Article
Dentistry, Oral Surgery & Medicine
Xiaotang Wang, Xiaocui Nie, Guoqiang Xu, Jiping Gao, Binhong Wang, Junting Yang, Guohua Song
Summary: miR-450b plays a crucial role in the tumorigenesis of oral squamous cell carcinoma (OSCC) by regulating the migration, invasion, and epithelial-mesenchymal transition (EMT) of OSCC cells through its target gene SERPINB2.
Article
Multidisciplinary Sciences
Wenli Zang, Junchao Liu, Fengxue Geng, Dongjuan Liu, Shuwei Zhang, Yuchao Li, Yaping Pan
Summary: This study found that butyrate can promote the migration and invasion of oral squamous cell carcinoma (OSCC) cells by inducing epithelial-mesenchymal transition (EMT), indicating that butyrate may contribute to the metastasis of OSCC.
Article
Immunology
Ying Lin, Ying Qi, Mingjing Jiang, Wei Huang, Bo Li
Summary: There is metabolic interaction between tumor cells and macrophages in oral squamous cell carcinoma (OSCC), which is associated with tumor cell migration, invasion, and epithelial-mesenchymal transition (EMT). GPNMB and CD44 are involved in this process and may serve as potential targets for treating OSCC.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Anatomy & Morphology
Xiao-Qin Liu, Yao Yao, Jing-Wen Mu, Feng-Ying Yang
Summary: This study found that high cytoplasmic expression of Sema4A is related to T classification, clinical stage, and nodal metastasis of OSCC patients. Patients with low cytoplasmic Sema4A expression showed higher microvessel density (MVD) and poorer prognosis in OSCC. Over-expression of Sema4A can inhibit the invasion, migration, and angiogenesis abilities of oral squamous cell carcinoma cells.
Article
Endocrinology & Metabolism
Yuanxin Chen, Zhijie Huang, Jianjiang Zhao, Bo Jia
Summary: This study verified the effect of Fusobacterium nucleatum (F. nucleatum) in oral squamous cell carcinoma (OSCC) and explored the possible molecular mechanism. The abundance of F. nucleatum was found to be higher in OSCC compared to paracancerous tissues. F. nucleatum can regulate cell proliferation, migration, and invasion, and promote the progression of OSCC through CCL20.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Pharmacology & Pharmacy
Danni Wang, Mei Tian, Yong Fu, Yawei Sun, Liang Ding, Xiaoxin Zhang, Yue Jing, Guowen Sun, Yanhong Ni, Yuxian Song
Summary: The study found that Halofuginone can inhibit the migration and invasion of oral squamous cell carcinoma (OSCC) by targeting cancer-associated fibroblasts (CAFs), and is involved in this process through inhibiting MMP2 secretion and the TGF-beta/Smad2/3 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuntao Sun, Hongyu Yang, Feng Wang, Shanshan Zhao
Summary: In this study, it was found that LPS- and TNF-alpha-induced inflammation suppressed the migration and invasion of OSCC cells, facilitated by upregulating Oct4 expression.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Xiaoyu Hu, Xin Shen, Jiangxue Tian
Summary: The research found that periodontitis positive correlated microbiota promotes the development of oral squamous cell carcinoma, while periodontitis negative correlated microbiota inhibits its development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Qiusheng Shan, Kiyofumi Takabatake, Haruka Omori, Hotaka Kawai, May Wathone Oo, Keisuke Nakano, Soichiro Ibaragi, Akira Sasaki, Hitoshi Nagatsuka
Summary: The study demonstrates that both VSCC-SCs and SCC-SCs may promote the progression of OSCC, with SCC-SCs showing a more prominent effect, indicating a potential regulatory mechanism for OSCC progression.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ze-Ying Zhang, Yuan-Yuan Sun, He-Chen Wang, Wei-Neng Fu, Chang-Fu Sun
Summary: The study revealed that DOCK6 is upregulated in oral squamous cell cancer and is associated with poor clinical outcomes. The increased expression of DOCK6 is correlated with enhanced migration and invasion of cancer cells. These findings suggest that DOCK6 may serve as a potential therapeutic target and prognostic indicator for OSCC patients.
