Article
Immunology
Wei Wu, Xin'an Wang, Wei Le, Chang Lu, Haopeng Li, Yaru Zhu, Xi Chen, Wenbin An, Chengdang Xu, Qiang Wu, Licheng Wang
Summary: In this study, the tumor microenvironment and immune cell infiltration were analyzed in patients with prostate cancer. High immune cell infiltration scores were associated with poor prognosis and decreased expression of immune-related genes. The TGF-beta and WNT-beta signaling pathways were enriched in the high infiltration score subgroup, suggesting a potential mechanism for immune suppression in prostate cancer patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Padmanabha Ganeshkodi Roopashree, Shilpa S. Shetty, Vijith Vittal Shetty, Suchetha Kumari Nalilu
Summary: This study aimed to determine the levels of medium-chain fatty acids in women with and without breast cancer. Results showed that breast cancer subjects had lower levels of caprylic acid and lauric acid, and higher levels of capric acid. Specifically, HER2- and ER-positive breast cancer subjects had even lower levels of caprylic acid and lauric acid. This suggests that lower levels of caprylic and lauric acid may be associated with a higher risk of breast cancer.
Review
Biochemistry & Molecular Biology
Annemarie J. F. Westheim, Lara M. Stoffels, Ludwig J. Dubois, Jeroen van Bergenhenegouwen, Ardy van Helvoort, Ramon C. J. Langen, Ronit Shiri-Sverdlov, Jan Theys
Summary: Cancer burden is increasing rapidly globally, with lifestyle factors such as unhealthy diet being major contributors. The specific fatty acids that contribute to a healthy and balanced diet in terms of cancer risk and prognosis are still unclear. This review explores the associations between intake of different fatty acids and cancer risk, as well as the effects of specific fatty acids on tumor cells and inflammation-induced cancer progression, highlighting challenges and opportunities for fatty acid tailored nutritional interventions.
Article
Oncology
S. G. Yammine, I. Huybrechts, C. Biessy, L. Dossus, S. Panico, M. J. Sanchez, V. Benetou, R. Turzanski-Fortner, V. Katzke, A. Idahl, G. Skeie, K. Standahl Olsen, A. Tjonneland, J. Halkjaer, S. Colorado-Yohar, A. K. Heath, E. Sonestedt, H. Sartor, M. B. Schulze, D. Palli, M. Crous-Bou, A. Dorronsoro, K. Overvad, A. Barricarte Gurrea, G. Severi, R. C. H. Vermeulen, T. M. Sandanger, R. C. Travis, T. Key, P. Amiano, B. Van Guelpen, M. Johansson, M. Sund, R. Tumino, N. Wareham, C. Sacerdote, V. Krogh, P. Brennan, E. Riboli, E. Weiderpass, M. J. Gunter, V. Chajes
Summary: Specific dietary fatty acids, such as gamma-linolenic acid and alpha-linolenic acid from plant sources, may be associated with lower risk of endometrial cancer.
Review
Biochemistry & Molecular Biology
Milica Zekovic, Uros Bumbasirevic, Marko Zivkovic, Tomislav Pejcic
Summary: Cancer, especially prostate cancer, is a heterogeneous disease with complex mutational landscape. Lipid metabolism alterations play a critical role in tumorigenesis and progression, influencing various processes in cancer development. Understanding the unique metabolic signature of prostate cancer could lead to novel approaches for diagnosis and clinical management of this complex pathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Roland Wedekind, Joseph A. Rothwell, Vivian Viallon, Pekka Keski-Rahkonen, Julie A. Schmidt, Veronique Chajes, Vna Katzke, Theron Johnson, Maria Santucci de Magistris, Vittorio Krogh, Pilar Amiano, Carlotta Sacerdote, Daniel Redondo-Sanchez, Jose Maria Huerta, Anne Tjonneland, Pratik Pokharel, Paula Jakszyn, Rosario Tumino, Eva Ardanaz, Torkjel M. Sandanger, Anna Winkvist, Johan Hultdin, Matthias B. Schulze, Elisabete Weiderpass, Marc J. Gunter, Inge Huybrechts, Augustin Scalbert
Summary: Circulating levels of acylcarnitines (ACs) are influenced by various factors such as age, sex, diet, and fasting status. Different types of ACs are associated with corresponding fatty acids in plasma, specific food intake, and concentrations of branched-chain amino acids. Understanding the determinants of ACs can help interpret their associations with disease risk and provide insights into potential dietary and lifestyle factors for disease prevention.
