MRN (MRE11-RAD50-NBS1) Complex in Human Cancer and Prognostic Implications in Colorectal Cancer

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

DNA damage response and repair in colorectal cancer: Defects, regulation and therapeutic implications

(2018) Mohammad Mirza-Aghazadeh-Attari et al.   DNA REPAIR

Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis

(2018) Vincent Ho et al.   BMC CANCER

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Are Colon and Rectal Cancer Two Different Tumor Entities? A Proposal to Abandon the Term Colorectal Cancer

(2018) Stephan Paschke et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Early Postoperative Low Expression of RAD50 in Rectal Cancer Patients Associates with Disease-Free Survival

(2017) Vincent Ho et al.   Cancers

High Expression of MRE11–RAD50–NBS1 Is Associated with Poor Prognosis and Chemoresistance in Gastric Cancer

(2016) BOLAG LTAN et al.   ANTICANCER RESEARCH

Current topics in the multimodality treatment of locally advanced rectal cancer

(2016) Suzanne Russo et al.   Future Oncology

Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer

(2016) Daniel Chubb et al.   Nature Communications

MRE11 and ATM Expression Levels Predict Rectal Cancer Survival and Their Association with Radiotherapy Response

(2016) Vincent Ho et al.   PLoS One

The interplay between DNA repair and autophagy in cancer therapy

(2015) Dan Zhang et al.   CANCER BIOLOGY & THERAPY

Rectal and colon cancer: Not just a different anatomic site

(2015) K. Tamas et al.   CANCER TREATMENT REVIEWS

Targeting the DNA Damage Response in Cancer

(2015) Mark J. O’Connor   MOLECULAR CELL

Expression of DNA double-strand break repair proteins predicts the response and prognosis of colorectal cancer patients undergoing oxaliplatin-based chemotherapy

(2015) KEISUKE IHARA et al.   ONCOLOGY REPORTS

ATM and ATR as therapeutic targets in cancer

(2015) Anika Maria Weber et al.   PHARMACOLOGY & THERAPEUTICS

Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair

(2015) Julien Lafrance-Vanasse et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Colorectal cancer

(2015) Ernst J. Kuipers et al.   Nature Reviews Disease Primers

Multicenter retrospective analysis of metastatic colorectal cancer (CRC) with high-level microsatellite instability (MSI-H)

(2014) J. Goldstein et al.   ANNALS OF ONCOLOGY

Predictive markers of radiotherapy-induced rectal cancer regression

(2014) J-S Shin et al.   JOURNAL OF CLINICAL PATHOLOGY

Concerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - Implication in modification of radiation damage

(2014) Anuranjani et al.   Redox Biology

Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity

(2013) Kevin M. Foote et al.   JOURNAL OF MEDICINAL CHEMISTRY

Colorectal cancer

(2013) Hermann Brenner et al.   LANCET

The MRN protein complex genes: MRE11 and RAD50 and susceptibility to head and neck cancers

(2013) Iwona Ziółkowska-Suchanek et al.   Molecular Cancer

Molecular Pathways: Microsatellite Instability in Colorectal Cancer: Prognostic, Predictive, and Therapeutic Implications

(2012) F. A. Sinicrope et al.   CLINICAL CANCER RESEARCH

Role of MRE11 in Cell Proliferation, Tumor Invasion, and DNA Repair in Breast Cancer

(2012) Shyng-Shiou F. Yuan et al.   JNCI-Journal of the National Cancer Institute

MRE11 Deficiency Increases Sensitivity to Poly(ADP-ribose) Polymerase Inhibition in Microsatellite Unstable Colorectal Cancers

(2011) E. Vilar et al.   CANCER RESEARCH

Differential regulation of MRN (Mre11–Rad50–Nbs1) complex subunits and telomerase activity in cancer cells

(2010) C.V. Kavitha et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mre11–Rad50–Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks

(2010) Gareth J. Williams et al.   DNA REPAIR

Microsatellite instability in colorectal cancer—the stable evidence

(2010) Eduardo Vilar et al.   Nature Reviews Clinical Oncology

DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints

(2010) Zhongsheng You et al.   TRENDS IN CELL BIOLOGY

Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates

(2009) Brenda K. Edwards et al.   CANCER

Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines

(2008) E Vilar et al.   BRITISH JOURNAL OF CANCER

DNA Repair by the MRN Complex: Break It to Make It

(2008) Roland Kanaar et al.   CELL

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH