Article
Immunology
Grace A. Snyder, Shir Eliachar, Michael T. Connelly, Shani Talice, Uzi Hadad, Orly Gershoni-Yahalom, William E. Browne, Caroline V. Palmer, Benyamin Rosental, Nikki Traylor-Knowles
Summary: This study identified and characterized phagocytes from coral and sea anemones, demonstrating their role in engulfing bacteria, fungi, beads, as well as self and damaged cells. The findings also showed that phagocytic cells target antigens localize to low pH phagolysosomes, and the inhibition of actin filament rearrangement interferes with efficient particle phagocytosis. Additionally, cellular markers for lysolitic vesicles and reactive oxygen species were found to correlate with hexacorallian phagocytes, laying a foundation for better understanding of their immune cell biology.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Edna Ayerim Mandujano-Tinoco, Eliya Sultan, Aner Ottolenghi, Orly Gershoni-Yahalom, Benyamin Rosental
Summary: The evolution of the immune system is aimed at protecting organisms from infections and providing regenerative capacities and tissue maintenance. Despite the diverse range of effector cells, common features and interesting convergent mechanisms can be observed across different animals. The review explores the evolution of phagocytic and cytotoxic immune lineages, highlighting the diverse function plasticity within evolved immune effector cells.
Article
Multidisciplinary Sciences
Nehal A. Younis, Hasnaa Thabit, Salma I. El-Samannoudy, Marwa M. Attia
Summary: This study evaluated the immunological status of Oreochromis niloticus (O. niloticus) by examining the presence of encysted metacercariae and assessing immune responses and biochemical markers in infected fish. The prevalence of encysted metacercariae from the family Cyathocotylidae (Prohemistomum vivax) was 25%. Infected organs showed elevated expression of immune-related genes, and infected fish exhibited higher levels of liver enzymes (AST, ALT), blood glucose, cortisol, and lysozyme activity compared to non-infected fish.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Lise Vanderkelen, Joris M. Van Herreweghe, Chris W. Michiels
Summary: This study developed a novel tool for detecting and differentiating lysozymes in animal fluids using affinity chromatography with inhibitors. Validation on blue mussels revealed the important role of g-type lysozyme in innate immunity, while the i-type lysozyme showed no contribution.
Article
Fisheries
Roohi Fatima, P. S. Nilofer, K. Karthikeyan, R. Vidya, Toshiaki Itami, R. Sudhakaran
Summary: The study examines the potential of Portieria hornemannii extract in enhancing disease resistance and immune response in Tilapia. The results indicate that feeding Tilapia with PH extract can improve their survival rate after infection and have significant effects on immune related genes and immune parameters.
Article
Nutrition & Dietetics
Naichaya Chamroonkul, Natthapat Rujeerapaiboon, Pimsiri Sripongpun, Apichat Kaewdech, Teerha Piratvisuth
Summary: This study aimed to determine the effect of branched-chain amino acid (BCAA) granules on phagocytic activity in patients with cirrhosis-associated immune dysfunction (CAID). The results showed that BCAA granules significantly improved the phagocytic activity in patients, but a longer follow-up period is needed to demonstrate the effect on infection prevention.
FRONTIERS IN NUTRITION
(2023)
Article
Genetics & Heredity
Naomi L. P. Keehnen, Lisa Fors, Peter Jarver, Anna-Lena Spetz, Soren Nylin, Ulrich Theopold, Christopher W. Wheat
Summary: Insects rely on their innate immune system to interact with their microbiota, with populations of butterflies found to differ in phagocytic capability and genetic variation related to phagocytosis. Enrichment analysis identified genes involved in glutamine metabolism as potentially underlying these phenotypic differences.
Article
Environmental Sciences
G. N. Nirmala, Akshata Sharma, Venkataraghavan Ragunathan
Summary: This study investigated the aquatic toxicity of DCM on Oreochromis mossambicus and explored ways to improve the fish's immune system to combat DCM-induced oxidative stress and neurotoxic effects. Results suggested that DCM has the potential to induce oxidative stress and neurotoxicity in fish, while phytochemicals from Aloe vera can enhance the immune system to counteract the neurotoxic effects of DCM.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2022)
Article
Food Science & Technology
Jiamei Wang, Tengfei Fu, Xiaohan Sang, Yafu Liu
Summary: This study aimed to investigate the effects of high voltage atmospheric cold plasma (HVACP) treatment on the microbial amount and diversity of fresh tilapia fillets during refrigerator storage. The results showed that long treatment time effectively reduced the amount of all bacteria, and the treated fillets had significantly lower microbial amounts compared to the control group during storage. Furthermore, microbial species and abundance varied with storage time.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Fisheries
Mayumi Fernanda Aracati, Susana Luporini de Oliveira, Leticia Franchin Rodrigues, Camila Carlino da Costa, Alessandra Cristina de Moraes, Ed Johnny da Rosa Prado, Dayanne Carla Fernandes, Thais Heloisa Vaz Farias, Silas Fernandes Eto, Ives Charlie-Silva, Marco Antonio de Andrade Belo
Summary: This study evaluated the anti-inflammatory effect of zafirlukast, an antagonist of cysteinyl leukotriene receptors, in Oreochromis niloticus during acute inflammatory reaction induced by Aeromonas hydrophila bacterins. The results showed that zafirlukast treatment dose-dependently reduced the accumulation of inflammatory cells, particularly granulocytes and macrophages. Zafirlukast-treated fish also exhibited decreased blood leukocyte counts and reactive oxygen species production.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biology
Sevdan Yilmaz, Sebahattin Ergun, Ekrem Sanver Celik, Mohamed Banni, Ehsan Ahmadifar, Mahmoud A. O. Dawood
Summary: This study evaluated the response of Oreochromissp. to cold stress through two experiments. Different species of fish showed species-specific physiological and anti-stressor responses at optimal temperatures and cold water conditions.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Samar S. Negm, Nahla E. M. Ismael, Amany I. Ahmed, Amel M. El Asely, Mohammed A. E. Naiel
Summary: The study investigated the effects of brown seaweeds on Tilapia under high stocking rate conditions. Results showed that supplementing diets with Sargassum improved fish growth and feed efficiency, while mitigating the negative impacts of high stocking density.
JOURNAL OF APPLIED PHYCOLOGY
(2021)
Article
Immunology
Nguyen Bao Trung, Tan-Phat Nguyen, Hao-Yun Hsueh, Jiun-Yan Loh, Eakapol Wangkahart, Alice Sui Fung Wong, Po-Tsang Lee
Summary: Nile tilapia is one of the most important food fish globally, but the farming industry has faced challenges from pathogen infections. In this study, researchers discovered that OnSARM1 serves as a negative regulator by inhibiting NF-kappa B activity, impacting the transcript levels of proinflammatory cytokines and antimicrobial peptides.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Tan Phat Nguyen, Bao Trung Nguyen, Fan-Hua Nan, Meng-Chou Lee, Po-Tsang Lee
Summary: Nile tilapia (Oreochromis niloticus) is an important food fish species mainly cultivated in tropical and subtropical countries. This study focuses on Toll-like receptors (TLRs) and the clonation of OnTLR23 in fish cells. The study also explores the interaction of OnTLR23 with other molecules and its potential role in immune responses.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Nguyen Vu Linh, Le Thanh Dien, Wattana Panphut, Anat Thapinta, Saengchan Senapin, Sophie St-Hilaire, Channarong Rodkhum, Ha Thanh Dong
Summary: The study showed that ozone nanobubble (NB-O3) can activate the innate immunity genes of Nile tilapia, improving their resistance to bacterial infections and increasing survival rates.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Venkatachalam Angamuthu, M. Shanmugavadivu, G. Nagarajan, Bharath Kumar Velmurugan
CHEMICO-BIOLOGICAL INTERACTIONS
(2019)
Review
Cell Biology
Bharath Kumar Velmurugan, Lohanathan Bharathi Priya, Paramasivan Poornima, Li-Jen Lee, Rathinasamy Baskaran
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
C. -Y. Huang, B. K. Velmurugan, M. -C. Chen, C. H. Day, W. -S. Chien, V. V. Padma, H. -C. Wu, T. -H. Lin, H. -H. Hsu, C. -H. Shen
BIOTECHNIC & HISTOCHEMISTRY
(2019)
Article
Oncology
Bharath Kumar Velmurugan, Hsin-Kai Wang, Chia-Min Chung, Chien-Hsun Lee, Lan-Ru Huang, Kun-Tu Yeh, Shu-Hui Lin
CANCER MANAGEMENT AND RESEARCH
(2019)
Review
Biochemistry & Molecular Biology
Nagarajan Ganesan, Rathinasamy Baskaran, Bharath Kumar Velmurugan, Nguyen Chi Thanh
JOURNAL OF FOOD BIOCHEMISTRY
(2019)
Article
Biotechnology & Applied Microbiology
Bharath Kumar Velmurugan, Chun-Hung Hua, Ming-Hsui Tsai, Chi-Pin Lee, Chia-Min Chung, Ying-Chin Ko
BIOTECHNIC & HISTOCHEMISTRY
(2020)
Review
Food Science & Technology
Dinh-Chuong Pham, M. A. Shibu, B. Mahalakshmi, Bharath Kumar Velmurugan
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2020)
Review
Oncology
B. Mahalakshmi, Rathinasamy Baskaran, M. Shanmugavadivu, Ngoc Tuan Nguyen, Bharath Kumar Velmurugan
Review
Biochemistry & Molecular Biology
Marthandam Asokan Shibu, Mahalakshmi Bharath, Bharath Kumar Velmurugan
Summary: This review highlights the critical role of ferroptosis in various diseases and its specific mechanisms in Parkinson's disease, emphasizing the role of neuroinflammation. Personalized treatment strategies for PD pathology and relevant clinical trials are also discussed in the article.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
V. Bharath Kumar, Jen-Tsun Lin, B. Mahalakshmi, Yi-Ching Chuang, Hsin-Yu Ho, Chia-Chieh Lin, Yu-Sheng Lo, Ming-Ju Hsieh, Mu-Kuan Chen
Summary: The study demonstrates that platyphyllenone significantly inhibits the motility, migration, and invasion of oral cancer cells by modulating specific proteins and signaling pathways, indicating its potential as an anti-metastatic agent in oral cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Rudolf Kiefer, Daniel Georg Weis, Bharath Kumar Velmurugan, Tarmo Tamm, Gerald Urban
Summary: In this study, the ion transport and effects of high synthesis potential on conductive polymer actuators are investigated, revealing the impact of synthesis potential on the activity and structure of the actuator. EQCM analysis allows for the determination of appropriate potential windows for increased control over devices.
Article
Polymer Science
Rudolf Kiefer, Quoc Bao Le, Bharath Kumar Velmurugan, Toribio F. Otero
Summary: The research investigates the electrochemical and mechanical properties of films formed by polypyrrole (PPy) with different additives under various potential ranges, showing that PPy-PEO/DBS films exhibit a higher strain range and stability, making them suitable for applications in artificial muscles.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Ming-Ju Hsieh, Chih-Yang Huang, Rudolf Kiefer, Shin-Da Lee, Nancy Maurya, Bharath Kumar Velmurugan
Summary: Lycopene, a powerful antioxidant found in foods like tomatoes, plays a significant role in maintaining cardiac health by reducing the progression of cardiovascular disease and thrombotic complications. This review explores the potential cardio-protective effects of lycopene, including in vitro, in vivo, and clinical trials, as well as its bioavailability and pharmacokinetics. However, the protective role of lycopene against cardiovascular disease and its toxicity remain controversial.
Article
Cell & Tissue Engineering
Yu-Hsun Chang, V. Bharath Kumar, Yao-Tseng Wen, Chih-Yang Huang, Rong-Kung Tsai, Dah-Ching Ding
Summary: This study demonstrates the successful differentiation of human umbilical cord mesenchymal stem cells (HUCMSCs) into retinal pigment epithelial (RPE)-like cells using a co-culture system. The induced cells showed the characteristic markers and functions of RPE cells, including engulfing photoreceptor outer segments and secreting neurotrophic factors. These findings provide fundamental information for the clinical-scale generation of RPE-like cells from HUCMSCs.
CELL TRANSPLANTATION
(2022)