Article
Engineering, Biomedical
Xinyu Zhang, Zichen Cao, Chuanhui Song, Zheng Wei, Meng Zhou, Si Chen, Jianchuan Ran, Hongbo Zhang, Huihui Zou, Shengwei Han, Yu Cai, Wei Han
Summary: Impressive results have been achieved in cancer treatment through immunotherapy. However, the abnormally high cholesterol metabolism in the tumor microenvironment (TME) hinders immunotherapy's effectiveness in patients with oral squamous cell carcinoma (OSCC). A cholesterol-modulating nanoplatform (PYT NP) was developed in this study to restore the normal immune microenvironment by reducing cholesterol in the TME, inhibiting tumor cell proliferation, and triggering immunogenic cell death. Equipped with a near-infrared photosensitizer (Y8), the nanoplatform promotes immune activation and intra-tumor infiltration for photoimmunotherapy. PYT NPs show great potential in sensitized OSCC immunotherapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Giuseppe Angellotti, Giulia Di Prima, Elena Belfiore, Giuseppina Campisi, Viviana De Caro
Summary: Oral squamous cell carcinoma (OSCC) is a prevalent and aggressive cancer, and conventional treatments have limitations. Resveratrol (RSV), a natural compound, has shown potential for treating OSCC due to its antiproliferative, antimetastatic, and proapoptotic effects. RSV also synergizes with chemotherapeutics and overcomes drug resistance. However, there is a lack of specific investigations on RSV's effects in different administration routes and vehicles. RSV-loaded liposomes have demonstrated efficacy against OSCC models, suggesting the development of drug delivery systems as a turning point in oral cancer treatment.
Article
Chemistry, Multidisciplinary
Po-Chun Chen, Bor-Chyuan Su, Tien-Li Ma, Ying Chui Hong, Yu-Wen Chen, Thi Thuy Tien Vo, Luo-Yun Wu, Tzu-Yu Peng, Ching-Shuen Wang, I-Ta Lee
Summary: This study aimed to determine the potential of combining Refametinib with 5-Fluorouracil (5-FU) in treating oral squamous cell carcinoma (OSCC). The results showed that the combination treatment was more effective in suppressing cell proliferation, promoting apoptosis, and reducing PD-L1 expression, suggesting a new promising strategy for OSCC treatment.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Sungwoo Jo, Eunhee Yang, Yechan Lee, Dongkyu Jeon, Wan Namkung
Summary: The study identified cinobufagin as a novel regulator that can downregulate the expression of ANO1 in oral squamous cell carcinoma cells CAL-27, leading to inhibition of cell proliferation, migration, and induction of apoptosis. These findings suggest that downregulation of ANO1 by cinobufagin may be a potential mechanism for its anticancer effects in OSCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Jianchuan Ran, Tao Liu, Chuanhui Song, Zheng Wei, Chuanchao Tang, Zichen Cao, Huihui Zou, Xinyu Zhang, Yu Cai, Wei Han
Summary: This study demonstrates a rhythmically controlled mild-temperature photothermal therapy (mPTT) using organic photothermal nanoparticles. The rhythm mPTT shows improved antitumor efficacy and induction of tumor-specific immune responses. The temperature-dependent release of damage-associated molecular patterns (DAMPs) during mPTT-induced immunogenic cancer cell death (ICD) enhances immune activation. The results suggest that rhythm mPTT has significant potential for clinical applications in tumor treatment.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Environmental
Chuanhui Song, Xinyu Zhang, Zichen Cao, Zheng Wei, Meng Zhou, Yufeng Wang, Shengwei Han, Yu Cai, Wei Han
Summary: Immunotherapy is hindered by the immune suppression caused by high cholesterol concentration in the tumor microenvironment. To address this issue, researchers have developed a cholesterol-regulate nanoplatform that can reduce cholesterol levels and activate the immune system to enhance the effectiveness of tumor immunotherapy. Both in vitro and in vivo experiments have demonstrated that this nanoplatform can effectively kill tumor cells, regulate cholesterol levels, and stimulate the immune system, providing a new strategy for overcoming immune suppression in the tumor microenvironment and paving the way for adjuvant immunotherapy.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Xinyu Zhang, Yong Han, Shuli Liu, Bing Guo, Shengming Xu, Yue He, Liu Liu
Summary: This study revealed the overexpression of USP30 in OSCC and demonstrated its role in cell viability and glutamine consumption through deubiquitylation activity. The utilization of USP30 inhibitor MF-094 loaded in nanoparticles effectively inhibited cell viability and glutamine consumption of OSCC, providing a novel strategy for treating OSCC.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Chemistry, Inorganic & Nuclear
Parameshwar Jakinala, Harikrishna Naik Lavudi, Neelima Angali, Santhosh Ganderla, Krishna K. Inampudi, Sai Balaji Andugulapati, M. Srinivas, Madhumohan Rao Katika
Summary: A novel approach using buffalo grass extract for the formation of ZnO-Ag nanocomposites is cost-effective, eco-friendly, and has high anticancer and antibacterial activities. Phenol and octadecanoic acid are the major phytochemical compounds involved in the biosynthesis of ZnO-Ag nanocomposites. The biosynthesized ZnO-Ag nanocomposites show strong antibacterial activity, with significant cell death observed in oral squamous cell carcinoma cell lines, suggesting potential applications as antimicrobial agents and for human carcinoma treatments.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Review
Medicine, General & Internal
Ashley Wysong
Summary: Squamous-cell carcinoma is a common type of cancer in humans, with most cases being localized and treatable, but a small percentage of cases that recur or spread can be fatal. Immunocompromised patients are at particularly high risk.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Environmental Sciences
Yuan-Ting Yang, Ming-Ju Hsieh, Yi-Ching Chuang, Chia-Chieh Lin, Yu-Sheng Lo, Hsin-Yu Ho, V. Bharath Kumar, Jiunn-Liang Ko
Summary: The study demonstrates that Picrasidine I shows significant anticancer activity against oral squamous cell carcinoma cells at different concentrations by regulating cell cycle and inducing apoptosis.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Zhi Wang, Lina Zhang, Ting Wu, Xu Pan, Le Li, Yong Liu
Summary: Lidocaine demonstrates suppressive effects on viability, migration, invasion, and tumor formation of oral squamous cell carcinoma. IGF2BP2 expression correlates with poor survival and is downregulated by lidocaine. Lidocaine decreases IGF2BP2 levels, affecting caveolin-1 stability, and overexpression of caveolin-1 partially reverses the suppressive effects of lidocaine on oral squamous cell carcinoma progression.
Article
Biology
Li-Qiao R. Ling, Zichen Lin, Rita Paolini, Camile S. Farah, Michael McCullough, Mathew A. W. T. Lim, Antonio Celentano
Summary: Oral squamous cell carcinoma (OSCC) is a common type of cancer, and anticoagulant usage is increasing. This study aimed to investigate the effects of anticoagulants on OSCC cell lines and their interactions with the drug 5-fluorouracil (5-FU). The results showed that commonly prescribed anticoagulants have antiproliferative effects on OSCC cells and can reduce cell migration. However, most of the anticoagulants tested reduced the effectiveness of the chemotherapeutic agent 5-FU, suggesting potential flaws in current pharmacological management. Further research is needed to translate these findings to animal models.
Article
Chemistry, Medicinal
Rituraj Bharadwaj, Subhash Medhi
Summary: Folic acid (FA) conjugated solid lipid nanoparticle (SLN) loaded with paclitaxel (PTX) and ascorbic acid (AA) showed biphasic drug release, high efficiency against OSCC induced animal model, and better therapeutic efficacy compared to normal drug in pharmacokinetic and biodistribution studies.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Article
Oncology
Zixian Huang, Xi Rui, Chen Yi, Yongju Chen, Rui Chen, Yancan Liang, Yan Wang, Weicheng Yao, Xiaoding Xu, Zhiquan Huang
Summary: This study identified LCN2 as a potential target for the treatment of OSCC. Inhibition of LCN2 expression effectively inhibited OSCC proliferation and metastasis by inhibiting EGFR phosphorylation and downstream signaling activation. LCN2 enhances the recycling of EGFR, activating the EGFR-MEK-ERK cascade. Inhibition of LCN2 significantly inhibited EGFR activation, leading to significant inhibition of tumor growth and metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Materials Science, Biomaterials
Qian Chen, Tianhe Shan, Yanjie Liang, Yujing Xu, Enyu Shi, Yue Wang, Changyi Li, Yinsong Wang, Mingxin Cao
Summary: A biomimetic phototherapeutic nanoagent named PBAE/IR780@DMV has been developed for comprehensive treatment of oral squamous cell carcinoma (OSCC). By combining photothermal therapy (PTT), photodynamic therapy (PDT), and immune stimulation, this nanoagent demonstrated strong antitumor effects against OSCC both in vitro and in vivo.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)