Article
Orthopedics
Feng Gu, Ke Zhang, Wan-an Zhu, Zhenjiang Sui, Jiangbi Li, Xiaoping Xie, Tiecheng Yu
Summary: The study showed that a silicon rubber sealed channel can induce self-healing of long bone by promoting endochondral osteogenesis and preventing fibrous tissue from entering the fracture end. This research has potential implications for the treatment of large bone defects.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Biochemistry & Molecular Biology
Yuhan Chang, Chih-Chien Hu, Ying-Yu Wu, Steve W. N. Ueng, Chih-Hsiang Chang, Mei-Feng Chen
Summary: Bacterial infection in orthopedic surgery poses challenges due to the impact of cell wall components released post-treatment on bone healing processes. This study explored the effects of LPS on bone healing and cell activity, finding ibudilast effective in reversing LPS-induced inhibition of osteoblast activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Lianglong Chen, Chaoyang Huang, Yu Zhong, Yujia Chen, Huihui Zhang, Zijun Zheng, Ziwei Jiang, Xuerong Wei, Yujie Peng, Lei Huang, Libin Niu, Yanbin Gao, Jun Ma, Lei Yang
Summary: In this study, a compound network with physical-chemical double cross-linking was constructed using chemical cross-linking and the intertwining of ADM and chito-san chains under freezing conditions. The heparin-modified composite scaffold with good biocompatibility and cell/tissue affinity significantly promoted cell adhesion and proliferation to achieve adequate fixation and slow down the release of CGF. Polydopamine nanoparticles with excellent photothermal conversion ability promoted the survival of rat autologous skin grafts. In conclusion, this multifunctional composite scaffold shows great potential in delivering CGF to promote healing of full-thickness skin defects.
Article
Biotechnology & Applied Microbiology
Lei Wang, Yan Qu, Wenjun Li, Kai Wang, Song Qin
Summary: The study aimed to investigate the repair effect of tilapia collagen on acute wounds and its effect on the expression level of related genes and their metabolic direction in the repair process. The wound healing effect was observed and evaluated using characterization, histology, and immunohistochemistry. Techniques such as RT-PCR, fluorescence tracer, and frozen section were used to observe the effect of fish collagen on gene expression and metabolic direction in wound repair.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Biomedical
H. W. Kido, P. R. Gabbai-Armelin, A. M. P. Magri, K. R. Fernandes, M. A. Cruz, A. F. Santana, H. M. Caliari, J. R. Parisi, I. R. Avanzi, J. K. M. B. Daguano, R. N. Granito, C. A. Fortulan, A. C. M. Renno
Summary: This study developed bone regenerative therapeutic strategies by adding bone marrow stromal cells (BMSC) to bioglass/collagen (BG/COL) scaffolds. An in vivo study using Wistar rats with critical-size bone defects showed that implantation of BMSC on BG/COL scaffolds effectively stimulated new bone formation and increased the expression of markers related to bone repair. These findings suggest that BG/COL scaffolds and BMSCs hold promise as a therapeutic approach for bone regeneration.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2023)
Article
Cell & Tissue Engineering
Xiankun Cao, Wenxin He, Kewei Rong, Shenggui Xu, Zhiqian Chen, Yuwei Liang, Shuai Han, Yifan Zhou, Xiao Yang, Hui Ma, An Qin, Jie Zhao
Summary: This study revealed that DZNep enhances osteoblast differentiation and mineralization through the EZH2-H3K27me3-Wnt4 axis, while also promotes osteoclast formation via the EZH2-H3K27me3-Foxc1 axis. This enhanced osteogenesis and osteoclastogenesis resulted in accelerated bone defect healing in mice.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Gen Li, Yin Zhang, Jiezhou Wu, Renhao Yang, Qi Sun, Yidong Xu, Bo Wang, Ming Cai, Yang Xu, Chengyu Zhuang, Lei Wang
Summary: This study explores the effects and mechanism of adipose stem cells-derived exosomes (ADSCs-Exos) and ADSCs-Exos modified tissue engineering scaffold on bone defect repair. The results demonstrate that ADSCs-Exos promote the proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), and ADSCs-Exos modified scaffold enhances the repair of BMSCs and bone defects both in vitro and in vivo.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Esther Wehrle, Duncan C. Tourolle ne Betts, Gisela A. Kuhn, Erica Floreani, Malavika H. Nambiar, Bryant J. Schroeder, Sandra Hofmann, Ralph Mueller
Summary: This study examined the therapeutic effects of collagen and BMP-2 treatment on bone defects of different sizes using micro-CT imaging. It was found that BMP-2 significantly accelerated the healing process and increased the union rate, indicating its potential for improving bone regeneration outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Polymer Science
Pengwu Xu, Shuai Tan, Deyu Niu, Qian Wang, Tianxi Liu, Weijun Yang, Piming Ma
Summary: This study investigates the use of PCL as a toughening agent to improve the strength and toughness of PGA materials using extrusion-casting thermal stretching method. High temperature promotes PGA crystallization but reduces toughness, while low temperature increases molecular chain orientation but lowers crystallinity.
