Article
Gastroenterology & Hepatology
Sonja Boatman, Thomas Kaiser, Harika Nalluri-Butz, Mohammad Haneef Khan, Matthew Dietz, Julia Kohn, Abigail J. Johnson, Wolfgang B. Gaertner, Christopher Staley, Cyrus Jahansouz
Summary: The interaction between host diet and gut microbiota plays a significant role in perioperative complications, particularly anastomotic leak. This study used a murine surgical model to investigate the impact of diet and fecal microbial transplantation (FMT) on the intestinal microbiota and their relationship to anastomotic leak. The results showed that a Western diet leads to dysbiosis in the gut microbiota and increased rates of anastomotic leak, while FMT from healthy donors on a lean diet reduces the risk of anastomotic leak. A microbial index was also developed to predict the occurrence of leak.
Article
Agriculture, Dairy & Animal Science
Chengbo Zhang, Junmin Chen, Qian Wu, Bo Xu, Zunxi Huang
Summary: Insufficient maternal milk is a major factor contributing to the low survival rate of young Asian elephants. The study suggests that goat milk is not suitable for young elephants, while yak milk may be an ideal source of supplemental milk. Evaluating the relationship between milk sources and the microbiomes of young elephants can help establish optimal breast milk supplementation to improve offspring survival rates.
Article
Microbiology
Jingjing Li, Yujia Chu, Wenwen Yao, Hui Wu, Jiang Feng
Summary: This study revealed differences in diet and gut microbial composition between lactating and non-lactating Asian particolored bats. Lactating bats consume a more diverse and protein-rich diet, with changes in the abundance of specific gut microbes to help them adapt to these dietary changes.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Nutrition & Dietetics
Kalina Sikorska-Zimny, Luciano Beneduce
Summary: Glucosinolates and their derivatives are secondary plant metabolites abundant in Brassicaceae, with benefits for human health such as anti-inflammatory and anti-cancer effects. However, their formation requires enzymatic reactions catalyzed by myrosinase enzyme. The human gut microbiome can provide myrosinase activity, potentially enhancing the beneficial effects of these compounds.
Article
Microbiology
Wei Mi, Zhiyong Hu, Lanlan Xu, Xiangyu Bian, Wu Lian, Shuying Yin, Shuying Zhao, Weina Gao, Changjiang Guo, Tala Shi
Summary: Quercetin increases the abundance of butyrate-producing bacteria, which leads to increased butyrate production and accelerated carbohydrate and energy metabolism, while reducing cell motility and endotoxemia. This results in the enhancement of gut barrier function.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Bowei Zhang, Congying Zhao, Xuejiao Zhang, Xiang Li, Yunhui Zhang, Xiaoxia Liu, Jia Yin, Xinyang Li, Jin Wang, Shuo Wang
Summary: The prevalence of inflammatory bowel disease is increasing, causing a global burden. Certain amino acids have been found to be beneficial for mucosal healing and colitis remission. This study investigated the effects of diets enriched in amino acids and intact proteins on colitis in mice, revealing the critical role of gut microbiota in the prevention of colitis by an elemental diet.
