The Molecular Mechanism of Vitamin E as a Bone-Protecting Agent: A Review on Current Evidence

Effects of tocotrienol from Bixa orellana (annatto) on bone histomorphometry in a male osteoporosis model induced by buserelin

(2018) Nur-Vaizura Mohamad et al.   BIOMEDICINE & PHARMACOTHERAPY

Osteoporosis is associated with metabolic syndrome induced by high-carbohydrate high-fat diet in a rat model

(2018) Sok Kuan Wong et al.   BIOMEDICINE & PHARMACOTHERAPY

Exploring the potential of tocotrienol from Bixa orellana as a single agent targeting metabolic syndrome and bone loss

(2018) Sok Kuan Wong et al.   BONE

Tocotrienol supplementation suppressed bone resorption and oxidative stress in postmenopausal osteopenic women: a 12-week randomized double-blinded placebo-controlled trial

(2018) C.-L. Shen et al.   OSTEOPOROSIS INTERNATIONAL

Effects of metabolic syndrome on bone mineral density, histomorphometry and remodelling markers in male rats

(2018) Sok Kuan Wong et al.   PLoS One

The effects of palm tocotrienol on metabolic syndrome and bone loss in male rats induced by high-carbohydrate high-fat diet

(2018) Sok Kuan Wong et al.   Journal of Functional Foods

Effect of tocotrienol from Bixa orellana (annatto) on bone microstructure, calcium content, and biomechanical strength in a model of male osteoporosis induced by buserelin

(2018) Nur Vaizura Mohamad et al.   Drug Design Development and Therapy

Annatto-derived tocotrienol stimulates osteogenic activity in preosteoblastic MC3T3-E1 cells: a temporal sequential study

(2018) Wan Nuraini Wan Hasan et al.   Drug Design Development and Therapy

Gamma-Tocotrienol Stimulates the Proliferation, Differentiation, and Mineralization in Osteoblastic MC3T3-E1 Cells

(2018) Weili Xu et al.   Journal of Chemistry

Interferon-Gamma-Mediated Osteoimmunology

(2018) Mengjia Tang et al.   Frontiers in Immunology

The bone remodelling cycle

(2018) JS Kenkre et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Annatto-extracted tocotrienols improve glucose homeostasis and bone properties in high-fat diet-induced type 2 diabetic mice by decreasing the inflammatory response

(2018) Chwan-Li Shen et al.   Scientific Reports

The Effects of Vitamin E from Elaeis guineensis (Oil Palm) in a Rat Model of Bone Loss Due to Metabolic Syndrome

(2018) Sok Wong et al.   International Journal of Environmental Research and Public Health

High-Dietary Alpha-Tocopherol or Mixed Tocotrienols Have No Effect on Bone Mass, Density, or Turnover in Male Rats During Skeletal Maturation

(2017) Katherine G. Tennant et al.   JOURNAL OF MEDICINAL FOOD

The Effects of Tocotrienol and Lovastatin Co-Supplementation on Bone Dynamic Histomorphometry and Bone Morphogenetic Protein-2 Expression in Rats with Estrogen Deficiency

(2017) Kok-Yong Chin et al.   Nutrients

Plasma leptin values in postmenopausal women with osteoporosis

(2017) Hikmet Kocyigit et al.   Bosnian Journal of Basic Medical Sciences

Association of serum leptin with bone mineral density in postmenopausal osteoporotic females

(2016) Saba Tariq et al.   GYNECOLOGICAL ENDOCRINOLOGY

The roles of interferons in osteoclasts and osteoclastogenesis

(2016) Qi Xiong et al.   JOINT BONE SPINE

Vitamin E homologues α- and γ-tocopherol are not associated with bone turnover markers or bone mineral density in peri-menopausal and post-menopausal women

(2016) T. C. Yang et al.   OSTEOPOROSIS INTERNATIONAL

The Effects of Annatto Tocotrienol on Bone Biomechanical Strength and Bone Calcium Content in an Animal Model of Osteoporosis Due to Testosterone Deficiency

(2016) Kok-Yong Chin et al.   Nutrients

MicroRNA-194 promotes osteoblast differentiation via downregulating STAT1

(2015) Jun Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Roles of leptin in bone metabolism and bone diseases

(2015) Xu Xu Chen et al.   JOURNAL OF BONE AND MINERAL METABOLISM

DCIR Maintains Bone Homeostasis by Regulating IFN-γ Production in T Cells

(2015) Takumi Maruhashi et al.   JOURNAL OF IMMUNOLOGY

The PI3K/AKT cell signaling pathway is involved in regulation of osteoporosis

(2015) Jian-Cheng Xi et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

The use of delta-tocotrienol and lovastatin for anti-osteoporotic therapy

(2015) Saif Abdul-Majeed et al.   LIFE SCIENCES

The biological effects of tocotrienol on bone: a review on evidence from rodent models

(2015) Kok-Yong Chin et al.   Drug Design Development and Therapy

The Effects of Targeted Deliveries of Lovastatin and Tocotrienol on Ossification-Related Gene Expressions in Fracture Healing in an Osteoporosis Rat Model

(2015) Nurul Ibrahim et al.   International Journal of Environmental Research and Public Health

Insulin-like growth factor-1 is a mediator of age-related decline of bone health status in men

(2014) Kok-Yong Chin et al.   Aging Male

MicroRNA-17/20a inhibits glucocorticoid-induced osteoclast differentiation and function through targeting RANKL expression in osteoblast cells

(2014) Changgui Shi et al.   BONE

γ-Tocotrienol protects against ovariectomy-induced bone loss via mevalonate pathway as HMG-CoA reductase inhibitor

(2014) Lili Deng et al.   BONE

Annatto Tocotrienol Improves Indices of Bone Static Histomorphometry in Osteoporosis Due to Testosterone Deficiency in Rats

(2014) Kok-Yong Chin et al.   Nutrients

The Effects of α-Tocopherol on Bone: A Double-Edged Sword?

(2014) Kok-Yong Chin et al.   Nutrients

Effects of annatto-derived tocotrienol supplementation on osteoporosis induced by testosterone deficiency in rats

(2014) Kok-Yong Chin et al.   Clinical Interventions in Aging

Tocotrienol supplementation in postmenopausal osteoporosis: evidence from a laboratory study

(2013) N Muhammad et al.   Clinics

Update on Statins: Hope for Osteoporotic Fracture Healing Treatment

(2013) Nurul Ibrahim et al.   CURRENT DRUG TARGETS

Effects of vitamin E on expressions of eight microRNAs in the liver of Nile tilapia (Oreochromis niloticus)

(2013) Xue-Lian Tang et al.   FISH & SHELLFISH IMMUNOLOGY

Direct Inhibition of Osteoclast Formation and Activity by the Vitamin E Isomer gamma-Tocotrienol

(2013) Brooks et al.   INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH

Osteogenic Activity of Collagen Peptide via ERK/MAPK Pathway Mediated Boosting of Collagen Synthesis and Its Therapeutic Efficacy in Osteoporotic Bone by Back-Scattered Electron Imaging and Microarchitecture Analysis

(2013) Hye Kim et al.   MOLECULES

Effect of interferon-γ on the fusion of mononuclear osteoclasts into bone-resorbing osteoclasts

(2012) Jeung-Woo Kim et al.   BMB Reports

Effects of Palm Vitamin E on Bone-Formation-Related Gene Expression in Nicotine-Treated Rats

(2012) Seham Salem Ahmed Abukhadir et al.   Evidence-based Complementary and Alternative Medicine

Two Different Isomers of Vitamin E Prevent Bone Loss in Postmenopausal Osteoporosis Rat Model

(2012) Norliza Muhammad et al.   Evidence-based Complementary and Alternative Medicine

Effects of Tocotrienol and Lovastatin Combination on Osteoblast and Osteoclast Activity in Estrogen-Deficient Osteoporosis

(2012) Saif Abdul-Majeed et al.   Evidence-based Complementary and Alternative Medicine

Effects of Low-Dose versus High-Doseγ-Tocotrienol on the Bone Cells Exposed to the Hydrogen Peroxide-Induced Oxidative Stress and Apoptosis

(2012) Nizar Abd Manan et al.   Evidence-based Complementary and Alternative Medicine

TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation

(2012) Guiqian Chen et al.   International Journal of Biological Sciences

Vitamin E decreases bone mass by stimulating osteoclast fusion

(2012) Koji Fujita et al.   NATURE MEDICINE

Inflammatory bone loss: pathogenesis and therapeutic intervention

(2012) Kurt Redlich et al.   NATURE REVIEWS DRUG DISCOVERY

Interferon Gamma Inhibits Adipogenesis In Vitro and Prevents Marrow Fat Infiltration in Oophorectomized Mice

(2012) Christopher Vidal et al.   STEM CELLS

Palm Tocotrienol Supplementation Enhanced Bone Formation in Oestrogen-Deficient Rats

(2012) Ima Nirwana Soelaiman et al.   International Journal of Endocrinology

An in vitro study of osteoblast vitality influenced by the vitamins C and E

(2012) Kent Urban et al.   Head & Face Medicine

Disorders of Bone Remodeling

(2011) Xu Feng et al.   Annual Review of Pathology-Mechanisms of Disease

Vitamin E reversed nicotine-induced toxic effects on bone biochemical markers in male rats

(2011) Mohamed Norazlina et al.   Archives of Medical Science

α-Tocotrienol inhibits osteoclastic bone resorption by suppressing RANKL expression and signaling and bone resorbing activity

(2011) Hyunil Ha et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

IFN-γ directly inhibits TNF-α-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas/Fas ligand interactions

(2011) Haruka Kohara et al.   IMMUNOLOGY LETTERS

Osteoblast-specific Transcription Factor Osterix (Osx) Is an Upstream Regulator of Satb2 during Bone Formation

(2011) Wanjin Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fibroblast Growth Factor 2 Stimulation of Osteoblast Differentiation and Bone Formation Is Mediated by Modulation of the Wnt Signaling Pathway

(2011) Yurong Fei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanisms of the Biphasic Effects of Interferon-γ on Osteoclastogenesis

(2011) Jing Cheng et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

RANKL/RANK—beyond bones

(2011) Reiko Hanada et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Effects of α-tocopherol on the early phase of osteoporotic fracture healing

(2011) Ahmad Nazrun Shuid et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Parathyroid hormone regulates osteoblast differentiation in a Wnt/β-catenin-dependent manner

(2011) Ye Tian et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The effects of adiponectin and leptin on changes in bone mineral density

(2011) K. E. Barbour et al.   OSTEOPOROSIS INTERNATIONAL

A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2

(2011) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Roles of SATB2 in Osteogenic Differentiation and Bone Regeneration

(2011) Jin Zhang et al.   TISSUE ENGINEERING PART A

Forkhead Homeobox Type O Transcription Factors in the Responses to Oxidative Stress

(2010) Peter Storz   ANTIOXIDANTS & REDOX SIGNALING

Osteoporosis and inflammation

(2010) Paulo Gustavo Sampaio Lacativa et al.   Arquivos Brasileiros de Endocrinologia e Metabologia

Association of Oxidative Stress with Postmenopausal Osteoporosis and the Effects of Hydrogen Peroxide on Osteoclast Formation in Human Bone Marrow Cell Cultures

(2010) Ki Hyun Baek et al.   CALCIFIED TISSUE INTERNATIONAL

Neogenin, a Receptor for Bone Morphogenetic Proteins

(2010) Meiko Hagihara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beneficial effects of vitamin E isomer supplementation on static and dynamic bone histomorphometry parameters in normal male rats

(2010) Muhammad Zulfadli Mehat et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms

(2010) Robert L Jilka et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Adiponectin increases BMP-2 expression in osteoblasts via AdipoR receptor signaling pathway

(2010) Chun-Yin Huang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Supplementation of ascorbic acid and alpha-tocopherol is useful to preventing bone loss linked to oxidative stress in elderly

(2010) M. Ruiz-Ramos et al.   Journal of Nutrition Health & Aging

Effects of Vitamin E on the Osteoblast Differentiation

(2010) Satoshi SOETA et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Effect of adiponectin on ATDC5 proliferation, differentiation and signaling pathways

(2010) T. Delessa Challa et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner

(2009) Kana Miyamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effect of local sequential VEGF and BMP-2 delivery on ectopic and orthotopic bone regeneration

(2009) Diederik H.R. Kempen et al.   BIOMATERIALS

Oxidative stress and bone mineral density in elderly men: Antioxidant activity of alpha-tocopherol

(2009) Bengt Östman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Trolox Prevents Osteoclastogenesis by Suppressing RANKL Expression and Signaling

(2009) Jong-Ho Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vitamin E exhibits bone anabolic actions in normal male rats

(2009) Ahmad Nazrun Shuid et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Monocyte Chemoattractant Protein-1 (MCP-1): An Overview

(2009) Satish L. Deshmane et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Oxidative stress and metabolic syndrome

(2009) Christian K. Roberts et al.   LIFE SCIENCES

Palm Tocotrienol Exerted Better Antioxidant Activities in Bone than α-Tocopherol

(2008) Sandra Maniam et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

IGF-I secreted by osteoblasts acts as a potent chemotactic factor for osteoblasts

(2008) Manando Nakasaki et al.   BONE

Beneficial Effects of Tocotrienol and Tocopherol on Bone Histomorphometric Parameters in Sprague–Dawley Male Rats After Nicotine Cessation

(2008) Hapidin Hermizi et al.   CALCIFIED TISSUE INTERNATIONAL

Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease

(2008) Ann E. Kearns et al.   ENDOCRINE REVIEWS

Vitamin E dependent microRNA regulation in rat liver

(2008) Sonja Gaedicke et al.   FEBS LETTERS

Tocotrienol Suppresses Adipocyte Differentiation and Akt Phosphorylation in 3T3-L1 Preadipocytes

(2008) Harumi Uto-Kondo et al.   JOURNAL OF NUTRITION

Oxidative stress in normal and impaired wound repair

(2008) M SCHAFER et al.   PHARMACOLOGICAL RESEARCH

Increased adipogenesis of osteoporotic human-mesenchymal stem cells (MSCs) characterizes by impaired leptin action

(2007) Pablo Astudillo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY