Article
Materials Science, Multidisciplinary
Deyu Yang, Zhou Fang, Rui Kang, Kehai Liu
Summary: A new composite electrospun scaffold for pelvic organ prolapse showed promising potential in physicochemical characterizations and cell tests, indicating good biocompatibility and potential for pelvic floor regeneration.
MATERIALS & DESIGN
(2021)
Article
Obstetrics & Gynecology
Lauren Caldwell, Gabriela E. Halder, Gena Dunivan, Amanda B. White, Uchenna Ossai, Rebecca G. Rogers
Summary: This study describes the timing, quality, and patient concerns regarding the first sexual encounter after surgery for pelvic organ prolapse or urinary incontinence. Most women resumed intercourse 2-4 months post-surgery, with partners' desires, fears, and physician counseling strongly influencing the timing of the first sexual encounter. Reports of initial sexual activity after surgery are often positive, with improved self-image and sexual confidence.
OBSTETRICS AND GYNECOLOGY
(2021)
Article
Engineering, Biomedical
Sofie Husted Laursen, Signe Gellert Hansen, Mehmet Berat Taskin, Menglin Chen, Lise Wogensen, Jens Vinge Nygaard, Susanne Maigaard Axelsen
Summary: This study provides new insights into future pelvic organ prolapse (POP) repair in postmenopausal women by demonstrating the sufficient support and biocompatibility of electrospun polycaprolactone (PCL) meshes coated with stem cells and growth factor in elderly rats in the long term, thus highlighting its potential clinical significance.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Engineering, Biomedical
Beverly Miller, Wiley Wolfe, James L. Gentry, M. Gregory Grewal, Christopher B. Highley, Raffaella De Vita, Monique H. Vaughan, Steven R. Caliari
Summary: This study describes the first hydrogel biomaterial augmentation of uterosacral ligament suspension (USLS) in a rat model, using an injectable fibrous hydrogel composite. The hydrogel degrades over time and significantly improves the load required for tissue failure, potentially reducing the high failure rate associated with USLS procedures.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Urology & Nephrology
Roxanna E. Abhari, Matthew L. Izett-Kay, Hayley L. Morris, Rufus Cartwright, Sarah J. B. Snelling
Summary: Complications following transvaginal implantation of polypropylene mesh in pelvic floor reconstructive surgery are linked to the host immune response, the biomaterial properties of the mesh, patient-specific and surgical risk factors, as well as shortcomings in mesh development. These factors contribute to pain and other complications experienced by patients after transvaginal mesh placement.
NATURE REVIEWS UROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Amelia Seifalian, Zeinab Basma, Alex Digesu, Vikram Khullar
Summary: This study critically evaluates the use of polypropylene (PP) pelvic mesh in the treatment of pelvic organ prolapse (POP), and proposes the use of advanced materials as an alternative to PP mesh. Results show that the physical properties of PP mesh, including its viscoelastic properties and lack of tissue integration, contribute to complications. The banning of PP mesh in multiple countries highlights the need for the development of alternative pelvic mesh materials.
Article
Medicine, General & Internal
Aleksandra Kaminska, Katarzyna Skorupska, Agnieszka Kubik-Komar, Konrad Futyma, Joanna Filipczak, Tomasz Rechberger
Summary: This study compared the effects of VNTR and TVM surgeries on quality of sexual life after pelvic organ prolapse treatment, showing significant improvements in both groups. However, there were no significant differences in the assessment of quality of sexual life between the analyzed groups of patients, indicating that both surgical methods are effective in improving quality of life in sexually active patients with symptomatic POP.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Guorui Zhang, Yuxin Dai, Jinghe Lang
Summary: This study explored the possibility and strategy of mesenchymal stem cells (MSCs) in treating pelvic floor dysfunction nerve injury by transplanting MSCs into a rat model. The results showed that MSC transplantation improved nerve content, with even better effects when MSCs were loaded on a gelatin scaffold. This research provides an improved strategy for regenerative medicine in pelvic floor disorders in the future.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Materials Science, Biomaterials
Zahrina Mardina, Jeffrey Venezuela, Christopher Maher, Zhiming Shi, Matthew S. Dargusch, Andrej Atrens
Summary: Pelvic organ prolapse occurs when the weakening of pelvic floor muscles and tissue leads to the herniation of surrounding organs into the vagina and/or rectum. Permanent meshes, while effective, have high complication rates and are banned in many countries. There is a need for a new material that can provide tissue support without complications.
BIOMATERIALS SCIENCE
(2022)
Article
Surgery
Tommaso Simoncini, Andrea Panattoni, Mustafa Aktas, Jozef Ampe, Cornelia Betschart, Alexander L. A. Bloemendaal, Stephan Buse, Giuseppe Campagna, Marta Caretto, Mauro Cervigni, Esther C. J. Consten, Hugo H. Davila, Jean Dubuisson, Eloy Espin-Basany, Bernardina Fabiani, Jean-Luc Faucheron, Andrea Giannini, Brooke Gurland, Dieter Hahnloser, Ralf Joukhadar, Paolo Mannella, Liliana Mereu, Jacopo Martellucci, Guillaume Meurette, Maria Magdalena Montt Guevara, Carlo Ratto, Barry A. O'Reilly, Christl Reisenauer, Eleonora Russo, Steven Schraffordt Koops, Shahab Siddiqi, Alessandro Sturiale, Gabriele Naldini
Summary: This study aimed to address the role of robotic pelvic floor reconstructive procedures through expert opinion. The results showed that robotic surgery has significant technical advantages over standard laparoscopy and is particularly important for complex reconstructive procedures, although benefits can be found in less challenging cases as well. However, more research is needed to objectively assess the specific settings where robotic surgery would provide the most benefit.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Biotechnology & Applied Microbiology
Quan Zhou, Man Lu, Guo-Sheng Li, Gan-Lu Peng, Yan-Feng Song
Summary: In recent decades, there has been extensive attention on the application of mesh for repairing pelvic floor defects. However, a large body of related literature has not been systematically summarized. This study aimed to summarize and visualize the literature on pelvic organ prolapse repair with mesh using bibliometrics. The findings showed that the reasonable application of mesh and avoiding mesh complications are still the most concerned topics in pelvic organ prolapse research.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Medicine, General & Internal
Zhi-Jing Sun, Xiu-Qi Wang, Jing-He Lang, Tao Xu, Yong-Xian Lu, Ke-Qin Hua, Jin-Song Han, Huai-Fang Li, Xiao-Wen Tong, Ping Wang, Jian-Liu Wang, Xin Yang, Xiang-Hua Huang, Pei-Shu Liu, Yan-Feng Song, Hang-Mei Jin, Jing-Yan Xie, Lu-Wen Wang, Qing-Kai Wu, Jian Gong, Yan Wang, Li-Qun Wang, Zhao-Ai Li, Hui-Cheng Xu, Zhi-Jun Xia, Li-Na Gu, Qing Liu, Lan Zhu
Summary: This study outlined the development of Chinese pelvic floor surgeries related to pelvic organ prolapse over the past 14 years and found that the rate of synthetic mesh procedures increased while that of non-mesh procedures decreased significantly. The rate of transvaginal placement of surgical mesh procedures decreased while the rate of laparoscopic sacrocolpopexy procedures increased significantly.
CHINESE MEDICAL JOURNAL
(2021)
Review
Engineering, Biomedical
Deyu Yang, Min Zhang, Kehai Liu
Summary: Pelvic organ prolapse (POP) is a common chronic illness that greatly impacts women's quality of life. Tissue engineering has made significant progress in its treatment, with an emphasis on biological scaffolds. However, there are still challenges in pelvic floor reconstruction, such as the development of ideal scaffolds, selection of optimal seed cells, and growth factors that need to be addressed for further advancement in this field.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Obstetrics & Gynecology
Nemi M. Shah, Alexander A. Berger, Zimin Zhuang, Jasmine Tan-Kim, Shawn A. Menefee
Summary: This study aims to analyze the long-term risk of reoperation for recurrent prolapse among different apical suspension procedures. The results show that colpocleisis and sacrocolpopexy offer the most durable obliterative and reconstructive prolapse repairs, respectively. The all-cause reoperation rates are lowest after colpocleisis, but similar among reconstructive apical suspension procedures.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Review
Medicine, General & Internal
Renaud de Tayrac, Danielle D. Antosh, Kaven Baessler, Cecilia Cheon, Xavier Deffieux, Robert Gutman, Joseph Lee, Charles Nager, Alexis Schizas, Vivian Sung, Christopher Maher
Summary: This article provides a summary of the evidence-based surgical management pathway for pelvic organ prolapse in the 2021 ICI guidelines and outlines the evidence used to inform these recommendations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Yuting Wang, Yingchun Su, Yanping Zhang, Menglin Chen
Summary: Nanocomposite percolation networks are of increasing interest in the field of wearable devices. By adjusting the contact area, the overall resistance and strain sensor's gauge factor of the network can be controlled.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Materials Science, Biomaterials
Ana Sancho, Mehmet Berat Taskin, Laura Wistlich, Philipp Stahlhut, Katharina Wittmann, Angela Rossi, Jurgen Groll
Summary: The distribution and density of ligands play a crucial role in cell adhesion on planar substrates. Fibrous structures are the most natural environment for cells, leading to increased adhesion force per area even at lower ligand density. Cell behavior differs significantly between planar and topographical surfaces.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Isra H. Ali, Amgad Ouf, Fatma Elshishiny, Mehmet Berat Taskin, Jie Song, Mingdong Dong, Menglin Chen, Rania Siam, Wael Mamdouh
Summary: This study aimed to prepare electrospun chitosan/gelatin nanofiber scaffolds reinforced with different amounts of graphene nanosheets for antibacterial and wound-healing applications. The results showed that nanofibers reinforced with 0.15% graphene nanosheets had the smallest diameter and highest porosity, and exhibited significant inhibition effects against Escherichia coli and Staphylococcus aureus. Moreover, the graphene nanosheets greatly enhanced cell migration capacity.
Article
Chemistry, Multidisciplinary
Ali Doryab, Mehmet Berat Taskin, Philipp Stahlhut, Juergen Groll, Otmar Schmid
Summary: In this study, an organ- and disease-specific in vitro mini-lung fibrosis model with noninvasive real-time monitoring of cell mechanics was introduced as a functional readout for lung fibrosis. A biomimetic ultrathin basement membrane was developed to establish a multiculture model, and a millifluidic bioreactor system with dose-controlled aerosolized drug delivery was used. Real-time measurement of cell/tissue stiffness was shown as a clinical biomarker for fibrosis progression/attenuation upon drug treatment.
ADVANCED MATERIALS
(2022)
Article
Engineering, Biomedical
Sofie Husted Laursen, Signe Gellert Hansen, Mehmet Berat Taskin, Menglin Chen, Lise Wogensen, Jens Vinge Nygaard, Susanne Maigaard Axelsen
Summary: This study provides new insights into future pelvic organ prolapse (POP) repair in postmenopausal women by demonstrating the sufficient support and biocompatibility of electrospun polycaprolactone (PCL) meshes coated with stem cells and growth factor in elderly rats in the long term, thus highlighting its potential clinical significance.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
(2023)
Article
Engineering, Environmental
Yanping Zhang, Alice Le Friec, Di Sun, Menglin Chen
Summary: The development of flexible electronics with adjustable performance offers a promising approach for treating cardiac diseases, overcoming the limitations of conventional electronic systems due to biomechanical mismatches. By exploring the natural flow behavior of polymer melt in Melt electrowriting (MEW), researchers created a fibrous mesh electrode with a sinusoidal anisotropic structure resembling the collagen fiber architecture in the heart. This anisotropic, stretchable electrode mesh demonstrated the ability to synchronize cardiomyocyte beating through its biomimetic viscoelastic behavior and fine-tuned electrical properties, offering great potential for cardiac repair.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Youssif Merhi, Pablo F. Betancur, Teresa S. Ripolles, Charlotte Suetta, Morten R. Brage-Andersen, Sofie K. Hansen, Anders Frydenlund, Jens Vinge Nygaard, Peter H. Mikkelsen, Pablo P. Boix, Shweta Agarwala
Summary: Muscle atrophy is a common problem caused by immobilization and critical illness, leading to rehabilitation difficulties and increased mortality. This study presents a solution for preserving muscle mass through the use of a customized biocompatible neuromuscular electrical stimulation (NMES) device. The integration of dry and biocompatible electrodes into a compressive stocking textile was demonstrated, resulting in extended usage without skin irritation. Electrochemical analysis showed improved performance of the printed electrodes compared to commercial ones, and promising results were obtained in a hospital setting for muscle atrophy evaluation.
Article
Nanoscience & Nanotechnology
C. A. Mueller, P. Li, Y. Wang, M. Dong, B. Tian, M. Chen
Summary: Mounting evidence supports the central role of the nervous system in disease pathogenesis. Wireless electrical modulation of neural cells via opto-stimulation is an emerging approach to control neural behavior. This study successfully combines bionic fibers with nano-groove topography and opto-response to guide neurite outgrowth, providing a potential tool for studying nervous system/disease interaction.
MATERIALS TODAY NANO
(2023)
Article
Chemistry, Physical
Zhiqun Xie, Dionysios D. Dionysiou, Shuang Luo, Menglin Chen, Zongsu Wei
Summary: In order to enhance the utilization of peroxymonosulfate (PMS) and the stability of catalyst, a dual-reaction center catalyst Cu-Mg0.388Al2.408O4-BN was developed without expensive rare metals. The presence of Mg resulted in a positively charged surface, which facilitated the adsorption of bisphenol A (BPA) and PMS anions under neutral pH conditions. The formation of an electron-rich Cu center was achieved due to the relatively low electronegativity of Mg and the cation-pi interaction between Cu and boron nitride (BN). The combination of electrostatic attraction and dual-reaction center enabled the rapid degradation of BPA through electron transfer and subsequent activation of PMS.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2023)
Article
Chemistry, Applied
Farzaneh Nasrollahzadeh, Maria Julia Spotti, Kasper Skov, Tizazu Mekonen, Menglin Chen, Mario M. Martinez
Summary: The study investigates the impact of incorporating polar gelatin and non-polar zein on the mechanical properties of high moisture meat analogue prototypes. The addition of these proteins alters the elasticity and tenderness of the extrudates, with different effects observed for soy and mung bean prototypes. The concentration-dependent changes in protein structures and water mobility highlight the potential of multifunctional fillers and top-down/bottom-up approaches for creating plant-based structured foods with meat-like texture.
FOOD HYDROCOLLOIDS
(2023)
Article
Materials Science, Biomaterials
Jordi Amagat, Christoph Alexander Mueller, Bjarke Norrehvedde Jensen, Xuya Xiong, Yingchun Su, Natasja Porskjaer Christensen, Alice Le Friec, Mingdong Dong, Ying Fang, Menglin Chen
Summary: We developed an injectable, nanofibrous 2D flexible hydrogel sheet-based neural stimulation device that can be non-invasively implanted via syringe injection for optoelectrical and biochemical dual stimulation of neurons. The device consists of mechanically reinforced nanofibers loaded with photocatatlytic g-C3N4/GO nanoparticles for blue light stimulation and nerve growth factor (NGF) loaded nanofibers for biochemical stimulation of neural differentiation. This device represents a crucial early step in developing a minimally invasive system for neural stimulation.
BIOMATERIALS ADVANCES
(2023)
Article
Engineering, Electrical & Electronic
Bjarke Norrehvedde Jensen, Yuting Wang, Alice Le Friec, Sadegh Nabavi, Mingdong Dong, Dror Seliktar, Menglin Chen
Summary: A wireless electromagnetic neural stimulation patch has been developed, which combines electromagnetic induction and physical guidance cues to promote neural cell growth and treat neurological diseases. In vitro experiments confirmed the biocompatibility and efficacy of the patch's electromagnetic stimulation in promoting neurite outgrowth, demonstrating its great potential for non-invasive neurological therapeutics.
NPJ FLEXIBLE ELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Ruodan Xu, Junwei Gao, Can Cao, Mingfei Shi, Yonghui Zhang, Shihao Hong, Shijie Guo, Menglin Chen, Ping Song, Gaoshuang Fu, Jing Li, Tengxiao Liang, Yingchun Miao, Lu Tang, Jinsheng Yang, Ning Li, Mingdong Dong
Summary: This study investigates the susceptibility of Alzheimer's disease (AD) patients with Apolipoprotein (APOE) e4 to COVID-19 and the underlying mechanism. The findings demonstrate that AD patients have increased invasion of SARS-CoV-2 in their lung cells, along with altered expression of viral receptors and co-receptors. Additionally, the study shows that HDL mimetics can protect APOE e4-bearing lung cells against SARS-CoV-2 invasion, potentially offering a therapeutic strategy for COVID-19.
