Review
Biochemistry & Molecular Biology
Yongxia Zhao, Xiaochun Ye, Zhifeng Xiong, Awais Ihsan, Irma Ares, Marta Martinez, Bernardo Lopez-Torres, Maria-Rosa Martinez-Larranaga, Arturo Anadon, Xu Wang, Maria-Aranzazu Martinez
Summary: This review summarizes the role of increased ROS in DNA damage and the apoptosis of cancer cells caused by changes in cancer cell metabolism, as well as various anticancer therapies targeting ROS generation, in order to provide references for cancer therapies based on ROS generation.
Review
Biochemistry & Molecular Biology
Michel Fasnacht, Norbert Polacek
Summary: Since the great oxidation event, Earth's cellular life forms have had to deal with reactive oxygen species (ROS) affecting biomolecules and cellular metabolism. Increased ROS levels in the biosphere represent growing stress and shape species evolution. Systems have evolved to remove ROS and repair damage, but oxidative stress occurs if ROS surpass the cell's capacity.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Xiaochen Xie, Ye Zhang, Zhuo Wang, Shanshan Wang, Xiaoyou Jiang, Hongyan Cui, Tingting Zhou, Zheng He, Hao Feng, Qiqiang Guo, Xiaoyu Song, Liu Cao
Summary: ROS, initially considered pathological, are now recognized as signaling intermediates that promote cellular adaptation to stress through autophagy regulation. ATM protein, activated by ROS, is involved in autophagy regulation, maintaining genome stability and triggering cytoplasmic autophagy as a ROS sensor.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Ana Mesquita, James Glenn, Andreas Jenny
Summary: Autophagy is a major catabolic pathway crucial for cellular homeostasis and stress response. Endosomal microautophagy can be induced under stress conditions and regulated by various signaling pathways, suggesting its important role in disease prevention.
Article
Environmental Sciences
Sonalin Rath, Surajit Das
Summary: Bacteria thriving in the mangrove ecosystem play a significant role in elemental cycles, but their performance is influenced by climate change and environmental stressors. This study investigates the genotoxic effect of such stressors on mangrove bacteria and their adaptation strategies. The results show cellular injuries and DNA damage in response to stressors, with different bacterial strains exhibiting varying levels of tolerance and adaptive mechanisms.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Emily Ho, Carmen P. Wong, Janet C. King
Summary: Dr. Bruce Ames pioneered the understanding of oxidative stress, DNA damage, and the connection between micronutrient deficiencies and DNA damage. Zinc is essential for human health, playing a critical role in cellular antioxidant defense, DNA integrity, and immune function. Studies have shown that zinc deficiency is associated with oxidative stress, susceptibility to DNA damage, and chronic inflammation, emphasizing the importance of adequate nutrition for healthy aging.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Microbiology
Li Dong, Jianran Qin, Luyang Tai, Kangyi Mou, Xiaojun Liao, Fang Chen, Xiaosong Hu
Summary: The curcumin-mediated photodynamic technology (Cur-PDT) was found to effectively inactivate Bacillus subtilis by inducing cell redox state imbalance, damaging DNA, and disrupting membrane structures.
Review
Biochemistry & Molecular Biology
Meihui Wang, Zixu Wang, Yaoxing Chen, Yulan Dong
Summary: The rapid growth of obesity worldwide has had a significant impact on the prevalence of chronic kidney disease, particularly in developing countries. Obesity has been strongly associated with chronic kidney disease and is an independent risk factor for kidney disease. Histological changes in obesity-induced renal injury include glomerular or tubular hypertrophy, focal segmental glomerulosclerosis or bulbous sclerosis. Inflammation, renal hemodynamic changes, insulin resistance, and lipid metabolism disorders are all involved in the development and progression of obesity-induced nephropathy. However, there is currently no targeted treatment for obesity-related kidney disease. This review presents the use of RAS inhibitors, SGLT2 inhibitors, and melatonin to treat obesity-induced kidney injury. Melatonin, in particular, has shown potential in protecting against kidney damage caused by obesity through inhibiting inflammation and oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Antonio Rivas-Dominguez, Nuria Pastor, Laura Martinez-Lopez, Julia Colon-Perez, Beatriz Bermudez, Manuel Luis Orta
Summary: The high incidence of colorectal cancer in developed countries suggests a significant role of the environment as a causative factor. Dysbiosis, characterized by an unbalanced microbiota, can lead to intestinal damage and inflammation, promoting the occurrence of CRC.
Article
Oncology
Jiajing Niu, Jiamei Wang, Qi Zhang, Zhihua Zou, Yushuang Ding
Summary: The study revealed that sublethal doses of cinobufagin suppressed the viability of cancer cells by inducing oxidative stress, leading to DNA damage and cell cycle regulation that ultimately resulted in the induction of apoptosis.
CANCER CELL INTERNATIONAL
(2021)
Review
Food Science & Technology
Goran Gajski, Marko Geric, Ivone Jakasa, Ines Peremin, Ana-Marija Domijan, Marijana Vucic Lovrencic, Sanja Kezic, Martina Bituh, Vanessa Moraes de Andrade
Summary: The health benefits of a vegetarian diet are still debated, but it may have positive effects on oxidative stress and inflammation, while its impact on immune biomarkers is inconclusive.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Ruolei Wang, Lirong Liang, Misaki Matsumoto, Kazumi Iwata, Atsushi Umemura, Feng He
Summary: The imbalance between reactive oxygen species (ROS) production and clearance causes oxidative stress and plays a central role in regulating cell and tissue physiology and pathology. ROS can either stimulate cancer survival and growth or cause cell death depending on their concentration. The transcription factor NRF2 has dual roles in carcinogenesis, where short-term activation suppresses tissue injury, inflammation, and cancer initiation, while constitutive activation confers advantages for cancer cells' survival and growth. NRF2 hyperactivation, as an adaptive cancer phenotype, regulates multiple aspects of cancer development, metastasis, and resistance to anticancer therapy.
Article
Environmental Sciences
Priyanka Prasad, Sushant Kumar Singh, Sukanya Ghosh, Suchisnigdha Dutta, Dona Sinha
Summary: This study investigated the impact of different exposure levels of arsenic in groundwater on cellular redox status, DNA damage, and repair mechanisms in rural women of West Bengal. The results showed a dose-dependent relationship between arsenic exposure levels and oxidative stress, DNA damage, and suppression of DNA repair proteins. Additionally, the exposed population had a very high risk of cancer.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Geriatrics & Gerontology
S. G. Chowdhury, S. Misra, Parimal Karmakar
Summary: Ageing is a multi-factorial phenomenon, and accumulation of DNA damage or mutations is a dominant theory which contributes largely to the development of ageing and age-related diseases. Obesity is a complex chronic disease that affects multiple organs and tissues, and it has been found to be associated with higher loads of DNA damage. The present review focuses on the involvement of DNA metabolism in the development of obesity and how it accelerates ageing in mammals.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Review
Medicine, Research & Experimental
Satomi Miwa, Sonu Kashyap, Eduardo Chini, Thomas von Zglinicki
Summary: This article summarizes the importance of mitochondrial dysfunction in aging and cell senescence, discusses its relationship with cellular senescence, and proposes an anti-aging therapy that targets mitochondrial dysfunction.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Biochemistry & Molecular Biology
Michal Ciebiera, Marta Wlodarczyk, Stanislaw Zgliczynski, Tomasz Lozinski, Klaudia Walczak, Artur Czekierdowski
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Pharmacology & Pharmacy
Grazyna Kubiak-Tomaszewska, Piotr Tomaszewski, Jan Pachecka, Marta Struga, Wioletta Olejarz, Magdalena Mielczarek-Puta, Grazyna Nowicka
Article
Environmental Sciences
Aneta Slabuszewska-Jozwiak, Marta Wlodarczyk, Krzysztof Kilian, Zbigniew Rogulski, Michal Ciebiera, Jolanta Szymanska-Majchrzak, Kornelia Zareba, Jacek Krzysztof Szymanski, Dorota Raczkiewicz, Grazyna Nowicka, Grzegorz Jakiel
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Review
Biochemistry & Molecular Biology
Marta Wlodarczyk, Grazyna Nowicka, Michal Ciebiera, Mohamed Ali, Qiwei Yang, Ayman Al-Hendy
Summary: Uterine fibroids are benign tumors that can cause gynecologic and reproductive dysfunction. DNA methylation and demethylation reactions, regulated by TET enzymes, play a role in gene expression regulation. Dysregulation of TET enzymes may contribute to the development of uterine fibroids. Understanding the role of epigenetics in the pathogenesis of uterine fibroids may lead to the development of new fertility-sparing treatment methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Stepan Feduniw, Zuzanna Gaca, Olga Malinowska, Weronika Brunets, Magdalena Zgliczynska, Marta Wlodarczyk, Anna Wojcikiewicz, Michal Ciebiera
Summary: This study reviews the challenges and treatment options for preterm premature rupture of the membranes at the limit of viability, and proposes possible directions for future development.
Review
Oncology
Marta Wlodarczyk, Beata Pyrzynska
Summary: New approaches in adoptive immunotherapy using CAR-modified cells have been developing quickly, showing promise in clinical trials and gaining acceptance by global health agencies. While CAR-T therapy has proven effective in treating blood disorders, it is less efficient against solid tumors. Research is ongoing to modify CAR constructs and use different immune cells to improve efficacy and safety. This review focuses on recent achievements and the benefits of genetic engineering of NK cells in CAR therapy.
Review
Pharmacology & Pharmacy
Mohamed Ali, Michal Ciebiera, Marta Wlodarczyk, Samar Alkhrait, Elise Maajid, Qiwei Yang, Shih-Min Hsia, Ayman Al-Hendy
Summary: Uterine fibroids are the most common benign neoplasm in reproductive age women, and current treatment options have limitations. There is an urgent need for safe and effective non-surgical treatments.
Editorial Material
Obstetrics & Gynecology
Michal Ciebiera, Monika Abramiuk, Pawel Bartnik, Stepan Feduniw, Joanna Kacperczyk-Bartnik, Marta Wlodarczyk, Natalia Zeber-Lubecka
Summary: We are announcing a new vision for the Journal of Endometriosis and Pelvic Pain Disorders. Thanks to the contributions of former Editors-in-Chief, Associate Editors, and Editorial Board members, as well as our readers, the journal has a stable base and is continuing to grow. Our audience consists mainly of clinicians and scientists in the field of gynecology, particularly those focused on minimally-invasive gynecology and the pathophysiology of conditions like endometriosis, pelvic pain, and uterine fibroids. We publish high quality peer-reviewed research articles and reviews on the diagnosis and treatment of these conditions. Moving forward, we will prioritize addressing important current problems, controversial topics, and unresolved issues related to these poorly understood pathologies.
JOURNAL OF ENDOMETRIOSIS AND PELVIC PAIN DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Beata Jablonowska-Lietz, Grazyna Nowicka, Marta Wlodarczyk, Slawomir Rejowski, Maria Stasiowska, Malgorzata Wrzosek
Summary: This study investigated early predictors of effective weight loss to determine more effective therapeutic interventions. It found that the FTO rs9930506 gene variant had no effect on weight loss, while changes in weight were associated with changes in carbohydrate metabolism. Initial weight loss was the most predictive factor of weight loss success after 12 weeks.
Review
Obstetrics & Gynecology
Joanna Kacperczyk-Bartnik, Natalia Zeber-Lubecka, Stepan Feduniw, Pawel Bartnik, Marta Wlodarczyk, Monika Abramiuk, Michal Ciebiera
Summary: Previously, laparoscopic surgery was the gold standard for diagnosing endometriosis, but the latest guidelines recommend surgery only in certain cases and discourage the use of biomarker measurement for diagnosis. This narrative review explores non-invasive diagnostic approaches for endometriosis and critically analyzes studies cited in recent guidelines.
JOURNAL OF ENDOMETRIOSIS AND PELVIC PAIN DISORDERS
(2023)
Article
Medicine, General & Internal
Michal Ciebiera, Malgorzata Wrzosek, Cezary Wojtyla, Kornelia Zareba, Grazyna Nowicka, Grzegorz Jakiel, Marta Wlodarczyk
Summary: No significant association was found between three VDR polymorphisms and the incidence of uterine fibroids in Caucasian women. Larger sample sizes and studies involving multiple ethnic groups are needed for further investigation.
ARCHIVES OF MEDICAL SCIENCE
(2021)
