Article
Health Care Sciences & Services
Jing Yuan, David J. Libon, Cody Karjadi, Alvin F. A. Ang, Sherral Devine, Sanford H. Auerbach, Rhoda Au, Honghuang Lin
Summary: This study investigated the association between digital Clock Drawing Test (dCDT) features and cognitive performance across multiple domains. The results showed that dCDT features were significantly associated with both neuropsychological tests and mild cognitive impairment.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Review
Neurosciences
Qing Zhao, Xinxin Du, Wenhong Chen, Ting Zhang, Zhuo Xu
Summary: Alzheimer's disease is a global health issue with significant negative impacts. PET/CT and neuropsychological scales are useful for early identification and diagnosis, as well as offering early therapies. There is a lack of large-scale investigations focusing on the pathology of AD and MCI, hence further research is needed to understand the interaction between neuropsychological test scales and PET/CT measurements of disease progression.
FRONTIERS IN NEUROSCIENCE
(2023)
Review
Neurosciences
Anne R. Carlew, Alyssa Kaser, Jeff Schaffert, William Goette, Laura Lacritz, Heidi Rossetti
Summary: Through a review of the literature, it was found that the neuropsychological actuarial method has some utility in diagnosing mild cognitive impairment (MCI) in large-scale homogenous databases, but its accuracy relative to consensus diagnostic methods is unclear, and emerging evidence suggests that the neuropsychological actuarial method may be more prone to diagnostic errors in more demographically diverse populations.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Health Care Sciences & Services
Huitong Ding, Amiya Mandapati, Cody Karjadi, Ting Fang Alvin Ang, Sophia Lu, Xiao Miao, James Glass, Rhoda Au, Honghuang Lin
Summary: This study investigated the association between acoustic features and cognitive disorders, finding that multiple acoustic features were significantly associated with neuropsychological test performance and mild cognitive impairment (MCI). The study also proposed acoustic composite scores as potential digital biomarkers for early cognitive impairment monitoring.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Behavioral Sciences
Davide Quaranta, Naike Caraglia, Federica L'Abbate, Guido Maria Giuffre, Valeria Guglielmi, Giovanna Masone Iacobucci, Paolo Maria Rossini, Paolo Calabresi, Camillo Marra
Summary: Early impairment of semantic memory could predict the progression to Alzheimer's disease before the onset of memory disorders, and the discrepancy between phonological and semantic verbal fluency tests could be able to detect this impairment in advance.
BRAIN AND BEHAVIOR
(2023)
Review
Medicine, General & Internal
Zihan Ding, Tsz-Lok Lee, Agnes S. Chan
Summary: The current systematic review aims to identify digital cognitive biomarkers from computerized tests for detecting dementia and mild cognitive impairment (MCI), and evaluates their diagnostic performance. Results showed that digital cognitive biomarkers achieved comparable or better diagnostic performance than traditional tests, and have the potential to be sensitive markers for MCI and dementia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Dan Li, Yue-Yi Yu, Nan Hu, Min Zhang, Li Liu, Li-Mei Fan, Shi-Shuang Ruan, Fen Wang
Summary: This study compared the reliability and validity of the color-picture version of BNT (CP-BNT) and the black-and-white version of BNT (BW-BNT) in differentiating amnestic mild cognitive impairment (aMCI) or mild Alzheimer's disease (AD) from cognitive normals. The results showed that CP-BNT outperformed BW-BNT in terms of diagnostic accuracy and reliability.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Letteria Tomasello, Leonardo Carlucci, Angelina Lagana, Santi Galletta, Chiara Valeria Marinelli, Massimo Raffaele, Pierluigi Zoccolotti
Summary: This study examined the effectiveness of EEG resting state and neuropsychological performances in distinguishing between different types of dementia or mild cognitive impairment (MCI) in comparison to control subjects. The results showed that patients with Alzheimer's disease (AD) and Fronto-Temporal Dementia (FTD) exhibited greater theta activation in posterior areas compared to MCI and control groups. AD patients also had higher delta band activity in temporal-occipital areas compared to controls and MCI patients. The joint use of cognitive and neurophysiological data can provide converging evidence for monitoring cognitive skills in individuals at risk.
