Article
Multidisciplinary Sciences
Mariachiara Carestia, Massimo Andreoni, Ersilia Buonomo, Fausto Ciccacci, Luigi De Angelis, Gerardo De Carolis, Patrizia De Filippis, Daniele Di Giovanni, Leonardo Emberti Gialloreti, Carla Fontana, Luca Guarente, Andrea Magrini, Marco Mattei, Stefania Moramarco, Laura Morciano, Claudia Mosconi, Stefano Orlando, Giuseppe Quintavalle, Fabio Riccardi, Viviana Santoro, Leonardo Palombi
Summary: In Italy, the integration of microbiology laboratory data with electronic health records (EHRs) has provided a valuable tool for evaluating healthcare-associated infections (HAIs) and antimicrobial resistance (AMR). This study successfully established a management system that accurately assessed the burden of HAIs and the impact of AMR. Despite a low percentage of HAIs caused by antimicrobial resistant bacteria, the contribution of AMR to increased mortality risk was significant.
Article
Immunology
Tim Du, Kelly B. Choi, Anada Silva, George R. Golding, Linda Pelude, Romeo Hizon, Ghada N. Al-Rawahi, James Brooks, Blanda Chow, Jun C. Collet, Jeannette L. Comeau, Ian Davis, Gerald A. Evans, Charles Frenette, Guanghong Han, Jennie Johnstone, Pamela Kibsey, Kevin C. Katz, Joanne M. Langley, Bonita E. Lee, Yves Longtin, Dominik Mertz, Jessica Minion, Michelle Science, Jocelyn A. Srigley, Paula Stagg, Kathryn N. Suh, Nisha Thampi, Alice Wong, Susy S. Hota
Summary: We investigated the epidemiology and molecular characteristics of healthcare-associated and community-associated Clostridioides difficile infection (CDI) in adult patients in Canadian hospitals. Our study found higher mortality rate associated with healthcare-associated CDI, and a decrease in both healthcare-associated and community-associated CDI rates from 2015 to 2019. Certain ribotypes were more commonly associated with CDI-related deaths.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Nicolas Francisco Fernandez-Martinez, Mario Rivera-Izquierdo, Rocio Ortiz-Gonzalez-Serna, Virginia Martinez-Ruiz, Pablo Lardelli-Claret, Adrian Hugo Aginagalde-Llorente, Maria del Carmen Valero-Ubierna, Maria Auxiliadora Vergara-Diaz, Nicola Lorusso
Summary: This study indicates that social factors should be considered when investigating healthcare-associated infections caused by multidrug-resistant bacteria. The heterogeneity in the incidence of cases between municipalities in Andalusia may be explained by social determinants of health, as well as under-notification.
Review
Infectious Diseases
Jessica L. Fraser, Athman Mwatondo, Yewande H. Alimi, Jay K. Varma, Victor J. Del Rio Vilas
Summary: In Africa, there is a significant under-detection and under-reporting of healthcare-associated infection outbreaks over the 10-year period. The quality and timeliness of reporting need to be improved to ensure changes in public health practice.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Microbiology
Flora Cruz-Lopez, Adrian Martinez-Melendez, Elvira Garza-Gonzalez
Summary: Healthcare-associated infections (HAIs) are a global public health concern and are associated with high mortality and antimicrobial resistance. The hospital environment serves as a potential reservoir for pathogenic microbial strains, which can persist on medical equipment surfaces, patient surroundings, and patient and healthcare worker surfaces. Understanding the hospital microbiota can provide knowledge on the relationship between commensal and pathogenic microorganisms, their role in HAI development, and the environmental conditions that promote their proliferation.
Article
Immunology
Richard E. Nelson, Kelly M. Hatfield, Hannah Wolford, Matthew H. Samore, R. Douglas Scott, Sujan C. Reddy, Babatunde Olubajo, Prabasaj Paul, John A. Jernigan, James Baggs
Summary: This study estimated the healthcare costs associated with infections due to multidrug-resistant bacteria in the United States, revealing that these infections resulted in substantial healthcare costs.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Immunology
Ayman Elbehiry, Eman Marzouk, Adil Abalkhail, Yasmine El-Garawany, Sulaiman Anagreyyah, Yaser Alnafea, Abdulaziz M. Almuzaini, Waleed Alwarhi, Mohammed Rawway, Abdelmaged Draz
Summary: The growing risk of antimicrobial resistance (AMR) has negative impacts on the healthcare system, calling for the development of quick diagnostic tools and new treatment approaches to combat multidrug-resistant pathogens in healthcare-associated infections (HAIs).
Article
Infectious Diseases
Paula Soza-Ossandon, Dacil Rivera, Kasim Allel, Gerardo Gonzalez-Rocha, Mario Quezada-Aguiluz, Ivan San Martin, Patricia Garcia, Andrea Moreno-Switt
Summary: Healthcare-associated infections caused by Staphylococcus, particularly Staphylococcus aureus, pose a high risk to human and animal health. The study identified methicillin resistant staphylococci in equine patients and hospital environments, showing the presence of multidrug resistance genes and potential transmission risks. Tackling antimicrobial resistance within equine hospitals should involve wider control over antimicrobial consumption and reducing exposure to AMR reservoirs in animals to prevent cross-transmission of drug-resistant Staphylococcus.
Article
Immunology
Richard E. Nelson, David Hynn, Amanda Jezek, Matthew H. Samore
Summary: This study analyzed data from the Department of Veterans Affairs in the United States and found that infections due to multidrug-resistant bacteria were associated with high healthcare costs and mortality rates. Efforts to prevent these infections could save a significant number of lives and healthcare resources.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Infectious Diseases
Massimo Sartelli, Stefano Bartoli, Felice Borghi, Stefano Busani, Andrea Carsetti, Fausto Catena, Nicola Cillara, Federico Coccolini, Andrea Cortegiani, Francesco Cortese, Elisa Fabbri, Domitilla Foghetti, Francesco Forfori, Antonino Giarratano, Francesco Maria Labricciosa, Pierluigi Marini, Claudio Mastroianni, Angelo Pan, Daniela Pasero, Marco Scatizzi, Bruno Viaggi, Maria Luisa Moro
Summary: Healthcare-associated infections (HAIs) have negative impacts on patients and also incur additional costs to the healthcare system. With the rise of antibiotic resistance, preventing HAIs has become more crucial. It is an important indicator of healthcare quality and patient safety, and should be prioritized by all health systems worldwide.
Article
Infectious Diseases
Petros Ioannou, Eirini Astrinaki, Efsevia Vitsaxaki, Emmanouil Bolikas, Despoina Christofaki, Apostolia Salvaraki, Eirini Lagoudaki, Eleni Ioannidou, Stamatis Karakonstantis, Stamatina Saplamidou, Christos Cleovoulou, Eleni Stamataki, Stavroula Ilia, Argyri Messaritaki, Michaela Avdi, Anthoula Chalkiadaki, Styliani Papathanasaki, Chrisanthi Markopoulou, Evagelia Magouli, Maria Moustaki, Vasileia-Athina Kataxaki, Panagiotis Skevakis, Nikolaos Spernovasilis, Georgios Chamilos, Diamantis P. Kofteridis
Summary: The prevalence of healthcare-associated infections (HAIs) and antimicrobial use among hospitalized patients in Crete, Greece was found to be similar to the national levels despite the COVID-19 pandemic. However, the prevalence of HAIs and antimicrobial use remains high, emphasizing the need for adequate infection control and antimicrobial stewardship interventions.
Article
Infectious Diseases
Abbas Al Mutair, Saad Alhumaid, Zainab Al Alawi, Abdul Rehman Z. Zaidi, Ahmed J. Alzahrani, Jaffar A. Al-Tawfiq, Haifa Al-Shammari, Ali A. Rabaan, Osamah Khojah, Awad Al-Omari
Summary: The study conducted in three private tertiary-care hospitals in Saudi Arabia revealed that a significant number of pathogens were responsible for healthcare-associated infections, with Escherichia coli, Klebsiella spp., and Staphylococcus aureus being the most common causative organisms. Gram-negative pathogens were more likely to cause infections compared to Gram-positive bacteria, with extended-spectrum cephalosporin-resistant E. coli being the most prevalent resistant pathogen.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2021)
Article
Health Care Sciences & Services
Yu-Ren Lin, Yen-Yue Lin, Chia-Peng Yu, Ya-Sung Yang, Chun-Gu Cheng, Chun-An Cheng
Summary: The incidence density of HAIs in Taiwan ICUs has decreased, but the proportions of Klebsiella pneumoniae and Enterococcus faecium have significantly increased. The proportions of carbapenem-resistant K. pneumoniae and vancomycin-resistant E. faecium have also shown a significant increase over time.
Article
Public, Environmental & Occupational Health
Tingting Le, Ling Wang, Chaoying Zeng, Leiwen Fu, Zhihua Liu, Jing Hu
Summary: Nosocomial and healthcare-associated K. pneumoniae infections displayed similar clinical features and antimicrobial resistance, differing from community-acquired infections. CRKP and ESBL-producing strains were mainly found in HCA and nosocomial groups, showing clonal diversity. Cross transmission of CRKP existed among HCA and nosocomial patients, suggesting the need for consistent empirical therapy and resistance surveillance for these infections.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Review
Infectious Diseases
Mona Al Dabbagh, Mohammad Alghounaim, Rana H. Almaghrabi, Ghassan Dbaibo, Ghassan Ghatasheh, Hanan M. Ibrahim, Mohamed Abdel Aziz, Ashraf Hassanien, Naglaa Mohamed
Summary: This review examines the prevalence of healthcare-associated infections (HAIs) caused by Gram-negative bacteria (GNB) in pediatric patients in the Middle East. The study found that Klebsiella species/K. pneumoniae and Escherichia coli were the most common GNB associated with infections, with high rates of carbapenem resistance and multidrug resistance (MDR). The review highlights the need for enhanced implementation of infection control, antimicrobial stewardship programs, and antimicrobial resistance surveillance in the region.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Public, Environmental & Occupational Health
Aidyn Gurbanovych Salmanov, Sergiy Yuriovych Vdovychenko, Oleksandr Ivanovych Litus, Victor Ivanovych Litus, Yuriy Anatoliovych Bisyuk, Tetiana Mykolaivna Bondarenko, Lena Levonivna Davtian, Tetiana F. Olifirova, Mariya V. Leleka, Oleksandr Ivanovych Kovalchuk, Iryna Viktorivna Dzevulska, Vladyslav Vladyslavovych Moroz, Rostislav Felixovich Kaminsky, Zinaida Egorovna Zhegulovych, Iryna Valeriivna Kerechanyn
AMERICAN JOURNAL OF INFECTION CONTROL
(2019)
Article
Endocrinology & Metabolism
Maryna Neborachko, Aleksandr Pkhakadze, Iryna Vlasenko
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS
(2019)