Article
Microbiology
Zubaidah Hasain, Raja Affendi Raja Ali, Shairah Abdul Razak, Kamalrul Azlan Azizan, Emad El-Omar, Nurul Huda Razalli, Norfilza Mohd Mokhtar
Summary: The study found that dietary intake is an important predictor of gut microbiota dysbiosis in post-GDM women, and is associated with obesity, low-grade inflammation, and poor glycemic control. Hence, modifying dietary intake to reshape gut microbiota composition is a promising strategy for preventing T2DM in post-GDM women.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Medicine, Research & Experimental
Wanying Feng, Zhihua Yang, Yangxi Liu, Rui Chen, Zhihui Song, Guiyun Pan, Yuhang Zhang, Zehui Guo, Xinya Ding, Lu Chen, Yi Wang
Summary: All species have a physiological need for sleep, which plays a crucial role in preserving and restoring physiological processes. Recent research points to the influence of gut microbiota on brain function, revealing their relationship. Dysregulation of the gut-brain axis is found to be linked to insomnia, with certain gut microbiota metabolites and disturbances worsening the condition. Traditional Chinese medicine offers unique advantages in treating insomnia, and exploring its scientific relevance to gut microbiota may lead to new concepts and improved therapeutics.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Agriculture, Multidisciplinary
Chenyu Xue, Hao Lv, Ying Li, Na Dong, Yanhui Wang, Jiale Zhou, Baoming Shi, Anshan Shan
Summary: This study investigated the effects of oleanolic acid on gut health, including gut microbiota and intestinal epithelial immunity, using Illumina MiSeq sequencing and Illumina HiSeq (RNA-seq) technology. The results showed that oleanolic acid can improve intestinal health by optimizing gut microbiota and altering the immune function of intestinal epithelial cells.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Review
Immunology
Manlian Zhu, Xia Liu, Yiru Ye, Xiumei Yan, Yiwen Cheng, Longyou Zhao, Feng Chen, Zongxin Ling
Summary: Parkinson's disease is a common neurodegenerative disease characterized by motor dysfunction. Gut dysbiosis is involved in the development and progression of PD, and the gut microbiota can be considered as a potential diagnostic and therapeutic target. Gut dysbiosis influences the progression and onset of PD by increasing intestinal permeability, aggravating neuroinflammation, aggregating abnormal levels of alpha-synuclein fibrils, increasing oxidative stress, and decreasing neurotransmitter production.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Haifeng Lan, Wei Hong, Dongyang Qian, Fang Peng, Haiqing Li, Chunxiao Liang, Min Du, Jinlan Gu, Junxuan Mai, Bo Bai, Gongyong Peng
Summary: This study demonstrated the effects of quercetin therapy on gut microbiota and metabolism in a rat model of osteoarthritis (OA), showing that quercetin could partially improve the intestinal flora disorder and fecal metabolite abnormalities. Differences were observed at both the class and genus levels in OA rats compared to control rats, as well as significant alterations in acetic acid, propionic acid, and 24 metabolites among the three groups.
Article
Food Science & Technology
Baoming Tian, Jianhua Zhao, Min Zhang, Zhifei Chen, Qingyu Ma, Huicui Liu, Chenxi Nie, Ziqi Zhang, Wei An, Juxiu Li
Summary: The study suggests that anthocyanins from Lycium ruthenicum (ACs) can reduce weight gain, increase SCFA-producing bacteria, decrease endotoxin-producing bacteria, and lower endotoxin levels by modulating the gut microbiota. This leads to alleviation of colonic barrier dysfunction and inflammation induced by a high-fat diet.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Pajau Vangay, Tonya Ward, Sarah Lucas, Lalit K. Beura, Dominique Sabas, Max Abramson, Lisa Till, Susan L. Hoops, Purna Kashyap, Ryan C. Hunter, David Masopust, Dan Knights
Summary: In this study, the differential effects of human gut microbiota from the United States and rural Thailand on the murine gut mucosa and immune system were assessed. The results suggest that Western-associated human gut microbes contribute to a pro-inflammatory immune response.
Review
Immunology
Chenxi Zhang, Peng Xue, Haiyan Zhang, Chenxi Tan, Shiyao Zhao, Xudong Li, Lihui Sun, Huihui Zheng, Jun Wang, Baoling Zhang, Weiya Lang
Summary: This review provides an overview of the role of the gut microbiota in adult neurogenesis and proposes the potential effects of traditional Chinese medicine on neurogenesis through regulation of the gut microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Maria Botia-Sanchez, Georgina Galicia, Lorena Albaladejo-Marico, Daniel Toro-Dominguez, Maria Morell, Raquel Marcos-Fernandez, Abelardo Margolles, Marta E. Alarcon-Riquelme
Summary: Systemic lupus erythematosus is an autoimmune disease that can cause intestinal inflammation, leading to changes in the intestinal barrier and gut microbiota composition, which can in turn affect the interaction between the host immune system and gut microbiota.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Elmira Aliabadi, Melanie Urbanek-Quaing, Benjamin Maasoumy, Birgit Bremer, Martin Grasshoff, Yang Li, Christian E. Niehaus, Heiner Wedemeyer, Anke R. M. Kraft, Markus Cornberg
Summary: The study found that HBV-specific T cell responses in hepatitis B patients are influenced by age and HBcrAg levels rather than HBsAg levels. Additionally, age and HBcrAg levels may impact cell response to PD-L1 inhibition.
Article
Allergy
Bowen Zhang, Lennart M. Roesner, Stephan Traidl, Valerie A. C. M. Koeken, Cheng-Jian Xu, Thomas Werfel, Yang Li
Summary: Single-cell analysis of atopic dermatitis and psoriasis patients revealed disease-specific T cell clusters and identified cell type-specific gene expression associated with inflammation signatures and disease severity. The study shed light on the complexity of inflammatory responses and provided valuable insights for further investigation and therapeutic approaches for these chronic inflammatory skin diseases.
Article
Immunology
Mariska Kerstholt, Freek R. van de Schoor, Marije Oosting, Simone J. C. F. M. Moorlag, Yang Li, Martin Jaeger, Wouter A. van der Heijden, Rahajeng N. Tunjungputri, Jessica C. dos Santos, Brenda Kischker, Hedwig D. Vrijmoeth, M. E. Baarsma, Bart-Jan Kullberg, Mihaela Lupse, Joppe W. Hovius, Cees C. van den Wijngaard, Mihai G. Netea, Quirijn de Mast, Leo A. B. Joosten
Summary: This study reveals that B. burgdorferi infection decreases cytokine production in cells and lowers glycolysis. MFAP3L gene is found to influence lactate production and mediate this effect through ERK2 activation and platelet degranulation. Platelet-derived factors, such as CXCL7, play important roles in B. burgdorferi-induced cytokine production.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Changyu Wu, Qing Hu, Xichun Peng, Jianming Luo, Guangwen Zhang
Summary: In this study, it was found that marine fish protein peptide (MFPP) effectively reduced serum uric acid levels, alleviated kidney inflammation, restored beneficial bacteria abundance and intestinal barrier function. Therefore, MFPP has the potential to be included in dietary intervention as a therapeutic strategy to relieve hyperuricemia.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agronomy
Xiquan Wang, Hongyuan Zhang, Zhizhong Zhang, Chenping Zhang, Kai Zhang, Huancheng Pang, Stephen M. Bell, Yuyi Li, Ji Chen
Summary: The relationship between salt-affected soils and their adjacent river systems is important for addressing the challenges of soil salinization in agriculture. A study found that the distance along the river is closely related to the level of soil salinization, with soil salinity increasing as the distance along the river increases. This is likely due to the leaching of ions from upstream soils and their accumulation in downstream soils.
AGRICULTURAL WATER MANAGEMENT
(2023)
Article
Biochemistry & Molecular Biology
Jose Manuel Sanchez-Maldonado, Antonio Jose Cabrera-Serrano, Subhayan Chattopadhyay, Daniele Campa, Maria del Pilar Garrido, Angelica Macauda, Rob Ter Horst, Andres Jerez, Mihai G. G. Netea, Yang Li, Kari Hemminki, Federico Canzian, Asta Foersti, Juan Sainz
Summary: This study found that obesity-related genetic variants do not impact the risk of developing MM, based on genomic association studies conducted in German and Spanish populations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Antonio Jose Cabrera-Serrano, Jose Manuel Sanchez-Maldonado, Rob ter Horst, Angelica Macauda, Paloma Garcia-Martin, Yolanda Benavente, Stefano Landi, Alyssa Clay-Gilmour, Yasmeen Niazi, Blanca Espinet, Juan Jose Rodriguez-Sevilla, Eva Maria Perez, Rossana Maffei, Gonzalo Blanco, Matteo Giaccherini, James R. Cerhan, Roberto Marasca, Miguel Angel Lopez-Nevot, Tzu Chen-Liang, Hauke Thomsen, Irene Gamez, Daniele Campa, Victor Moreno, Silvia de Sanjose, Rafael Marcos-Gragera, Maria Garcia-Alvarez, Trinidad Dierssen-Sotos, Andres Jerez, Aleksandra Butrym, Aaron D. Norman, Mario Luppi, Susan L. Slager, Kari Hemminki, Yang Li, Sonja I. Berndt, Delphine Casabonne, Miguel Alcoceba, Anna Puiggros, Mihai G. Netea, Asta Foersti, Federico Canzian, Juan Sainz
