Article
Multidisciplinary Sciences
Hyunmin Ko, Hyo Kee Kim, Chris Chung, Ahram Han, Seung-Kee Min, Jongwon Ha, Sangil Min
Summary: In this post hoc analysis, there was no significant association found between medication adherence and intrapatient variability (IPV) of tacrolimus concentrations among kidney transplant recipients. Both electronic monitoring and self-reported adherence did not affect the IPV of tacrolimus levels in this study.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, Research & Experimental
Kim L. W. Bunthof, Linda Al-Hassany, Gizal Nakshbandi, Dennis A. Hesselink, Ron H. N. van Schaik, Marc A. G. J. ten Dam, Marije C. Baas, Luuk B. Hilbrands, Teun van Gelder
Summary: Statins are associated with a reduced risk of diabetes and diabetes-related complications. Previous research has shown that statins can not only lower cholesterol levels, but may also be beneficial for patients with diabetes.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Lauren Schumacher, Abbie D. Leino, Jeong M. Park
Summary: High intrapatient variability (IPV) of tacrolimus concentrations has been associated with poor outcomes, including acute rejection, de novo donor specific antibody (dnDSA) formation, graft loss, and patient mortality in solid organ transplant (SOT) recipients. Evaluation of IPV-directed interventions is limited and further research on this topic is needed to improve transplant outcomes.
Article
Pharmacology & Pharmacy
Arnaud Del Bello, Clotilde Gaible, Nathalie Longlune, Anne-Laure Hebral, Laure Esposito, Peggy Gandia, Nassim Kamar
Summary: The study examined the modifications of tacrolimus intra-patient variability (IPV) in solid organ transplant recipients after switching from immediate-release or prolonged-release tacrolimus to extended-release LCP-tacrolimus. The switch was considered safe, with no significant impact on tacrolimus IPV observed.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Hematology
Ken Sagou, Nobuaki Fukushima, Shun Ukai, Miyo Goto, Kazutaka Ozeki, Akio Kohno
Summary: Variability in the concentration or the concentration/dose ratio of Tacrolimus is associated with the incidence of transplant-associated thrombotic microangiopathy (TA-TMA) and nonrelapse mortality (NRM).
INTERNATIONAL JOURNAL OF HEMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Nikola Stefanovic, Radmila Velickovic-Radovanovic, Katarina Dankovic, Ivan Pavlovic, Aleksandra Catic-Dordevic, Jelena Basic, Milena Despotovic, Tatjana Jevtovic-Stoimenov, Branka Mitic, Tatjana Cvetkovic
Summary: This study found that patients with high Tac IPV and low C-0/D values may have an increased risk of lower eGFR values in the three-year period following kidney transplantation, particularly for those with lower eGFR at 6 months and a history of acute rejection. The contribution of CYP3A5 genotype to lower C-0/D values suggests an indirect impact on long-term graft function. Identifying patients at risk of graft function deterioration in the long term post-transplantation period may be possible through simultaneous assessment of Tac IPV, C-0/D, and CYP3A5 genotype.
Article
Chemistry, Medicinal
Daniel N. Marco, Maria Queralt Salas, Gonzalo Gutierrez-Garcia, Ines Monge, Gisela Riu, Esther Carcelero, Joan Ramon Roma, Noemi Llobet, Jordi Arcarons, Maria Suarez-Lledo, Nuria Martinez, Alexandra Pedraza, Ariadna Domenech, Laura Rosinol, Francesc Fernandez-Aviles, Alvaro Urbano-Ispizua, Montserrat Rovira, Merce Brunet, Carmen Martinez
Summary: This study retrospectively evaluated the pharmacokinetic variability (IPV) of Tacrolimus (Tac) and its impact on graft-versus-host disease (GVHD) in allogeneic stem cell transplant recipients. The study found that high Tac IPV was associated with an increased risk of GVHD and could serve as a marker to identify patients at higher risk of developing GVHD.
Article
Biochemistry & Molecular Biology
Ewa Kwiatkowska, Kazimierz Ciechanowski, Leszek Domanski, Violetta Dziedziejko, Jaroslaw Przybycinski, Andrzej Pawlik
Summary: In this study, the researchers examined the effects of the metabolism rate of tacrolimus on long-term renal graft function. They found that the concentration/dose ratio (C/D ratio) can be used to assess this effect, but the intrapatient variability (IPV) was not influenced by the C/D ratio. Furthermore, the C/D ratio values increased significantly over time.
Article
Medical Laboratory Technology
Aleixandra Mendoza Rojas, Dennis A. Hesselink, Nicole M. van Besouw, Marjolein Dieterich, Ronella de Kuiper, Carla C. Baan, Teun van Gelder
Summary: The study found a correlation between high intrapatient variability in tacrolimus exposure and decreased kidney allograft survival, as well as a higher prevalence of donor-specific anti-Human Leukocyte Antigen antibodies in patients with subtherapeutic concentrations of tacrolimus.
THERAPEUTIC DRUG MONITORING
(2022)
Article
Pharmacology & Pharmacy
Benedetta C. Sallustio, Benjamin D. Noll, Rong Hu, Daniel T. Barratt, Jonathan Tuke, Janet K. Coller, Graeme R. Russ, Andrew A. Somogyi
Summary: Recipient and donor CYP3A5 and ABCB1 3435C>T genotypes do not determine allograft tacrolimus exposure in kidney transplant recipients. However, tacrolimus dose and C-0Blood are significant predictors of C-Graft, and the relationship between C-0Blood and C-Graft appears to differ in the presence or absence of acute nephrotoxicity.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Cristina Dopazo, Itxarone Bilbao, Sonia Garcia, Concepcion Gomez-Gavara, Mireia Caralt, Isabel Campos-Varela, Lluis Castells, Ernest Hidalgo, Francisco Moreso, Bruno Montoro, Ramon Charco
Summary: This study aimed to investigate the association between intrapatient variability (IPV) of tacrolimus pharmacokinetics at 6 months after liver transplantation (LT) and patient outcomes. The results suggest that high IPV between the third and sixth months after LT is associated with poorer patient survival rates and impaired renal function.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Anita Yang, Roxanne McKnight, Alyson Prom, Megan Byrne, Rickey A. Evans, Christina T. Doligalski
Summary: The integration of a dedicated lung transplant pharmacist into the multidisciplinary team and allowing them to make dose adjustments for tacrolimus improved 1-year intrapatient variability and clinical outcomes for lung transplant recipients.
JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY
(2023)
Article
Multidisciplinary Sciences
Vei Mah, Yahya Elshimali, Alison Chu, Neda A. Moatamed, Jamar P. Uzzell, Jessica Tsui, Stephen Schettler, Hania Shakeri, Madhuri Wadehra
Summary: The expression of ALDH1 in endometrial hyperplasia and cancer showed significant changes, suggesting its potential as an early marker for predicting endometrial cancer development. This study suggests that ALDH1 can serve as an independent prognostic indicator for patients with endometrial hyperplasia who may progress to cancer.
SCIENTIFIC REPORTS
(2021)
Article
Transplantation
Rhea Jabbour, Andreas Heinzel, Roman Reindl-Schwaighofer, Mariella G. Gregorich, Heinz Regele, Nicolas Kozakowski, Johannes Klaeger, Gottfried Fischer, Alexander Kainz, Jan U. Becker, Chris Wiebe, Rainer Oberbauer
Summary: This retrospective cohort study aimed to investigate the association between HLA histocompatibility and the progression of chronic histologic lesions in kidney allografts. The results showed that HLA mismatch scores were not associated with the progression of histologic lesions, except for arteriolar hyalinosis, specifically HLA-EMMA DRB1. However, the established associations of dnDSA formation with HLA mismatch and microvascular inflammation were confirmed in the cohort.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Pharmacology & Pharmacy
Chengcheng Shi, Liang Yan, Jie Gao, Shitong Chen, Lirong Zhang
Summary: The DNA methylation of ABCB1 gene affects individual differences in tacrolimus blood concentrations following liver transplantation. Methylation levels of specific CpG sites in ABCB1 were found to be related to tacrolimus concentrations. Therefore, ABCB1 DNA methylation in donor livers may play a significant role in determining tacrolimus blood concentrations after liver transplantation.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Caroline S. Foo, Rana Abdelnabi, Suzanne J. F. Kaptein, Xin Zhang, Sebastiaan ter Horst, Raf Mols, Leen Delang, Joana Rocha-Pereira, Lotte Coelmont, Pieter Leyssen, Kai Dallmeier, Valentijn Vergote, Elisabeth Heylen, Laura Vangeel, Arnab K. Chatterjee, Pieter P. Annaert, Patrick F. Augustijns, Steven De Jonghe, Dirk Jochmans, Mieke Gouwy, Seppe Cambier, Jennifer Vandooren, Paul Proost, Christine van Laer, Birgit Weynand, Johan Neyts
Summary: Nelfinavir, an HIV protease inhibitor, shows antiviral activity against SARS-CoV-2 and can improve lung pathology induced by the virus in hamsters. It enhances the number and functionality of neutrophils and promotes their migration. Another combination of HIV protease inhibitors, Lopinavir/Ritonavir, also has a similar protective effect in this model.
ANTIVIRAL RESEARCH
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Nina Nauwelaerts, Thomas Bouillon, Neel Deferm, Bart Lammens, Pieter Annaert
Meeting Abstract
Biochemistry & Molecular Biology
Kristof De Vos, Pieter Annaert
Article
Biochemistry & Molecular Biology
Axelle Cooreman, Anne Caufriez, Andres Tabernilla, Raf Van Campenhout, Kaat Leroy, Prashant Kadam, Julen Sanz Serrano, Bruna dos Santos Rodrigues, Pieter Annaert, Mathieu Vinken
Summary: This study investigated the effects of several drugs proposed for treating COVID-19 on Cx43 hemichannels. The results showed that a combination of lopinavir and ritonavir, as well as remdesivir, reduced Cx43 mRNA levels, but none of the drugs affected Cx43 protein expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Erwin Dreesen, Matthias Gijsen, Omar Elkayal, Pieter Annaert, Yves Debaveye, Joost Wauters, Mats O. Karlsson, Isabel Spriet
Summary: The study aimed to determine an optimized ceftriaxone dosage regimen based on the probability of developing augmented renal clearance (ARC) in critically ill patients with community-acquired pneumonia (CAP). It was found that critically ill patients with CAP who have a high probability of developing ARC may benefit from twice-daily 2 g ceftriaxone dosing for achieving adequate exposure on the next day.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Pediatrics
Elif Keles, Pia Wintermark, Floris Groenendaal, Noor Borloo, Anne Smits, Annouschka Laenen, Djalila Mekahli, Pieter Annaert, Suzan Sahin, Mehmet Yekta Oncel, Valerie Chock, Didem Armangil, Esin Koc, Malcolm R. Battin, Adam Frymoyer, Karel Allegaert
Summary: There is a large variability in kidney function and injury in neonates with neonatal encephalopathy treated with therapeutic hypothermia. Using serum creatinine centiles over postnatal age may provide more valuable information in these neonates. Understanding postnatal age-related patterns enables clinicians to better assess kidney function and tailor treatment.
Article
Virology
Olga Mineeva-Sangwo, Joan Marti-Carreras, Evert Cleenders, Dirk Kuypers, Piet Maes, Graciela Andrei, Maarten Naesens, Robert Snoeck
Summary: In this study, the researchers analyzed samples from kidney transplant patients and identified multiple subgroups of BK polyomavirus. However, no significant genetic features related to high plasma viral load were found.
Article
Pharmacology & Pharmacy
Nina Nauwelaerts, Michael Ceulemans, Neel Deferm, An Eerdekens, Bart Lammens, Yeghig Armoudjian, Kristel Van Calsteren, Karel Allegaert, Loes de Vries, Pieter Annaert, Anne Smits
Summary: The study found low concentrations of sildenafil and bosentan in human milk, with low daily doses ingested by the nursing infant. However, the Relative Infant Dose calculated for both medications were within safe range. The mother reported that the infant's general health was optimal until the sampling days.
FRONTIERS IN PHARMACOLOGY
(2022)
Letter
Pediatrics
Karel Allegaert, Djalila Mekahli, Pia Wintermark, Floris Groenendaal, Noor Borloo, Annouschka Laenen, Pieter Annaert, Suzan Sahin, Mehmet Yekta Oncel, Valerie Y. Chock, Didem Armangil, Esin Koc, Malcolm R. Battin, Adam Frymoyer, Elif Keles, Anne Smits
News Item
Toxicology
J. Stam, P. Olinga, P. Annaert, R. Bischoff, J. C. Wolters
TOXICOLOGY LETTERS
(2022)
Article
Oncology
Getahun Befirdu Abza, Jemal Hussien Ahmed, Abdu Adem Yesufe, Edom Seife, Mengistu Erkie, Isabel Spriet, Legese Chelkeba, Pieter Annaert
Summary: Hepatitis B virus (HBV) is an important risk factor for hepatocellular carcinoma (HCC). The clinical conditions and survival of patients with HCC in Ethiopia are poor. Patients who received antiviral therapy had better survival outcomes than those who did not. Therefore, it is crucial to increase vaccination coverage and access to antiviral drugs against hepatitis to reduce the devastation of HCC.
Article
Pharmacology & Pharmacy
Yeghig Armoudjian, Qi Lin, Bart Lammens, Johan Van Daele, Pieter Annaert
Summary: The IMI project ConcePTION was launched to fill the knowledge gap of using medicines during pregnancy and lactation. A high-throughput, robust, and reliable liquid chromatography tandem mass spectrometry method was developed and validated to determine the concentrations of amoxicillin in a large number of minipig plasma and milk samples.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS
(2023)
Article
Pharmacology & Pharmacy
Julia Macente, Nina Nauwelaerts, Francesca M. Russo, Jan Deprest, Karel Allegaert, Bart Lammens, Rodolfo Hernandes Bonan, Jessica M. Turner, Sailesh Kumar, Andrea Diniz, Frederico S. Martins, Pieter Annaert
Summary: This study aims to use physiologically-based pharmacokinetic modeling to predict the maternal dose required for therapeutic fetal exposure in the treatment of congenital diaphragmatic hernia.
FRONTIERS IN PHARMACOLOGY
(2023)
Meeting Abstract
Neurosciences
Nina Nauwelaerts, Michael Ceulemans, Neel Deferm, An Eer-Dekens, Bart Lammens, Yeghig Armoudjian, Kristel VanCalsteren, Karel Allegaert, Loes de Vries, Pieter Annaert, Anne Smits
NEUROTOXICOLOGY AND TERATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Karel Allegaert, Mohammad Yaseen Abbasi, Pieter Annaert, Olusola Olafuyi
Summary: The article introduces a structured approach, physiologically based pharmacokinetic (PBPK) modeling and simulation, to inform pharmacotherapy in preterm neonates. Through a systematic search, the authors collected information on the applications and optimization efforts of PBPK software packages in preterm neonates. It is suggested that collaboration between clinicians and modelers can help improve PBPK models despite existing knowledge gaps and uncertainties in their application.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2022)