Article
Medicine, General & Internal
Francesco Moro, Feliciana Mariotti, Anna Pira, Naomi De Luca, Biagio Didona, Gianluca Pagnanelli, Giovanni Di Zenzo
Summary: This article reports a case of a patient with multiple sclerosis and scleroderma who developed severe bullous pemphigoid. The disease may be triggered by an immune response to BP180 and BP230.
FRONTIERS IN MEDICINE
(2022)
Article
Dermatology
W. Masmoudi, M. Vaillant, S. Vassileva, A. Patsatsi, G. Quereux, C. Moltrasio, C. Abasq, C. Prost-Squarcioni, D. Kottler, D. Kiritsi, N. Litrowski, P. Plantin, L. Friedrichsen, A. Zebrowska, S. Duvert-Lehembre, S. Hofmann, V Ferranti, F. Jouen, P. Joly, V Hebert
Summary: This study suggests cut-off values of 20-57 for BPDAI to distinguish mild, moderate and severe BP, and confirms that it is a robust tool to assess BP severity precisely. The intraclass correlation coefficient for BPDAI was high, and improvement in BPDAI score was correlated with decrease in anti-BP180 ELISA value.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Medicine, General & Internal
Carlo Alberto Maronese, Marzia Caproni, Chiara Moltrasio, Giovanni Genovese, Pamela Vezzoli, Paolo Sena, Giulia Previtali, Emanuele Cozzani, Giulia Gasparini, Aurora Parodi, Laura Atzori, Emiliano Antiga, Roberto Maglie, Francesco Moro, Elena Biancamaria Mariotti, Alberto Corra, Sabatino Pallotta, Biagio Didona, Angelo Valerio Marzano, Giovanni Di Zenzo
Summary: Bullous pemphigoid (BP) is an autoimmune disease that COVID-19 vaccines may induce. An Italian study collected data of BP patients associated with COVID-19 vaccines and found that these patients have similar characteristics to idiopathic BP, but with a slight male predominance and reduced humoral response to BP230.
FRONTIERS IN MEDICINE
(2022)
Article
Dermatology
A. Lamberts, N. Kotnik, G. F. H. Diercks, J. M. Meijer, G. Di Zenzo, H. H. Pas, M. F. Jonkman, B. F. Gibbs, U. Raap, B. Horvath
Summary: Total IgE levels were elevated in a significant percentage of both NBP and BP patients, with IgE being present in both serum and skin. The study suggests a common IgE-dependent mechanism in both diseases, such as pruritus, but further research is needed to determine if IgE contributes to blister formation in BP.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Article
Immunology
Roberto Maglie, Maria Efenesia Baffa, Francesca Montefusco, Carlo Pipito, Stefano Senatore, Marco Capassoni, Vincenza Maio, Marco Matucci Cerinic, Emiliano Antiga, Serena Guiducci
Summary: This article describes the unusual occurrence of bullous pemphigoid (BP) in a female patient with a concomitant history of generalized morphea and cutaneous and genital lichen sclerosus. The study provides a literature review on cases of BP in patients with localized scleroderma or lichen sclerosus and discusses the immunological mechanisms that may have contributed to the emergence of BP in the patient.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Sascha Staender, Enno Schmidt, Detlef Zillikens, Ralf J. Ludwig, Khalaf Kridin
Summary: Some patients with bullous pemphigoid have mucosal involvement, which is associated with the absence of anti-BP230 antibodies and peripheral eosinophilia.
JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
(2021)
Article
Dermatology
Yen-Chi Shih, Huijie Yuan, Jia Shen, Jie Zheng, Meng Pan
Summary: The study found that anti-BP230 IgE is more frequently observed in topical-steroid-therapy-resistant patients with bullous pemphigoid, and it prefers the R1 domain of BP230, which is not included in commercially available testing kits. Detection of anti-BP230 IgE can serve as an indicator for initiating systemic steroid therapy.
JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Khalaf Kridin, Nina van Beek, Elena Buehler, Anne S. Kochan, Mahdy Ranjbar, Stefan Beissert, Detlef Zillikens, Claudia Guenther, Enno Schmidt
Summary: This retrospective cohort study evaluated the characteristics associated with refractory disease course and blindness among patients with mucous membrane pemphigoid (MMP) and the association of different treatment strategies with the prognostic outcome. The study found that MMP patients with anti-LAD-1 IgA and anti-DEJ IgG reactivity should be carefully monitored. While initial bilateral ocular disease and scarring ocular lesions were associated with blindness, patients initially presenting with unilateral and nonscarring ocular disease may still develop severe vision impairment.
Article
Dermatology
Florine Guerrois, Elsa Hassan, Thomas Bettuzzi, Vannina Seta, Claire Goulvestre, Lamia Jelti, Thibaut Belmondo, Pierre Wolkenstein, Selim Aractingi, Saskia Ingen-Housz-Oro, Nicolas Dupin
Summary: The study identified three different clusters of BP, including one corresponding to severe BP1801 BP230- BP with features common to mucous membrane pemphigoid.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Dermatology
Florine Guerrois, Elsa Hassan, Thomas Bettuzzi, Vannina Seta, Claire Goulvestre, Lamia Jelti, Thibaut Belmondo, Pierre Wolkenstein, Selim Aractingi, Saskia Ingen-Housz-Oro, Nicolas Dupin
Summary: This study identifies three different clusters of Bullous pemphigoid (BP), one of which has common features with mucous membrane pemphigoid. Understanding the different clinical and biological profiles of BP is crucial in the diagnosis and treatment of the disease.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Immunology
Dario Didona, Luca Scarsella, Milad Fehresti, Farzan Solimani, Hazem A. Juratli, Manuel Goebel, Stefan Muehlenbein, Lily Holiangu, Josquin Pieper, Vera Korff, Thomas Schmidt, Cassian Sitaru, Ruediger Eming, Michael Hertl, Robert Pollmann
Summary: Bullous pemphigoid is an autoimmune disorder in elderly individuals characterized by serum IgG autoantibodies. Chronic pruritus in the elderly may be related to autoimmunity, and therapeutic application of clobetasol propionate ointment in BP patients has been shown to reduce BP180-specific T cells and improve symptoms.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Bianca Opelka, Enno Schmidt, Stephanie Goletz
Summary: Pemphigoid diseases are autoimmune skin blistering diseases characterized by autoantibodies against proteins of the cutaneous basement membrane zone. The interaction between autoantibodies and BP180 antigen leads to immune cell activation, inflammation, and blister formation. The clinical phenotype of the disease is influenced by the specificity of antibodies and epitopes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
S. Staender, E. Schmidt, D. Zillikens, D. Thaci, R. J. Ludwig, K. Kridin
Summary: Patients with both BP and psoriasis present at a younger age with a milder disease phenotype, lower levels of pathogenic autoantibodies, and specific linear C3 deposits along the dermal-epidermal junction detected by direct immunofluorescence microscopy.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Immunology
Connor Cole, Keshavamurthy Vinay, Luca Borradori, Kyle T. Amber
Summary: Bullous pemphigoid is an autoimmune blistering disease caused by autoantibodies. While typically considered complement-mediated, recent evidence suggests complement-independent mechanisms may also contribute to tissue damage and blister formation, opening new perspectives for targeted treatments.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Nina van Beek, Khalaf Kridin, Elena Buhler, Anne S. Kochan, Sascha Stander, Ralf J. Ludwig, Detlef Zillikens, Enno Schmidt, Claudia Gunther
Summary: This study aimed to characterize the clinical, immunoserological, and immunopathological features of patients with MMP, finding that the most frequently targeted antigen was BP180. Ocular disease was inversely associated with oral and nasal involvement and was associated with an increased risk of malignant neoplasms. Anti-laminin 332 reactivity was associated with malignant neoplasms, while anti-BP180 NC16A immunoglobulin G seropositivity was associated with the absence of ocular lesions.
Review
Nursing
Heli Kerimaa, Heidi Ruotsalainen, Helvi Kyngas, Jouko Miettunen, Tarja Polkki
Summary: This systematic review found that certain preparatory interventions can reduce parental anxiety and stress, and alleviate children's fear and pain. However, more randomized controlled trials are needed to determine the most effective methods for preparing parents and children for day surgery.
JOURNAL OF CLINICAL NURSING
(2023)
Article
Psychiatry
Marjo Seppanen, Tiina Lankila, Juha Auvinen, Jouko Miettunen, Raija Korpelainen, Markku Timonen
Summary: This study examined the cultural differences of Beck Depression Inventory (BDI-II) symptoms among different countries. The results showed significant differences in symptom scores between countries, highlighting the importance of considering cultural differences when interpreting BDI-II item scores.
Article
Psychiatry
Antti Mustonen, Anni-Emilia Alakokkare, James G. Scott, Anu-Helmi Halt, Miika Vuori, Tuula Hurtig, Alina Rodriguez, Jouko Miettunen, Solja Niemela
Summary: This study investigated the association between symptoms of attention deficit hyperactive disorder (ADHD) in adolescents and risk of mortality. The results showed that higher scores in inattentive, hyperactive, and combined symptoms were associated with increased risk of death. However, this association was partially attenuated by adolescent substance use.
NORDIC JOURNAL OF PSYCHIATRY
(2023)
Article
Psychology, Clinical
Maria Protsenko, Martta Kerkela, Jouko Miettunen, Juha Auvinen, Marjo-Riitta Jarvelin, Peter B. Jones, Mika Gissler, Juha Veijola
Summary: There is a familial association between parental severe mental illness (SMI) and obesity in middle-aged offspring, especially in the offspring of mothers with SMI.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Dermatology
Outi Lindgren, Gwenaelle Le Menn, Jussi Tuusa, Zhi Jane Chen, Kaisa Tasanen, Nina Kokkonen
Summary: Deletion of exon 18 from Col17a1 in transgenic ANC14A mice leads to the absence of the NC14A domain, which corresponds to the immunodominant epitope in bullous pemphigoid. Before the age of 1 year, 84% of ANC14A mice develop severe itch and skin erosion. Further characterization reveals acanthosis, subepidermal blistering, and inflammatory cell infiltrates in the lesional skin, along with linear complement C3, IgG, and/or IgA deposition. Increased expression of IL-17-associated cytokines and changes in immune cell proportions are observed. Treatment with anti-IL-17A decreases the expression of certain cytokines in the nonlesional skin.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Jussi Tuusa, Nina Kokkonen, Anja Mattila, Laura Huilaja, Outi Varpuluoma, Sirpa Rannikko, Virpi Glumoff, Jouko Miettunen, Kaisa Tasanen
Summary: Dipeptidyl peptidase 4 inhibitors (DPP4is), commonly used drugs for type 2 diabetes, increase the risk of bullous pemphigoid (BP). The mechanism leading to the loss of immunological tolerance and the differences between DPP4i-associated BP (DPP4i-BP) and regular BP are largely unknown. This study analyzed cytokine expression in lesional and nonlesional skin samples of patients with regular BP or DPP4i-BP, and found distinct molecular fingerprints between the two.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Psychiatry
Tuomas Majuri, Anni-Emilia Alakokkare, Marianne Haapea, Tanja Nordstrom, Jouko Miettunen, Erika Jaaskelainen, Leena Ala-Mursula
Summary: This study compared employment trajectories among individuals with schizophrenia, other psychoses, and without psychosis. The findings showed that most individuals with mental illnesses had unstable employment trajectories, indicating a higher risk of unemployment and part-time work. The study highlights the importance of improving labor market attachment during the early stages of mental illness.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Business
Mikko Vaaramo, Leena Ala-Mursula, Jouko Miettunen, Marko Korhonen
Summary: This study examines the differences in economic preferences and temperament traits between different categories of business leaders (i.e., managers, self-employed with employees, self-employed without employees) and paid employees. The results show that business leaders generally have different economic preferences and temperament traits compared to paid employees. The temperament trait of novelty-seeking seems relevant for becoming a manager, while the economic preference of risk-taking appears important for becoming self-employed.
SMALL BUSINESS ECONOMICS
(2023)
Article
Psychiatry
Johanna Palomaki, Sebastian Therman, Martta Kerkela, Marjo-Riitta Jarvelin, Peter Jones, Graham K. Murray, Tanja Nordstrom, Markus Heinimaa, Jouko Miettunen, Juha Veijola, Tiina Riekki
Summary: This study examined the relationship between specific adolescent psychotic-like symptoms and psychiatric disorders. Three symptoms were found to be associated with the onset of psychosis, which is a significant finding.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Article
Public, Environmental & Occupational Health
Anna-Kaisa Karppanen, Jouko Miettunen, Tuula Hurtig, Tanja Nordstroem, Tuija Tammelin, Raija Korpelainen
Summary: This population-based birth cohort study examines the associations between self-reported temperament at age 31 and self-reported leisure-time physical activity (MVPA) levels and changes from age 31 to age 46. The results suggest that temperament may play a role in determining the level and sustainability of MVPA.
Article
Clinical Neurology
Nurul Hanis Ramzi, Juha Auvinen, Juha Veijola, Jouko Miettunen, Leena Ala-Mursula, Sylvain Sebert, Sirkka Keinanen-Kiukaanniemi, Rauli Svento, Jari Jokelainen, Fotios Drenos, Terence M. Dovey, Marjo-Riitta Jarvelin, Alexandra I. F. Blakemore
Summary: This study examined the relationship between depressive symptoms and body mass index (BMI) in adults, and found a significant correlation between them. Depressive symptoms were found to partially and completely mediate the effects of BMI over a 15-year period. These findings have important implications for future clinical obesity research.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Health Policy & Services
Tomi Bergstrom, Jaakko Seikkula, Selma Gaily-Luoma, Jouko Miettunen, Mia Kurtti
Summary: In the Open Dialogue (OD) based psychiatric services, adolescent patients receive less medication and are more likely to be treated as outpatients compared to standard services. This study aimed to evaluate the association between treatment under OD and the probability of suicide compared to standard psychiatric care. The results show no statistically significant differences in 5-year suicide hazard ratios between the OD group and the comparison group.
COMMUNITY MENTAL HEALTH JOURNAL
(2023)