoking phenotypes, while weaker for teacher-reported aggression compared to mother- and self-reported aggression.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Developmental Biology
Alexandra J. Noble, John F. Pearson, Alasdair D. Noble, Joseph M. Boden, L. John Horwood, Martin A. Kennedy, Amy J. Osborne
Summary: Maternal tobacco smoking during pregnancy is associated with a higher prevalence of conduct problem in offspring, possibly mediated by alterations in DNA methylation.
REPRODUCTION FERTILITY AND DEVELOPMENT
(2022)
Article
Multidisciplinary Sciences
Alan Aitchison, John F. Pearson, Rachel Purcell, Frank A. Frizelle, Jacqueline Keenan
Summary: This study investigated the presence of F. nucleatum DNA in colorectal cancer (CRC) patients and primary care patients. The findings showed that F. nucleatum was present at similar rates in stool samples from both groups, indicating that it may be a biomarker for increased risk of disease. However, molecular evidence of F. nucleatum did not predict the progression of colonic lesions.
Article
Genetics & Heredity
Leonie M. Hitchman, Allamanda Faatoese, Tony R. Merriman, Allison L. Miller, Yusmiati Liau, Oscar E. E. Graham, Ping Siu Kee, John F. Pearson, Tony Fakahau, Vicky A. Cameron, Martin A. Kennedy, Simran D. S. Maggo
Summary: The study examines the range and frequency of CYP2D6 variants in a sample of 202 Maori and Pacific people in New Zealand. It identifies previously unreported variants and constructs new suballeles and star alleles. The findings highlight the importance of accurately analyzing CYP2D6 genetic variations for pharmacogenetic purposes in this population.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Zoe Ward, Sebastian Schmeier, John Pearson, Vicky A. Cameron, Chris M. Frampton, Richard W. Troughton, Rob N. Doughty, A. Mark Richards, Anna P. Pilbrow
Summary: We developed a short-read RNA-Seq protocol to detect mRNAs, lncRNAs, and circRNAs in plasma for the discovery of novel markers for coronary artery disease (CAD) and heart failure (HF). We found that circulating levels of multiple coding and non-coding transcripts were altered in association with CAD, including several mitochondrial mRNAs. These findings suggest that circulating levels of these transcripts could potentially be used to identify asymptomatic individuals with established CAD before an acute coronary event.
Article
Biology
Christopher Hakkaart, John F. Pearson, Louise Marquart, Joe Dennis, George A. R. Wiggins, Daniel R. Barnes, Bridget A. Robinson, Peter D. Mace, Kristiina Aittomaki, Irene L. Andrulis, Banu K. Arun, Jacopo Azzollini, Judith Balmana, Rosa B. Barkardottir, Sami Belhadj, Lieke Berger, Marinus J. Blok, Susanne E. Boonen, Julika Borde, Angela R. Bradbury, Joan Brunet, Saundra S. Buys, Maria A. Caligo, Ian Campbell, Wendy K. Chung, Kathleen B. M. Claes, Marie-Agnes Collonge-Rame, Jackie Cook, Casey Cosgrove, Fergus J. Couch, Mary B. Daly, Sita Dandiker, Rosemarie Davidson, Miguel de la Hoya, Robin de Putter, Capucine Delnatte, Mallika Dhawan, Orland Diez, Yuan Chun Ding, Susan M. Domchek, Alan Donaldson, Jacqueline Eason, Douglas F. Easton, Hans Ehrencrona, Christoph Engel, D. Gareth Evans, Ulrike Faust, Lidia Feliubadalo, Florentia Fostira, Eitan Friedman, Megan Frone, Debra Frost, Judy Garber, Simon A. Gayther, Andrea Gehrig, Paul Gesta, Andrew K. Godwin, David E. Goldgar, Mark H. Greene, Eric Hahnen, Christopher R. Hake, Ute Hamann, Thomas V. O. Hansen, Jan Hauke, Julia Hentschel, Natalie Herold, Ellen Honisch, Peter J. Hulick, Evgeny N. Imyanitov, Claudine Isaacs, Louise Izatt, Angel Izquierdo, Anna Jakubowska, Paul A. James, Ramunas Janavicius, Esther M. John, Vijai Joseph, Beth Y. Karlan, Zoe Kemp, Judy Kirk, Irene Konstantopoulou, Marco Koudijs, Ava Kwong, Yael Laitman, Fiona Lalloo, Christine Lasset, Charlotte Lautrup, Conxi Lazaro, Clementine Legrand, Goska Leslie, Fabienne Lesueur, Phuong L. Mai, Siranoush Manoukian, Veronique Mari, John W. M. Martens, Lesley McGuffog, Noura Mebirouk, Alfons Meindl, Austin Miller, Marco Montagna, Lidia Moserle, Emmanuelle Mouret-Fourme, Hannah Musgrave, Sophie Nambot, Katherine L. Nathanson, Susan L. Neuhausen, Heli Nevanlinna, Joanne Ngeow Yuen Yie, Tu Nguyen-Dumont, Liene Nikitina-Zake, Kenneth Offit, Edith Olah, Olufunmilayo I. Olopade, Ana Osorio, Claus-Eric Ott, Sue K. Park, Michael T. Parsons, Inge Sokilde Pedersen, Ana Peixoto, Pedro Perez-Segura, Paolo Peterlongo, Timea Pocza, Paolo Radice, Juliane Ramser, Johanna Rantala, Gustavo C. Rodriguez, Karina Ronlund, Efraim H. Rosenberg, Maria Rossing, Rita K. Schmutzler, Payal D. Shah, Saba Sharif, Priyanka Sharma, Lucy E. Side, Jacques Simard, Christian F. Singer, Katie Snape, Doris Steinemann, Dominique Stoppa-Lyonnet, Christian Sutter, Yen Yen Tan, Manuel R. Teixeira, Soo Hwang Teo, Mads Thomassen, Darcy L. Thull, Marc Tischkowitz, Amanda E. Toland, Alison H. Trainer, Vishakha Tripathi, Nadine Tung, Klaartje van Engelen, Elizabeth J. van Rensburg, Ana Vega, Alessandra Viel, Lisa Walker, Jeffrey N. Weitzel, Marike R. Wevers, Georgia Chenevix-Trench, Amanda B. Spurdle, Antonis C. Antoniou, Logan C. Walker
Summary: The risk of germline copy number variants (CNVs) in BRCA1 and BRCA2 pathogenic variant carriers in breast cancer is assessed. CNVs overlapping SULT1A1 decrease breast cancer risk in BRCA1 carriers. Functional analyses show that reduced SULT1A1 expression is associated with reduced cellular proliferation and DNA damage.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Mark Jesus M. Magbanua, Laura van 't Veer, Amy S. Clark, A. Jo Chien, Judy C. Boughey, Hyo S. Han, Anne Wallace, Heather Beckwith, Minetta C. Liu, Christina Yau, E. Paul Wileyto, Andrea Ordonez, Tulasi I. Solanki, Feng Hsiao, Jen Chieh Lee, Amrita Basu, Lamorna Brown Swigart, Jane Perlmutter, Amy L. Delson, Lauren Bayne, Shannon Deluca, Stephanie S. Yee, Erica L. Carpenter, Laura J. Esserman, John W. Park, Lewis A. Chodosh, Angela DeMichele
Summary: This study found that disseminated tumor cells (DTCs) expressing epithelial markers in the bone marrow are associated with recurrence and death after neoadjuvant chemotherapy (NAC). Younger age, larger tumor size, and residual disease at surgery are risk factors for DTC-positivity in the bone marrow.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Gastroenterology & Hepatology
Mei Sze Lee, Alben Thomas, John F. Pearson, Rachel Purcell, Francis Frizelle, Tamara Glyn
Summary: A study found that patients over the age of 40 years presenting with appendicitis have an increased risk of being diagnosed with colorectal cancer (CRC) over the subsequent 3 years. The rate of CRC was significantly higher in this cohort compared to the background population. It is recommended to perform luminal investigation on adults aged 40 years and over who present with acute appendicitis.
