Matrine attenuates high‐fat diet‐induced in vivo and ox‐LDL‐induced in vitro vascular injury by regulating the PKCα/eNOS and PI3K/Akt/eNOS pathways

Klotho ameliorates oxidized low density lipoprotein (ox-LDL)-induced oxidative stress via regulating LOX-1 and PI3K/Akt/eNOS pathways

(2017) Yansheng Yao et al.   Lipids in Health and Disease

eNOS S-nitrosylates β-actin on Cys374 and regulates PKC-θ at the immune synapse by impairing actin binding to profilin-1

(2017) Almudena García-Ortiz et al.   PLOS BIOLOGY

The role of dietary fat in obesity-induced insulin resistance

(2016) Denise E. Lackey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

SIRT1/Atg5/autophagy are involved in the antiatherosclerosis effects of ursolic acid

(2016) Qixiao Jiang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Impact of Rosuvastatin Treatment on HDL-Induced PKC-βII and eNOS Phosphorylation in Endothelial Cells and Its Relation to Flow-Mediated Dilatation in Patients with Chronic Heart Failure

(2016) Ephraim B. Winzer et al.   Cardiology Research and Practice

Matrine pretreatment improves cardiac function in rats with diabetic cardiomyopathy via suppressing ROS/TLR-4 signaling pathway

(2015) Zhong-wei Liu et al.   ACTA PHARMACOLOGICA SINICA

Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway

(2015) Sha-Sha Xing et al.   VASCULAR PHARMACOLOGY

Dectin-1 Regulates Hepatic Fibrosis and Hepatocarcinogenesis by Suppressing TLR4 Signaling Pathways

(2015) Lena Seifert et al.   Cell Reports

Paeonol protects rat vascular endothelial cells from ox-LDL-induced injury in vitro via downregulating microRNA-21 expression and TNF-α release

(2014) Ya-rong Liu et al.   ACTA PHARMACOLOGICA SINICA

Traditional Chinese Medicine: A Treasured Natural Resource of Anticancer Drug Research and Development

(2014) Chao-Yun Wang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Osteocalcin attenuates high fat diet-induced impairment of endothelium-dependent relaxation through Akt/eNOS-dependent pathway

(2014) Jianxin Dou et al.   Cardiovascular Diabetology

Optimized Protein Kinase Cθ (PKCθ) Inhibitors Reveal Only Modest Anti-inflammatory Efficacy in a Rodent Model of Arthritis

(2014) Dawn M. George et al.   JOURNAL OF MEDICINAL CHEMISTRY

Matrine improved the function of heart failure in rats via inhibiting apoptosis and blocking β3-adrenoreceptor/endothelial nitric oxide synthase pathway

(2014) JIANGBO YU et al.   Molecular Medicine Reports

The Epidemiology of Obesity: A Big Picture

(2014) Adela Hruby et al.   PHARMACOECONOMICS

PKC-Dependent Phosphorylation of eNOS at T495 Regulates eNOS Coupling and Endothelial Barrier Function in Response to G+ -Toxins

(2014) Feng Chen et al.   PLoS One

Association of All-Cause Mortality With Overweight and Obesity Using Standard Body Mass Index Categories

(2013) Katherine M. Flegal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Klotho Regulates Retinal Pigment Epithelial Functions and Protects Against Oxidative Stress

(2013) M. Kokkinaki et al.   JOURNAL OF NEUROSCIENCE

Overview of Epidemiology and Contribution of Obesity to Cardiovascular Disease

(2013) Marjorie Bastien et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Immunological changes of chronic oral exposure to depleted uranium in mice

(2013) Yuhui Hao et al.   TOXICOLOGY

Puerarin attenuates endothelial insulin resistance through inhibition of inflammatory response in an IKKβ/IRS-1-dependent manner

(2012) Fang Huang et al.   BIOCHIMIE

Regulation of endothelial nitric oxide synthase and asymmetric dimethylarginine by matrine attenuates isoproterenol-induced acute myocardial injury in rats

(2012) Xiaobing Li et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Kakkalide ameliorates endothelial insulin resistance by suppressing reactive oxygen species-associated inflammation (葛花苷通过抑制活性氧相关的炎症改善内皮细胞胰岛素抵抗)

(2012) Dongyan Zhang et al.   Journal of Diabetes

Glucagon-like peptide-1 activates endothelial nitric oxide synthase in human umbilical vein endothelial cells

(2011) Li Ding et al.   ACTA PHARMACOLOGICA SINICA

Alterações vasculares em ratos obesos por dieta rica em gordura: papel da Via L-arginina/NO Endotelial

(2011) Thiago Bruder Nascimento et al.   Arquivos Brasileiros de Cardiologia

Endothelial dysfunction in cardiovascular and endocrine-metabolic diseases: an update

(2011) A.P. Davel et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Pyridoxine inhibits endothelial NOS uncoupling induced by oxidized low-density lipoprotein via the PKCα signalling pathway in human umbilical vein endothelial cells

(2011) Liping Xie et al.   BRITISH JOURNAL OF PHARMACOLOGY

High fat diet induces central obesity, insulin resistance and microvascular dysfunction in hamsters

(2011) Rute R.S. Costa et al.   MICROVASCULAR RESEARCH

Regulation of arginine transport and metabolism by Protein Kinase Cα in endothelial cells: stimulation of CAT2 transporters and arginase activity

(2010) Rossana Visigalli et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Advanced glycation end products increase endothelial permeability through the RAGE/Rho signaling pathway

(2009) Akiko Hirose et al.   FEBS LETTERS

Impact of matrine on inflammation related factors in rat intestinal microvascular endothelial cells

(2009) Zhanwei Suo et al.   JOURNAL OF ETHNOPHARMACOLOGY

Obesity and Cardiovascular Disease

(2009) Carl J. Lavie et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY