Review
Immunology
Neil MacRitchie, Valentina Di Francesco, Miguel Filipe Moreira Marques Ferreira, Tomasz J. Guzik, Paolo Decuzzi, Pasquale Maffia
Summary: Theranostics is an emerging field in clinical and preclinical research that combines diagnostics and therapy to simultaneously diagnose and treat pathologies. Nanoparticles are extensively used in theranostics due to their potential for targeting specific organs and multifunctionality, with key applications in imaging and treatment of cardiovascular inflammation being discussed in this review.
SEMINARS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rachel Hair, Junichi R. Sakaki, Ock K. Chun
Summary: By 2050, the percentage of individuals over the age of 60 is projected to reach 22%, with chronic diseases associated with aging presenting challenges for this demographic. Anthocyanins and the gut microbiome have shown positive effects on cardiovascular and bone health, as well as potential in cancer prevention and treatment.
Review
Hematology
Megan V. Perkins, Sarah B. Joseph, Dirk P. Dittmer, Nigel Mackman
Summary: HIV infection has transitioned from a fatal disease to a chronic one managed by antiretroviral therapy. However, long-term HIV infection is associated with chronic inflammation, which can lead to cardiovascular disease and thrombosis. More research is needed to understand the mechanisms driving inflammation in PLWH and develop better therapies to reduce chronic inflammation and improve overall mortality.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Biology
Aishat Motolani, Matthew Martin, Mengyao Sun, Tao Lu
Summary: As research on PRMT5's role in diseases progresses, it has been found to play crucial roles in many important biological functions. Its involvement in cancer and inflammatory diseases is well-documented, highlighting the importance of developing better treatment strategies.
Review
Biochemistry & Molecular Biology
Yunzhe Wang, Chenyang Zhang, Yuxiang Wang, Xiuping Liu, Zhao Zhang
Summary: This review summarized recent studies on the pathological mechanisms and potential clinical utility of eRNAs in human diseases. The findings indicate the significant therapeutic potential of eRNAs in diagnosis, prognosis, and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Maranda S. Cantrell, Alejandro Soto-Avellaneda, Jackson D. Wall, Aaron D. Ajeti, Brad E. Morrison, Lisa R. Warner, Owen M. McDougal
Summary: Drug development is a complex, slow, and expensive process, but repurposing existing drugs with known safety profiles approved by the FDA for clinical trials can mitigate these challenges. Cardiovascular and neurodegenerative diseases pose significant treatment obstacles, necessitating the exploration of new drugs with better efficacy, guided by mechanistic insights into disease progression. Researchers are focusing on repurposing drugs for potential pharmacological treatments targeting inflammation in cardiovascular and neurodegenerative diseases.
Article
Clinical Neurology
Hartej Gill, Nelson B. Rodrigues, Rodrigo B. Mansur, CeAnn A. Marks, Joshua D. DiVincenzo, Felicia Ceban, Joshua D. Rosenblat, Bing Cao, Jonathan M. Lieberman, Roger Ho, Roger S. McIntyre
Summary: This study aimed to evaluate the antidepressant effects of adjunctive infliximab treatment in BD patients and understand its impact on cardiovascular disease (CVD) risk. The results showed no significant differences between the infliximab-treated and placebo group in terms of Framingham risk scores (FRS), mean arterial blood pressure (MAP), and total cholesterol (TC). This suggests that immune system targets have complex effects on CVD in psychiatric populations.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Daniela Sorriento, Guido Iaccarino
Summary: Fabry disease is a lysosomal storage disorder caused by defects in alpha-galactosidase A activity, leading to a high variability in clinical presentation. Cardiovascular dysfunction is a common symptom and a leading cause of death in patients, with therapy focused on restoring GAL activity. Other mechanisms are also involved in the disease's development, potentially serving as useful therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Adel Abo Mansour, Franziska Krautter, Zhaogong Zhi, Asif Jilani Iqbal, Carlota Recio
Summary: Galectins, particularly galectin-1, -3, and -9, are widely expressed by immune cells and play important roles in cellular communication, migration, and survival. These proteins are highly expressed by inflammatory cells and are involved in the regulation of immune responses. They play significant roles in cardiovascular diseases and metabolic disorders and can be potential therapeutic targets.