Summary: Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults worldwide. However, a study found that the GWAS-identified risk variants for CLL do not significantly impact overall survival and disease progression in CLL patients. The polygenic risk scores (PRSs) built with these risk variants also have limited accuracy in predicting patient survival and disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Esther Clavero, Jose Manuel Sanchez-Maldonado, Angelica Macauda, Rob Ter Horst, Belem Sampaio-Marques, Artur Jurczyszyn, Alyssa Clay-Gilmour, Angelika Stein, Michelle A. T. Hildebrandt, Niels Weinhold, Gabriele Buda, Ramon Garcia-Sanz, Waldemar Tomczak, Ulla Vogel, Andres Jerez, Daria Zawirska, Marzena Watek, Jonathan N. Hofmann, Stefano Landi, John J. Spinelli, Aleksandra Butrym, Abhishek Kumar, Joaquin Martinez-Lopez, Sara Galimberti, Maria Eugenia Sarasquete, Edyta Subocz, Elzbieta Iskierka-Jazdzewska, Graham G. Giles, Malwina Rybicka-Ramos, Marcin Kruszewski, Niels Abildgaard, Francisco Garcia Verdejo, Pedro Sanchez Rovira, Miguel Inacio da Silva Filho, Katalin Kadar, Malgorzata Razny, Wendy Cozen, Matteo Pelosini, Manuel Jurado, Parveen Bhatti, Marek Dudzinski, Agnieszka Druzd-Sitek, Enrico Orciuolo, Yang Li, Aaron D. Norman, Jan Maciej Zaucha, Rui Manuel Reis, Miroslaw Markiewicz, Juan Jose Rodriguez Sevilla, Vibeke Andersen, Krzysztof Jamroziak, Kari Hemminki, Sonja I. Berndt, Vicent Rajkumar, Grzegorz Mazur, Shaji K. Kumar, Paula Ludovico, Arnon Nagler, Stephen J. Chanock, Charles Dumontet, Mitchell J. Machiela, Judit Varkonyi, Nicola J. Camp, Elad Ziv, Annette Juul Vangsted, Elizabeth E. Brown, Daniele Campa, Celine M. Vachon, Mihai G. Netea, Federico Canzian, Asta Foersti, Juan Sainz
Summary: By conducting a meta-analysis on the germline genetic data of 234 autophagy-related genes from three independent study populations, we investigated the influence of autophagy-related variants on the risk of Multiple Myeloma (MM) and examined the functional mechanisms behind the observed associations. We identified SNPs within the six CD46, IKBKE, PARK2, ULK4, ATG5, and CDKN2A loci associated with MM risk and found that their effect on disease risk was mediated by specific subsets of immune cells, as well as vitamin D3-, MCP-2-, and IL20-dependent mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Aiping Zhang, Xiao Wang, Yunying Fang, Xueyang Sun, Ehsan Tavakkoli, Yuyi Li, Di Wu, Zhangliu Du
Summary: A 9-year field trial in a temperate agroecosystem of North China reveals that biochar application is more effective than stubble management in increasing soil organic carbon accumulation and preservation, especially in microaggregates and organo-mineral complexes.
JOURNAL OF SOILS AND SEDIMENTS
(2023)
Article
Agronomy
Mengmeng Chen, Yuling Zhang, Chunwei Gao, Shirong Zhang, Lu Liu, Lipeng Wu, Yuyi Li, Xiaodong Ding
Summary: Organic fertilizer addition plays a significant role in promoting soil organic carbon (SOC) storage, as shown by a 9-year field experiment in saline-alkaline paddy soil. The addition of organic fertilizer increased the content of humic acid-C and humin-C, as well as 2:1 type clay minerals, which were positively correlated with SOC storage. Moreover, the abundance of specific bacteria was increased with organic fertilization, promoting the transformation of clay minerals and further enhancing SOC storage.
Article
Green & Sustainable Science & Technology
Na Liu, Wenhao Feng, Hongyuan Zhang, Fangdi Chang, Jing Wang, Yuyi Li, Huancheng Pang
Summary: The addition of straw interlayer in the 0.40 m soil depth can effectively reduce salt accumulation in surface soils and alleviate salt stress on crop growth and development. However, the positive effects of straw interlayer are weakened with straw decomposition, and the suitability of using sand for saline soil amelioration needs further investigation.
