Article
Medicine, Research & Experimental
Jiaxin Liu, Mengmeng Zhao, Zhenghao Chen, Yang Xu, Liqiang Guo, Shaoyong Wang, Yan Li, Benkang Shi, Xiulin Zhang, Xiao-Dong Jin
Summary: TRPM3 channels expressed on sensory terminals of the human ureter play a key role in inhibitory sensory neurotransmission and modulate ureter motility via the CGRP-cAMP-PKA signal pathway. Targeting TRPM3 may be a pharmacological strategy for promoting the passage of ureter stones.
Article
Multidisciplinary Sciences
Kenichiro Shimazaki, Takehiro Yajima, Hiroyuki Ichikawa, Tadasu Sato
Summary: The study demonstrated the presence of GAL-immunoreactive cells and nerve fibers in the rat dura mater, suggesting a potential role of GAL in nociceptive transmission or modulation as well as immune mechanisms of the dura mater. GAL was commonly expressed in the cerebral falx and cerebellar dura mater, with co-expression of CGRP-immunoreactivity, and in a substantial proportion of sensory neurons innervating the dura mater in the trigeminal ganglion.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Isabella Mai Christiansen, Jacob C. A. Edvinsson, Philip Reducha, Lars Edvinsson, Kristian Agmund Haanes
Summary: The present study demonstrates that ACEA alone does not exhibit antimigraine potential due to its dual agonistic properties, resulting in activation of both CB1 and TRPV1.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Endocrinology & Metabolism
Kuldeep Makwana, Harshita Chodavarapu, Nancy Morones, Jingyi Chi, William Barr, Edward Novinbakht, Yidan Wang, Peter Tuan Nguyen, Predrag Jovanovic, Paul Cohen, Celine E. Riera
Summary: The study revealed that genetic ablation of heat-sensing CGRPa neurons promotes resistance to weight gain upon high-fat diet feeding and increases energy expenditure in mice by reducing lipid deposition, enhancing fatty acid oxidation gene expression, and increasing lipolysis in adipocytes, as well as enhancing mitochondrial respiration in iBAT.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Takehiro Yajima, Tadasu Sato, Hiroshi Hosokawa, Teruyoshi Kondo, Hiroyuki Ichikawa
Summary: This study demonstrates the expression and distribution of TRPM7 in rat lumbar dorsal root ganglion (DRG) neurons, highlighting its association with other TRP channels and involvement in peripheral targets. The findings suggest that TRPM7 is involved in response to noxious stimulation and that nerve injury can decrease TRPM7 expression in DRG neurons.
JOURNAL OF CHEMICAL NEUROANATOMY
(2022)
Article
Pharmacology & Pharmacy
Dingding Liu, Lulu Chang, Jingru Wang, Qiang Zhu, Ning Jiang, Mudassar Azhar, Ayaz Ahmed, Guirong Zeng
Summary: This study evaluated the effect of Xiongmatang (XMT) extract on rats with migraine induced by inflammatory soup. The results showed that XMT extract improved the behavioral performance of rats and improved the pathological changes in the trigeminal nerve. Further experiments demonstrated that XMT extract regulated the activity of the TRPV1-CGRP/CGRP-R pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Qian Yu, Yu Zhao, Xinyue Zhang, Wenjie Li, Hongyin Zhang, Songlan Piao, Guangzhe Li, Mingming Yan
Summary: Sanhuang ointment (SHO) has been found to have anti-inflammatory and anti-vascular permeability effects, which can effectively alleviate the symptoms of hemorrhoids.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Anatomy & Morphology
Tadasu Sato, Takehiro Yajima, Shiori Saijyo, Kenichiro Shimazaki, Tomiko Nishitani, Tomohiro Hoshika, Yoshihiro Nishitani, Hiroyuki Ichikawa, Itaru Mizoguchi, Tomohiro Fukunaga
Summary: The study revealed abundant expression of alpha-synuclein in sensory ganglia, with co-expression with calcitonin gene-related peptide and transient receptor potential cation channel subfamily V member 1. Immunoreactive nerve fibers were found in oral and cervical viscerae, as well as in the upper airway, potentially playing a role in nociceptive and chemosensory transduction.
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER
(2021)
Article
Clinical Neurology
Johanna Kleeberg-Hartmann, Birgit Vogler, Karl Messlinger
Summary: The study found that petasin and isopetasin can reduce CGRP release by inhibiting the activity of TRPA1 and TRPV1 receptor channels, potentially playing a role in the prophylactic effect against migraine. These results reveal the potential mechanisms by which petasins may reduce migraine attacks.
JOURNAL OF HEADACHE AND PAIN
(2021)
Article
Surgery
Hiroya Akabori, Hiroshi Yamamoto, Tomoharu Shimizu, Yoshihiro Endo, Tohru Tani, Masaji Tani
Summary: This study investigated the role of TRPV1-positive peripheral sensory efferents in hemodynamic responses after hemorrhagic shock. The findings suggest that the TRPV1 antagonist capsazepine and the calcitonin gene-related peptide receptor antagonist hCGRP(8-37) can improve survival rates after hemorrhagic shock and maintain tissue oxygenation and metabolic conditions.
Article
Clinical Neurology
Judit Rosta, Mate Toth, Nadine Friedrich, Peter Santha, Gabor Jancso, Maria Dux
Summary: This study found that insulin can stimulate meningeal nociceptor functions by activating TRPV1 receptors and increasing dural blood flow. Insulin also sensitizes neural and vascular TRPV1 receptors to stimulation. Insulin receptors colocalize with TRPV1 receptors and CGRP in trigeminal ganglion neurons. These findings suggest a potential link between insulin and susceptibility to migraine headaches.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Anatomy & Morphology
Safdar Jawaid, Amanda Herring, Paulina M. Getsy, Stephen J. Lewis, Michiko Watanabe, Hana Kolesova
Summary: Vagal afferents regulate various physiological functions and stimulation of nodose ganglia by infrared light may involve temperature-sensitive TRP ion channels. The spatial localization of six TRP channels, including TRPV1, TRPV4, TRPM3, TRPM8, TRPA1, and TRPC1, was detected in nodose ganglia, with different patterns of expression and subcellular localization. The presence of these TRP channels in nodose ganglia provides a basis for further studies on their roles in sensory transmission and responses to stimuli such as exposure to infrared light.
JOURNAL OF ANATOMY
(2022)
Article
Clinical Neurology
Miklos Lengyel, Dominika Hajdu, Alice Dobolyi, Judit Rosta, Gabor Czirjak, Maria Dux, Peter Enyedi
Summary: The study found that inhibition of TRESK increased TRPV1-mediated calcium signal in dorsal root ganglion neurons and potentiated capsaicin-induced increases in calcitonin gene-related peptide release and meningeal blood flow. Activation of TRESK decreased capsaicin sensitivity in sensory neurons, leading to an attenuation of capsaicin-induced increase in meningeal blood flow. In animals lacking TRESK, TRPV1-mediated nociceptive reactions were not affected by TRESK modulators.
Article
Audiology & Speech-Language Pathology
Yijiang Bai, Jing Liu, Xuewen Wu, Bo Pang, Shuai Zhang, Mengzhu Jiang, Anhai Chen, Huping Huang, Yongjia Chen, Yuan Zeng, Lingyun Mei, Kelei Gao
Summary: Aminoglycoside antibiotics are a common cause of sensorineural hearing loss. The nonselective cation channel, TRPV1, has been found to contribute to the susceptibility of immature spiral ganglion neurons (SGNs) to aminoglycoside-induced damage.
Article
Multidisciplinary Sciences
Diane M. Bogdan, Keith Studholme, Adriana DiBua, Chris Gordon, Martha P. Kanjiya, Mei Yu, Michelino Puopolo, Martin Kaczocha
Summary: The endocannabinoid anandamide can produce both anti-pain effects and exacerbate pain. FABP5 plays a key role in regulating the levels of endocannabinoids in nociceptors, affecting pain perception. Decreasing the expression of FABP5 can increase the levels of endocannabinoids, leading to anti-pain effects.
SCIENTIFIC REPORTS
(2022)