CLINICAL NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Alicja Chrzanowska, Dagmara Kurpios-Piec, Barbara Zyzynska-Granica, Ewelina Kiernozek-Kalinska, Wen Xin Lay, Andrzej K. Ciechanowicz, Marta Struga
Summary: The positive trend in cancer treatment management is to explore the antineoplastic potential of widely used and safe drugs with different clinical purposes. Moxifloxacin, a fourth-generation fluoroquinolone with broad-spectrum antibacterial activity, has shown promising cytotoxic potential as moxifloxacin conjugates with fatty acids. These conjugates exhibited stronger cytotoxic activity than free moxifloxacin, especially with oleic and stearic acid, without toxicity to normal cells. The conjugates activated caspases 3/7 and induced late apoptosis in cancer cells, and also showed potential anti-inflammatory effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Immunology
Jiahua Pan, Zehua Ma, Bo Liu, Hongyang Qian, Xiaoguang Shao, Jiazhou Liu, Qi Wang, Wei Xue
Summary: In this study, two distinct subtypes of CAFs with different molecular characteristics and biological functions were identified in the prostate cancer microenvironment. Similar CAFs were also found in bone metastatic prostate cancer lesions. The transcriptional factor regulatory network associated with CAFs-C1 was found to be related to castration resistance and poor prognosis, as well as treatment resistance to immune checkpoint inhibitors.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Zhengliang Zhang, Weixi Wang, Piaoping Kong, Kangle Feng, Chunhua Liu, Tao Sun, Yiwen Sang, Xiuzhi Duan, Zhihua Tao, Weiwei Liu
Summary: Prostate cancer, the most common malignant tumor of the male urological system, poses a severe threat to the survival of middle-aged and elderly males worldwide. This review summarizes recent research advances in lipid metabolic pathways (fatty acids, cholesterol, and phospholipids) in prostate cancer. It discusses the metabolism of fatty acids, the role of cholesterol in pathogenesis and evolution, and the association of different types of phospholipids with cancer progression. Additionally, it highlights the clinical value of lipid metabolism proteins and lipids themselves as diagnostic and prognostic indicators, as well as therapeutic targets in prostate cancer.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Patrick E. Gelbach, Stacey D. Finley
Summary: This study investigates the metabolic states of M1 and M2 macrophages using computational models and identifies key differences between them. Perturbations in metabolism are identified to promote the metabolic state of M2 macrophages to resemble M1 cells.
Review
Oncology
Natalia Scaglia, Yesica Romina Frontini-Lopez, Giorgia Zadra
Summary: Advanced prostate cancer is the fifth leading cause of cancer death globally. Lipids and their metabolism have been increasingly recognized as playing a role in PCa development, progression, and metastasis. Targeting enzymes and transporters involved in lipid metabolism is a growing focus in therapeutic approaches for PCa. Studies also support dietary modulation in improving the efficacy of standard care and synthetic lethality in PCa treatment.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mathilde Cancel, William Pouillot, Karine Maheo, Alix Fontaine, David Crottes, Gaelle Fromont
Summary: Adipose tissue, both periprostatic and metastatic sites, plays a role in prostate cancer aggressiveness through various molecular interactions. The effects on cancer cells may depend on the balance between pro- and anti-tumor components of the tissue. Genetic and environmental factors like obesity and diet can modulate these interactions and impact the growth and metastatic potential of prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Public, Environmental & Occupational Health
Sabine Naudin, Joshua N. Sampson, Steven C. Moore, Demetrius Albanes, Neal D. Freedman, Stephanie J. Weinstein, Rachael Stolzenberg-Solomon
Summary: The study found that abnormal lipid metabolism in prospective studies is associated with pancreatic ductal carcinoma (PDAC). A comprehensive investigation of two prospective studies revealed that 43 lipid species were associated with PDAC.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Review
Food Science & Technology
Mojtaba Yousefi, Niloofar Eshaghian, Neda Heidarzadeh-Esfahani, Gholamreza Askari, Hamid Rasekhi, Omid Sadeghi
Summary: The study aimed to summarize the findings on the association between dietary intake and tissue biomarkers of linoleic acid (LA) with the risk of prostate cancer. Higher tissue levels of LA were found to be associated with a reduced risk of prostate cancer, while no significant association was found for dietary intake of LA and the risk of prostate cancer.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Oncology
Elom K. Aglago, Neil Murphy, Inge Huybrechts, Genevieve Nicolas, Corinne Casagrande, Veronika Fedirko, Elisabete Weiderpass, Joseph A. Rothwell, Christina C. Dahm, Anja Olsen, Anne Tjonneland, Rudolf Kaaks, Verena Katzke, Matthias B. Schulze, Giovanna Masala, Claudia Agnoli, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Bas H. Bueno-de-Mesquita, Jeroen W. G. Derksen, Guri Skeie, Inger Torhild Gram, Magritt Brustad, Paula Jakszyn, Maria-Jose Sanchez, Pilar Amiano, Jose Maria Huerta, Ulrika Ericson, Maria Wennberg, Aurora Perez-Cornago, Alicia K. Heath, Mazda Jenab, Veronique Chajes, Marc J. Gunter
Summary: Epidemiologic studies suggest that total and individual saturated fatty acids as well as fatty acids of industrial origin may play a role in the etiology of CRC. Both dietary and plasma levels of myristic acid were inversely associated with colon cancer risk, indicating a need for further research.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Oncology
Doris S. M. Chan, Rita Vieira, Leila Abar, Dagfinn Aune, Katia Balducci, Margarita Cariolou, Darren C. Greenwood, Georgios Markozannes, Neesha Nanu, Nerea Becerra-Tomas, Edward L. Giovannucci, Marc J. Gunter, Alan A. Jackson, Ellen Kampman, Vivien Lund, Kate Allen, Nigel T. Brockton, Helen Croker, Daphne Katsikioti, Deirdre McGinley-Gieser, Panagiota Mitrou, Martin Wiseman, Amanda J. Cross, Elio Riboli, Steven K. Clinton, Anne McTiernan, Teresa Norat, Konstantinos K. Tsilidis
Summary: A systematic review found strong evidence linking higher postdiagnosis body mass index (BMI) to increased all-cause mortality, breast cancer-specific mortality, and second primary breast cancer. Waist circumference, waist-hip-ratio, and weight change were also associated with breast cancer prognosis. Further research is needed to understand the impact of body composition on breast cancer outcomes.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Konstantinos K. Tsilidis, Margarita Cariolou, Nerea Becerra-Tomas, Katia Balducci, Rita Vieira, Leila Abar, Dagfinn Aune, Georgios Markozannes, Neesha Nanu, Darren C. Greenwood, Edward L. Giovannucci, Marc J. Gunter, Alan A. Jackson, Ellen Kampman, Vivien Lund, Kate Allen, Nigel T. Brockton, Helen Croker, Daphne Katsikioti, Deirdre McGinley-Gieser, Panagiota Mitrou, Martin Wiseman, Amanda J. Cross, Elio Riboli, Steven K. Clinton, Anne McTiernan, Teresa Norat, Doris S. M. Chan
Summary: Based on systematic reviews and meta-analyses, this study found a strong association between postdiagnosis body fatness and higher all-cause mortality, breast cancer-specific mortality, and second primary breast cancer. Limited evidence suggests a relationship between body fatness and breast cancer recurrence and nonbreast cancer-related mortality. Limited-suggestive evidence indicates a lower risk of all-cause mortality and breast cancer-specific mortality with recreational physical activity. Data on dietary factors is limited. The study emphasizes the importance of lifestyle recommendations to avoid obesity and engage in physical activity for breast cancer patients.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Economics
Zuzana Spacirova, Stephen Kaptoge, Leticia Garcia-Mochon, Miguel Rodriguez Barranco, Maria Jose Sanchez Perez, Nicola P. Bondonno, Anne Tjonneland, Elisabete Weiderpass, Sara Grioni, Jaime Espin, Carlotta Sacerdote, Catarina Schiborn, Giovanna Masala, Sandra M. Colorado-Yohar, Lois Kim, Karel G. M. Moons, Gunnar Engstrom, Matthias B. Schulze, Lea Bresson, Concepcion Moreno-Iribas, David Epstein