Article
Immunology
Yasmine Hachemi, Anna E. Rapp, Sooyeon Lee, Ann-Kristin Dorn, Benjamin T. Krueger, Kathrin Kaiser, Anita Ignatius, Jan Tuckermann
Summary: Effective GR dimerization plays a role in trauma-induced compromised fracture healing, as revealed by a study on mice with decreased GR dimerization ability. GR(dim) mice were found to be protected from the impairment of fracture healing caused by additional thorax trauma.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Engineering, Multidisciplinary
Qing-Yi Zhang, Jie Tan, Rong Nie, Yu-Ting Song, Xing -Li Zhou, Zi-Yuan Feng, Kai Huang, Chen -Yu Zou, Qi-Juan Yuan, Long-Mei Zhao, Xiu-Zhen Zhang, Yan-Lin Jiang, Li -Min Liu, Jesse Li -Ling, Hui-Qi Xie
Summary: Tannic acid and interleukin-10 are added to small intestinal submucosa (SIS) hydrogel to create a composite hydrogel with enhanced immunomodulatory activity. The composite hydrogel shows improved properties such as swelling, anti-degradation, free radical scavenging, and sustained interleukin-10 release. It also promotes M2c macrophage polarization, collagen synthesis, angiogenesis, and extracellular matrix remodeling, thus expanding the clinical applications of SIS hydrogel.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Orthopedics
Marjan Bahraminasab, Athar Talebi, Nesa Doostmohammadi, Samaneh Arab, Ali Ghanbari, Sam Zarbakhsh
Summary: This study investigated the in-vivo healing of critical-sized bony defects using cell-free and stem cell-seeded 3D-printed PLA scaffolds in rat calvaria bone. The results demonstrated that both types of scaffolds exhibited excellent healing capabilities compared to the empty defect controls, with the formation of new bone and connective tissues after 8 and 12 weeks postoperatively. Furthermore, the PLA + Cell scaffolds showed higher filled area, bone formation, and bone maturation after 12 weeks.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Medicine, Research & Experimental
Natalia Ivanjko, Nikola Stokovic, Marina Milesevic, Viktorija Rumenovic, Reinhard Windhager, Kuber T. Sampath, Natasa Kovacic, Danka Grcevic, Slobodan Vukicevic
Summary: Bone morphogenetic proteins (BMPs) require a suitable delivery system for treating spinal and bone defects. INFUSE, the only commercially available BMP-based device, has major disadvantages. A novel device called OSTEOGROW, containing BMP6 dispersed within autologous blood coagulum, shows promising results for bone regeneration. This study compares the release dynamics and cellular response of OSTEOGROW and INFUSE implants and demonstrates that OSTEOGROW is superior in inducing bone formation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Chemistry, Multidisciplinary
Yuhe Zhu, Nanjue Cao, Yue Zhang, Guangxiu Cao, Chunping Hao, Keda Liu, Xiaoming Li, Wei Wang
Summary: This study combined concentrated growth factor (CGF) with nano-hydroxyapatite/collagen (nHAC) to repair rabbit mandibular defects. The results showed that the nHAC/CGF material promoted new bone formation and exhibited superior bone continuity, maturity, and biomechanical properties compared to nHAC alone. These findings provide new insights for the application of bone tissue engineering scaffold materials in oral clinics.
Article
Cell Biology
Tie Liu, Wen Fang, Gang Wu, Yining Li, Janak L. Pathak, Yuelian Liu
Summary: This study investigated the bone defect healing potential of biomimetically fabricated low dose BMP2-doped CaP (BMP2.BioCaP) grafts in sheep humerus/femoral defects. The results showed that BMP2.BioCaP grafts had strong bone regenerative potential, comparable to autologous bone graft and more effective than DBB grafts, while exhibiting lower immunogenicity.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Toxicology
Asieh Karimani, Hossein Hosseinzadeh, Soghra Mehri, Amir Hossein Jafarian, Seyed Akbar Kamali, Amir Hooshang Mohammadpour, Gholamreza Karimi
Summary: The study revealed that acrylamide had higher toxicity to diabetic rats, potentially due to more severe liver and kidney tissue lesions induced by it.