Review
Geriatrics & Gerontology
Baker K. K. Bat, Joyce Y. C. Chan, Tak Kit Chan, Zhaohua Huo, Benjamin H. K. Yip, Martin C. S. Wong, Kelvin K. F. Tsoi
Summary: This study compared the diagnostic performance between drawing under instructions and image copying for cognitive screening. The results showed that while there were differences in sensitivity and specificity between drawing under instructions and image copying, the diagnostic performance of the two methods was similar. The majority of studies used the clock-drawing test as the screening test. Self-screening for dementia at home may be feasible in the future.
AGING & MENTAL HEALTH
(2022)
Article
Geriatrics & Gerontology
Ziying Yang, Wenbo Zhang, Dunxiu Liu, Shan-shan Zhang, Yong Tang, Jiaqi Song, Jinfeng Long, Jun Yang, Hong Jiang, Yaling Li, Xintong Liu, Yang Lu, Fu Ding
Summary: This study aimed to investigate the effects of sport stacking on cognition and brain function in patients with mild Alzheimer's disease (AD) and mild cognitive impairment (MCI). The results showed that sport stacking can improve patients' learning ability and daily life skills, and increase the expression of neuroprotective growth factors, leading to improved neurocognitive performance.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Psychology, Clinical
Joyce Y. C. Chan, Baker K. K. Bat, Adrian Wong, Tak Kit Chan, Zhaohua Huo, Benjamin H. K. Yip, Timothy C. Y. Kowk, Kelvin K. F. Tsoi
Summary: Digital and paper-and-pencil drawing tests show potential diagnostic performance in screening mild cognitive impairment and dementia, with digital clock drawing test demonstrating better performance in MCI screening.
NEUROPSYCHOLOGY REVIEW
(2022)
Article
Psychology, Clinical
Yanlu Huang, Feng-Feng Pan, Lin Huang, Qihao Guo
Summary: This study developed a clock drawing test scoring system with process assessment and explored its diagnostic value in mild cognitive impairment (MCI) and early Alzheimer's disease (AD). The new scoring system, CDT5, showed better discriminatory power in distinguishing AD patients from normal controls (NC) compared to other scoring systems. However, its role in identifying patients with MCI needs further exploration.
Article
Neurosciences
Yan Wang, Xuming Gu, Wenju Hou, Meng Zhao, Li Sun, Chunjie Guo
Summary: This paper proposes a novel semi-supervised method using neuropsychological test scores and scarce labeled data, which introduces difference regularization and consistency regularization with pseudo-labeling. The experimental results show that DSSL achieves the best accuracy and stability in classifying AD, MCI, and NC compared to other semi-supervised methods.
Article
Health Care Sciences & Services
Jingsong Wu, Jingnan Tu, Zhizhen Liu, Lei Cao, Youze He, Jia Huang, Jing Tao, Mabel N. K. Wong, Lidian Chen, Tatia M. C. Lee, Chetwyn C. H. Chan
Summary: The Efficient Online MCI Screening System (EOmciSS) is a self-paced cognitive test developed for identification of community-dwelling older adults with mild cognitive impairment(MCI) risks. This study validated the EOmciSS and found that it has higher sensitivity and specificity compared to other screening systems. Depressive symptoms were also found to be influential in the test performance and MCI risk.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Neurosciences
Anna Marcisz, Joanna Polanska
Summary: This study aimed to find T1-weighted MRI-based markers for Alzheimer's disease and mild cognitive impairment (MCI) to improve screening. The proposed model achieved good results in detecting AD and improving MCI detection quality. The model can detect AD patients earlier than standard medical diagnosis.
JOURNAL OF ALZHEIMERS DISEASE
(2023)