m6A Reader YTHDF2 Regulates LPS-Induced Inflammatory Response

ZFP36L1 and AUF1 Induction Contribute to the Suppression of Inflammatory Mediators Expression by Globular Adiponectin via Autophagy Induction in Macrophages

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HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g

(2018) Xiaoli Cai et al.   CANCER LETTERS

Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism

(2018) Ying Yang et al.   CELL RESEARCH

MKK4 from Litopenaeus vannamei is a regulator of p38 MAPK kinase and involved in anti-bacterial response

(2018) Sheng Wang et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2

(2018) Mengnuo Chen et al.   HEPATOLOGY

Wood-cultivated ginseng exerts anti-inflammatory effect in LPS-stimulated RAW264.7 cells

(2018) Su Bin Park et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

K313, a novel benzoxazole derivative, exhibits anti-inflammatory properties via inhibiting GSK3β activity in LPS-induced RAW264.7 macrophages

(2018) Bo-Bo Zhao et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Anti-inflammatory sesquiterpenoids from the Traditional Chinese Medicine Salvia plebeia : Regulates pro-inflammatory mediators through inhibition of NF-κB and Erk1/2 signaling pathways in LPS-induced Raw264.7 cells

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Tryptophan-Mediated Interactions between Tristetraprolin and the CNOT9 Subunit Are Required for CCR4-NOT Deadenylase Complex Recruitment

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Pterostilbene and 4′-Methoxyresveratrol Inhibited Lipopolysaccharide-Induced Inflammatory Response in RAW264.7 Macrophages

(2018) Yun Yao et al.   MOLECULES

Regulation of the ARE-binding proteins, TTP (tristetraprolin) and HuR (human antigen R), in inflammatory response in astrocytes

(2018) Alina A. Astakhova et al.   NEUROCHEMISTRY INTERNATIONAL

Modification of N6-methyladenosine RNA methylation on heat shock protein expression

(2018) Jiayao Yu et al.   PLoS One

RNA epitranscriptomics: Regulation of infection of RNA and DNA viruses by N 6 -methyladenosine (m6 A)

(2018) Brandon Tan et al.   REVIEWS IN MEDICAL VIROLOGY

N6-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi's sarcoma-associated herpesvirus infection

(2018) Charles R. Hesser et al.   PLoS Pathogens

YTH Domain: A Family of N 6 -methyladenosine (m 6 A) Readers

(2018) Shanhui Liao et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion

(2018) Zhenrui Li et al.   CELL RESEARCH

Targeted m6A Reader Proteins To Study Epitranscriptomic Regulation of Single RNAs

(2018) Simone Rauch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma

(2018) Li Zhong et al.   CANCER LETTERS

Pathogenetic insights from the treatment of rheumatoid arthritis

(2017) Iain B McInnes et al.   LANCET

m 6 A Facilitates eIF4F-Independent mRNA Translation

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MAP4K4 is a novel MAPK/ERK pathway regulator required for lung adenocarcinoma maintenance

(2017) Xuan Gao et al.   Molecular Oncology

m6A modulates haematopoietic stem and progenitor cell specification

(2017) Chunxia Zhang et al.   NATURE

Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance

(2017) A Visvanathan et al.   ONCOGENE

The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation

(2016) Christopher Tiedje et al.   NUCLEIC ACIDS RESEARCH

m6A: Signaling for mRNA splicing

(2016) Samir Adhikari et al.   RNA Biology

Map4k4 Signaling Nodes in Metabolic and Cardiovascular Diseases

(2016) Joseph V. Virbasius et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

YTHDF2 destabilizes m6A-containing RNA through direct recruitment of the CCR4–NOT deadenylase complex

(2016) Hao Du et al.   Nature Communications

Thioredoxin Activates MKK4-NFκB Pathway in a Redox-dependent Manner to Control Manganese Superoxide Dismutase Gene Expression in Endothelial Cells

(2015) Venkatesh Kundumani-Sridharan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipopolysaccharide-induced tumor necrosis factor-α factor enhances inflammation and is associated with cancer (Review)

(2015) JUNRONG ZOU et al.   Molecular Medicine Reports

m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

(2015) Shay Geula et al.   SCIENCE

Endothelial protein kinase MAP4K4 promotes vascular inflammation and atherosclerosis

(2015) Rachel J. Roth Flach et al.   Nature Communications

Crystal structure of the YTH domain of YTHDF2 reveals mechanism for recognition of N6-methyladenosine

(2014) Tingting Zhu et al.   CELL RESEARCH

Structure of the YTH domain of human YTHDF2 in complex with an m6A mononucleotide reveals an aromatic cage for m6A recognition

(2014) Fudong Li et al.   CELL RESEARCH

MAP4K4 deletion inhibits proliferation and activation of CD4+ T cell and promotes T regulatory cell generation in vitro

(2014) Hongpeng Huang et al.   CELLULAR IMMUNOLOGY

A census of human RNA-binding proteins

(2014) Stefanie Gerstberger et al.   NATURE REVIEWS GENETICS

Transcriptome-wide N6-methyladenosine profiling of rice callus and leaf reveals the presence of tissue-specific competitors involved in selective mRNA modification

(2014) Yuli Li et al.   RNA Biology

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

Structural basis for the recruitment of the human CCR4–NOT deadenylase complex by tristetraprolin

(2013) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE