PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease

Fabrication of a triptolide-loaded and poly-γ-glutamic acid-based amphiphilic nanoparticle for the treatment of rheumatoid arthritis

(2018) Li Zhang et al.   International Journal of Nanomedicine

A ROR1–HER3–lncRNA signalling axis modulates the Hippo–YAP pathway to regulate bone metastasis

(2017) Chunlai Li et al.   NATURE CELL BIOLOGY

The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors

(2017) Aifu Lin et al.   NATURE CELL BIOLOGY

Expression of ganglioside GD2, reprogram the lipid metabolism and EMT phenotype in bladder cancer

(2017) Venkatrao Vantaku et al.   Oncotarget

Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway

(2017) Xiao-yu Li et al.   Molecular Therapy-Nucleic Acids

Types of Ubiquitin Ligases

(2016) Francesca Ester Morreale et al.   CELL

Tensin2-deficient mice on FVB/N background develop severe glomerular disease

(2016) Kozue UCHIO-YAMADA et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer

(2016) Aifu Lin et al.   NATURE CELL BIOLOGY

Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog

(2016) Maria Edeling et al.   Nature Reviews Nephrology

TGF-β: the master regulator of fibrosis

(2016) Xiao-ming Meng et al.   Nature Reviews Nephrology

Influence of Verapamil on Pharmacokinetics of Triptolide in Rats

(2015) Yichuan Zhang et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis

(2015) Sara Lovisa et al.   NATURE MEDICINE

Targeting EMT to reverse renal fibrosis

(2015) Susan J. Allison   Nature Reviews Nephrology

Diabetic Kidney Disease: A Report From an ADA Consensus Conference

(2014) Katherine R. Tuttle et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Triptolide-Containing Formulation in Patients With Autosomal Dominant Polycystic Kidney Disease and Proteinuria: An Uncontrolled Trial

(2014) Dongping Chen et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

TAB1: A Target of Triptolide in Macrophages

(2014) Yan Lu et al.   CHEMISTRY & BIOLOGY

Role of CYP3A in regulating hepatic clearance and hepatotoxicity of triptolide in rat liver microsomes and sandwich-cultured hepatocytes

(2014) Guolin Shen et al.   FOOD AND CHEMICAL TOXICOLOGY

Interleukin-6 Signaling Drives Fibrosis in Unresolved Inflammation

(2014) Ceri A. Fielding et al.   IMMUNITY

SCF ubiquitin ligase-targeted therapies

(2014) Jeffrey R. Skaar et al.   NATURE REVIEWS DRUG DISCOVERY

RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination

(2013) Meredith B. Metzger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering

(2013) Hui Yang et al.   CELL

Discovery of RG7388, a Potent and Selective p53–MDM2 Inhibitor in Clinical Development

(2013) Qingjie Ding et al.   JOURNAL OF MEDICINAL CHEMISTRY

Epithelial–mesenchymal transition of renal tubules: Divergent processes of repairing in acute or chronic injury?

(2013) Y.S. Jiang et al.   MEDICAL HYPOTHESES

Origin and function of myofibroblasts in kidney fibrosis

(2013) Valerie S LeBleu et al.   NATURE MEDICINE

Anti-Fibrosis Therapy and Diabetic Nephropathy

(2012) Anil Karihaloo   Current Diabetes Reports

Mitochondrial dysfunction accounts for aldosterone-induced epithelial-to-mesenchymal transition of renal proximal tubular epithelial cells

(2012) Yanggang Yuan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sonic Hedgehog Signaling Mediates Epithelial-Mesenchymal Communication and Promotes Renal Fibrosis

(2012) H. Ding et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The functions and regulation of the PTEN tumour suppressor

(2012) Min Sup Song et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The role of EMT in renal fibrosis

(2011) Rosemarie M. Carew et al.   CELL AND TISSUE RESEARCH

Triptolide Directly Inhibits dCTP Pyrophosphatase

(2011) Timothy W. Corson et al.   CHEMBIOCHEM

XPB, a subunit of TFIIH, is a target of the natural product triptolide

(2011) Denis V Titov et al.   Nature Chemical Biology

Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells

(2010) Ramani Soundararajan et al.   CANCER BIOLOGY & THERAPY

BTBR Ob/Ob Mutant Mice Model Progressive Diabetic Nephropathy

(2010) K. L. Hudkins et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulation of Dedifferentiation and Redifferentiation in Renal Proximal Tubular Cells by the Epidermal Growth Factor Receptor

(2008) M. A. Hallman et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Triptolide Reduces Cystogenesis in a Model of ADPKD

(2008) S. J. Leuenroth et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Role of Inflammatory Cytokines in Diabetic Nephropathy

(2008) J. F. Navarro-Gonzalez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY