Article
Gastroenterology & Hepatology
Jooyoung Lee, Jung Ho Bae, Su Jin Chung, Hae Yeon Kang, Seung Joo Kang, Min-Sun Kwak, Ji Yeon Seo, Ji Hyun Song, Sun Young Yang, Jong In Yang, Seon Hee Lim, Jeong Yoon Yim, Joo Hyun Lim, Goh Eun Chung, Eun Hyo Jin, Ji Min Choi, Yoo Min Han, Joo Sung Kim
Summary: Comprehensive optical diagnosis training with WASP classification significantly increased the overall SDR of expert endoscopists, while it did not have a significant impact on ADR.
DIGESTIVE ENDOSCOPY
(2022)
Review
Gastroenterology & Hepatology
Takashi Murakami, Taro Kurosawa, Hirofumi Fukushima, Tomoyoshi Shibuya, Takashi Yao, Akihito Nagahara
Summary: The term sessile serrated lesion (SSL) was introduced in the 2019 WHO Classification of Tumours of the Digestive System as an early precursor lesion in the serrated neoplasia pathway. These lesions can quickly progress into dysplastic or invasive carcinomas with high lymphatic invasion potential.
DIGESTIVE ENDOSCOPY
(2022)
Article
Pathology
Filippo Cappello, Valentina Angerilli, Luca Dal Santo, Giada Munari, Marianna Sabbadin, Marcello Lo Mele, Gianmaria Pennelli, Claudio Luchini, Paola Parente, Stefano Lazzi, Matteo Fassan
Summary: Adenomatous dysplasia may develop in sessile serrated lesions (SSL) as part of the serrated lesion. However, some of these lesions may represent collisions between a serrated polyp and a conventional adenoma. Based on mutational analysis and MMR status, we found that adenomatous dysplasia in SSL may develop as part of the serrated lesion, while polyps morphologically classified as mixed lesions are more likely to be collision lesions.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Review
Cell Biology
Iris D. Nagtegaal, Dale C. Snover
Summary: The precursor lesion for around 30% of colon carcinomas, known as sessile serrated adenoma, remains controversial and has sparked debates over alternative names. Despite the term sessile serrated lesion being adopted by the World Health Organization in 2019, universal acceptance is still lacking.
Article
Oncology
Jung Ho Kim, Jeong Hoon Hong, Yoon-La Choi, Ji Ae Lee, Mi-kyoung Seo, Mi-Sook Lee, Sung Bin An, Min Jung Sung, Nam-Yun Cho, Sung-Su Kim, Young Kee Shin, Sangwoo Kim, Gyeong Hoon Kang
Summary: The study revealed that NTRK-rearranged colorectal tumors develop exclusively through the serrated neoplasia pathway and can be initiated from non-dysplastic SSLs without BRAF/KRAS mutations prior to full occurrence of MSI-high/CIMP-high.
JOURNAL OF PATHOLOGY
(2021)
Article
Pathology
Katherine E. Boylan, Priyanka Kanth, Don Delker, Mark W. Hazel, Kenneth M. Boucher, Kajsa Affolter, Fred Clayton, Kimberley J. Evason, Jolanta Jedrzkiewicz, Maria Pletneva, Wade Samowitz, Eric Swanson, Mary P. Bronner
Summary: Colonic SSLs are associated with 30% of colonic adenocarcinomas. Differentiating them from benign HPs is crucial but challenging. This study developed a pathologic scoring system combining morphology, location, and size to better distinguish these polyps. The system showed promising results in improving diagnosis with high reproducibility.
Review
Gastroenterology & Hepatology
Paul P. Shao, Changhan R. Shao, Tahmineh Romero, Felix W. Leung
Summary: This study found that water exchange significantly increases the detection rate of sessile serrated adenomas/polyps, and is superior to Endocuff and cap colonoscopy in detecting them.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Seung Wook Hong, Jeongseok Kim, Ji Young Lee, Jong-Soo Lee, Hye-Sook Chang, Hye Won Park, Gwang-Un Kim, Jiyoung Yoon, Byong Duk Ye, Jeong-Sik Byeon, Seung-Jae Myung, Suk-Kyun Yang, Jaewon Choe, Dong-Hoon Yang
Summary: This study found that individuals with synchronous SSL did not have a significantly increased risk of metachronous HRA/AA, but did have an increased risk of metachronous SSL compared to those without SSL.
DIGESTIVE ENDOSCOPY
(2022)
Article
Pathology
Phoenix D. Bell, Joseph C. Anderson, Amitabh Srivastava
Summary: The serrated pathway of carcinogenesis is still not fully understood, and limitations in endoscopic detection and pathologic interpretation of serrated polyps have implications on risk prediction and surveillance recommendations.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Medicine, General & Internal
Shin Ju Oh, Jung-Wook Kim, Chi Hyuk Oh
Summary: We report a rare case of a large pedunculated polyp with typical histological features of SSLs in the rectum. Endoscopic mucosal resection using a detachable snare was performed on the tumor for definite diagnosis and treatment.
Article
Oncology
Jiayu Li, Liuqing You, Zenghao Xu, Hao Bai, Xinglin Fei, Jinhua Yang, Qilong Li, Sangni Qian, Shujuan Lin, Mengling Tang, Jianbing Wang, Kun Chen, Mingjuan Jin
Summary: The study found that there is an inverse association between a healthy lifestyle and the risk of colorectal cancer precursors, particularly in the serrated pathway. Individuals with the healthiest lifestyle had a significantly lower risk of adenoma and serrated polyps compared to those with the least healthy lifestyle.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Toshihiro Nishizawa, Shuntaro Yoshida, Akira Toyoshima, Tomoharu Yamada, Yoshiki Sakaguchi, Taiga Irako, Hirotoshi Ebinuma, Takanori Kanai, Kazuhiko Koike, Osamu Toyoshima
Summary: This study aimed to develop a diagnostic score system for sessile serrated lesions (SSLs). The research found that tumor size, mucus cap, and indistinct borders were significant endoscopic features for the diagnosis of SSLs, and serrated polyps with these features should be removed during colonoscopy.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Microbiology
Heihachiro Nishimura, Hirokazu Fukui, Xuan Wang, Nobuhiko Ebisutani, Takashi Nakanishi, Toshihiko Tomita, Tadayuki Oshima, Seiichi Hirota, Hiroto Miwa
Summary: The study suggests that Fusobacterium nucleatum may play a role in the proliferation of sessile serrated adenoma/polyps (SSA/Ps) by promoting nuclear translocation of beta-catenin and expression of REG I alpha.
Article
Oncology
Daisuke Ohki, Nobutake Yamamichi, Yoshiki Sakaguchi, Yu Takahashi, Natsuko Kageyama-Yahara, Mitsue Yamamichi, Chihiro Takeuchi, Yosuke Tsuji, Yasuhiro Sakai, Kouhei Sakurai, Shuta Tomida, Kazuhiko Koike, Mitsuhiro Fujishiro
Summary: This study elucidates the gene expression characteristics of sessile serrated adenoma/polyp (SSA/P), showing a strong resemblance to microsatellite instability-high (MSI-H) colorectal cancer (CRC). The downregulation of CDX2 expression plays an essential molecular mechanism in the initial stage of SSA/P tumorigenesis.
Article
Gastroenterology & Hepatology
Jun Li, Kan Chen, Yunlei Wei, Di Zhang, Yuxin Wang, Xiaojia Hou, Ruijin Wu, Kangsheng Peng, Lei Li, Chao Huang, Yilong Wang, Linjuan Xun, Feng Liu
Summary: This study compared the effectiveness of LCI and NBI in detecting colorectal SSLs, and found no significant difference between the two methods. Both LCI and NBI were equally effective in detecting polyps and adenomas. Factors associated with SSL detection were bowel preparation score, withdrawal time, and operator experience.