Article
Biochemistry & Molecular Biology
Fatemeh Kalalinia, Zhila Taherzadeh, Nafiseh Jirofti, Nafise Amiri, Neda Foroghinia, Mona Beheshti, Bibi Sedigheh Fazly Bazzaz, Maryam Hashemi, Azadeh Shahroodi, Elham Pishavar, Seyed Abolghasem Sajadi Tabassi, Jebrail Movaffagh
Summary: This study successfully fabricated hybrid chitosan/polyethylene oxide/vancomycin nanofibers and found that CH/PEO/VCM 2.5% exhibited better mechanical properties and smaller fiber diameter. All nanofibers showed no significant cytotoxicity to normal cells and effectively inhibited bacterial growth. The wound healing process was promoted by CH/PEO/VCM 2.5%, with faster healing observed compared to other treatment groups.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Gastroenterology & Hepatology
Hojjatollah Nazari, Vahid Yaghoubi Naei, Asieh Heirani Tabasi, Abolfazl Badripour, Reza Akbari Asbagh, Mohammad Reza Keramati, Amirsina Sharifi, Behnam Behboudi, Alireza Kazemeini, Maryam Abbasi, Amir Keshvari, Seyed Mohsen Ahmadi Tafti
Summary: Regenerative medicine is an emerging therapeutic method that uses advanced technologies such as stem cells, exosomes, and tissue engineering to reconstruct tissues and organs, showing great potential in addressing the limitations of current medical and surgical procedures for treating perianal fistula in patients with Crohn's disease. These advanced methods, including stem cell therapy, exosome therapy, and tissue engineering, bridge the gap between laboratory research and clinical application, offering promising solutions for the treatment of inflammatory diseases like perianal fistula.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Pharmacology & Pharmacy
Hossein Shahdadi Sardou, Abbas Akhgari, Amir Hooshang Mohammadpour, Ali Beheshti Namdar, Hossein Kamali, Amir Hossein Jafarian, Hadi Afrasiabi Garekani, Fatemeh Sadeghi
Summary: The formulation design of colon-specific delivery of 5-aminosalicylic acid shows promise in the treatment of ulcerative colitis. This study used a factorial design to predict an optimal coating composition and coating level for the delivery of 5-ASA pellets. The coated pellets demonstrated improved therapeutic outcomes compared to commercially available delivery systems, potentially due to the pH and time-dependent release mechanism of the coating.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Editorial Material
Pharmacology & Pharmacy
Hossein Hosseinkhani
Summary: Developing 3D living systems can significantly improve biological tools, drug discovery, lead identification, and therapeutic approaches. The miniaturization of this approach allows for more experiments to be performed in a simpler manner.
CURRENT DRUG DELIVERY
(2022)
Review
Food Science & Technology
Elyas Nattagh-Eshtivani, Naseh Pahlavani, Golnaz Ranjbar, Jamshid Gholizadeh Navashenaq, Ammar Salehi-Sahlabadi, Trias Mahmudiono, Mohammed Nader Shalaby, Mohammadhassan Jokar, Mohsen Nematy, Hanieh Barghchi, Shahrzad Havakhah, Mona Maddahi, Mohammad Rashidmayvan, Maryam Khosravi
Summary: This study reviewed the possible effects of propolis on inflammation, oxidative stress, and lipid profile in patients with rheumatoid arthritis (RA). The evidence suggests that supplementation with propolis may have therapeutic effects on RA patients by inhibiting inflammatory cascades and reducing oxidative stress. Further research with larger sample sizes and different doses of propolis is needed to confirm these effects.
FOOD SCIENCE & NUTRITION
(2022)
Review
Cell Biology
Victoria A. Cornelius, Hojjat Naderi-Meshkin, Sophia Kelaini, Andriana Margariti
Summary: Vascular diseases are a major cause of global mortality, and iPSC technologies provide powerful tools for studying vascular health. RBPs play important roles in vascular diseases, contributing to understanding of disease mechanisms and development of new therapies.
Article
Materials Science, Textiles
Shahrbanoo Rahnama, Jebrail Movaffagh, Azadeh Shahroodi, Nafiseh Jirofti, Bibi Sedigheh Fazly Bazzaz, Monir Beyraghdari, Maryam Hashemi, Fatemeh Kalalinia
Summary: Chitosan/melittin nanofibers were fabricated and evaluated for their physicochemical properties, drug release, and antimicrobial activity. Animal studies demonstrated that Ch/Mel nanofibers have a good effect on the treatment of acne vulgaris.
JOURNAL OF INDUSTRIAL TEXTILES
(2022)
Article
Pharmacology & Pharmacy
Jebrail Movaffagh, Tanin Nourollahian, Saeed Khalatbari, Nafise Amiri, Bibi Sedigheh Fazly Bazzaz, Fatemeh Kalalinia
Summary: In this study, teicoplanin-loaded zein-chitosan-zein sandwichlike electrospun nanofibers were successfully fabricated for targeted drug delivery. The nanofibers demonstrated smooth and bead-free morphology with nanoscale diameter. The nanofibers showed good mechanical properties and sustained release of teicoplanin, and exhibited significantly higher antibacterial activity compared to neat zein-chitosan-zein nanofibers and teicoplanin alone.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2022)
Article
Oncology
Raheleh Amirkhah, Kathryn Gilroy, Sudhir B. B. Malla, Tamsin R. M. Lannagan, Ryan M. M. Byrne, Natalie C. C. Fisher, Shania M. M. Corry, Noha-Ehssan Mohamed, Hojjat Naderi-Meshkin, Megan L. L. Mills, Andrew D. D. Campbell, Rachel A. A. Ridgway, Baharak Ahmaderaghi, Richard Murray, Antoni Berenguer Llergo, Rebeca Sanz-Pamplona, Alberto Villanueva, Eduard Batlle, Ramon Salazar, Mark Lawler, Owen J. J. Sansom, Philip D. D. Dunne
Summary: In this study, three approaches for classifying human-to-mouse CRC tissue were developed, with MmCMS-C, a combined pathway system, showing the best accuracy in classifying epithelial-like subtypes (CMS2/3) of tumors. The results provide guidance for researchers to select suitable mouse models for studying human CRC subtypes.
BRITISH JOURNAL OF CANCER
(2023)
Article
Cell Biology
Vahid Moghimi, Jeiran Rahvarian, Zohreh Esmaeilzadeh, Najmeh Mohammad-Pour, Danial Babaki, Fatemeh Sadeghifar, Reza Jafarzadeh Esfehani, Hamid Reza Bidkhori, Nema Mohamadian Roshan, Madjid Momeni-Moghaddam, Hojjat Naderi-Meshkin
Summary: This study investigates the feasibility and effectiveness of using decellularized HAM (dAM) and stromal HAM (sAM) in combination with adipose-derived human mesenchymal stem cells (AdMSCs) to promote wound healing. The results showed that the expression level of VEGF was significantly higher in the sAM/AdMSCs group compared to the dAM/AdMSCs group. In vivo experiments demonstrated that wounds treated with sAM/AdMSCs had more vascularization and thicker collagen deposition compared to untreated wounds and wounds treated with dAM/AdMSCs.
Review
Pharmacology & Pharmacy
Hossein Hosseinkhani, Abraham J. Domb, Ghorbanali Sharifzadeh, Victoria Nahum
Summary: The development of biological methods has generated interest in the possibility to regenerate human tissues. Stem cell research, gene therapy, and tissue engineering have advanced tissue and organ regeneration technology. Technical issues still remain in gene therapy, especially in the clinical use of viral vectors. Non-viral gene transfection agents are emerging as potentially safe and effective alternatives for treating genetic and acquired diseases.
Review
Biochemistry & Molecular Biology
Mohammad Sadegh Lotfi, Fatemeh Kalalinia
Summary: Neurological disorders are a major cause of disability and death. Recent studies have shown that combining stem cells extracted from various tissues with natural stimuli can effectively treat neurological disorders. Flavonoids can induce stem cell differentiation into neurons, stimulate stem cell proliferation, migration, and survival, and increase the secretion of nutritional factors. In addition to their effects on stem cells, flavonoids also have therapeutic effects on the nervous system. Therefore, the simultaneous use of these compounds and stem cells can enhance the therapeutic effect.
NEUROCHEMICAL RESEARCH
(2023)
Article
Cell Biology
Shun Hay Pun, Karla M. O'Neill, Kevin S. Edgar, Eleanor K. Gill, Arya Moez, Hojjat Naderi-Meshkin, Sudhir B. Malla, Michelle B. Hookham, Mohammed Alsaggaf, Vinuthna Vani Madishetti, Bianca Botezatu, William King, Coy Brunssen, Henning Morawietz, Philip D. Dunne, Derek P. Brazil, Reinhold J. Medina, Chris J. Watson, David J. Grieve
Summary: This study aimed to investigate and define the contribution of NOX4 NADPH oxidase to hypoxia-induced dysfunction and explore its potential as a therapeutic target. The results showed that activation of the PLAC8-NOX4 signaling axis improved the angiogenic functions of CB-ECFCs under hypoxic conditions.
Article
Biochemistry & Molecular Biology
Nafiseh Jirofti, Maryam Hashemi, Ali Moradi, Fatemeh Kalalinia
Summary: This study developed a 3D printed crocin-loaded scaffold and demonstrated its good biocompatibility and mechanical properties through analysis of its structure, in vitro performance, and mechanical properties. It holds promise for applications in bone tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)