Summary: The objective of this article was to assess the cost-effectiveness of screening strategies for cardiovascular diseases (CVD). The study found that one-off screening using a uniform risk threshold is cost-effective compared to no systematic screening, but the results are sensitive to assumptions about CVD incidence rates.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2023)
Article
Nutrition & Dietetics
Nena Karavasiloglou, David J. Hughes, Neil Murphy, Lutz Schomburg, Qian Sun, Vartiter Seher, Sabine Rohrmann, Elisabete Weiderpass, Anne Tjonneland, Anja Olsen, Kim Overvad, Marie-Christine Boutron-Ruault, Francesca Romana Mancini, Yahya Mahamat-Saleh, Rudolf Kaaks, Tilman Kuhn, Matthias B. Schulze, Rosario Tumino, Salvatore Panico, Giovanna Masala, Valeria Pala, Carlotta Sacerdote, Jeroen W. G. Derksen, Guri Skeie, Anette Hjartaker, Cristina Lasheras, Antonio Agudo, Maria-Jose Sanchez, Maria-Dolores Chirlaque, Eva Ardanaz, Pilar Amiano, Bethany Van Guelpen, Bjorn Gylling, Kathryn E. Bradbury, Keren Papier, Heinz Freisling, Elom K. Aglago, Amanda J. Cross, Elio Riboli, Dagfinn Aune, Marc J. Gunter, Mazda Jenab
Summary: Two large European cohort studies found that circulating calcium concentrations were associated with colorectal cancer risk. In the EPIC cohort, total serum calcium was not associated with colorectal cancer, while in the UK-BB cohort, serum ionized calcium was inversely associated with colorectal cancer risk.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Review
Nutrition & Dietetics
Nikan Zargarzadeh, Seyed Mohammad Mousavi, Heitor O. Santos, Dagfinn Aune, Shirin Hasani-Ranjbar, Bagher Larijani, Ahmad Esmaillzadeh
Summary: This study examined the potential dose-response relationship between legume consumption and mortality rates in the general population. The results showed that higher legume intake was associated with a reduced risk of all-cause and stroke mortality, but there was no significant association with cardiovascular disease, coronary heart disease, and cancer mortality.
ADVANCES IN NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Makoto Hibino, Michael E. Halkos, Douglas A. Murphy, Nitish K. Dhingra, Raj Verma, Hiromi Hibino, Dagfinn Aune, Bobby Yanagawa, Deepak L. Bhatt, Subodh Verma
Summary: This study analyzed the mortality trends of rheumatic heart disease in high-income countries and found that there was a significant decrease in mortality rates in all countries except for Germany. The mortality rates had two peaks in younger and older age groups. The high mortality and unique trend in Germany require further investigation.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Nutrition & Dietetics
Leandro Teixeira Cacau, Giles T. Hanley-Cook, Inge Huybrechts, Stefaan De Henauw, Mathilde Kersting, Marcela Gonzalez-Gross, Frederic Gottrand, Marika Ferrari, Esther Nova, Manuel J. Castillo, Denes Molnar, Kurt Widhalm, Odysseas Androutsos, Yannis Manios, Peter Stehle, Carl Lachat, Dirce Maria Marchioni, Luis A. Moreno
Summary: This study assessed the relative validity of the Planetary Health Diet Index (PHDI) among European adolescents. The results showed that higher PHDI scores were associated with greater intake of nutrients from plant-source foods and lower intake of nutrients from animal-source foods. Furthermore, the PHDI was also related to plasma nutrient concentrations and adherence to the Mediterranean diet. Therefore, future research should explore adherence to the PHDI and long-term health outcomes.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Medicine, General & Internal
Xiaoshuang Feng, David C. Muller, Hana Zahed, Karine Alcala, Florence Guida, Karl Smith-Byrne, Jian-Min Yuan, Woon-Puay Koh, Renwei Wang, Roger L. Milne, Julie K. Bassett, Arnulf Langhammer, Kristian Hveem, Victoria L. Stevens, Ying Wang, Mikael Johansson, Anne Tjonneland, Rosario Tumino, Mahdi Sheikh, Mattias Johansson, Hilary A. Robbins
Summary: This study aimed to evaluate the association between circulating proteins and survival after lung cancer diagnosis, as well as their potential for improving prognosis prediction. The results showed that only CDCP1 remained statistically significant after accounting for multiple testing. In conclusion, blood proteins measured within 3 years prior to lung cancer diagnosis were not strongly associated with lung cancer survival and did not significantly improve prognosis prediction beyond clinical information.
Article
Medicine, General & Internal
Katharina Nimptsch, Krasimira Aleksandrova, Thu Thi Pham, Nikos Papadimitriou, Juergen Janke, Sofia Christakoudi, Alicia Heath, Anja Olsen, Anne Tjonneland, Matthias B. Schulze, Verena Katzke, Rudolf Kaaks, Bethany van Guelpen, Justin Harbs, Domenico Palli, Alessandra Macciotta, Fabrizio Pasanisi, Sandra Milena Colorado Yohar, Marcela Guevara, Pilar Amiano, Sara Grioni, Paula Gabriela Jakszyn, Jane C. Figueiredo, N. Jewel Samadder, Christopher I. Li, Victor Moreno, John D. Potter, Robert E. Schoen, Caroline Y. Um, Elisabete Weiderpass, Mazda Jenab, Marc J. Gunter, Tobias Pischon
Summary: The study suggests that circulating FABP-4 may not have a causal role in the development of colorectal cancer (CRC), although a positive association was observed in women through a cis-MR approach.
Article
Cardiac & Cardiovascular Systems
Makoto Hibino, Subodh Verma, Craig M. Jarret, Junichi Shimamura, Raj Verma, Hiromi Hibino, Cristian R. Baeza, Dagfinn Aune, Bobby Yanagawa, Akihiko Usui, Christoph A. Nienaber, Marc P. Pelletier
Summary: This study compared mortality trends from aortic dissection and rupture in the UK, Japan, the USA, and Canada. The findings showed a decreasing trend in age-standardized mortality rates from aortic rupture in all four countries, but an increasing trend in mortality from aortic dissection in Japan, the USA, and Canada. Further research is needed to understand these trends.
News Item
Oncology
Elio Riboli, Frederick A. Beland, Dirk W. Lachenmeier, M. Matilde Marques, David H. Phillips, Eva Schernhammer, Abdul Afghan, Ricardo Assuncao, Giovanna Caderni, J. Christopher Corton, Gisela de Aragao Umbuzeiro, Daphne de Jong, Melanie Deschasaux- Tanguy, Allison Hodge, Junko Ishihara, Dan D. Levy, Daniele Mandrioli, Marjorie L. Mccullough, Sarah A. Mcnaughton, Takeshi Morita, Anne P. Nugent, Kumiko Ogawa, Arun R. Pandiri, Consolato M. Sergi, Mathilde Touvier, Luoping Zhang, Lamia Benbrahim- Tallaa, Shirisha Chittiboyina, Danila Cuomo, Nathan L. Debono, Charlotte Debras, Aline de Conti, Fatiha El Ghissassi, Emma Fontvieille, Rhea Harewood, John Kaldor, Heidi Mattock, Elisa Pasqual, Gabrielle Rigutto, Hannah Simba, Eero Suonio, Susana Viegas, Roland Wedekind, Mary K. Schubauer-Berigan, Federica Madia
Correction
Oncology
Sonja I. Berndt, Joseph Vijai, Yolanda Benavente, Nicola J. Camp, Alexandra Nieters, Zhaoming Wang, Karin E. Smedby, Geffen Kleinstern, Henrik Hjalgrim, Caroline Besson, Christine F. Skibola, Lindsay M. Morton, Angela R. Brooks-Wilson, Lauren R. Teras, Charles Breeze, Joshua Arias, Hans-Olov Adami, Demetrius Albanes, Kenneth C. Anderson, Stephen M. Ansell, Bryan Bassig, Nikolaus Becker, Parveen Bhatti, Brenda M. Birmann, Paolo Boffetta, Paige M. Bracci, Paul Brennan, Elizabeth E. Brown, Laurie Burdett, Lisa A. Cannon-Albright, Ellen T. Chang, Brian C. H. Chiu, Charles C. Chung, Jacqueline Clavel, Pierluigi Cocco, Graham Colditz, Lucia Conde, David V. Conti, David G. Cox, Karen Curtin, Delphine Casabonne, Immaculata De Vivo, Arjan Diepstra, W. Ryan Diver, Ahmet Dogan, Christopher K. Edlund, Lenka Foretova, Joseph F. Fraumeni, Attilio Gabbas, Herve Ghesquieres, Graham G. Giles, Sally Glaser, Martha Glenn, Bengt Glimelius, Jian Gu, Thomas M. Habermann, Christopher A. Haiman, Corinne Haioun, Jonathan N. Hofmann, Theodore R. Holford, Elizabeth A. Holly, Amy Hutchinson, Aalin Izhar, Rebecca D. Jackson, Ruth F. Jarrett, Rudolph Kaaks, Eleanor Kane, Laurence N. Kolonel, Yinfei Kong, Peter Kraft, Anne Kricker, Annette Lake, Qing Lan, Charles Lawrence, Dalin Li, Mark Liebow, Brian K. Link, Corrado Magnani, Marc Maynadie, James McKay, Mads Melbye, Lucia Miligi, Roger L. Milne, Thierry J. Molina, Alain Monnereau, Rebecca Montalvan, Kari E. North, Anne J. Novak, Kenan Onel, Mark P. Purdue, Kristin A. Rand, Elio Riboli, Jacques Riby, Eve Roman, Gilles Salles, Douglas W. Sborov, Richard K. Severson, Tait D. Shanafelt, Martyn T. Smith, Alexandra Smith, Kevin W. Song, Lei Song, Melissa C. Southey, John J. Spinelli, Anthony Staines, Deborah Stephens, Heather J. Sutherland, Kaitlyn Tkachuk, Carrie A. Thompson, Herve Tilly, Lesley F. Tinker, Ruth C. Travis, Jenny Turner, Celine M. Vachon, Claire M. Vajdic, Anke Van den Berg, David J. Van den Berg, Roel C. H. Vermeulen, Paolo Vineis, Sophia S. Wang, Elisabete Weiderpass, George J. Weiner, Stephanie Weinstein, Nicole Wong Doo, Yuanqing Ye, Meredith Yeager, Kai Yu, Anne Zeleniuch-Jacquotte, Yawei Zhang, Tongzhang Zheng, Elad Ziv, Joshua Sampson, Nilanjan Chatterjee, Kenneth Offit, Wendy Cozen, Xifeng Wu, James R. Cerhan, Stephen J. Chanock, Susan L. Slager, Nathaniel Rothman
Article
Nutrition & Dietetics
Inge Huybrechts, Inarie Jacobs, Elom K. Aglago, Sahar Yammine, Michele Matta, Julie A. Schmidt, Corinne Casagrande, Genevieve Nicolas, Carine Biessy, Heleen Van Puyvelde, Augustin Scalbert, Jeroen W. G. Derksen, Yvonne T. van der Schouw, Sara Grioni, Pilar Amiano, Jytte Halkjaer, Anne Tjonneland, Jose M. Huerta, Leila Lujan-Barroso, Domenico Palli, Marc J. Gunter, Aurora Perez-Cornago, Veronique Chajes
Summary: This study aims to investigate the relationship between dietary fatty acid (FA) intake and plasma phospholipid (PL) FA levels in the EPIC cohort. Dietary intake of 60 individual FAs was estimated using validated questionnaires, and plasma PL FA concentrations were measured in non-fasting venous plasma samples. The results showed moderate positive correlations between FA intakes and plasma PL FA levels for certain FAs, especially for health-enhancing long-chain polyunsaturated FAs and health-deteriorating trans-FA.
Article
Oncology
Burcu F. Darst, Ed Saunders, Tokhir Dadaev, Xin Sheng, Peggy Wan, Loreall Pooler, Lucy Y. Xia, Stephen Chanock, Sonja I. Berndt, Ying Wang, Alpa V. Patel, Demetrius Albanes, Stephanie J. Weinstein, Vincent Gnanapragasam, Chad Huff, Fergus J. Couch, Alicja Wolk, Graham G. Giles, Tu Nguyen-Dumont, Roger L. Milne, Mark M. Pomerantz, Julie A. Schmidt, Ruth C. Travis, Timothy J. Key, Konrad H. Stopsack, Lorelei A. Mucci, William J. Catalona, Beth Marosy, Kurt N. Hetrick, Kimberly F. Doheny, Robert J. Macinnis, Melissa C. Southey, Rosalind A. Eeles, Fredrik Wiklund, David V. Conti, Zsofia Kote-Jarai, Christopher A. Haiman
Summary: This study identified genes associated with aggressive prostate cancer through exome sequencing. The findings provide support for the use of DNA repair and cancer susceptibility genes in disease management and suggest extending testing to men with nonaggressive disease.
