Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 120, Issue 8, Pages 13085-13094Publisher
WILEY
DOI: 10.1002/jcb.28580
Keywords
GSK3 beta; osteoblast; platycodin D; sirtuin 1 (SIRT1); beta-catenin
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Funding
- National Research Foundation of Korea (NRF)
- Korea government (MSIP) [2015M3A9B6053068, NRF-2017R1A2B4008966, 2018R1D1A1B07040449, NRF-2017R1A4A1015860]
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Previous studies have suggested that platycodin D is implicated in bone biology and ameliorates osteoporosis development. Platycodin D repressed the osteoclast activity and enhanced bone mineral density in the mouse model. However, the effects of platycodin D on osteoblast differentiation have not been elucidated yet. In C3H10T1/2 cells, platycodin D upregulated osteogenic markers including alkaline phosphatase (ALP), bone sialoprotein, and collagen type 1 alpha 1, and transcription factors, such as Runx2 and osterix, subsequently enhancing the bone mineralization. In a molecular mechanism study, platycodin D induced beta-catenin nuclear accumulation by upregulating GSK3 beta phosphorylation. Furthermore, platycodin D upregulated the ALP activity and enhanced the mineralization process in osteoblast cells via the sirtuin 1/beta-catenin pathways. Taken together, these results suggested that platycodin D could be an effective therapeutic compound against osteoporosis because of its regulatory effects during the osteoblast differentiation.
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