Review
Neurosciences
Katarzyna Mlyniec
Summary: Zinc plays a crucial role in the pathophysiology and antidepressant response of depression, interacting with various neuropeptides like GPR39 and BDNF. Reduced zinc levels are associated with depression, and zinc-mediated signaling may influence depressive-like behavior.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Neurosciences
Anupam Sah, Maria Kharitonova, Katarzyna Mlyniec
Summary: Studies have shown that GPR39 knockout mice exhibit enhanced passive coping behavior, abnormal neuronal activity in specific brain regions, and resistance to traditional antidepressants. Imipramine partially reduces passive coping behavior by attenuating hyperactivity in the prefrontal cortex, but does not modulate abnormal brain activity in all regions. Antidepressant effects are suggested to be mediated through both GPR39-dependent and independent pathways in the brain.
Article
Immunology
Shucai Xie, Xili Jiang, Desislava Met Doycheva, Hui Shi, Peng Jin, Ling Gao, Rui Liu, Jie Xiao, Xiao Hu, Jiping Tang, Lina Zhang, John H. Zhang
Summary: This study revealed that GPR39 attenuated neuroinflammation post-HIE through the SIRT1/PGC-1α/Nrf2 pathway, enhancing neuroprotective effects.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Cell Biology
Urszula Doboszewska, Katarzyna Socala, Mateusz Pierog, Dorota Nieoczym, Jan Sawicki, Adam Sajnog, Bernadeta Szewczyk, Katarzyna Mlyniec, Ireneusz Sowa, Danuta Baralkiewicz, Piotr Wlaz
Summary: The G-protein coupled receptor 39 (GPR39) is a potential target for future drugs, and its pharmacology is not fully understood. Zinc acts as an endogenous agonist or an allosteric modulator for GPR39, while TC-G 1008 is a synthetic agonist. Zinc also enhances the activity of TC-G 1008 at GPR39. Activation of GPR39 by TC-G 1008 promotes epileptogenesis in an epilepsy model and decreases seizure threshold in a seizure test. The amount of zinc in the diet contributes to the effects of TC-G 1008 in vivo.
Article
Biochemistry & Molecular Biology
Urszula Doboszewska, Katarzyna Socala, Mateusz Pierog, Dorota Nieoczym, Jan Sawicki, Malgorzata Szafarz, Kinga Gawel, Anna Rafalo-Ulinska, Adam Sajnog, Elzbieta Wyska, Camila V. Esguerra, Bernadeta Szewczyk, Marzena Mackowiak, Danuta Baralkiewicz, Katarzyna Mlyniec, Gabriel Nowak, Ireneusz Sowa, Piotr Wlaz
Summary: This study found that TC-G 1008 exacerbated seizures and epileptogenesis, but its mechanism may not be solely through activating the GPR39 receptor. Therefore, activating GPR39 may not be a viable therapeutic strategy for treating epilepsy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Cell Biology
Urszula Doboszewska, Jan Sawicki, Adam Sajnog, Aleksandra Szopa, Anna Serefko, Katarzyna Socala, Mateusz Pierog, Dorota Nieoczym, Katarzyna Mlyniec, Gabriel Nowak, Danuta Baralkiewicz, Ireneusz Sowa, Piotr Wlaz
Summary: This study reveals the relationship between magnesium homeostasis and certain types of acute or chronic seizures, but does not explicitly support the role of GPR39 in mediating magnesium balance in the hippocampus in the latter model.
Review
Biochemistry & Molecular Biology
Yifan Xu, Anthony P. Barnes, Nabil J. Alkayed
Summary: This review examines the role of GPR39 as a zinc-responsive member of the ghrelin family of G protein-coupled receptors in regulating various neurovascular and neurologic functions. It also discusses its expression pattern in the central nervous system and its recognized role in neurovascular, neurological, and neuropsychiatric disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Dominika Siodlak, Gabriel Nowak, Katarzyna Mlyniec
Summary: This article discusses the importance of zinc signaling in brain function and its relationship with depression. Research suggests that zinc deficiency and disturbances in the zinc receptor may serve as neurobiological indicators of pathological states, while antidepressants may treat depression by affecting zinc signaling.
BRAIN RESEARCH BULLETIN
(2021)
Review
Biochemistry & Molecular Biology
Anna Laitakari, Lingzhi Liu, Thomas M. Frimurer, Birgitte Holst
Summary: GPR39 is a widely expressed G-protein coupled receptor in various tissues, activated by changes in extracellular Zn2+ concentration. It plays important roles in physiological functions and in diseases such as inflammation, cardiovascular diseases, bone formation, male fertility, addiction, and cancer. Novel synthetic agonists have revealed new functions, presenting opportunities for drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Gabriela Starowicz, Dominika Siodlak, Gabriel Nowak, Katarzyna Mlyniec
Summary: This study aimed to investigate the role of glutamatergic and GABAergic system activation in TC-G 1008 antidepressant-like effects and the disruptions caused by a low-zinc diet. The results showed that the antidepressant-like effect of TC-G 1008 was blocked by NMDA and picrotoxin, and joint administration with muscimol or SCH50911 showed a trend towards decreased immobility time. A zinc-deficient diet resulted in dysregulation of GluN1, PSD95, and KCC2 protein expression. These findings suggest the important role of glutamate/GABA signaling in the antidepressant-like effect of TC-G 1008 and imply that GPR39 may be a novel target for the development of antidepressants.
PHARMACOLOGICAL REPORTS
(2023)
Review
Pharmacology & Pharmacy
Katarzyna Mlyniec, Dominika Siodlak, Urszula Doboszewska, Gabriel Nowak
Summary: The relevance of oligomerization for the pharmacology of depression is supported by evidence mainly from in vitro studies and neuropsychopharmacological studies. It has been found that GPR39 may mediate the antidepressant action of monoaminergic antidepressants, indicating its potential as a target for novel antidepressant drugs. Further research on oligomerization is crucial for the development of new antidepressants.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Panpan Yang, Qiushi Feng, Lingxiao Meng, Rong Tang, Yujun Jiang, Hongrui Liu, Haipeng Si, Minqi Li
Summary: This study explores the dual mechanism of TC-G 1008 in ameliorating osteoblast apoptosis under oxidative stress through ROS elimination and ASK1/Trx signal suppression, both of which contribute to increased Prx1 expression, suggesting that TC-G 1008 has great potential in the clinical treatment of osteoporosis.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2022)
Article
Immunology
Cecilie V. Vollmond, Malte M. Tetens, Fie W. Paulsen, Jan Gerstoft, Gitte Kronborg, Isik S. Johansen, Carsten S. Larsen, Lothar Wiese, Michael Dalager-Pedersen, Steffen Leth, Preben B. Mortensen, Anne-Mette Lebech, Niels Obel, Lars H. Omland
Summary: In this nationwide, population-based, matched cohort study in Denmark, we found that people with HIV have an increased risk of depression, receipt of antidepressants, treatment with electroconvulsive therapy, and suicide compared to the general population. This risk decreases after 2 years but remains higher than the general population. Familial factors are unlikely to explain this risk.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Ziying Chen, Flora Gordillo-Martinez, Lei Jiang, Pengcheng He, Wanzi Hong, Xuebiao Wei, Katherine A. Staines, Vicky E. Macrae, Chunxiang Zhang, Danqing Yu, Xiaodong Fu, Dongxing Zhu
Summary: The study suggests that zinc may act as a novel inhibitor of CAVD by regulating GPR39-dependent ERK1/2 signaling pathway to inhibit cell calcification, and zinc transporter ZIP13 and ZIP14 play important roles in regulating cell calcification and osteogenic differentiation. Zinc supplementation could be a potential therapeutic strategy for CAVD.
CARDIOVASCULAR RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Pengpeng Xia, Li Yan, Xingduo Ji, Yunping Wu, Siqi Lian, Guoqiang Zhu
Summary: G protein-coupled receptor 39 (GPR39) is a zinc-sensing receptor that plays a crucial role in regulating animal intestinal health. It can sense changes in extracellular zinc ions, mediate ion transport, maintain intestinal homeostasis, and improve barrier function. GPR39 has become a potential target for studying animal intestinal diseases, providing new directions for prevention and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Agata Krakowska, Piotr Zieba, Anna Wlodarczyk, Katarzyna Kala, Katarzyna Sulkowska-Ziaja, Emilia Bernas, Agnieszka Sekara, Beata Ostachowicz, Bozena Muszynska
Article
Multidisciplinary Sciences
Natalia Janik-Olchawa, Agnieszka Drozdz, Damian Ryszawy, Maciej Pudelek, Karolina Planeta, Zuzanna Setkowicz, Maciej Sniegocki, Andrzej Zadlo, Beata Ostachowicz, Joanna Chwiej
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Karolina Planeta, Zuzanna Setkowicz, Natalia Janik-Olchawa, Katarzyna Matusiak, Damian Ryszawy, Agnieszka Drozdz, Krzysztof Janeczko, Beata Ostachowicz, Joanna Chwiej
ACS CHEMICAL NEUROSCIENCE
(2020)
Article
Neurosciences
Paulina Misztak, Magdalena Sowa-Kucma, Bernadeta Szewczyk, Gabriel Nowak
Summary: The study evaluated the impact of SAHA on the expression of several key proteins in the brain's signal transduction pathways, as well as the concentration of the oxidative stress product MDA. SAHA may prevent oxidative stress by decreasing MDA concentration and increasing p-AMPK expression, while also boosting neuroprotective and antidepressant protein levels.
NEUROTOXICITY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Marek Krol, Grzegorz Slifirski, Jerzy Kleps, Szymon Ulenberg, Mariusz Belka, Tomasz Baczek, Agata Siwek, Katarzyna Stachowicz, Bernadeta Szewczyk, Gabriel Nowak, Beata Duszynska, Franciszek Herold
Summary: Novel compounds with high affinities for 5-HT1A receptor were synthesized and characterized through a series of experiments, showing potential for therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Dominika Siodlak, Gabriel Nowak, Katarzyna Mlyniec
Summary: This article discusses the importance of zinc signaling in brain function and its relationship with depression. Research suggests that zinc deficiency and disturbances in the zinc receptor may serve as neurobiological indicators of pathological states, while antidepressants may treat depression by affecting zinc signaling.
BRAIN RESEARCH BULLETIN
(2021)
Article
Chemistry, Applied
Katarzyna Kala, Agata Krakowska, Agnieszka Szewczyk, Beata Ostachowicz, Kornelia Szczurek, Agata Fijalkowska, Bozena Muszynska
Summary: This study examined the release of bioelements and phenolic compounds from edible mushrooms enriched with zinc, selenium, and L-phenylalanine, both individually and in combination, through a simulated human gastrointestinal digestion method. The results indicated that mycelium of Lentinula edodes showed the best health-promoting properties, with significant increases in the synthesis of p-hydroxybenzoic and protocatechuic acid when a mixture was added. Additionally, enriched Agaricus bisporus mycelium had the highest extraction amounts of selenium and zinc.
Review
Pharmacology & Pharmacy
Katarzyna Mlyniec, Dominika Siodlak, Urszula Doboszewska, Gabriel Nowak
Summary: The relevance of oligomerization for the pharmacology of depression is supported by evidence mainly from in vitro studies and neuropsychopharmacological studies. It has been found that GPR39 may mediate the antidepressant action of monoaminergic antidepressants, indicating its potential as a target for novel antidepressant drugs. Further research on oligomerization is crucial for the development of new antidepressants.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Medicine, General & Internal
Michal Skalski, Anna Mach, Piotr Januszko, Beata Ryszewska-Pokrasniewicz, Agata Biernacka, Gabriel Nowak, Andrzej Pilc, Ewa Poleszak, Maria Radziwon-Zaleska
Summary: The study aimed to evaluate the effects of psychotropic medications on the bioelectrical activity of the brain using pharmaco-EEG. Results showed the highest treatment response in the group receiving fluoxetine augmented with Mg ions, while the group receiving tricyclic antidepressants had the lowest response rates. Achieving remission was associated with a positive pharmaco-EEG profile 6 hours after administration of the first dose in the fluoxetine+Mg group.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Paulina Misztak, Magdalena Sowa-Kucma, Patrycja Panczyszyn-Trzewik, Bernadeta Szewczyk, Gabriel Nowak
Summary: Chronic stress is a key factor in the development of depressive symptoms. The combination of fluoxetine and zinc induces a more pronounced antidepressant effect in the chronic restraint stress model. Zinc supplementation enhances the effectiveness of fluoxetine and plays a role in epigenetic regulation.
Article
Neurosciences
Anupam Sah, Maria Kharitonova, Katarzyna Mlyniec
Summary: Studies have shown that GPR39 knockout mice exhibit enhanced passive coping behavior, abnormal neuronal activity in specific brain regions, and resistance to traditional antidepressants. Imipramine partially reduces passive coping behavior by attenuating hyperactivity in the prefrontal cortex, but does not modulate abnormal brain activity in all regions. Antidepressant effects are suggested to be mediated through both GPR39-dependent and independent pathways in the brain.
Article
Biochemistry & Molecular Biology
Magdalena Szczerbowska-Boruchowska, Artur D. Surowka, Beata Ostachowicz, Kaja Piana, Anna Spaleniak, Pawel Wrobel, Joanna Dudala, Agata Ziomber-Lisiak
Summary: Early detection of subclinical obesity-driven changes is challenging. Existing measures like BMI often fail to provide accurate estimations. Whole-organ analysis of chemical elements shows promise as a new approach for identifying obesity markers.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2023)
Article
Biochemistry & Molecular Biology
Agata Ziomber-Lisiak, Kaja Piana, Beata Ostachowicz, Pawel Wrobel, Paula Kasprzyk, Jolanta Kaszuba-Zwoinska, Agnieszka Baranowska-Chowaniec, Kajetan Juszczak, Magdalena Szczerbowska-Boruchowska
Summary: The study aimed to identify new markers related to excessive body adiposity by determining serum FGF-19 and FGF-21 concentrations, elemental chemistry, and correlation analysis. It found characteristics and new markers in obese rats, with rubidium playing an important role in distinguishing animal groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Gabriela Starowicz, Dominika Siodlak, Gabriel Nowak, Katarzyna Mlyniec
Summary: This study aimed to investigate the role of glutamatergic and GABAergic system activation in TC-G 1008 antidepressant-like effects and the disruptions caused by a low-zinc diet. The results showed that the antidepressant-like effect of TC-G 1008 was blocked by NMDA and picrotoxin, and joint administration with muscimol or SCH50911 showed a trend towards decreased immobility time. A zinc-deficient diet resulted in dysregulation of GluN1, PSD95, and KCC2 protein expression. These findings suggest the important role of glutamate/GABA signaling in the antidepressant-like effect of TC-G 1008 and imply that GPR39 may be a novel target for the development of antidepressants.
