Review
Medicine, General & Internal
Reham M. Dawood, Ghada Maher Salum, Mai Abd El-Meguid
Summary: The COVID-19 pandemic has caused global health crisis, with lung injury and acute respiratory distress syndrome (ARDS) being the principal causes of mortality. Liver injury or dysfunction has also been observed in COVID-19 patients, and it may serve as a prognostic factor for ARDS development. The spectrum of liver damage in COVID-19 is caused by various factors including viral proteins, inflammation, hypoxemia, antiviral drugs, and preexisting liver disease. This review focuses on the epidemiological features, potential causes, and strategies for managing and preventing hepatic injury in COVID-19 patients.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Article
Nutrition & Dietetics
Daniel de Luis, David Primo, Olatz Izaola, Juan Jose Lopez
Summary: Partial meal replacement (pMR) diet is an effective method to lose weight and improve metabolic parameters in patients with obesity and high fatty liver index (FLI).
Article
Obstetrics & Gynecology
John J. Byrne, Angela Seasley, David B. Nelson, Donald D. Mcintire, F. Gary Cunningham
Summary: Acute fatty liver of pregnancy (AFLP) and hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome have overlapping clinical and laboratory findings, making differentiation difficult. However, levels of fibrinogen, creatinine, cholesterol, and total bilirubin can be used to differentiate between these two syndromes. AFLP is associated with more severe hepatic and renal dysfunction and coagulopathy.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Review
Nutrition & Dietetics
Georgios Kalopitas, Christina Antza, Ioannis Doundoulakis, Antonis Siargkas, Elias Kouroumalis, Georgios Germanidis, Myrto Samara, Michail Chourdakis
Summary: This meta-analysis aimed to evaluate the efficacy of silymarin in treating NAFLD, and found that silymarin led to a significant reduction in transaminase levels. However, potential flaws related to study quality were identified, emphasizing the need for further well-designed studies to validate the findings.
Article
Nutrition & Dietetics
Jun-Hyuk Lee, Yu-Jin Kwon, Hye Sun Lee, Jee Hye Han, Boyoung Joung, Sung Jin Kim
Summary: This study identified an association between fatty liver and elevated intraocular pressure (EIOP), finding that fatty liver is independently associated with EIOP. Fatty liver primarily affects EIOP through a direct effect on intraocular pressure. Evaluation of EIOP should be considered in patients with fatty liver.
Article
Gastroenterology & Hepatology
Ricardo Ulises Macias-Rodriguez, Alberto Adrian Solis-Ortega, Victoria J. Ornelas-Arroyo, Astrid Ruiz-Margain, Maria Sarai Gonzalez-Huezo, Nestor A. Urdiales-Moran, Berenice M. Roman-Calleja, Juan M. Mayorquin-Aguilar, Jose A. Gonzalez-Regueiro, Alejandro Campos-Murguia, Israel Vicente Toledo-Coronado, Monica Chapa-Ibarguengoitia, Bernardo Valencia-Pena, Carlos Fernando Martinez-Cabrera, Nayelli C. Flores-Garcia
Summary: There is currently no prognostic score specifically aimed at evaluating the risk of severe disease in patients with MAFLD. This study evaluates the prognostic performance of an index based on lactate dehydrogenase and transaminases in patients with COVID-19 and MAFLD.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Jasbir Makker, Hassan Tariq, Kishore Kumar, Madhavi Ravi, Danial Haris Shaikh, Vivien Leung, Umar Hayat, Muhammad T. Hassan, Harish Patel, Suresh Nayudu, Sridhar Chilimuri
Summary: The study revealed that a significant number of patients with type-2 diabetes mellitus have nonalcoholic fatty liver disease, grade 3 steatosis, and advanced hepatic fibrosis, even when their alanine aminotransferase levels are normal.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Gastroenterology & Hepatology
Lim Rong, Daniel Ch'ng, Pingping Jia, Kelvin K. F. Tsoi, Sunny H. Wong, Joseph J. Y. Sung
Summary: Patients with NAFLD can benefit from microbiome-targeted therapies such as probiotics, prebiotics, and synbiotics, as they have shown significant improvements in liver-related outcomes. However, the heterogeneity in strains, dosage, and formulation of probiotics in existing literature limits the generalizability of these findings.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Tarana Gupta, Hemant Sharma
Summary: The COVID-19 pandemic has had a significant impact on patients with chronic diseases, particularly those with chronic liver diseases who are at an increased risk of mortality. Factors such as viral infection, drug treatment, and chronic liver diseases can lead to liver function abnormalities, while metabolic syndrome, obesity, diabetes, and non-alcoholic fatty liver disease worsen the outcomes of COVID-19.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Endocrinology & Metabolism
Chang-Hoon Lee, Kyung-Do Han, Da Hye Kim, Min-Sun Kwak
Summary: This study suggests that persistent NAFLD is associated with higher risks of all-cause mortality, MI, and stroke. Repeated evaluations of NAFLD status using FLI measurements could help identify higher-risk groups and potentially guide prevention and treatment strategies.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Walter Masson, Martin Lobo, Gerardo Masson, Graciela Molinero, Paola Casciato
Summary: This meta-analysis demonstrates that in patients with abnormal liver tests at baseline, a more intensive statin-based lipid-lowering therapy shows similar liver safety and cardiovascular benefits compared to less intensive treatment or placebo.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Multidisciplinary Sciences
Rahanuma Raihanu Kathak, Abu Hasan Sumon, Noyan Hossain Molla, Mahmudul Hasan, Rakib Miah, Humaira Rashid Tuba, Ahsan Habib, Nurshad Ali
Summary: The study found a high prevalence of dyslipidemia and liver enzyme abnormalities among Bangladeshi adults. Serum GGT levels showed an independent association with all lipid components. Moreover, patients with dyslipidemia have a higher risk of liver diseases.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Akiko Eguchi, Motoh Iwasa
Summary: Liver-type fatty acid-binding protein (L-FABP) is a potential biomarker in human liver diseases, especially in hepatocellular carcinoma (HCC), indicating prognostic significance.
PHARMACEUTICAL RESEARCH
(2021)
Article
Pediatrics
Kanwar Saini, Rishi Bolia, Nowneet Kumar Bhat
Summary: Sepsis-associated liver injury (SALI) occurs as a result of systemic and microcirculatory changes caused by sepsis. This study found an association between SALI occurrence and higher pSOFA scores, and SALI development increases the risk of mortality in children with sepsis.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Nutrition & Dietetics
Ulrich Cuntz, Ulrich Voderholzer
Summary: This study investigates the relationship between hypertransaminasemia and malnutrition, and suggests that transaminase levels can reflect both liver cell damage and metabolic situation under conditions of energy deficiency. The findings show that below a BMI of about 13, the nutritional status becomes critical and the energy supply depends more on liver autophagy, leading to a significant increase in transaminases. Refeeding can quickly normalize transaminase levels and stabilize metabolism.
