Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Physical
M. Yasmin Begum
Summary: In this study, nanomedicine based drug delivery design for two small-molecule API drugs was performed using advanced computational methods. Molecular dynamics simulations were used to investigate the co-loading of doxorubicin and gemcitabine on pristine and functionalized carbon nanotubes (CNTs). The results showed that functionalized CNTs had stronger binding energy with drugs due to electrostatic interactions, and CNT-FA exhibited the highest amount of GEM encapsulation. Encapsulation of drugs was analyzed using radial function analysis, and the optimal selection for co-loading of DOX and GEM was found to be CNT-DA in a molar ratio of 1:2 (DOX:GEM).
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Pharmacology & Pharmacy
Debra Wu, Douglas Vogus, Vinu Krishnan, Marta Broto, Anusha Pusuluri, Zongmin Zhao, Neha Kapate, Samir Mitragotri
Summary: The study introduced a prodrug 5FUR-W for improved loading in liposomes, showing significant anti-tumor effects in a breast cancer model.
Article
Chemistry, Multidisciplinary
Xiangdong Xue, Marina Ricci, Haijing Qu, Aaron Lindstrom, Dalin Zhang, Hao Wu, Tzu-Yin Lin, Yuanpei Li
Summary: The development of iron-crosslinked rosmarinic liposomes (Rososomes) presents a novel strategy with robust stability, high drug loading, and synergistic anti-cancer efficacy. The crosslinked Rososomes demonstrate better anticancer efficacy compared to free rosmarinic acid, doxorubicin, non-crosslinked Rososome, and DOXIL on a syngeneic mouse model of breast cancer.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Medicine, Research & Experimental
Ximing Zhang, Fangxue Zhao, Jing Feng, Cong Chen, Zhonggui He, Mengchi Sun, Jin Sun
Summary: In this study, an ionizable PTX prodrug (PTXP) was designed to achieve remote loading of liposomal formulations. Compared to marketable PTX liposomes, PTXP liposomes showed higher loading efficiency and encapsulation efficiency, as well as demonstrated stability, prolonged circulation time, high tumor site accumulation, potent anti-tumor effects, and safety in vitro and in vivo.
MOLECULAR PHARMACEUTICS
(2023)
Article
Acoustics
Jia-Ling Ruan, Richard J. Browning, Yesna O. Yildiz, Luca Bau, Sukanta Kamila, Michael D. Gray, Lisa Folkes, Alix Hampson, Anthony P. McHale, John F. Callan, Borivoj Vojnovic, Anne E. Kiltie, Eleanor Stride
Summary: In this study, three different microbubble-based approaches for delivering the chemotherapy drug gemcitabine were compared. Among them, GembioMB showed a statistically significant increase in cleaved caspase 3 expression in the tumor cells, indicating gemcitabine-induced apoptosis.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Wenqing Liang, Yongqiang Dong, Ruyi Shao, Songou Zhang, Xudong Wu, Xiaogang Huang, Bin Sun, Bin Zeng, Jiayi Zhao
Summary: Osteosarcoma is a common bone malignancy in children and adolescents. Conventional therapeutic strategies have limitations and can cause toxicity and drug resistance. Nanomaterial-based drug delivery systems, particularly liposomes, show promise in providing targeted therapy and enhancing safety and efficacy.
JOURNAL OF DRUG TARGETING
(2022)
Article
Engineering, Biomedical
Hussain AlSadiq, Karnaker Tupally, Robert Vogel, Harendra S. Parekh, Martin Veidt
Summary: This study investigates the behavior of MBs and ELIPs clusters after ultrasonication stops. It found that both agents form clusters at low pressures and the de-clustering behavior is due to Brownian motion rather than electrostatic repulsion.
PHYSICS IN MEDICINE AND BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shao-Ling Huang, Melanie R. Moody, Xing Yin, David D. McPherson, Hyunggun Kim
Summary: Atherosclerosis is a complex disease characterized by pathological changes in the vascular wall. Liposomes loaded with nitric oxide and rosiglitazone were prepared and delivered via intra-arterial administration in a rabbit model of acute arterial injury. The co-delivery system demonstrated anti-inflammatory and anti-proliferative effects, reducing intimal thickening.
Article
Pharmacology & Pharmacy
Huamin Liang, Fengming Zou, Qingwang Liu, Beilei Wang, Liyi Fu, Xiaofei Liang, Jing Liu, Qingsong Liu
Summary: The NC@Lipo system combines the advantages of drug nanocrystals and liposomes for targeted delivery of hydrophobic drugs to tumors. It offers high drug loading, good colloidal stability, and prolonged circulation, leading to improved tumor accumulation and antitumor efficacy in vivo.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Xiangwei Xu, Yanhua Liu, Shanshan Shao, Jinbo Li, Zhaochu Xu, Yueling Yin, Linxiang Zhao, Yongjun Wang, Dan Liu
Summary: This research improves the drug loading efficiency of poorly water-soluble drugs into liposomes and enhances their anti-tumor effect by designing and synthesizing a series of novel paclitaxel boronic acid derivatives.
Review
Pharmacology & Pharmacy
Danielle E. Large, Rudolf G. Abdelmessih, Elizabeth A. Fink, Debra T. Auguste
Summary: Liposomal drug delivery is a highly adaptable therapeutic platform for treating a wide range of diseases. The molecular diversity in liposome composition enables drug delivery with unique physiological functions, such as pH response and reduced systemic toxicity.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Article
Chemistry, Medicinal
Qi Liu, Lijun Luo, Xiaofeng Gao, Di Zhang, Xinqian Feng, Peng Yang, Hui Li, Shengjun Mao
Summary: AML is a threatening disease with complications, drug resistance, and high recurrence rates. This study explored the synergistic effect of daunorubicin and homoharringtonine in treating AML and developed a folic acid-modified co-delivery system to improve therapeutic efficacy. The results showed that the folic acid-modified co-delivery system exhibited better cellular uptake, cytotoxicity, tumor targeting ability, and safety profile compared to free combinational drugs and non-modified co-delivery system.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Engineering, Environmental
Biao Liu, Jinrong Wang, Yongbo Peng, Hongliang Zeng, Qun Zhang, Minhua Deng, Wei Xiang, Jiahao Liu, Xing Hu, Xuewen Liu, Jianfei Xie, Weibin Hou, Jin Tang, Zhi Long, Long Wang, Jianye Liu
Summary: Conventional chemotherapy cannot specifically target cancer cells, leading to damage to normal tissues and organs. In addition, cancer stem cells (CSCs)-induced tumor regrowth and drug resistance limit the effectiveness of certain chemotherapy drugs. This study developed a CD71/CD44 dual-aptamer-gemcitabine (CD71-CD44-GEMs) conjugate for treating bladder cancer by targeting bladder cancer cells and bladder CSCs. The results showed that CD71-CD44-GEMs had selective binding and high inhibitory effects on bladder cancer both in vitro and in vivo. It also exhibited stronger binding affinity and inhibitory efficacy compared to CD71-GEMs or CD44-GEMs in bladder cancer. Therefore, CD71-CD44-GEMs represents a promising approach for bladder cancer treatment as it can effectively target both bladder cancer cells and CSCs and deliver drugs efficiently.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Yusuke Kono, Renpei Kamino, Soma Hirabayashi, Takuya Kishimoto, Himi Kanbara, Saki Danjo, Mika Hosokawa, Ken-ichi Ogawara
Summary: Mesenchymal stem cells (MSCs) have the potential to target tumors, making them a promising drug carrier for cancer therapy. To ensure the viability and activity of MSCs, it is preferable to load anti-cancer drugs on the surface, rather than directly introducing them into the cells.
Article
Biophysics
Deniz Atila, Dilek Keskin, Yuan-Ling Lee, Feng-Huei Lin, Vasif Hasirci, Aysen Tezcaner
Summary: Injectable hydrogels have potential in dental pulp regeneration due to their ability to fill non-uniform voids. In this study, gelatin methacrylate/thiolated pectin hydrogels carrying electrospun core/shell fibers were designed for vital pulp regeneration. The release of melatonin and Tideglusib from the fibers induced stem cell proliferation and odontoblastic differentiation. This hydrogel system holds promise for pulp tissue regeneration.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Pharmacology & Pharmacy
Heba K. Mohammed-Ahmed, Mustafa Nakipoglu, Aysen Tezcaner, Dilek Keskin, Zafer Evis
Summary: Graphene quantum dots (GQDs) have been widely used in biomedical applications, particularly in anticancer drug delivery. This study investigated the use of graphene oxide quantum dots conjugated with glucosamine and boric acid (GOQDs-GlcN-BA) for cancer therapy. The nanocomposite showed enhanced loading and release of the anticancer drug doxorubicin, as well as increased cytotoxicity against breast cancer cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Materials Science, Ceramics
Hossein Jodati, Aysen Tezcaner, Zafer Evis, Ammar Z. Alshemary, Erdal celik
Summary: In this study, Baghdadite (BAG) nanoparticles with superior properties were successfully synthesized using a modified sol-gel route. The synthesized BAG nanoparticles demonstrated good biocompatibility, bioactivity, and mechanical strength, making them a promising biomaterial for bone defect treatment.