PHARMACOLOGICAL REPORTS
(2023)
Article
Clinical Neurology
Jai Carmichael, Jennie Ponsford, Kate Rachel Gould, Gershon Spitz
Summary: The traditional approaches to measuring depression after traumatic brain injury (TBI) have limitations. This study adopted a symptom-oriented approach and found that post-TBI depression is highly heterogeneous. Different depressive symptoms have distinct associations with personal, injury-related, treatment, and outcome factors.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Xiaoning Sun, Min Chen, Guanghai Wang, Fan Jiang
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Aleksander Kwas
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Josine E. Verhoeven, Laura K. M. Han, Brenda W. J. H. Penninx
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Review
Clinical Neurology
Erin Crowe, Petra K. Staiger, Steven J. Bowe, Imogen Rehm, Richard Moulding, Caitlyn Herrick, David J. Hallford
Summary: This study aimed to integrate the evidence regarding the relationship between emotion regulation difficulties and TTM symptoms, and found that individuals with higher levels of TTM severity appear to exhibit decreased overall emotion regulation abilities and strategies.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Fjolla Berisha, Marjolaine Rivest-Beauregard, Jai Shah, Michelle Lonergan, Alain Brunet
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yi-Tseng Tsai, Tzu-Jung Chuang, Sriyani Padmalatha Konara Mudiyanselage, Han-Chang Ku, Yi-Lin Wu, Chung-Yi Li, Nai-Ying Ko
Summary: Sleep disturbances are associated with higher suicide rates, and this association is independent of depression. Paying attention to sleep disturbances among PLHIV is crucial when monitoring suicidal ideation.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Junyou Chen, Ingrid D. Lui, Yu Cheng Hsu, Paul S. F. Yip
Summary: Despite rapid social changes in Hong Kong, marriage remains a strong protective factor against suicide for both men and women, particularly among younger individuals. Increasing suicide rates among divorced/separated, never-married, or widowed individuals suggest a need for more psychosocial support.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
A. Perry, K. Gordon-Smith, K. J. S. Lewis, A. Di Florio, N. Craddock, L. Jones, I. Jones
Summary: This study found that the experience of losing at least one night of sleep was associated with an increased risk of postpartum psychosis in women with bipolar disorder. Sleep quality in late pregnancy was not associated with postpartum psychosis, and perinatal sleep disruption was not associated with postpartum depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Dear J. Affect Disord, Mark J. Niciu, Robert C. Meisner, Brent R. Carr, Ali A. Farooqui, David Feifel, Adam Kaplin, Paul M. Kim, Christopher D. Schneck, Jennifer L. Vande Voort, Sagar Parikh, E. Jeremy Kendrick
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Tao Wang, Li Yang, Lan Yang, Bao-Peng Liu, Cun-Xian Jia
Summary: This study systematically reviewed the association between psychological pain and suicidality in patients with major depressive disorder (MDD). The results showed that psychological pain was a risk factor for suicidality in MDD patients, especially for those of advancing age. Reducing psychological pain in MDD patients is important for preventing suicidality.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Letter
Clinical Neurology
Juan Carlos Hugues, Abel Nogueira-Lopeza, Maeva Flayellea, Cora von Hammersteind, Joel Billieuxa
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Ogechi Cynthia Onyeka, Samuel D. Spencer, Alison Salloum, Katie Jiannetto, Eric A. Storch
Summary: This study examined the relationship among family accommodation (FA), posttraumatic stress symptoms (PTSS), and functional impairment. The results showed that FA was significantly associated with PTSS and functional impairment. Baseline FA partially mediated the relationship between baseline PTSS and functional impairment. Changes in FA from pre- to post-treatment were associated with relevant outcome variables at post-treatment and 12-month follow-up.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Yumeng Shi, Chao Yu
Summary: This study found a negative correlation between the intake of active microbes in the diet and depression.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Clinical Neurology
Qiurui Nie, Yu Shen, Mengqin Luo, Zhiyong Sheng, Rui Zhou, Guangmin Li, Wei Huang, Shenjian Chen
Summary: The study assessed the sleep duration, sleep disorders, and trouble sleeping among adults in the United States from 2005 to 2018, revealing a high prevalence of abnormal sleep durations and increasing rates of sleep disorders and trouble sleeping.
JOURNAL OF AFFECTIVE DISORDERS
(2024)