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Medicine, Research & Experimental
Qiuer Liang, Tianhao Liu, Tingting Guo, Wencong Tao, Xudong Chen, Weihao Chen, Liguo Chen, Ya Xiao
Summary: The study showed that inhibiting ATF4 can improve renal damage and fibrosis in DN mice, as well as restore autophagy. In cell experiments, inhibition of ATF4 can increase autophagosome numbers, improve autophagic flux, and decrease Collagen type 4 (Col-IV) levels.
Article
Medicine, Research & Experimental
Aili Cao, Jianhua Li, Morad Asadi, John M. Basgen, Bingbing Zhu, Zhengzi Yi, Song Jiang, Tomohito Doke, Osama El Shamy, Niralee Patel, Paolo Cravedi, Evren U. Azeloglu, Kirk N. Campbell, Madhav Menon, Steve Coca, Weijia Zhang, Hao Wang, Ke Zen, Zhihong Liu, Barbara Murphy, John C. He, Vivette D. D'Agati, Katalin Susztak, Lewis Kaufman
Summary: DACH1 is a key gene in DKD that, when underexpressed, increases podocyte vulnerability to injury.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Dana Saad, Cristina Paissoni, Antonio Chaves-Sanjuan, Marco Nardini, Roberto Mantovani, Nerina Gnesutta, Carlo Camilloni
Summary: E2F1 as a master regulator of cell-cycle progression binds DNA as a heterodimer with DP partners, with an asymmetric contribution of dynamics in the complex. Tumor mutations in the flexible regions of the complex could affect protein function context-dependently, suggesting fundamental contributions of DP proteins in distinct aspects of E2F biology.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Xuhui Fan, Meng Liu, Li Fei, Zhihui Huang, Yufeng Yan
Summary: This study investigates the role of circFOXM1 in the progression of glioblastoma (GBM). Results show that circFOXM1 is highly expressed in GBM tissues and cells, and its silencing inhibits GBM cell proliferation, migration, invasion, and glutaminolysis. CircFOXM1 acts as a sponge of miR-577 to enhance GBM progression by targeting E2F5, suggesting it as a potential biomarker for GBM treatment.
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2022)
Article
Medicine, Research & Experimental
Baolin Wang, Hang Yin, Hongmei Zhang, Tiantian Wang
Summary: The study demonstrates that circNRIP1 contributes to keloid progression by aiding in pre-miR-503 maturation through stabilizing FXR1 and impeding its degradation. High expression of circNRIP1 in keloid tissue and fibroblasts suggests its potential as a therapeutic target for keloid treatment.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Immunology
Jianqiang Wang, Yuanshan Han, Fang Huang, Liuhuan Tang, Jianfei Mu, Ying Liang
Summary: Diabetic foot ulcer is a serious complication of diabetes, and M1 macrophage-derived sEVs miR-503 targeting IGF1R in HUVECs inhibits IGF1R expression, leading to HUVEC dysfunction and impeding wound healing in diabetic patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jeeyoun Jung, Woo Yeong Park, Yun Jin Kim, Mikyung Kim, Misun Choe, Kyubok Jin, Ji Hae Seo, Eunyoung Ha
Summary: This study demonstrates that 3-OHB delays the progression of diabetic nephropathy (DN) by enhancing autophagy and inhibiting oxidative stress, as observed in both in vivo and in vitro models.
