Journal
JOURNAL OF COMPARATIVE NEUROLOGY
Volume 527, Issue 13, Pages 2190-2199Publisher
WILEY
DOI: 10.1002/cne.24674
Keywords
axonal reconstruction; long-range circuits; whole-brain imaging
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Funding
- Howard Hughes Medical Institute
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Reconstruction of the axonal projection patterns of single neurons has been an important tool for understanding both the diversity of cell types in the brain and the logic of information flow between brain regions. Innovative approaches now enable the complete reconstruction of axonal projection patterns of individual neurons with vastly increased throughput. Here, we review how advances in genetic, imaging, and computational techniques have been exploited for axonal reconstruction. We also discuss how new innovations could enable the integration of genetic and physiological information with axonal morphology for producing a census of cell types in the mammalian brain at scale.
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