ARCHIVES OF ORAL BIOLOGY
(2022)
Article
Oncology
Adjabhak Wongviriya, Richard M. Shelton, Paul R. Cooper, Michael R. Milward, Gabriel Landini
Summary: This study aimed to determine the involvement of S1PR2 in EGF-induced migration and invasion of OSCC lines, as well as any potential crosstalk between the two pathways. The results demonstrated that S1PR2 inhibition reduced EGF-induced migration, invasion, and Rac1 activity. However, S1PR2 activation did not enhance the effect of EGF on migration, invasion, or Rac1 activity. Additionally, EGF promoted S1P production through the upregulation of Sphk1.
CANCER CELL INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Tiina Koivikko, Priscila Campioni Rodrigues, Mari Vehvilaeinen, Petra Hyvonen, Elias Sundquist, Riikka K. Arffman, Ahmed Al-Samadi, Hanna Valimaa, Tuula Salo, Maija Risteli
Summary: This study investigates the predominance of HSV-1 in oral HSV infections and its effect on oral tongue squamous cell carcinoma (OTSCC). The results show that HSV-1 is the predominant type in oral HSV infections and is also detected in OTSCC samples without clinical significance. Furthermore, low doses of HSV-1 do not affect cell survival or invasion in OTSCC.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Xin Li, Weidong Yang
Summary: This study found that CLDN7 expression is low in OSCC tissues and that overexpression of CLDN7 inhibits the proliferation, invasion, and migration of OSCC cells. IRF2 was found to bind to the CLDN7 promoter and regulate its expression, also affecting the functions of OSCC cells.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Oncology
Jing Deng, Maolin Wu
Summary: COX10-AS1 is downregulated in oral squamous cell carcinoma and can act as a tumor suppressor through the miR-361-5p/SPRY1 axis.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Nyein Nyein Chan, Manabu Yamazaki, Satoshi Maruyama, Tatsuya Abe, Kenta Haga, Masami Kawaharada, Kenji Izumi, Tadaharu Kobayashi, Jun-ichi Tanuma
Summary: Cholesterol plays a significant role in cancer progression, particularly in oral squamous cell carcinoma (OSCC) pathogenesis. This study investigates the effects of cholesterol on OSCC cells by manipulating the expression of CAV1, a cholesterol-binding protein involved in intracellular cholesterol transport. The results suggest that cholesterol promotes OSCC cell migration and that CAV1 expression may serve as a prognostic marker for OSCC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Cheng-wan Xia, Jiong-ru Pan, Lei Fan, Qi Xiao, Yumei Pu, Yu-Xin Wang
Article
Environmental Sciences
Yumei Pu, Shiqi Hu, Yongfeng Chen, Qian Zhang, Chengwan Xia, Han Deng, Yuxin Wang, Qingang Hu
Summary: The study evaluated the effects of thymoquinone nanoencapsulated carrier on hamster buccal pouch cancer and found that TQ/Ca-alg-PVA carrier has potential anticancer effects, restoring biochemical markers in DMBA-induced oral tissues, and reducing the expression of inflammatory and PI3K/AKT/mTOR signaling pathways.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Pathology
Yumei Pu, Liang Ding, Yujia Wang, Yuxin Wang, Sheng Chen, Xiaofeng Huang, Zhifeng He, Yanhong Ni, Qingang Hu
Summary: This study aimed to assess the depth of invasion and worst pattern of invasion in early-stage oral squamous cell carcinoma, and found that the biopsy pattern of invasion could predict the worst pattern of invasion and depth of invasion preoperatively.
Article
Dentistry, Oral Surgery & Medicine
Zezheng Wang, Shuang Zhang, Yumei Pu, Yuxin Wang, Zitong Lin, Zhiyong Wang
Summary: The study found that CBCT is reliable in determining the presence of mandible invasion but less so for nerve invasion. There was an average deviation of 2.97 mm in the assessment of bone invasion boundary using CBCT compared with histopathological standards. The study highlights the importance of considering this deviation in bone invasion boundary estimation during osteotomy for OSCC.
Article
Oncology
Cheng-Wan Xia, Shi-Qi Hu, Qun-Zhi Zhou, Rong-Lin Gan, Jiong-Ru Pan, Qian Zhang, Yu-Mei Pu, Shen Chen, Qin-Gang Hu, Yu-Xin Wang
Summary: The study utilized Lugol's iodine-enhanced micro-CT imaging to explore the feasibility of locating metastatic lesions in lymph nodes, identifying new imaging parameters to potentially reduce the false-negative rate in pathological examinations.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Qian Zhang, Yuxin Wang, Chengwan Xia, Liang Ding, Yumei Pu, Xiaobei Hu, Huiming Cai, Qingang Hu
Summary: In this study, the heterogeneity of cancer-associated fibroblasts (CAFs) in head and neck squamous cell carcinoma (HNSCC) was investigated. Eight CAFs subclusters were identified, with three of them showing prognostic relevance. These three CAFs subclusters displayed distinct phenotypes enriched in myofibroblast function, extracellular matrix (ECM) remodeling, and antigen-presenting function, respectively.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Review
Medicine, General & Internal
Yongfeng Chen, Qi Xiao, Weina Zou, Chengwan Xia, Hongling Yin, Yumei Pu, Yuxin Wang, Kai Zhang
Summary: This study concluded that ICG applied to SLNB can effectively predict the status of regional lymph nodes in patients with oral cavity cancer, with high sensitivity and diagnostic odds ratio.
Article
Materials Science, Biomaterials
Shiqi Hu, Bin Huang, Yumei Pu, Chengwan Xia, Qian Zhang, Sulong Guo, Yuxin Wang, Xiaofeng Huang
Summary: A new TADF nanomaterial with satisfactory photostability was synthesized and shown to target lysosomes in oral cancer cells, inhibiting xenograft tumor growth in mouse models using PDT. Low radiation intensity during treatment caused minimal damage to normal tissues, opening new possibilities for developing PDT drugs for biomedical applications in the future.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Medical Laboratory Technology
Hongling Yin, Qian Zhang, Qunzhi Zhou, Chengwan Xia, Yumei Pu, Yuxin Wang
Summary: Liquid exosomal miRNAs have potential as biomarkers for cancer diagnosis, especially when based on multiple miRNAs.
CLINICAL LABORATORY
(2021)
Article
Oncology
Qian Zhang, Yongfeng Chen, Shi-Qi Hu, Yu-Mei Pu, Kai Zhang, Yu-Xin Wang
ANNALS OF TRANSLATIONAL MEDICINE
(2020)
Article
Chemistry, Multidisciplinary
Chengwan Xia, Jiongru Pan, Jianquan Wang, Yumei Pu, Qian Zhang, Shiqi Hu, Qingang Hu, Yuxin Wang
Article
Chemistry, Multidisciplinary
Qian Zhang, Qi Xiao, Honglin Yin, Chengwan Xia, Yumei Pu, Zhifeng He, Qingang Hu, Jianquan Wang, Yuxin Wang
Article
Materials Science, Biomaterials
Lei Fan, Jianquan Wang, Chengwan Xia, Qian Zhang, Yumei Pu, Liang Chen, Jianfang Chen, Yuxin Wang
JOURNAL OF MATERIALS CHEMISTRY B
(2020)
Article
Materials Science, Biomaterials
Yuxin Wang, Diya Xie, Jiongru Pan, Chengwan Xia, Lei Fan, Yumei Pu, Qian Zhang, Yan Hong Ni, Jianquan Wang, Qingang Hu
BIOMATERIALS SCIENCE
(2019)