Article
Peripheral Vascular Disease
Till Schuette, Sarah M. Kedziora, Nadine Haase, Florian Herse, Andreas Busjahn, Anna Birukov, Natalia Alenina, Dominik N. Mueller, Michael Bader, Michael Schupp, Ralf Dechend, Kristin Kraeker, Michaela Golic
Summary: A study conducted on a rat model found that maternal diabetes during pregnancy without obesity did not have a negative impact on the metabolic health of male offspring. There were no significant differences in blood glucose control between offspring exposed to maternal hyperglycemia and those from control pregnancies. Intrauterine exposure to hyperglycemia and hyperinsulinemia without obesity did not lead to fetal programming of diabetes and obesity in this particular model.
Article
Neurosciences
Dongquan Huang, Jie Gao, Chong Li, Caihong Nong, Wenting Huang, Xifen Zheng, Sirou Li, Yongzheng Peng
Summary: The study revealed that A. muciniphila(sub) can improve OLZ-induced hyperglycemia, decrease hepatic gluconeogenic enzyme activity, alleviate insulin resistance, and reduce systemic inflammation caused by OLZ.
PSYCHOPHARMACOLOGY
(2021)
Review
Behavioral Sciences
Hesham Shamshoum, Kyle D. Medak, David C. Wright
Summary: Antipsychotic medications are associated with an increased risk of metabolic side effects, including chronic effects as well as rapid disturbances in glucose and lipid metabolism with each dose. Research has been attempting to elucidate treatment approaches to reduce the risk of drug-induced impairments in fuel metabolism.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Review
Clinical Neurology
Muhammad Youshay Jawad, Yazen Alnefeesi, Leanna M. W. Lui, Felicia Ceban, David C. J. Chen-Li, Kayla Teopiz, Saja Jaberi, Emily S. Gillissie, Joshua D. Di Vincenzo, Joshua D. Rosenblat, Roger S. McIntyre
Summary: The combination treatment of OLZ/SAM is associated with reduced weight gain compared to OLZ monotherapy in adults with schizophrenia. It retains similar clinical efficacy as OLZ with improved tolerability.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Endocrinology & Metabolism
Danielle K. Longmore, Jessica E. Miller, Siroon Bekkering, Christoph Saner, Edin Mifsud, Yanshan Zhu, Richard Saffery, Alistair Nichol, Graham Colditz, Kirsty R. Short, David P. Burgner
Summary: In adults hospitalized with COVID-19, overweight, obesity, and diabetes were associated with increased odds of requiring respiratory support but were not associated with death. In patients with diabetes, the odds of severe COVID-19 were not increased above the BMI-associated risk.
Article
Geriatrics & Gerontology
Chaojun Yang, Xiaocan Jia, Yuping Wang, Jingwen Fan, Chenyu Zhao, Yongli Yang, Xuezhong Shi
Summary: This study examines the prevalence, intervention, and control of metabolic syndrome (MetS) among US adults from 1999 to 2018, finding a significant increase in MetS prevalence during this time period. Factors such as smoking and vigorous activity were found to influence MetS prevalence. Elevated blood glucose and obesity were identified as the main causes of MetS burden. The study suggests that targeting specific populations for treatment and lifestyle modification could improve the control of blood glucose and obesity.
Review
Physiology
Faidon Magkos, Dominic N. Reeds, Bettina Mittendorfer
Summary: This paper provides an overview of the evolution of hyperglycemia definition and the changes in glucose dynamics that lead to fasting and postprandial hyperglycemia. Extensive research has contributed to our understanding of different types of hyperglycemia, such as prediabetes and diabetes, and their subtypes, as well as their relationships with medical complications and strategies for prevention and treatment.
PHYSIOLOGICAL REVIEWS
(2023)
Article
Critical Care Medicine
Erick D. Lewis, Holden C. Williams, Maria E. C. Bruno, Arnold J. Stromberg, Hiroshi Saito, Lance A. Johnson, Marlene E. Starr
Summary: Despite the known deleterious effects of obesity, clinical data indicate that overweight or obese patients experience higher rates of sepsis survival compared to normal and underweight patients; a phenomenon called the obesity paradox. This study used a mouse model to test the existence of the obesity paradox in sepsis and found that obese mice had higher survival rates but more significant organ injury.