COLORECTAL DISEASE
(2023)
Article
Clinical Neurology
Ida Amir, Ben J. Thomson, Jenny Herrod, Melanie Anne Souter, Jill Mustard, John F. Pearson, Philip Bird
Summary: This study evaluates the impact of early cochlear implantation on language development and the influence of socioeconomic status on language skills. The results indicate that children identified through newborn hearing screening have the advantage of earlier implantation and can achieve age-appropriate language after 2 years of implantation.
OTOLOGY & NEUROTOLOGY
(2023)
Article
Health Care Sciences & Services
Timothy C. R. Prickett, John F. Pearson, Richard W. Troughton, Martin A. Kennedy, Eric A. Espiner
Summary: This study aims to re-examine participants from a previous health study to determine whether premature aging of the heart and blood vessels is associated with low BNP and high CNP levels. Confirmation of these findings can lead to early detection and improved outcomes for individuals at high risk.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Anesthesiology
John Pearson, Cameron Jacobson, Nkemdirim Ugochukwu, Elliot Asare, Kelvin Kan, Nathan Pace, Jiuying Han, Neng Wan, Robert Schonberger, Michael Andreae
INTERNATIONAL ANESTHESIOLOGY CLINICS
(2023)
Article
Surgery
Nasya Thompson, Grace Gatenby, Oliver Waddell, Rachel Purcell, Jacqui Keenan, John F. Pearson, Francis Frizelle, Tamara Glyn
Summary: The incidence of early onset colorectal cancer (EOCRC) is increasing in those under 50 years of age, while the overall incidence of colorectal cancer is decreasing. This study aimed to investigate the characteristics and outcomes of EOCRC patients and compare them with late onset colorectal cancer (LOCRC).
ANZ JOURNAL OF SURGERY
(2023)
Article
Biotechnology & Applied Microbiology
Marta F. Nabais, Simon M. Laws, Tian Lin, Costanza L. Vallerga, Nicola J. Armstrong, Ian P. Blair, John B. Kwok, Karen A. Mather, George D. Mellick, Perminder S. Sachdev, Leanne Wallace, Anjali K. Henders, Ramona A. J. Zwamborn, Paul J. Hop, Katie Lunnon, Ehsan Pishva, Janou A. Y. Roubroeks, Hilkka Soininen, Magda Tsolaki, Patrizia Mecocci, Simon Lovestone, Iwona Kloszewska, Bruno Vellas, Sarah Furlong, Fleur C. Garton, Robert D. Henderson, Susan Mathers, Pamela A. McCombe, Merrilee Needham, Shyuan T. Ngo, Garth Nicholson, Roger Pamphlett, Dominic B. Rowe, Frederik J. Steyn, Kelly L. Williams, Tim J. Anderson, Steven R. Bentley, John Dalrymple-Alford, Javed Fowder, Jacob Gratten, Glenda Halliday, Ian B. Hickie, Martin Kennedy, Simon J. G. Lewis, Grant W. Montgomery, John Pearson, Toni L. Pitcher, Peter Silburn, Futao Zhang, Peter M. Visscher, Jian Yang, Anna J. Stevenson, Robert F. Hillary, Riccardo E. Marioni, Sarah E. Harris, Ian J. Deary, Ashley R. Jones, Aleksey Shatunov, Alfredo Iacoangeli, Wouter van Rheenen, Leonard H. van den Berg, Pamela J. Shaw, Cristopher E. Shaw, Karen E. Morrison, Ammar Al-Chalabi, Jan H. Veldink, Eilis Hannon, Jonathan Mill, Naomi R. Wray, Allan F. McRae
Summary: This study identified shared differentially methylated positions in whole blood between neurodegenerative disorders, indicating shared pathogenic mechanisms. Immune abnormalities caused by different neurodegenerative diseases may be interrelated to some extent.