JOURNAL OF THE KOREAN CERAMIC SOCIETY
(2023)
Review
Chemistry, Multidisciplinary
Mustafa Nakipoglu, Aysen Tezcaner, Christopher H. Contag, Nasim Annabi, Nureddin Ashammakhi
Summary: Bioadhesives with antimicrobial properties enable easier and safer treatment of wounds. However, designing these biomaterials with the required properties can be challenging. Developing bioadhesives with tunable physical, chemical, and biological properties is crucial for future advancements.
ADVANCED MATERIALS
(2023)
Article
Polymer Science
Ali Deniz Dalgic, Deniz Atila, Aysen Tezcaner, Senih Gurses, Dilek Keskin
Summary: Sustained release of a bioactive agent from a tissue engineering scaffold is achieved through novel scaffold design using appropriate techniques and materials. In this study, an electrospun scaffold with diatom silica frustules was developed to improve osteogenic activity by controlled melatonin delivery. The polymer coat on the frustules successfully lowered melatonin release, and the developed scaffold system significantly improved ALP activity of Saos-2 cells. The silica nature of diatom frustules holds potential use for bone tissue engineering.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Engineering, Biomedical
Hossein Jodati, Zafer Evis, Aysen Tezcaner, Ammar Z. Alshemary, Ali Motameni
Summary: Composite scaffolds made of boron-doped hydroxyapatite and baghdadite were successfully prepared. The incorporation of baghdadite increased scaffold porosity, surface area, and micropore volumes. The composite scaffolds exhibited higher degradation rates, enhanced cell proliferation, and greater osteogenic differentiation compared to the boron-doped hydroxyapatite scaffolds. Despite being slightly weaker, the compressive strengths of the composite scaffolds were higher than other baghdadite-based composite scaffolds reported in the literature. Overall, the novel composite scaffolds combined the advantages of both components and advanced the development of ideal scaffolds for bone tissue engineering.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Gercem Altunordu, Aysen Tezcaner, Zafer Evis, Dilek Keskin
Summary: This study investigated the use of dual bioceramics in bone tissue engineering scaffolds and compared their properties with other scaffolds. Results showed that the introduction of dual bioceramics improved the mineralization and cell proliferation of the scaffolds, suggesting their potential for bone tissue engineering applications.
Correction
Engineering, Biomedical
Mustafa Bahadir Guner, Ali Deniz Dalgic, Aysen Tezcaner, Sedat Yilanci, Dilek Keskin
BIOMEDICAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Gulhan Isik, Ahmet Engin Pazarceviren, Zafer Evis, Aysen Tezcaner
Summary: This study aimed to develop a biocompatible and osteoconductive bone cement. The results showed that the addition of silk fibroin improved the physical, mechanical, and biological properties of the cement, and promoted osteogenic differentiation of bone cells.
JOURNAL OF MATERIALS RESEARCH
(2023)
Article
Engineering, Biomedical
Ahmet E. Pazarceviren, Zafer Evis, Tayfun Dikmen, Korhan Altunbas, Mustafa Yaprakci, Dilek Keskin, Aysen Tezcaner
Summary: This study fabricated a boron-doped hydroxyapatite (BHT)-loaded alginate/gelatin-based (A/G) hydrogel coating on titanium to support bone integration. The BHT significantly enhanced osteogenic and angiogenic maturation and induced a mild innate immune response. The A/G/BHT coating demonstrated strong adhesion, long shelf-life, and promoted the integration of the implant in a rabbit femur osteochondral model within 2 months.
BIO-DESIGN AND MANUFACTURING
(2023)
Article
Environmental Sciences
Nehir Arik, Evrim Elcin, Aysen Tezcaner, Huseyin A. Oktem
Summary: In recent years, the detrimental effects of heavy metals on the environment and living organisms have become more significant. Monitoring the levels of heavy metals in water using whole-cell bioreporters is crucial. This study immobilized arsenic bacterial bioreporters using polycaprolactone electrospun fibers and evaluated their performance in arsenic detection. The results will contribute to the development of new methods for environmental arsenic monitoring.
ENVIRONMENTAL TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Sanaossadat Sadreddini, Hossein Jodati, Zafer Evis, Dilek Keskin
Summary: Bioceramic/polymer composites have gained considerable attention in recent years for treating hard tissue damage. In this study, we successfully synthesized a novel bioceramic called barium-doped baghdadite (Ba-BAG) and developed fibrous composite polymer scaffolds containing different amounts of baghdadite (BAG) and Ba-BAG for bone regeneration. The presence of BAG and Ba-BAG in the polymer scaffolds increased bioactivity and controlled the degradation rate of the scaffolds.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)