Article
Engineering, Biomedical
Liping Ouyang, Baohui Chen, Xingdan Liu, Donghui Wang, Yang Li, Yun Liao, Kelvin W. K. Yeung, Xuanyong Liu
Summary: In this study, we fabricated a nanowire-like composite material called P@C, which can mimic the bio-functions of antimicrobial peptides (AMPs). P@C exhibits excellent antibacterial property and osteoimmunomodulation, making it an effective treatment for periprosthetic joint infection and bone repair.
BIOACTIVE MATERIALS
(2023)
Article
Immunology
Konstantin Foehse, Buesra Geckin, Martijn Zoodsma, Gizem Kilic, Zhaoli Liu, Rutger J. Roering, Gijs J. Overheul, Josephine van de Maata, Ozlem Buluta, Jacobien J. Hoogerwerf, Jaap ten Oever, Elles Simonetti, Heiner Schaal, Ortwin Adams, Lisa Mueller, Philipp Niklas Ostermann, Frank L. van de Veerdonk, Leo A. B. Joosten, Bart L. Haagmans, Reinout van Crevel, Ronald P. van Rij, Corine Geurtsvankessel, Marien I. de Jonge, Yang Li, Jorge Dominguez-Andres, Mihai G. Netea
Summary: The mRNA-based BNT162b2 vaccine provides protection against severe disease and mortality caused by SARS-CoV-2 by inducing specific antibody and T-cell responses. The vaccine also modulates innate immune responses and induces long-term changes in immune cells.
CLINICAL IMMUNOLOGY
(2023)
Letter
Oncology
Angelica Macauda, Klara Briem, Alyssa Clay-Gilmour, Wendy Cozen, Asta Foersti, Matteo Giaccherini, Chiara Corradi, Juan Sainz, Yasmeen Niazi, Rob ter Horst, Yang Li, Mihai G. Netea, Ulla Vogel, Kari Hemminki, Susan L. Slager, Judit Varkonyi, Vibeke Andersen, Elzbieta Iskierka-Jazdzewska, Joaquin Martinez-Lopez, Jan Zaucha, Nicola J. Camp, S. Vincent Rajkumar, Agnieszka Druzd-Sitek, Parveen Bhatti, Stephen J. Chanock, Shaji K. Kumar, Edyta Subocz, Grzegorz Mazur, Stefano Landi, Mitchell J. Machiela, Andres Jerez, Aaron D. Norman, Michelle A. T. Hildebrandt, Katalin Kadar, Sonja I. Berndt, Elad Ziv, Gabriele Buda, Arnon Nagler, Charles Dumontet, Malgorzata Razny, Marzena Watek, Aleksandra Butrym, Norbert Grzasko, Marek Dudzinski, Malwina Rybicka-Ramos, Eva-Laure Matera, Ramon Garcia-Sanz, Hartmut Goldschmidt, Krzysztof Jamroziak, Artur Jurczyszyn, Esther Clavero, Graham G. Giles, Matteo Pelosini, Daria Zawirska, Marcin Kruszewski, Herlander Marques, Eva Haastrup, Jose Manuel Sanchez-Maldonado, Uta Bertsch, Marcin Rymko, Marc-Steffen Raab, Elizabeth E. Brown, Jonathan N. Hofmann, Celine Vachon, Daniele Campa, Federico Canzian
Article
Cell Biology
Bowen Zhang, Zhenhua Zhang, Valerie A. C. M. Koeken, Saumya Kumar, Michelle Aillaud, Hsin-Chieh Tsay, Zhaoli Liu, Anke R. M. Kraft, Chai Fen Soon, Ivan Odak, Berislav Bosnjak, Anna Vlot, Morris A. Swertz, Uwe Ohler, Robert Geffers, Thomas Illig, Jochen Huehn, Antoine-Emmanuel Saliba, Leif Erik Sander, Reinhold Foerster, Cheng-Jian Xu, Markus Cornberg, Leon N. Schulte, Yang Li
Summary: This study identifies diverse genetic and epigenetic regulators that contribute to the severity of COVID-19 through single-cell analysis of patients.