Determining the pharmacokinetics of nicotinic drugs in the endoplasmic reticulum using biosensors

Intracellular GPCRs Play Key Roles in Synaptic Plasticity

(2018) Yuh-Jiin I. Jong et al.   ACS Chemical Neuroscience

Microscopy Using Fluorescent Drug Biosensors for “Inside-Out Pharmacology”

(2018) Anand K. Muthusamy et al.   BIOPHYSICAL JOURNAL

A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action

(2018) Miriam Stoeber et al.   NEURON

Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors

(2018) Tommaso Patriarchi et al.   SCIENCE

Stability, affinity, and chromatic variants of the glutamate sensor iGluSnFR

(2018) Jonathan S. Marvin et al.   NATURE METHODS

Integrating macromolecular X-ray diffraction data with the graphical user interface iMosflm

(2017) Harold R Powell et al.   Nature Protocols

Varenicline improves motor and cognitive deficits and decreases depressive-like behaviour in late-stage YAC128 mice

(2017) Ailsa L. McGregor et al.   NEUROPHARMACOLOGY

Deciphering the molecular mechanism responsible for GCaMP6m's Ca2+-dependent change in fluorescence

(2017) Lauren M. Barnett et al.   PLoS One

Selective and regulated trapping of nicotinic receptor weak base ligands and relevance to smoking cessation

(2017) Anitha P Govind et al.   eLife

Smoking-Relevant Nicotine Concentration Attenuates the Unfolded Protein Response in Dopaminergic Neurons

(2016) R. Srinivasan et al.   JOURNAL OF NEUROSCIENCE

Menthol Alone Upregulates Midbrain nAChRs, Alters nAChR Subtype Stoichiometry, Alters Dopamine Neuron Firing Frequency, and Prevents Nicotine Reward

(2016) B. J. Henderson et al.   JOURNAL OF NEUROSCIENCE

X-ray structure of the human α4β2 nicotinic receptor

(2016) Claudio L. Morales-Perez et al.   NATURE

Ketamine Inside Neurons?

(2015) Henry A. Lester et al.   AMERICAN JOURNAL OF PSYCHIATRY

Dopaminergic and cholinergic learning mechanisms in nicotine addiction

(2015) Manivannan Subramaniyan et al.   Annals of the New York Academy of Sciences

High membrane permeability for melatonin

(2015) Haijie Yu et al.   JOURNAL OF GENERAL PHYSIOLOGY

Inside-out neuropharmacology of nicotinic drugs

(2015) Brandon J. Henderson et al.   NEUROPHARMACOLOGY

The nicotinic cholinergic system function in the human brain

(2015) Frauke Nees   NEUROPHARMACOLOGY

Chronic treatment with varenicline changes expression of four nAChR binding sites in mice

(2015) Michael J. Marks et al.   NEUROPHARMACOLOGY

Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states

(2015) Marina R. Picciotto et al.   NEUROPHARMACOLOGY

Nicotinic alteration of decision-making

(2015) Jérémie Naudé et al.   NEUROPHARMACOLOGY

Functional Probes of Drug–Receptor Interactions Implicated by Structural Studies: Cys-Loop Receptors Provide a Fertile Testing Ground

(2014) Ethan B. Van Arnam et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacological chaperoning of nAChRs: A therapeutic target for Parkinson's disease

(2014) Rahul Srinivasan et al.   PHARMACOLOGICAL RESEARCH

An optimized fluorescent probe for visualizing glutamate neurotransmission

(2013) Jonathan S Marvin et al.   NATURE METHODS

Potential therapeutic uses of mecamylamine and its stereoisomers

(2013) Justin R. Nickell et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Psychiatric Drugs Bind to Classical Targets Within Early Exocytotic Pathways: Therapeutic Effects

(2012) Henry A. Lester et al.   BIOLOGICAL PSYCHIATRY

An introduction to data reduction: space-group determination, scaling and intensity statistics

(2011) Philip R. Evans   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structures of the substrate-binding protein provide insights into the multiple compatible solute binding specificities of theBacillus subtilisABC transporter OpuC

(2011) Yang Du et al.   BIOCHEMICAL JOURNAL

Trafficking of α4* Nicotinic Receptors Revealed by Superecliptic Phluorin

(2011) Christopher I. Richards et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Crystal Structure of the Substrate-Binding Protein OpuBC from Bacillus subtilis in Complex with Choline

(2011) Marco Pittelkow et al.   JOURNAL OF MOLECULAR BIOLOGY

Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses

(2011) Julie M. Miwa et al.   NEURON

Superfolder GFP Is Fluorescent in Oxidizing Environments When Targeted via the Sec Translocon

(2011) Deborah E. Aronson et al.   TRAFFIC

Varenicline in the treatment of tobacco dependence

(2011) Karl Fagerstrom   Neuropsychiatric Disease and Treatment

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Pre-clinical properties of the α4β2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence

(2010) H Rollema et al.   BRITISH JOURNAL OF PHARMACOLOGY

A structural classification of substrate-binding proteins

(2010) Ronnie P.-A. Berntsson et al.   FEBS LETTERS

Nicotine up-regulates α4β2 nicotinic receptors and ER exit sites via stoichiometry-dependent chaperoning

(2010) Rahul Srinivasan et al.   JOURNAL OF GENERAL PHYSIOLOGY

Parallel Anxiolytic-Like Effects and Upregulation of Neuronal Nicotinic Acetylcholine Receptors Following Chronic Nicotine and Varenicline

(2010) J. R. Turner et al.   NICOTINE & TOBACCO RESEARCH

Ligand Binding and Crystal Structures of the Substrate-Binding Domain of the ABC Transporter OpuA

(2010) Justina C. Wolters et al.   PLoS One

Nicotine is a Selective Pharmacological Chaperone of Acetylcholine Receptor Number and Stoichiometry. Implications for Drug Discovery

(2009) Henry A. Lester et al.   AAPS Journal

Nicotine-induced upregulation of nicotinic receptors: Underlying mechanisms and relevance to nicotine addiction

(2009) Anitha P. Govind et al.   BIOCHEMICAL PHARMACOLOGY

Single-Molecule Imaging of a Fluorescent Unnatural Amino Acid Incorporated Into Nicotinic Receptors

(2009) Rigo Pantoja et al.   BIOPHYSICAL JOURNAL

Intracellular Metabotropic Glutamate Receptor 5 (mGluR5) Activates Signaling Cascades Distinct from Cell Surface Counterparts

(2009) Yuh-Jiin I. Jong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRET

(2009) Fraser J. Moss et al.   JOURNAL OF GENERAL PHYSIOLOGY

Sensors and regulators of intracellular pH

(2009) Joseph R. Casey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal Structures of the Choline/Acetylcholine Substrate-binding Protein ChoX fromSinorhizobium melilotiin the Liganded and Unliganded-Closed States

(2008) Christine Oswald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY