Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 234, Issue 9, Pages 16609-16618Publisher
WILEY
DOI: 10.1002/jcp.28335
Keywords
GLS; glutamine catabolism; melanoma; miR-217; OIP5-AS1
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Funding
- National Natural Science Foundation of China [81672999, 81802726]
- Health and Family Planning Science and Technology Key project Foundation of Zhenjiang city [SHW2017004]
- Clinical Medical Science and Technology Development Fund of Jiangsu University [JLY20160002]
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The long noncoding RNA (lncRNA) OIP5-AS1 has been considered to promote the growth and metastasis of many human tumors. However, the role of OIP5-AS1 in melanoma has not been reported. In this study, we found that OIP5-AS1 levels were significantly elevated in melanoma tissue and that high OIP5-AS1 expression was an independent risk factor for the poor survival of patients with melanoma. miR-217 suppressed glutamine catabolism in melanoma cells by targeting glutaminase (GLS), the rate-limiting enzyme of glutamine catabolism. We also demonstrated that OIP5-AS1 acted as a sponge of miR-217 to upregulate GLS expression, thus promoting glutamine catabolism and melanoma growth. Overall, this result elucidates a new mechanism for OIP5-AS1 in metabolism in melanoma and provides a potential therapeutic target for patients with melanoma.
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