Article
Cardiac & Cardiovascular Systems
Naoto Katakami, Tomoya Mita, Norikazu Maeda, Yasunori Sato, Hirotaka Watada, Iichiro Shimomura
Summary: This study investigated the effects of tofogliflozin on the tissue characteristics of the carotid arterial wall in type 2 diabetes patients. The results showed that there were no significant changes in the tissue characteristics of the carotid arterial wall in either the tofogliflozin or conventional treatment group during the 104-week treatment period.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Zahraa Abdul Sater, Cheryl Cero, Anne E. Pierce, Hannah J. Lea, Houssein Abdul Sater, Kenneth Y. Zhu, Naili Liu, Yinyan Ma, Oksana Gavrilova, Aaron M. Cypess
Summary: The combination therapy of ALA and a beta 3-AR agonist showed significant improvements in body composition and inflammation levels in diet-induced obese mice. Mice receiving ALA+CL had significantly reduced body weight and body fat percentage, along with lower inflammation levels in adipose tissue compared to other groups. This suggests that targeting AT immune modulation could be a potential therapeutic strategy for obesity.
Review
Endocrinology & Metabolism
Natja Launbo, Emilie H. Zobel, Bernt Johan von Scholten, Kristine Faerch, Peter G. Jorgensen, Regitse H. Christensen
Summary: This systematic review and meta-analysis found that exercise, diet, bariatric surgery, and pharmaceutical interventions can reduce cardiac adipose tissue volume. The study included 34 studies, with evidence supporting the effectiveness of these interventions.
Article
Endocrinology & Metabolism
Nozomu Yamasaki, Yoshifumi Tamura, Hideyoshi Kaga, Motonori Sato, Mai Kiya, Satoshi Kadowaki, Ruriko Suzuki, Yasuhiko Furukawa, Daisuke Sugimoto, Takashi Funayama, Yuki Someya, Saori Kakehi, Shuko Nojiri, Hiroaki Satoh, Ryuzo Kawamori, Hirotaka Watada
Summary: The study showed that the decrease in plasma glucose levels induced by the sodium-glucose co-transporter-2 inhibitor is essential for the increase in endogenous glucose production and the decrease in insulin secretion.
DIABETES OBESITY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Karen E. Elkind-Hirsch, N. Chappell, Ericka Seidemann, John Storment, Drake Bellanger
Summary: EQW/DAPA and PHEN/TPM showed the most significant reduction in weight and body fat, as well as improvements in blood glucose levels and insulin sensitivity. All drugs resulted in decreases in fasting glucose, testosterone, FAI, and blood pressure.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Hideyuki Okuma, Kentaro Mori, Suguru Nakamura, Tetsuo Sekine, Yoshihiro Ogawa, Kyoichiro Tsuchiya
Summary: SGLT2 inhibitor ipragliflozin (Ipra) reduces urinary albumin excretion and glomerular hypertrophy in high-fat diet (HFD)-fed mice. The expansion of perirenal fat (PRAT) induced by Ipra may play an important role in improving diabetic nephropathy (DN) in HFD-fed mice by reducing leptin levels and inhibiting glomerular endothelial cells (GECs) proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Junya Hanaguri, Harumasa Yokota, Akifumi Kushiyama, Sakura Kushiyama, Masahisa Watanabe, Satoru Yamagami, Taiji Nagaoka
Summary: The study suggests that tofogliflozin improves retinal blood flow dysregulation, neural retinal dysfunction, and impaired neurovascular coupling in type 2 diabetic mice. Tofogliflozin treatment leads to sustained decrease in blood glucose levels and improves retinal neuronal function and blood flow responses. Additionally, tofogliflozin inhibits the activation of retinal glial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Yasuhiro Matsubayashi, Akihiro Yoshida, Hideki Suganami, Momoko Oe, Takaaki Sato, Yuta Yaguchi, Kazuya Fujihara, Takaho Yamada, Shiro Tanaka, Kohei Kaku, Hirohito Sone
Summary: SGLT2 inhibitor tofogliflozin has significant effects on estimated plasma volume (ePV), brain natriuretic peptide (BNP), and body weight (BW) in patients with type 2 diabetes. Long-term administration leads to decreases in ePV, BNP, and BW, while discontinuation results in significant increases in these parameters with correlations observed between ePV, BNP, and BW changes.
DIABETES OBESITY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Kelvin Ho Man Kwok, Daniel P. Andersson, Mikael Ryden, Peter Arner
Summary: The study showed that women with obesity who have undergone bariatric surgery and achieved BMI normalization exhibit improved maximum in vivo antilipolytic effect of insulin, with changes in circulating fatty acids reaching a normal state while glycerol changes do not show significant differences in relative terms.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Cell Biology
Kentaro Murakami, Yusuke Sasaki, Masato Asahiyama, Wataru Yano, Toshiaki Takizawa, Wakana Kamiya, Yoshihiro Matsumura, Motonobu Anai, Tsuyoshi Osawa, Jean-Charles Fruchart, Jamila Fruchart-Najib, Hiroyuki Aburatani, Juro Sakai, Tatsuhiko Kodama, Toshiya Tanaka
Summary: In this study, the combination treatment of a selective PPAR alpha modulator and a sodium-glucose cotransporter 2 inhibitor was evaluated for its effects on the progression of non-alcoholic steatosis in a mouse model. The results showed that the combination treatment significantly alleviated hyperglycemia and hypertriglyceridemia, reduced ballooning degeneration of hepatocytes, and improved survival rates and tumor numbers in the liver. This suggests that the combination therapy has therapeutic potential in preventing the progression of non-alcoholic steatosis to hepatocellular carcinoma.
Article
Clinical Neurology
Tian Xiao, Laurens van Kleef, M. Kamran Ikram, Robert De Knegt, M. Arfan Ikram
Summary: The study found no significant association between nonalcoholic fatty liver disease (NAFLD) and fibrosis with an increased risk for incident dementia among the elderly. In fact, NAFLD was even protective in the first 5 years of follow-up before dementia onset.
Article
Nutrition & Dietetics
Chao Zhang, Jonathan Salamon, Ren Zhang
Summary: This study investigated the relationship between fibrinogen and tissue plasminogen activator levels and changes in adipose tissue, finding that tissue plasminogen activator levels were more affected during weight loss, while fibrinogen levels remained relatively stable.
Article
Cardiac & Cardiovascular Systems
Naoto Katakami, Tomoya Mita, Hidenori Yoshii, Toshihiko Shiraiwa, Tetsuyuki Yasuda, Yosuke Okada, Keiichi Torimoto, Yutaka Umayahara, Hideaki Kaneto, Takeshi Osonoi, Tsunehiko Yamamoto, Nobuichi Kuribayashi, Kazuhisa Maeda, Hiroki Yokoyama, Keisuke Kosugi, Kentaro Ohtoshi, Isao Hayashi, Satoru Sumitani, Mamiko Tsugawa, Kayoko Ryomoto, Hideki Taki, Tadashi Nakamura, Satoshi Kawashima, Yasunori Sato, Hirotaka Watada, Iichiro Shimomura
Summary: The study evaluated the effects of tofogliflozin on brachial-ankle pulse wave velocity in patients with type 2 diabetes without a history of apparent cardiovascular disease. Tofogliflozin significantly inhibited the increased baPWV, suggesting that it suppressed the progression of arterial stiffness in these patients.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Endocrinology & Metabolism
Oscar Osorio-Conles, Amanda Jimenez, Ainitze Ibarzabal, Jose Maria Balibrea, Ana de Hollanda, Josep Vidal
Summary: This study found that the impact of type 2 diabetes mellitus on limited weight loss after bariatric surgery is controversial. The study revealed that type 2 diabetes is associated with a 5% lesser mid-term weight loss. Additionally, dysregulated expression of the ATG7 gene in subcutaneous adipose tissue may contribute to limited weight loss after surgery.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Birgitta W. van der Kolk, Maheswary Muniandy, Dorota Kaminska, Marcus Alvarez, Arthur Ko, Zong Miao, Armand Valsesia, Dominique Langin, Maija Vaittinen, Mirva Paakkonen, Riikka Jokinen, Sanna Kaye, Sini Heinonen, Kirsi A. Virtanen, Daniel P. Andersson, Ville Mannisto, Wim H. Saris, Arne Astrup, Mikael Ryden, Ellen E. Blaak, Paivi Pajukanta, Jussi Pihlajamaki, Kirsi H. Pietilainen
Summary: This study investigated the changes in subcutaneous adipose tissue (SAT) mitochondria following diet-induced and bariatric surgery-induced weight-loss interventions in 4 independent weight-loss studies. The results showed that diet-induced weight loss led to downregulation of oxidative phosphorylation genes, while surgery-induced weight loss led to upregulation of these genes, providing insights into potential molecular targets for weight-loss success.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Satoshi Mori, Hiroshi Hagino, Toshitsugu Sugimoto, Shiro Tanaka, Yuji Mitomo, Kaito Takahashi, Teruki Sone, Toshitaka Nakamura, Satoshi Soen
Summary: This study aimed to determine whether sequential therapy with teriparatide, followed by alendronate, is more effective in preventing fractures compared to monotherapy with alendronate. The results showed that in women with osteoporosis at high risk of fracture, once-weekly teriparatide injection followed by alendronate significantly reduced the incidence of morphometric vertebral fractures compared to alendronate monotherapy.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Taeko Osawa, Kazuya Fujihara, Mayuko Harada Yamada, Yuta Yaguchi, Takaaki Sato, Masaru Kitazawa, Yasuhiro Matsubayashi, Takaho Yamada, Satoru Kodama, Hirohito Sone
Summary: This study aimed to investigate the associations between urinary protein and reduced glomerular filtration rate (eGFR) and the risk of starting dialysis. The results showed that the severity of urinary protein and eGFR were independent predictors of starting dialysis, and the risk was higher in individuals with diabetes mellitus.
DIABETOLOGY INTERNATIONAL
(2023)
Article
Peripheral Vascular Disease
Ayako Kobayashi, Kazuya Fujihara, Mayuko Harada Yamada, Takaaki Sato, Yuta Yaguchi, Masaru Kitazawa, Yasuhiro Matsubayashi, Midori Iwanaga, Takaho Yamada, Satoru Kodama, Hirohito Sone
Summary: This study investigated the combined effects of blood pressure and glycemic status on the risk of heart failure using a Japanese claims database. The results showed that the relationship between blood pressure and heart failure risk weakened with worsening of glucose metabolism. In patients with diabetes, comprehensive management of risk factors other than blood pressure may be essential to prevent heart failure.
JOURNAL OF HYPERTENSION
(2023)
Review
Medicine, General & Internal
Satoru Kodama, Kazuya Fujihara, Hajime Ishiguro, Yasuhiro Matsubayashi, Masaru Kitazawa, Midori Iwanaga, Takaho Yamada, Kiminori Kato, Yoshimi Nakagawa, Shiro Tanaka, Hitoshi Shimano, Hirohito Sone
Summary: This network meta-analysis aimed to find optimal glucose-lowering drug treatment regimens in terms of glycemic control and hypoglycemia risk for patients with type 2 diabetes. The use of insulin and non-insulin glucose-lowering agents showed better glycemic control and lower risk of hypoglycemia. Certain combinations of insulin and non-insulin agents were identified as high-efficacy and relatively high-efficacy options for glycemic control. Clinicians should consider appropriate combinations of non-insulin agents to reduce hypoglycemia risk before switching to insulin therapies and be willing to add non-insulin agents to insulin for further improvement in glycemic control.
JOURNAL OF INVESTIGATIVE MEDICINE
(2023)
Article
Endocrinology & Metabolism
Maki Kawasaki, Naoko Arata, Takashi Sugiyama, Tatsumi Moriya, Atsuo Itakuda, Ichiro Yasuhi, Yasuko Uchigata, Eiji Kawasaki, Hirohito Sone, Yuji Hiramatsu
Summary: This study aimed to establish a prospective registry system for gestational diabetes mellitus (GDM) in Japan and to clarify the actual status of GDM according to the International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. The results showed that the risk of low birth weight (LBW) and small-for-gestational age in the GDM group was significantly higher than in the normal glucose tolerance (NGT) group.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Kazuya Fujihara, Laymon Khin, Koshiro Murai, Yurie Yamazaki, Kahori Tsuruoka, Noriko Yagyuda, Katsuya Yamazaki, Hiroshi Maegawa, Shiro Tanaka, Satoru Kodama, Hirohito Sone
Summary: This study aimed to determine the incidence of remission and 1-year relapse in patients with type 2 diabetes and associated factors. The overall incidence of remission in Japanese patients was 10.5 per 1000 person-years, with higher rates for those with HbA1c levels of 48 to 53 mmol/mol (6.5% to 6.9%), those taking no glucose-lowering drugs at baseline, and those with a =10% BMI reduction in 1 year. Shorter duration, lower baseline HbA1c, higher baseline BMI, greater BMI reduction at 1 year, and no glucose-lowering drugs at baseline were significantly associated with remission. Among those with remission, approximately two-thirds relapsed within 1 year. Longer duration, lower baseline BMI, and lower BMI reduction at 1 year were significantly associated with relapse.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, General & Internal
Yuhki Sakurai, Nobumasa Ohara, Yumi Fukai, Yasuhiro Seki, Katsuhiko Akiyama, Yuichiro Yoneoka, Toshinori Takada, Takashi Tani, Kenshi Terajima, Tetsutaro Ozawa, Hirohito Sone
Summary: A 56-year-old man with anorexia for 2.5 months presented with sweating, weakness, left hemiplegia, and hemispatial neglect. Magnetic resonance imaging showed no abnormalities, but magnetic resonance angiography revealed narrowing of the right middle cerebral artery. Neurological symptoms and arterial narrowing resolved after correction of hypoglycemia. Adrenal insufficiency was identified through endocrinological examinations. Hemiplegia is a rare but important neurological manifestation of hypoglycemia, possibly caused by combined hypoglycemia and decreased blood flow leading to regional neuroglycopenia and ischemia.
Article
Sport Sciences
Takaaki Sato, Kazuya Fujihara, Mayuko Harada Yamada, Kaori Chou, Yuta Yaguchi, Masaru Kitazawa, Hajime Ishiguro, Taeko Osawa, Takaho Yamada, Satoru Kodama, Kiminori Kato, Hirohito Sone
Summary: A new Physical Score (PS) was developed and its association with metabolic diseases among Japanese individuals was elucidated. The PS was calculated based on physical fitness indicators and showed a significant association with an increased risk of metabolic diseases, especially metabolic syndrome. The PS was found to be a useful and simple non-invasive tool for screening Japanese people for metabolic diseases.
JOURNAL OF SPORTS SCIENCE AND MEDICINE
(2023)
Article
Endocrinology & Metabolism
Hirohito Sone
JOURNAL OF DIABETES INVESTIGATION
(2023)
Review
Endocrinology & Metabolism
Kazuya Fujihara, Hirohito Sone
Summary: Globally, the number of people with diabetes mellitus has increased by four times in the past 30 years, and approximately one in 11 adults worldwide have diabetes mellitus. Managing blood glucose levels is crucial for diabetes care due to its impact on the quality of life and mortality rates of the patients. Various classes of antihyperglycemic drugs are available, but the application of clinical trial results to actual clinical practice is challenging. Machine learning approaches in drug treatment strategies for diabetes care have been slow to be adopted.
DIABETES & METABOLISM JOURNAL
(2023)
Article
Public, Environmental & Occupational Health
Kazuya Fujihara, Mayuko Yamada Harada, Chika Horikawa, Midori Iwanaga, Hirofumi Tanaka, Hitoshi Nomura, Yasuharu Sui, Kyouhei Tanabe, Takaho Yamada, Satoru Kodama, Kiminori Kato, Hirohito Sone
Summary: This study developed a machine learning model to predict weight change over three years. It found that lifestyle had a significant impact on weight in individuals with high BMI and in young people. The model showed comparable accuracy to multiple regression, suggesting its potential for personalized weight management.
FRONTIERS IN PUBLIC HEALTH
(2023)
Correction
Nutrition & Dietetics
Kanako Sumi, Yuiko Hatanaka, Reina Takahashi, Naoko Wada, Chihiro Ono, Yuri Sakamoto, Hirohito Sone, Kaoruko Iida
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Hiroki Yokoyama, Shin-ichi Araki, Koichi Kawai, Katsuya Yamazaki, Osamu Tomonaga, Hajime Maeda, Masafumi Ohtaki, Hiromi Obata, Hirohito Sone, Daijiro Kabata, Ayumi Shintani, Hiroshi Maegawa, JDDM Study Group
Summary: This study aimed to investigate the reduction in all-cause mortality and cardiovascular disease morbidity in type 2 diabetes patients over the past decade in real-world practice. The results showed a significant reduction in cardiovascular disease in the recent cohort, implying the impact of treatment advances.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Public, Environmental & Occupational Health
Hisashi Noma, Munechika Misumi, Shiro Tanaka
Summary: Ordinary logistic regression analyses are widely used in case-cohort studies, but their odds ratio estimates cannot be interpreted as relative risk measures unless the event rate is low. This study introduces pseudo-Poisson and pseudo-normal linear regression methods that can estimate risk ratios and risk differences. By using weighting and auxiliary variable information, these estimators provide accurate and precise results. These alternative approaches are recommended for case-cohort studies, especially when the event rate is not low.
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Hiroaki Ohta, Yukari Uemura, Teruki Sone, Shiro Tanaka, Satoshi Soen, Satoshi Mori, Hiroshi Hagino, Masao Fukunaga, Toshitaka Nakamura, Hajime Orimo, Masataka Shiraki
Summary: The positive link between osteoporosis and hypercholesterolemia has been acknowledged, and bone resorption inhibitors, such as nitrogen-containing bisphosphonates (N-BP) and selective estrogen receptor modulators (SERMs), have been found to lower serum cholesterol levels. However, the association between baseline cholesterol level and incident fracture rate under treatment with these inhibitors has not been studied. This research investigated the relationship between vertebral fracture incidents and baseline cholesterol levels, as well as the cholesterol-lowering effects of N-BP and SERM in osteoporosis patients.
CALCIFIED TISSUE INTERNATIONAL
(2023)