Article
Orthopedics
Jay R. Ebert, Michael Fallon, David J. Wood, Gregory C. Janes
Summary: The study found that an accelerated return to full weight bearing after matrix-induced autologous chondrocyte implantation (MACI) at 6 weeks provided comparable clinical and MRI-based outcomes beyond 5 years post-surgery, without jeopardizing the graft. This 6-week protocol is faster than previously proposed and studied protocols.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Article
Orthopedics
David Grevenstein, Andreas Mamilos, Volker H. Schmitt, Tanja Niedermair, Willi Wagner, C. James Kirkpatrick, Christoph Brochhausen
Summary: The study analyzed histological and immunohistological findings from five patients who underwent spheroid-based autologous chondrocyte transplantation after traumatic lesions of the knee, showing excellent histological results in terms of hyaline articular cartilage regeneration. This indicates that spheroid-based autologous chondrocyte transplantation is a promising strategy for treating traumatic lesions of the knee's articular cartilage.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Article
Orthopedics
Nicholas Pasic, Hannah L. L. Bradsell, Andres Barandiaran, Avi A. S. Robinson, Brian J. J. Cole, Armando F. F. Vidal, Rachel M. M. Frank
Summary: This study retrospectively reviewed 46 patients who underwent a MACI (or ACI) biopsy and found that only 26.1% of the patients required cartilage transplantation surgery. Additionally, the reoperation rate after surgery was 16.7%. Therefore, arthroscopic surgery performed in conjunction with the biopsy appeared to be sufficient in improving function and reducing pain in patients with knee FCDs.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2023)
Article
Orthopedics
Jay R. Ebert, Michael Fallon, David J. Wood, Gregory C. Janes
Summary: MACI showed high levels of satisfaction and adequate graft survivorship as visualized on MRI at 10.5 to 16 years after surgery. Most patients reported high levels of satisfaction with their ability to participate in sports, but previous surgical procedures may be negatively associated with certain outcome measures.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
Yufeng Liu, Ning Ma, Zhe Zhao, Quanyi Guo
Summary: This retrospective study evaluated the safety, efficacy, and outcomes of using allogenic next-generation MACI for the treatment of cartilage defects in the knee joint. The results showed that this method is a safe and effective option with lasting benefits for over 5 years. The size of the defects was found to have a significant impact on postoperative clinical outcomes.
ORTHOPAEDIC SURGERY
(2023)
Article
Orthopedics
Clemente Ibarra, Enrique Villalobos, Antonio Madrazo-Ibarra, Cristina Velasquillo, Valentin Martinez-Lopez, Aldo Izaguirre, Anell Olivos-Meza, Socorro Cortes-Gonzalez, Francisco Javier Perez-Jimenez, Alberto Vargas-Ramirez, Gilberto Franco-Sanchez, Luis Guillermo Ibarra-Ibarra
Summary: The study found that patients who underwent MACT had significantly better structural outcomes compared to those who underwent MFx at 1 to 6 years postoperatively. Both groups of patients showed significant clinical improvements at final follow-up compared with their preoperative status. MACT demonstrated superiority at 4 years for the majority of the KOOS subscales and for the Tegner scale at 4 to 6 years, with a higher responder rate and lower failure rate in the MACT group at final follow-up.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Orthopedics
Jialing Lyu, Hongli Geng, Weimin Zhu, Dingfu Li, Kang Chen, Hui Ye, Jun Xia
Summary: This study found that good quality cartilage repair tissue is associated with patellofemoral osteoarthritis (PFOA) at a three year follow-up after matrix-induced autologous chondrocyte implantation (MACI). MACI can lead to significant pain relief and restoration of knee joint function.
INTERNATIONAL ORTHOPAEDICS
(2023)
Article
Surgery
Le Wang, Han Li, Yiguo Cao, Cheng Song, Qi Chen, Jun Hao, Weiguo Zhang, Kang Tian
Summary: This case report introduces a technique for autologous chondrocyte patch fabrication for knee joint cartilage defects, and presents four typical cases demonstrating clinical improvement and good quality of repaired tissue with a 2-year follow-up.
FRONTIERS IN SURGERY
(2022)
Article
Orthopedics
Enrique Villalobos, Antonio Madrazo-Ibarra, Valentin Martinez, Anell Olivos-Meza, Cristina Velasquillo, Socorro Cortes Gonzalez, Aldo Izaguirre, Carmina Ortega-Sanchez, Ricardo Gonzalez, Carmen Parra-Cid, Francisco Javier Perez-Jimenez, Clemente Ibarra
Summary: Based on a pilot clinical study, arthroscopic matrix-encapsulated autologous chondrocyte implantation (AMECI) demonstrated promising outcomes for treating focal chondral lesions, with improvements in clinical scores, MRI T2-mapping, and MOCART evaluations, along with a low failure rate and favorable ICRS arthroscopic evaluation at mid-term follow-up. The feasibility of implementing AMECI across multiple institutions in a metropolitan area under strict biosecurity measures was also confirmed.
Review
Orthopedics
Filippo Migliorini, Joerg Eschweiler, Filippo Spiezia, Bryan J. M. van de Wall, Matthias Knobe, Markus Tingart, Nicola Maffulli
Summary: In midterm follow-up, arthroscopy and mini-arthrotomy approaches for matrix-induced autologous chondrocyte implantation in knee show similar outcomes, including duration of symptoms, age, body mass index, gender, defect size, Tegner Score, Lysholm Score, International Knee Documentation Committee (IKDC) Score, as well as failure rate and revision rate.
JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
(2021)
Article
Orthopedics
Yoshikazu Sumida, Kaori Nakamura, Sven Feil, Maja Siebold, Joachim Kirsch, Rainer Siebold
Summary: Arthroscopic second-look evaluation showed that all-arthroscopic ACI for patellar cartilage defects resulted in high-quality cartilage regeneration, with most lesions classified as normal or nearly normal. Overall, the majority of defects were repaired effectively, indicating the reproducibility and reliability of the procedure.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Review
Orthopedics
Alessandra Colombini, F. Libonati, S. Lopa, G. M. Peretti, M. Moretti, L. de Girolamo
Summary: This study evaluated the long-term efficacy of autologous chondrocyte implantation (ACI) and matrix-assisted chondrocyte implantation (MACI) in treating knee cartilage defects in patients with osteoarthritis (OA). Results showed that both ACI and MACI showed sustained clinical improvements and delayed the need for arthroplasty.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Review
Biology
Filippo Migliorini, Raju Vaishya, Andreas Bell, Christian D. Weber, Christian Goetze, Nicola Maffulli
Summary: This systematic review investigated the midterm results of three common types of membrane fixation for mACI and found that the no-fixation group performed better in certain aspects.
Review
Medicine, General & Internal
Filippo Migliorini, Nicola Maffulli, Alice Baroncini, Matthias Knobe, Markus Tingart, Joerg Eschweiler
Summary: The treatment of chondral defects of the talus is challenging, with membrane-induced autologous chondrocyte implantation (mACI) and autologous matrix-induced chondrogenesis (AMIC) proposed as methods. There is controversy over whether AMIC provides better outcomes compared to mACI for chondral regeneration, with further research needed to clarify the best treatment method.
BRITISH MEDICAL BULLETIN
(2021)
Review
Medicine, General & Internal
Filippo Migliorini, Joerg Eschweiler, Christian Goetze, Arne Driessen, Markus Tingart, Nicola Maffulli
Summary: Chondral defects of the knee are common and challenging to treat. Both AMIC and mACI have been used for managing these defects, but their equivalent outcomes at midterm follow-up are debated. Further studies are needed to investigate whether AMIC provides superior outcomes compared to mACI.
BRITISH MEDICAL BULLETIN
(2022)
Article
Surgery
Jay R. Ebert, Nils O. Nivbrant, Victoria Petrov, Piers Yates, David J. Wood
Summary: This study evaluated the 2-year clinical results and periprosthetic bone mineral density (BMD) changes in patients undergoing primary cemented total hip arthroplasty (THA) using a new femoral stem. The results showed that the new stem demonstrated good clinical outcomes, consistent BMD changes, and similar patterns of post-operative micromotion compared to other successful cemented stems.
ANZ JOURNAL OF SURGERY
(2022)
Article
Orthopedics
Michael Beere, Jay R. Ebert, Brendan Joss, Timothy Ackland
Summary: This study investigated the suitability of isometric strength testing methods as an alternative to isokinetic assessment for identifying knee extensor strength asymmetry. The results suggest that isometric methods can be used to assess knee extensor strength in the absence of isokinetic testing equipment, with consideration of test angles being important. ACL reconstruction patients demonstrated greater asymmetry in knee extensor strength compared to healthy controls, highlighting the importance of assessing strength deficits in this population.
Article
Orthopedics
Jay R. Ebert, Robert Nairn, William Breidahl, Peter T. Annear
Summary: Comparable outcomes were observed after double-bundle ACLR using autologous hamstrings with, or without, LARS augmentation. Therefore, while these outcomes do not justify the additional use of synthetic augmentation given the lack of further benefit and additional cost, higher rates of graft failure, synovitis and early osteoarthritic change previously reported were not observed.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Review
Sport Sciences
David S. Logerstedt, Jay R. Ebert, Toran D. MacLeod, Bryan C. Heiderscheit, Tim J. Gabbett, Brian J. Eckenrode
Summary: Mechanical loading to the knee joint generates differential responses based on tissue capacity and tissue adaptation at the molecular and cellular levels. Rehabilitation following knee injury or surgery should focus on maximizing patient response to exercise while minimizing re-injury risk. Clinicians need to understand injured tissues, tissue-healing constraints, knee complex biomechanics, and training principles to provide appropriate loading progressions for rehabilitation.
Article
Orthopedics
Jay R. Ebert, Peter Edwards, Peter T. Annear
Summary: This study investigated the clinical and functional outcome of patients undergoing selective posterolateral (PLB) or anteromedial (AMB) bundle reconstruction. The results showed high levels of physical function and return to sport rates in patients following partial bundle reconstruction, without evidence of instability and a low re-injury rate.
Article
Nutrition & Dietetics
Marc K. K. Smith, Jonathan M. D. Staynor, Amar El-Sallam, Jay R. R. Ebert, Tim R. R. Ackland
Summary: Smartphone applications now provide accessible in-home monitoring of individual health biomarkers. This research assessed the longitudinal agreement of a novel smartphone application for measuring body composition during a weight loss intervention. The results showed small mean differences between the smartphone app and the ground truth methods, indicating acceptable accuracy. The smartphone app offers significant benefits in terms of cost, accessibility, and user comfort.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Orthopedics
Benjamin A. Southi, Callum Fryer, Jay Ebert, Tim Ackland, Markus S. Kuster, Nicholas D. Calvert
Summary: This study compared the kneeling ability and self-reported knee function of patients with distal tibia fractures managed with either intramedullary nailing (IMN) or open reduction internal fixation (ORIF) with compression plating. The results showed that patients with IMN had significantly worse kneeling function compared to their non-affected limb and the ORIF group. Additionally, the IMN group had worse overall knee function compared to the ORIF group.
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2023)
Article
Orthopedics
Jay R. Ebert, Antony C. Raymond, Randeep S. Aujla, Peter D'Alessandro
Summary: For patients with symptomatic FAIS lasting more than 6 months, intra-articular hip injection and structured exercise rehabilitation program can significantly improve hip pain, symptoms, and physical function, making nonoperative management possible.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Orthopedics
Jay R. Ebert, Mikhil Jain, Gregory C. Janes
Summary: This study aimed to evaluate the clinical outcome, patient satisfaction, re-injury and re-operation rates of patients 7-10 years after augmented hip abductor tendon repair. The results showed good clinical scores, high patient satisfaction and an acceptable re-injury rate at 7-10 years after the surgery.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Orthopedics
John P. Scanlon, Antony C. Raymond, Randeep S. Aujla, Satyen Gohil, Jay R. Ebert, Li-On Lam, Shahbaz S. Malik, Ashley Simpson, Jacobus H. Otto, Declan Neeson, Peter D'Alessandro
Summary: The study aims to report the outcomes of patients with osteochondral injuries secondary to acute traumatic patella dislocation treated with combined early fragment fixation and MPFL reconstruction using a quadriceps tendon graft. The results suggest that the combined approach using a quadriceps tendon graft offers good radiological and patient-reported outcomes.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Medicine, Research & Experimental
Jay R. Ebert, Agnes Magi, Eve Unt, Ele Prans, David J. Wood, Sulev Koks
Summary: This study aimed to identify genetic variations associated with high-level athletic performance and lower limb musculoskeletal injury. Through genome-wide association analysis, the researchers discovered single-nucleotide polymorphisms (SNPs) that are related to performance and injury. The findings are important for the development of individualized training and injury rehabilitation programs.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Orthopedics
Mira Marinova, Abayasankar Sundaram, Katie Holtham, Jay R. Ebert, David Wysocki, Daniel Meyerkort, Ross Radic
Summary: The study aimed to compare the effectiveness of cryocompression treatment with usual care protocol on early post-operative recovery following total knee arthroplasty. The results showed that cryocompression treatment significantly improved knee extension during the initial two-week intervention period, but no further significant differences were observed between the groups during or after the intervention.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Orthopedics
Jay R. Ebert, William Breidahl, Sven Klinken, Peter T. Annear
Summary: This study developed and assessed a MRI-based scoring tool for evaluating surgical repair after proximal hamstring avulsions and its correlation with patient-reported outcome. The results showed excellent reliability of the scoring tool and its potential value in both research and clinical settings.
JOURNAL OF ORTHOPAEDICS
(2023)
Article
Orthopedics
Jay R. Ebert, Peter Edwards, Peter T. Annear
Summary: This study evaluated the clinical outcomes of ACLR using autologous hamstrings augmented with suture tape. The results showed good clinical outcomes, high rates of return to sport, and low re-injury rates at 24 months.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)