CARDIOVASCULAR DIABETOLOGY
(2022)
Review
Geriatrics & Gerontology
Virna Margarita Martin Gimenez, Natalia de las Heras, Vicente Lahera, Jesus A. F. Tresguerres, Russel J. Reiter, Walter Manucha
Summary: Aging is a gradual process that leads to increased vulnerability to weakness, disease, and death. It affects cellular, organ, and overall organism functions, resulting in various dysfunctions and impairments. Aging is associated with the development and progression of diseases, particularly in the cardiovascular and central nervous systems.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Nunzio Montelione, Francesco Loreni, Antonio Nenna, Vincenzo Catanese, Lucia Scurto, Chiara Ferrisi, Mohamad Jawabra, Teresa Gabellini, Francesco Alberto Codispoti, Francesco Spinelli, Massimo Chello, Francesco Stilo
Summary: Atherosclerosis-related coronary artery disease (CAD) is the leading cause of mortality and morbidity worldwide. Statins have proved to be the most effective treatment, but there are limitations related to administration and side effects. Polymers and nanoparticles can enhance the effect of statins by increasing bioavailability and target specificity. Poly-lactic-co-glycolic acid (PLGA) is the most promising drug delivery system.
Review
Cardiac & Cardiovascular Systems
Ester S. Oh, Muzi Na, Connie J. Rogers
Summary: This study found that individuals with cardiometabolic disorders and CVD have a higher percentage of intermediate and non-classical monocytes compared to healthy controls, based on qualitative and meta-analysis of 27 studies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Xiangli Zhao, Sadaf Hasan, Benjamin Liou, Yi Lin, Ying Sun, Chuanju Liu
Summary: The study found that PGRN deficiency leads to neuron loss and activation of microglia and astrocytes in aged mice. Several characteristic neurodegenerative disease markers, including alpha-synuclein, TDP-43, Tau, and beta-amyloid, were accumulated in the brain tissue of PGRN-deficient mice. Moreover, higher aggregation of lipofuscin was observed in the brain tissue of PGRN-deficient mice, and autophagy was also defective.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Yuxuan Gong, Huaying Liu, Shen Ke, Li Zhuo, Haibin Wang
Summary: Cardiovascular disease remains a leading cause of death in China, and there is a need to develop innovative methods for identifying and managing these disorders. Nanomaterials offer multiple benefits in biomedicine, and this study reviews the scientific accomplishments in this field over the past few years.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Meei-Ling Sheu, Liang-Yi Pan, Cheng-Ning Yang, Jason Sheehan, Liang-Yu Pan, Weir-Chiang You, Chien-Chia Wang, Hung-Chuan Pan
Summary: Thrombin is closely related to neurodegenerative disorders, and AhR is well expressed in microglia cells involved in inflammatory disorders of the brain. This study found that deleting AhR aggravated the inflammatory response and neurodegenerative processes induced by thrombin in microglia cells, while an AhR agonist could inhibit these responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Rinaldo Patel, Priyanka Prabhu
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Pharmacology & Pharmacy
Pravin Shende, Amar Patil, Bala Prabhakar
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Monica Joshi, Mangal Nagarsenkar, Bala Prabhakar
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Monica Joshi, Bala Prabhakar
JOURNAL OF FOOD BIOCHEMISTRY
(2020)
Review
Chemistry, Multidisciplinary
Pravin Shende, Steffi Augustine, Bala Prabhakar
Review
Pharmacology & Pharmacy
Amar Patil, Roma Narvenker, Bala Prabhakar, Pravin Shende
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Pharmacology & Pharmacy
Namita Hegde, Kapil Juvale, Bala Prabhakar
Summary: This study reports the synthesis, characterization, and in vitro evaluation of dendritic lipopeptide oligomers with different surface properties. The synthesized compounds demonstrated the potential to form self-assembled polymeric nanoparticles and surfactant-like properties. A compound with a hydroxyl terminus showed hints of anticancer activity. These molecules have potential applications as drug delivery materials and warrant further investigation.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2022)
Article
Engineering, Biomedical
Bala Prabhakar, Rishi Kumar Singh, Khushwant S. Yadav
Summary: Glaucoma is an eye disease characterized by increased intraocular pressure, optic neuropathy, and visual field defects. Early and accurate diagnosis is crucial to prevent irreversible vision loss. Current conventional diagnostic methods are prone to misdiagnosis, leading to the exploration of artificial intelligence as a more advanced approach.
COMPUTERIZED MEDICAL IMAGING AND GRAPHICS
(2021)
Article
Pharmacology & Pharmacy
Monica Joshi, Bala Prabhakar
Summary: Rifampicin-loaded bovine serum albumin nanoparticles were prepared using a desolvation method with EDC as the cross-linking agent, showing a biphasic in vitro release pattern. The formulation demonstrated suitability for pulmonary delivery and the potential for reducing the dose required for tuberculosis treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Harshvardhan Jain, Bala Prabhakar, Pravin Shende
Summary: The nasal route of drug administration has been used for therapeutic purposes due to its easy access and non-invasive nature. It is preferred over other invasive approaches for treating CNS ailments. However, there are challenges in delivering drugs via the nasal route, such as mucociliary clearance and dose limitations. This review article discusses approaches to overcome these difficulties and enhance drug concentration in the brain.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Nivedita Das, Priyanka Prabhu
Summary: Cerebral malaria (CM) is a deadly complication of Plasmodium falciparum infection. The complex pathogenesis of CM and the challenges associated with its treatment require a multi-faceted approach. Resistance to current therapies, difficulties in delivering drugs to the brain, and the need to prevent oxidative stress and neuroinflammation are major obstacles in the treatment of CM. Research is focused on developing compounds that can target neuroinflammation, brain-targeted nanocarriers for drug delivery, and using a combination of antimalarial and anti-inflammatory or immunomodulatory molecules for CM treatment. Evaluation protocols for new therapies should include monitoring of neurological parameters alongside parasite load and survival.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Shweta Mishra, Bala Prabhakar, Prashant S. Kharkar, Anil M. Pethe
Summary: This study successfully extracted and prepared nanocrystalline cellulose (NCC) from banana peel powder (BPP). Under optimal conditions, the yield of NCC was 29.9%, with a particle size of 209 nm and a zeta potential of -43 mV. Characterization techniques including infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, and X-ray diffraction analysis confirmed the purification and crystal structure of NCC. Thermogravimetric analysis showed good stability of NCC.
Article
Chemistry, Multidisciplinary
Shweta Mishra, Khushwant S. Yadav, Bala Prabhakar
Summary: Nanocrystalline cellulose, with its unique physical and biological properties, has gained attention from researchers. The utilization of agricultural waste, such as sugarcane bagasse and banana peels, for the production of nanocrystalline cellulose can help protect the environment. Researchers optimized the concentration of these nanocrystalline cellulose materials as disintegrants in the preparation of Diclofenac potassium IR tablets. The tablets showed promising results and can be explored as a new disintegrant for solid oral dosage forms.
Article
Biotechnology & Applied Microbiology
Piyush Verma, Rishi Kumar Singh, Anubhav Wadhwa, Bala Prabhakar, Khushwant S. Yadav
Summary: This study developed liposomes and solid lipid nanoparticles for the delivery of Bimatoprost, a drug used to lower intraocular pressure in glaucoma treatment. The optimized liposomes showed better encapsulation efficiency and drug kinetics compared to solid lipid nanoparticles, and when loaded in a thermo-sensitive hydrogel, they effectively decreased intraocular pressure for 18 hours.
Article
Chemistry, Multidisciplinary
Namita Hegde, Kapil Juvale, Bala Prabhakar
Summary: This study investigates the pharmaceutical feasibility of a newly synthesized amino acid-derived polypeptide for drug delivery, demonstrating its potential in preparing nanosuspensions and successfully loading the anticancer drug, gefitinib.
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