Article
Oncology
Jianning Yao, Chunfeng Wang, Xuyang Dong, Yanzhen Zhang, Yanle Li, Haining Zhou, Lianfeng Zhang
Summary: The high expression of SNHG22 is associated with advanced clinicopathological factors and worse survival in CRC patients. Knockdown of SNHG22 inhibits CRC cell proliferation, apoptosis resistance, migration, and invasion in vitro, and hinders tumor growth in vivo. SNHG22 binds to miR-128-3p to attenuate its inhibitory effects on E2F3 expression levels and activity.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Maria Paula Zappia, Yong-Jae Kwon, Anton Westacott, Isabel Liseth, Hyun Min Lee, Abul B. M. M. K. Islam, Jiyeon Kim, Maxim V. Frolov
Summary: The transcription factor E2F is responsible for controlling the expression of cell cycle genes by binding to their promoters. However, its significance in the regulation of metabolic genes is not well understood. In this study, the researchers introduced mutations in the E2F sites of five metabolic genes in fruit flies and found varying effects on E2F recruitment and gene expression, with the glycolytic gene Pgk being the most affected. Loss of E2F regulation on the Pgk gene led to decreased glycolytic flux, ATP content, and abnormal mitochondrial morphology. The study highlights the importance of E2F regulation on metabolic genes and its impact on overall development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cell Biology
Fengxun Liu, Jia Guo, Yingjin Qiao, Shaokang Pan, Jiayu Duan, Dongwei Liu, Zhangsuo Liu
Summary: This study found that miR-138 plays a crucial role in the regulation of DN, and the miR-138-SIRT1-p38-TTP pathway may be a key factor in the development of DN.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Genetics & Heredity
Qianqian Wang, Zheng Cang, Lisha Shen, Wenfang Peng, Liuqing Xi, Xiaohong Jiang, Xiaoxu Ge, Bojin Xu, Shan Huang
Summary: The study revealed the crucial role of circ_0037128 in regulating diabetic nephropathy development through interaction with miR-17-3p, which in turn affects cell proliferation and fibrosis. AKT3 was identified as the target of miR-17-3p and showed elevated expression in the DN model.
Article
Physiology
Wenmin Dong, Huiqian Zhang, Cheng Zhao, Yun Luo, Ying Chen
Summary: The study revealed that silencing miR-150-5p played a protective role in the kidneys of DN mice by targeting SIRT1, leading to activation of AMPK-dependent autophagy.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Jing Song, Ziping Zhang
Summary: This study found that the expression of SNHG20 was significantly increased in RB tissues and cell lines, and it promotes cell proliferation, migration, and invasion through the miR-335-5p/E2F3 signaling axis.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Yiran Liang, Hong Liu, Jiaming Zhu, Nana Song, Zhihui Lu, Yi Fang, Jie Teng, Yan Dai, Xiaoqiang Ding
Summary: The study demonstrates that miR-34a activates the p53 signaling pathway to directly inhibit SIRT1, forming a positive feedback loop that contributes to podocyte injury in diabetic nephropathy. This plays a critical role in the pathogenesis of diabetic kidney disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Shuang Liu, Xi Chen, Siqing Zhang, Xinyu Wang, Xiaoliu Du, Jiahe Chen, Guoping Zhou
Summary: This study revealed that miR-106b-5p plays a role in regulating pulmonary fibrosis and epithelial-mesenchymal transition in asthma by targeting SIX1 through E2F1, suggesting a potential therapeutic target for asthma treatment.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Ting-Ting Ji, Ya-Kun Wang, Ying-Chun Zhu, Cong-Pu Gao, Xiao-Ying Li, Ji Li, Feng Bai, Shou-Jun Bai
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Cell Biology
Xiaowei Wang, Yong Xu, Ying-Chun Zhu, Ya-Kun Wang, Ji Li, Xiao-Ying Li, Tingting Ji, Shou-Jun Bai
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Cell Biology
Ji Li, Qian Li, Ying-Chun Zhu, Ya-Kun Wang, Cong-Pu Gao, Xiao-Ying Li, Tingting Ji, Shou-Jun Bai
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Cell Biology
Fangfang Zha, Xiaolu Qu, Bo Tang, Ji Li, Yakun Wang, PengXi Zheng, Tingting Ji, Chun Zhu, Shoujun Bai
Article
Endocrinology & Metabolism
Yingchun Zhu, Jiang Xu, Wenxing Liang, Ji Li, Linhong Feng, PengXi Zheng, Tingting Ji, Shoujun Bai
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2019)
Article
Cell Biology
Bo Tang, Weiliang Li, Tingting Ji, Xiaoying Li, Xiaolei Qu, Linhong Feng, Yingchun Zhu, Yinghui Qi, Chun Zhu, Shoujun Bai
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Cell Biology
Bo Tang, Weiliang Li, Ting-Ting Ji, Xiao-Ying Li, Xiaolei Qu, Linhong Feng, Shoujun Bai
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Genetics & Heredity
Yakun Wang, Yinghui Qi, Tingting Ji, Bo Tang, Xiaoying Li, Pengxi Zheng, Shoujun Bai
Summary: In diabetic nephropathy, the expression level of circ_LARP4 is lower than in normal cells. Overexpression of circ_LARP4 can inhibit cell proliferation and fibrosis, but increase cell apoptosis, possibly through its sponge action on miR-424.