Review
Cell Biology
Shuhui Li, Wei Meng, Ziyi Guo, Min Liu, Yanyun He, Yanli Li, Zhongliang Ma
Summary: Cancer, a leading cause of human death, has been found to be closely associated with MicroRNAs. The miR-183 cluster, composed of miR-183, miR-96, and miR-182, is transcribed as a polycistronic miRNA cluster. In most cases, these clusters promote cancer development through different pathways. Exosomes, as extracellular vesicles, play a crucial role in cellular communication and tissue microenvironment regulation. Interestingly, the miR-183 cluster can be detected in exosomes and plays a functional regulatory role in tumor development. This review summarizes the biogenesis and functions of the miR-183 cluster in prevalent cancers, its relationship with other non-coding RNAs, and discusses its potential as a target for cancer therapy.
Article
Biochemistry & Molecular Biology
Jack A. Prescott, Kathryn Balmanno, Jennifer P. Mitchell, Hanneke Okkenhaug, Simon J. Cook
Summary: IKK alpha plays a major role in canonical NF-Kappa B signaling in colorectal cells, while IKK beta is less efficient in compensating for the loss of IKK alpha. Different NF-Kappa B subunits exhibit different dependencies on these IKKs.
BIOCHEMICAL JOURNAL
(2022)
Article
Agriculture, Dairy & Animal Science
Wenxiu Ru, Kunpeng Liu, Jiameng Yang, Jianyong Liu, Xinglei Qi, Bizhi Huang, Hong Chen
Summary: In this study, we identified that the miR-183/96/182 cluster is highly expressed in bovine embryonic muscle and widely exists in other tissues. Functional assays demonstrated that the miR-183/96/182 cluster regulates the proliferation and differentiation of bovine myoblasts by targeting the FoxO1 gene.
Article
Cell Biology
Bjoern Schneider, Doreen William, Nora Lamp, Annette Zimpfer, Christian Henker, Carl Friedrich Classen, Andreas Erbersdobler
Summary: In this study, the researchers analyzed the miRNA expression profiles in GBM with or without EGFR amplification. They found that the miR-183/96/182 cluster was upregulated in EGFR-amplified tumors and that it was correlated with downregulation of FOXO1. These findings provide important insights into the molecular mechanisms of this tumor subtype and potential targets for miRNA-based therapies.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Medicine, Research & Experimental
Minakshi Rana, Andrea La Bella, Rivka Lederman, Bruce T. Volpe, Barbara Sherry, Betty Diamond
Summary: Sepsis survivors demonstrate impaired humoral response to antigen challenge, which is attributed to dysfunction in follicular dendritic cells (FDCs) and germinal center (GC) B cells.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Ophthalmology
Sharon McClellan, Ahalya Pitchaikannu, Robert Wright, Denise Bessert, Mason Iulianelli, Linda D. Hazlett, Shunbin Xu
Summary: Prophylactic knockdown of miR-183C was found to ameliorate Pseudomonas aeruginosa-induced keratitis by regulating innate immunity, corneal innervation, and neuroimmune interactions.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Oncology
Gunjan Mandal, Subir Biswas, Carmen M. Anadon, Xiaoqing Yu, Chandler D. Gatenbee, Sandhya Prabhakaran, Kyle K. Payne, Ricardo A. Chaurio, Alexandra Martin, Patrick Innamarato, Carlos Moran, John J. Powers, Carly M. Harro, Jessica A. Mine, Kimberly B. Sprenger, Kristen E. Rigolizzo, Xuefeng Wang, Tyler J. Curiel, Paulo C. Rodriguez, Alexander R. Anderson, Ozlen Saglam, Jose R. Conejo-Garcia
Summary: This study reveals the crucial role of humoral immunity in human endometrial cancer and provides insights for the development of novel immunotherapies against this prevalent malignancy. Coordinated cellular and humoral immune responses, particularly involving B cells and IgA:plgR interactions, determine the progression of endometrial cancer and its response to treatment.
Review
Cell Biology
Lingfeng Qiu, Yixi Zhang, Xun Zeng
Summary: The purpose of this review is to discuss the role of gamma delta T cells in humoral immune responses. Accumulating evidence indicates that gamma delta T cells, independent of alpha beta T cells, participate in multiple steps of humoral immunity, including B cell maturation, activation and differentiation, antibody production and class switching. Gamma delta T cells affect B cell function by directly interacting with B cells, secreting cytokines, or modulating alpha beta T cells.
INFLAMMATION RESEARCH
(2023)
Article
Mathematical & Computational Biology
Chihua Wu, Youlin Tuo, Gang Hu, Jing Luo
Summary: The study revealed a close relationship between miR-183-5p and the development of breast cancer, with high levels of miR-183-5p exacerbating cancer progression. The regulatory gene RGS2 was found to be low in BC and negatively correlated with miR-183-5p, with the two genes influencing cancer progression through their interaction.
COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
(2021)
Article
Immunology
Nivedya Swarnalekha, David Schreiner, Ludivine C. Litzler, Saadia Iftikhar, Daniel Kirchmeier, Marco Kunzli, Young Min Son, Jie Sun, Etori Aguiar Moreira, Carolyn G. King
Summary: Following influenza infection, long-lived T-RH cells are established in the lung, dependent on B cells in iBALT, for rapid response to subsequent infections. Deletion of Bcl6 in CD4(+) T cells results in redistribution of T cells and impaired local antibody production.
SCIENCE IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yaoying Wu, Hanning Wen, Zachary J. Bernstein, Kelly M. Hainline, Tykia S. Blakney, Kendra L. Congdon, David J. Snyder, John H. Sampson, Luis Sanchez-Perez, Joel H. Collier
Summary: The study demonstrates the potential clinical benefit of vaccine-induced antibody responses for tumor treatments when combined with simultaneous CD8(+) and CD4(+) responses, using a nanofiber vaccine design approach. Additionally, the study highlights the importance of supramolecular nanomaterials in developing multiepitope cancer vaccines.
Article
Obstetrics & Gynecology
Wang Yao, Siqi Wang, Xing Du, Chenggang Lin, Jinbi Zhang, Zengxiang Pan, Qifa Li
Summary: This study characterized the promoter region of the porcine miR-183-96-182 cluster and identified SMAD4 as a potential transcriptional activator of this cluster in GCs through direct binding to SBE motifs. The study also revealed a potential regulatory pathway involving TGF-beta 1/SMAD4/miR-183-96-182 cluster/FoxO1 in controlling follicular atresia and female reproduction.
REPRODUCTIVE SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Rong Fu, Zhangfeng Dou, Ning Li, Jinqi Zhang, Zhuoyu Li, Peng Yang
Summary: Cellular senescence induction by AVN C in colorectal cancer cells is mediated through transcriptional repression of the miR-183/96/182 cluster, leading to reduced levels of mature miR-183, -96, and -182. Additionally, AVN C facilitates p53-mediated p21 transactivation by suppressing beta-catenin.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Immunology
Jennifer A. Juno, Danika L. Hill
Summary: T follicular helper (Tfh) cells play a crucial role in the development, maintenance, and output of the germinal centre (GC) response, impacting vaccine immunity. Different cytokine environments influence Tfh cell differentiation, while sampling lymph nodes offers new avenues for studying GC responses directly.
CURRENT OPINION IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Sumita Mishra, Junfeng Ma, Desirae McKoy, Masayuki Sasaki, Federica Farinelli, Richard C. Page, Mark J. Ranek, Natasha Zachara, David A. Kass
Summary: This study reveals that the calcium channel TRPC6 is constitutively O-GlcNAcylated at Ser14, Thr70, and Thr221 in the N-terminus, and this O-GlcNAcylation plays a critical role in regulating TRPC6 channel conductance and NFAT activation.
Article
Immunology
Joseph N. Pucella, Wei-Feng Yen, Myoungjoo V. Kim, Joris van der Veeken, Nicholas D. Socci, Yukiko Naito, Ming O. Li, Naoharu Iwai, Jayanta Chaudhuri
JOURNAL OF IMMUNOLOGY
(2015)
Correction
Immunology
Joseph N. Pucella, Wei-Feng Yen, Myoungjoo V. Kim, Joris van der Veeken, Chong T. Luo, Nicholas D. Socci, Yukiko Naito, Ming O. Li, Naoharu Iwai, Jayanta Chaudhuri
JOURNAL OF IMMUNOLOGY
(2015)
Editorial Material
Biochemistry & Molecular Biology
Joseph N. Pucella, Jayanta Chaudhuri
Article
Multidisciplinary Sciences
Wei-Feng Yen, Ashutosh Chaudhry, Bharat Vaidyanathan, William T. Yewdell, Joseph N. Pucella, Rahul Sharma, Yulong Liang, Kaiyi Li, Alexander Y. Rudensky, Jayanta Chaudhuri
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Immunology
Bao Q. Vuong, Kayleigh Herrick-Reynolds, Bharat Vaidyanathan, Joseph N. Pucella, Anna J. Ucher, Nina M. Donghia, Xiwen Gu, Laura Nicolas, Urszula Nowak, Numa Rahman, Matthew P. Strout, Kevin D. Mills, Janet Stavnezer, Jayanta Chaudhuri
Review
Immunology
Bharat Vaidyanathan, Wei-Feng Yen, Joseph N. Pucella, Jayanta Chaudhuri
FRONTIERS IN IMMUNOLOGY
(2014)
Article
Cell Biology
Wei-Feng Yen, Rahul Sharma, Montserrat Cols, Colleen M. Lau, Ashutosh Chaudhry, Priyanka Chowdhury, William T. Yewdell, Bharat Vaidyanathan, Amy Sun, Maryaline Coffre, Joseph N. Pucella, Chun-Chin Chen, Maria Jasin, Joseph C. Sun, Alexander Y. Rudensky, Sergei B. Koralov, Jayanta Chaudhuri
Article
Immunology
Chetna Soni, Oriana A. Perez, William N. Voss, Joseph N. Pucella, Lee Serpas, Justin Mehl, Krystal L. Ching, Jule Goike, George Georgiou, Gregory C. Ippolito, Vanja Sisirak, Boris Reizis
Review
Cell Biology
Joseph N. Pucella, Samik Upadhaya, Boris Reizis
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 36, 2020
(2020)
Article
Immunology
Jue Feng, Joseph N. Pucella, Geunhyo Jang, Marcela Alcantara-Hernandez, Samik Upadhaya, Nicholas M. Adams, Alireza Khodadadi-Jamayran, Colleen M. Lau, Marlon Stoeckius, Stephanie Hao, Peter Smibert, Aristotelis Tsirigos, Juliana Idoyaga, Boris Reizis
Summary: This study investigates the developmental origins of dendritic cells (DCs) and reveals the shared origin of pDCs and cDCs, suggesting a revised scheme of DC development.
Article
Hematology
Jue Feng, Pei-Feng Hsu, Eduardo Esteva, Rossella Labella, Yueyang Wang, Alireza Khodadadi-Jamayran, Joseph Pucella, Cynthia Z. Liu, Arnaldo A. Arbini, Aristotelis Tsirigos, Stavroula Kousteni, Boris Reizis
Summary: Deletion of the 9p21 locus is associated with reduced survival in cancer patients and can lead to myelodysplastic syndrome/myeloproliferative neoplasm and aberrant bone formation in the bone marrow.