Article
Endocrinology & Metabolism
Seung Gyun Lim, Young Ah Lee, Han Na Jang, Sung Hye Kong, Chang Ho Ahn, Sang Wan Kim, Choong Ho Shin, Jung Hee Kim
Summary: The lack of long-term outcome studies in Asian adults with classic CAH due to 21-hydroxylase deficiency prompted this research. The findings demonstrate that adults with CAH have a higher metabolic risk compared to their age- and sex-matched controls, with significantly higher rates of hypertension and obesity observed. Additionally, factors such as TARTs in men and irregular menstruation in women were also examined, revealing a correlation with hormonal levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Ying Liu, Ping Shuai, Wanjing Chen, Yuping Liu, Dongyu Li
Summary: This study investigates the association between Helicobacter pylori (H. pylori) infection and metabolic syndrome (MetS) using five different criteria to define MetS. The results show that in males, the prevalence of MetS is higher in the H. pylori-positive group compared to the negative group, while in females, similar results are observed using three international criteria. Multivariate logistic regression analysis reveals a positive correlation between H. pylori infection and MetS in males. Additionally, H. pylori infection is found to be positively correlated with waist circumference in the general population, and with hypertension and hyperglycemia in males.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Youjin Zhang, Shiyun Li, Haiyan Nie, Xue Wang, Xuanxuan Li, Jinhui Wen, Mengxi Li, Yongyan Song
Summary: This study explores the relationships between the MC4R rs17782313 polymorphism, PGC1a rs8192678 polymorphism, and metabolic abnormalities in global populations. The findings are inconsistent and sometimes contradictory. The meta-analysis shows that the C allele of the MC4R rs17782313 polymorphism is associated with higher risks of obesity and hyperglycemia, while the PGC1a rs8192678 polymorphism has a weak correlation with glucometabolic disorder.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Sara E. Stinson, Anna E. Jonsson, Ierai Fernandez de Retana Alzola, Morten A. Lund, Christine Frithioff-Bojsoe, Louise Aas Holm, Cilius E. Fonvig, Oluf Pedersen, Lars Angquist, Thorkild I. A. Sorensen, Jens J. Holst, Michael Christiansen, Jens-Christian Holm, Bolette Hartmann, Torben Hansen
Summary: Elevated fasting glucagon concentrations in youth with overweight/obesity are associated with worsened cardiometabolic risk outcomes, except for hyperglycemia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, Research & Experimental
Hesham Shamshoum, Kyle D. Medak, Greg L. Mckie, Stewart Jeromson, Margaret K. Hahn, David C. Wright
Summary: Antipsychotic medications can cause metabolic side effects, and the standard care of using metformin is not effective for all patients. This study found that salsalate is equally effective as metformin in preventing weight gain and liver lipid accumulation caused by antipsychotic medications. However, metformin, either alone or in combination with salsalate, can improve glucose metabolism and increase energy expenditure.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell & Tissue Engineering
Yicheng Qi, Wen Liu, Xiangsheng Wang, Nan Lu, Minglan Yang, Wei Liu, Jing Ma
Summary: The study evaluates the effects of adipose-derived MSCs from obese mice on body weight and glucose homeostasis, finding that these cells can reduce weight gain and improve obesity-related hyperglycemia in obese mice. This improvement is possibly attributed to increased lipolysis of inguinal fat and restoration of insulin receptor expression in muscle. Additionally, differential expression of CD90 and reduced levels of MCP-1 in O-ADSCs suggest that autologous ADSCs from obese individuals may be more effective for treating obesity and related hyperglycemia.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Physiology
Vanessa Caruline Araujo-Silva, Alice Santos-Silva, Andressa Silva Lourenco, Cristielly Maria Barros-Barbosa, Rafaianne Queiroz Moraes-Souza, Thaigra Sousa Soares, Barshana Karki, Veronyca Goncalves Paula, Yuri Karen Sinzato, Debora Cristina Damasceno, Gustavo Tadeu Volpato
Summary: Exposure to maternal diabetes and high-fat/high-sugar diet during pregnancy leads to adverse effects on both maternal and fetal health, including increased blood sugar, embryonic loss rate, obesity index, caloric intake, and reduced gravid uterus weight. These effects may be related to inflammatory processes and intrauterine growth restriction.
FRONTIERS IN PHYSIOLOGY
(2021)