Article
Medicine, General & Internal
Teodora Yaneva-Sirakova, Latchezar Traykov, Kiril Karamfiloff, Ivo Petrov, Julieta Hristova, Dobrin Vassilev
Summary: Carotid stenting can affect the levels of neurotrophins, which are important for the survival, development, and function of neurons.
ANNALS OF MEDICINE
(2023)
Article
Neurosciences
Honghong Zhang, Xiaohui Chen, Ting Zheng, Mingxue Lin, Pinzhong Chen, Yanling Liao, Cansheng Gong, Fei Gao, Xiaochun Zheng
Summary: The study found that AMI can alleviate lidocaine-induced neurotoxicity mainly by inhibiting autophagy activity through upregulation of BDNF expression.
NEUROTOXICITY RESEARCH
(2021)
Article
Anatomy & Morphology
Kevin Puertas-Neyra, Nadia Galindo-Cabello, Leticia A. Hernandez-Rodriguez, Fernando Gonzalez-Perez, Jose Carlos Rodriguez-Cabello, Rogelio Gonzalez-Sarmiento, Jose Carlos Pastor, Ricardo Usategui-Martin, Ivan Fernandez-Bueno
Summary: Retinal neurodegenerative diseases are the leading causes of visual impairment and irreversible blindness worldwide. The development of broad-spectrum neuroprotective therapies is essential as current therapeutic options are limited. This study aims to understand the role of cell death mechanisms and autophagy in retinal neurodegenerative diseases, providing new insights for future therapeutic options.
FRONTIERS IN NEUROANATOMY
(2022)
Article
Biochemistry & Molecular Biology
Elisabetta Catalani, Silvia Bongiorni, Anna Rita Taddei, Marta Mezzetti, Federica Silvestri, Marco Coazzoli, Silvia Zecchini, Matteo Giovarelli, Cristiana Perrotta, Clara De Palma, Emilio Clementi, Marcello Ceci, Giorgio Prantera, Davide Cervia
Summary: The absence of full-length dystrophin leads to structural damages and impaired autophagy in the retina, affecting neuronal survival and visual properties. Reactivation of autophagy can prevent cell death and structural changes, improving the response to light in mutant flies. Overall, functional dystrophin is crucial for synapsis stabilization and proper neuronal survival in the retina.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Health Care Sciences & Services
Bartlomiej Ptaszek, Szymon Podsiadlo, Olga Czerwinska-Ledwig, Marcin Maciejczyk, Aneta Teleglow
Summary: The study aimed to compare the effects of 20 whole body cryotherapy sessions on iron levels and neuroplasticity biomarkers in women with MS and healthy women. Results showed no significant impact of WBC on these biomarkers in both groups.
Article
Ophthalmology
Yueru Li, Basma Baccouche, Olamide Olayinka, Anara Serikbaeva, Andrius Kazlauskas
Summary: The study reveals that VEGF/anti-VEGF controls endothelial cell permeability by regulating multiple members of the Wnt pathway, and activating this pathway helps strengthen the endothelial cell barrier. FDA-approved agents such as LiCl may serve as adjuvants to anti-VEGF therapy for blinding conditions like diabetic retinopathy.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Review
Chemistry, Applied
Biswajita Pradhan, Laxmidhar Rout, Jang-Seu Ki
Summary: Porphyran, a polysaccharide found in red seaweeds, has immunomodulatory, anti-inflammatory, and anti-cancer effects by boosting immunity and targeting apoptotic molecules, making it a potential chemotherapeutic or chemopreventive drug.
CARBOHYDRATE POLYMERS
(2023)
Article
Anesthesiology
Julia Sanchez-Sanchez, Cristina Vicente-Garcia, Daniel Canada-Garcia, Dionisio Martin-Zanca, Juan C. Arevalo
Summary: Pain serves as a protective mechanism against harmful stimuli, and the NGF/TrkA axis plays a crucial role as a pain mediator. However, the clinical approval of NGF antibodies is hindered due to side effects. This study reveals that ARMS/Kidins220, a scaffold protein for Trk receptors, modulates nociception. Reduction of ARMS/Kidins220 in TrkA-expressing cells results in hyperalgesia to certain stimuli, which can be reversed by simultaneous deletion of BDNF. Mechanistically, capsaicin-induced reduction of ARMS/Kidins220 leads to enhanced BDNF secretion. These findings highlight the role of ARMS/Kidins220 in the regulation of pain through the NGF/TrkA axis and BDNF secretion.
Review
Oncology
Chenming Zhong, Zijun Xie, Shiwei Duan
Summary: This article summarizes important predictive ncRNA biomarkers reported in cancer patients treated with different immunotherapeutic modalities including monoclonal antibodies, small molecule inhibitors, cancer vaccines, and CAR-T cells. In addition, a concise discussion on forthcoming perspectives is provided, outlining technical approaches for the optimal utilization of immune-modulatory ncRNA biomarkers as predictive tools and therapeutic targets.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Yimeng Sun, Feng Wen, Chun Yan, Lishi Su, Jiawen Luo, Wei Chi, Shaochong Zhang
Summary: Anti-VEGF drug bevacizumab may induce retinal hypoxia, but it also activates the HIF-1 alpha-BNIP3/FUNDC1 signaling pathway, leading to mitophagy that reduces oxidative stress and alleviates the deleterious effects.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Mashima Naksawat, Chosita Norkaew, Kantorn Charoensedtasin, Sittiruk Roytrakul, Dalina Tanyong
Summary: This study revealed the anti-leukemic effects and underlying mechanisms of menthol in NB4 and Molt-4 leukemic cell lines, including induction of apoptosis and autophagy through activating the caspase cascade, regulating BAX and p53/MDM2, and modulating autophagy via the ATG3/mTOR signaling pathway.
Review
Chemistry, Medicinal
Tatiana A. Gudasheva, Polina Y. Povarnina, Aleksey V. Tarasiuk, Sergey B. Seredenin
Summary: This review discusses the efforts to create low-molecular-weight mimetics of neurotrophins NGF and BDNF with improved pharmacokinetic properties and lacking side effects. Various peptide and nonpeptide mimetics have been produced to mimic the therapeutic effects of full-sized proteins by targeting specific receptors. The relationship between the structure of these mimetics and their action mechanisms and pharmacological properties are analyzed, with special attention given to dipeptide mimetics and their activation of different signal transduction pathways. Promising compounds at different stages of preclinical and clinical studies are also summarized.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Food Science & Technology
Hsin-Ling Yang, Sheng-Teng Huang, Zi-He Lyu, Asif Ali Bhat, Chithravel Vadivalagan, Yu-Lyu Yeh, You-Cheng Hseu
Summary: Coenzyme Q0 (CoQ0) from Antrodia camphorata exhibits therapeutic benefits in cancer treatment by activating apoptotic and autophagic cell death pathways.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Neurosciences
Domenico Ribatti, Diego Guidolin
Summary: Vascular and neuronal networks are formed through branching morphogenesis, and there is molecular crosstalk and common cues between nerves and blood vessels. Vascular endothelial growth factor (VEGF) affects the nervous system, while nerve growth factor (NGF) exhibits angiogenic properties. This study focuses on the morphogenesis and remodeling processes of vascular and neuronal networks.
BRAIN RESEARCH BULLETIN
(2022)
Article
Pharmacology & Pharmacy
Yazhuo Wang, Yang Xu, Jingrui Tan, Jiaxue Ye, Weizhen Cui, Jie Hou, Peiyu Liu, Jianwei Li, Shiyuan Wang, Qingyang Zhao
Summary: This study confirms the effectiveness of Qingre-Huazhuo-Jiangsuan-Recipe (QHJR), a modified formulation of Si-Miao-San (SMS), in treating Acute Gouty Arthritis (AGA). QHJR, as a traditional Chinese medicine formula, offers advantages such as minimal safety concerns and potential long-term use. The study suggests that QHJR may alleviate AGA by activating the AMPK/mTOR/ULK1 pathway, regulating autophagy levels and reducing inflammation. These findings provide new therapeutic approaches and ideas for the clinical treatment of AGA.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Ophthalmology
Fabiana Mallone, Marco Marenco, Rosalia Giustolisi, Rocco Plateroti, Alessandro Lambiase
Summary: This case report describes the successful treatment of persistent corneal epithelial defect in a patient with total limbal stem cell deficiency (LSCD) after severe firework-related ocular burn using autologous Platelet-Rich Plasma (PRP). The findings provide valuable information on the management of ocular burns, supporting the use of PRP in preventing corneal stromal melting and promoting epithelial coverage.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Giuseppe Maria Albanese, Giacomo Visioli, Ludovico Iannetti, Francesca Giovannetti, Marta Armentano, Enrico Romano, Federico Macario, Pasquale Fino, Magda Gharbiya
Summary: This study evaluated the association between choroidal thickness and persistent subretinal fluid (pSRF) after simple primary rhegmatogenous retinal detachment (RRD) repair. The results showed that patients with pSRF had lower choroidal and RPE thickness compared to those without pSRF. However, choroidal thickness was not a final predictor for pSRF, as it was mainly associated with macular involvement, surgical technique, and detachment duration.
ACTA OPHTHALMOLOGICA
(2023)
Article
Biochemistry & Molecular Biology
Magda Gharbiya, Giacomo Visioli, Alessandro Trebbastoni, Giuseppe Maria Albanese, Mayra Colardo, Fabrizia D'Antonio, Marco Segatto, Alessandro Lambiase
Summary: We conducted a study to evaluate the diagnostic role of AD biomarkers in tears and their association with retinal and choroidal microstructures. We found that tear A beta 1-42 levels had a high sensitivity and specificity in detecting MCI and AD patients. Additionally, A beta 1-42 levels were correlated with psychometric scores and choroidal thickness. Testing A beta 1-42 levels in tears could be a minimally invasive and cost-saving method for early detection and diagnosis of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alice Bruscolini, Angela Iannitelli, Marco Segatto, Pamela Rosso, Elena Fico, Marzia Buonfiglio, Alessandro Lambiase, Paola Tirassa
Summary: This study investigated the correlation between the expression levels of NGF and BDNF in tears and serum and ophthalmic and psycho-cognitive symptoms in Graves' Orbitopathy (GO) patients. The results showed that NGF and BDNF expression correlated with ophthalmic symptoms, while mature/precursor NGF and BDNF correlated with psycho-cognitive variables. This study is the first to suggest that changes in NGF and BDNF processing in tears and serum may be associated with ocular and cognitive alterations in GO patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Anna Maria Comberiati, Ludovico Iannetti, Raffaele Migliorini, Marta Armentano, Marika Graziani, Luca Celli, Anna Zambrano, Mauro Celli, Magda Gharbiya, Alessandro Lambiase
Summary: This study aims to evaluate ocular motility (OM) abnormalities associated with Ehlers-Danlos Syndrome (EDS). Patients with EDS underwent a complete orthoptic examination, and various OM alterations were observed in these patients. The results show that superior and medial rectus muscle hypofunction, as well as other abnormalities, are common in patients with EDS.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Alice Bruscolini, Giacomo Visioli, Marco Marenco, Veronica Cherubini, Anna Maria Comberiati, Gaspare Palaia, Massimo Ralli, Livia Ottolenghi, Alessandro Lambiase, Antonella Polimeni
Summary: Italy serves as a gateway for refugees and migrants entering Europe, with a significant number requiring socio-economic and health assistance. A new intervention strategy, known as the PROTECT project, aimed to evaluate the eye health of vulnerable applicants and international protection holders in the head-neck area. 3023 migrants participated in the project, with demographic factors and eye history collected through a questionnaire. Results showed a high prevalence of vision impairment, with various ocular diseases identified. The PROTECT project improves accessibility to preventive care for head-neck diseases and highlights the importance of early identification and prevention of ocular diseases in disadvantaged populations.
APPLIED SCIENCES-BASEL
(2023)
Review
Chemistry, Multidisciplinary
Valeria Iannucci, Priscilla Manni, Giulia Mecarelli, Sara Giammaria, Francesca Giovannetti, Alessandro Lambiase, Alice Bruscolini
Summary: Uveitic glaucoma (UG) is a common cause of secondary glaucoma in pediatric ophthalmology, caused by intraocular inflammation. Managing UG is challenging and requires a multidisciplinary approach. Overlap with steroid-induced glaucoma (SIG) is common, and there are limited papers discussing the treatment options for pediatric UG.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Marta Armentano, Luca Lucchino, Ludovico Alisi, Antonio Valerio Chicca, Valerio Di Martino, Emanuele Miraglia, Ludovico Iannetti, Anna Maria Comberiati, Sandra Giustini, Alessandro Lambiase, Antonietta Moramarco
Summary: Neurofibromatosis type 2 (NF2) is a genetically determined tumor-predisposing syndrome with ocular manifestations including cataracts, epiretinal membranes, retinal hamartomas, optic disk gliomas, and optic nerve sheath meningiomas. Other indirect signs such as optic disk edema, optical atrophy, motility disorders, pupil and lid dysfunction, and neurotrophic keratitis can also be observed.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Eustachio Attico, Giulia Galaverni, Andrea Torello, Elisa Bianchi, Susanna Bonacorsi, Lorena Losi, Rossella Manfredini, Alessandro Lambiase, Paolo Rama, Graziella Pellegrini
Summary: Total bilateral Limbal Stem Cell Deficiency is a pathological condition caused by the loss of corneal stem cells. Cultivated oral mucosa epithelial transplantation (COMET) is the only successful autologous treatment, but it often leads to abnormal corneal vascularization. This study identified a new marker, Paired Like Homeodomain 2 (PITX2), that distinguishes transplanted oral tissue from other epithelia, and also discovered differential expression of angiogenesis-related factors in the three epithelia, providing insights into the neovascularization mechanism in COMET-treated patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Fabiana Mallone, Ludovico Alisi, Luca Lucchino, Valerio Di Martino, Marcella Nebbioso, Marta Armentano, Alessandro Lambiase, Antonietta Moramarco
Summary: Neurofibromatosis type 1 (NF1) is a rare genetic disorder that affects the skin, nervous system, and eyes. Ocular diagnostic hallmarks of NF1 include various abnormalities in the eyes such as nodules, neurofibromas, and spots. Recent advancements in imaging techniques have allowed for better characterization of these eye abnormalities in NF1 patients. This paper reviews the latest progress in understanding and diagnosing choroidal and retinal abnormalities in NF1 patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Valeria Iannucci, Priscilla Manni, Ludovico Alisi, Giulia Mecarelli, Alessandro Lambiase, Alice Bruscolini
Summary: Ocular trauma is a common problem worldwide and can lead to secondary glaucoma. Angle recession, usually unilateral, is a major cause of post-traumatic glaucoma after blunt eye trauma. This paper investigates the possible causes of bilateral angle recession and presents a case of chronic post-traumatic glaucoma, possibly caused by an airbag.
Article
Medicine, General & Internal
Ludovico Iannetti, Fabio Scarinci, Ludovico Alisi, Marta Armentano, Lorenzo Sampalmieri, Maurizio La Cava, Magda Gharbiya
Summary: The characteristics of macular edema in young patients with idiopathic intermediate uveitis were described and correlated with visual acuity using spectral domain optical coherence tomography (SD-OCT). The study found a negative correlation between best-corrected visual acuity (BCVA) and Ellipsoid Zone disruption, cystoid pattern, central subfield thickness (CST), and serous retinal detachment.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Ludovico Iannetti, Fabio Scarinci, Ludovico Alisi, Alessandro Beccia, Andrea Cacciamani, Maria Carmela Saturno, Magda Gharbiya
Summary: This article reports an uncommon presentation of Eales disease associated with cocaine abuse, presenting as blurred vision in the left eye. Serologic panel was negative except for the heterozygous mutation of factor V Leiden. Clinical and biochemical parameters suggested a diagnosis of Eales disease. Treatment with dexamethasone and peripheral laser photocoagulation allowed symptom relief.
MEDICINA-LITHUANIA
(2023)
Letter
Ophthalmology
Alessandro Lambiase, Fabiana Mallone, Marta Sacchetti, Marco Segatto, Mayra Colardo, Valerio Di Martino, Alice Bruscolini