Journal
JOURNAL OF CLINICAL PERIODONTOLOGY
Volume 46, Issue -, Pages 103-123Publisher
WILEY
DOI: 10.1111/jcpe.13068
Keywords
-
Categories
Funding
- Swedish Research Council [K2015-52X-09495-28-4]
- Swedish government
- ALF [ALFGBG-725641]
- Osteology Foundation [14-049, 15-103]
- IngaBritt and Arne Lundberg Foundation
- Hjalmar Svensson Foundation
- Vilhelm and Martina Lundgren Vetenskapsfond
- Area of Advance Materials of Chalmers
- GU Biomaterials within the Strategic Research Area
Ask authors/readers for more resources
Aim To review the knowledge on the mechanisms controlling membrane-host interactions in guided bone regeneration (GBR) and investigate the possible role of GBR membranes as bioactive compartments in addition to their established role as barriers. Materials and Methods A narrative review was utilized based on in vitro, in vivo and available clinical studies on the cellular and molecular mechanisms underlying GBR and the possible bioactive role of membranes. Results Emerging data demonstrate that the membrane contributes bioactively to the regeneration of underlying defects. The cellular and molecular activities in the membrane are intimately linked to the promoted bone regeneration in the underlying defect. Along with the native bioactivity of GBR membranes, incorporating growth factors and cells in membranes or with graft materials may augment the regenerative processes in underlying defects. Conclusion In parallel with its barrier function, the membrane plays an active role in hosting and modulating the molecular activities of the membrane-associated cells during GBR. The biological events in the membrane are linked to the bone regenerative and remodelling processes in the underlying defect. Furthermore, the bone-promoting environments in the two compartments can likely be boosted by strategies targeting both material aspects of the membrane and host tissue responses.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available