Article
Cell Biology
Ryosuke Tashiro, Kuniyasu Niizuma, Jun Kasamatsu, Yuko Okuyama, Sherif Rashad, Atsuo Kikuchi, Miki Fujimura, Shigeo Kure, Naoto Ishii, Teiji Tominaga
Summary: The study found that RNF213 plays a critical role in antigen uptake, processing, and presentation, with Rnf213-KO and Rnf213-KI mice experiments showing that RNF213 deficiency leads to decreased antigen uptake and processing capabilities, resulting in the inability to effectively activate antigen-specific T cells.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Oncology
Tim B. Fessenden, Lauren E. Stopfer, Fiona Chatterjee, Julian Zulueta, Josh Mesfin, Therese Cordero Dumit, Irene Reijers, Esmee P. Hoefsmit, Christian Blank, Forest White, Stefani Spranger
Summary: Cytotoxic CD8(+) T cells must recognize tumor-derived antigens to achieve effective tumor elimination. Our study shows that dendritic cells induce cytotoxic CD8(+) T-cell responses by cross-presenting tumor-derived peptides, and the proportion of membrane-derived neoantigens is associated with reduced survival and treatment response.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Radhika R. Gudi, Nicolas Perez, Subha Karumuthil-Melethil, Gongbo Li, Chenthamarakshan Vasu
Summary: Enhancing T cell checkpoint receptor engagement during antigen presentation can modulate T cell function, suppress autoimmunity, and inhibit disease progression in T1D.
Review
Immunology
Takumi Kawasaki, Moe Ikegawa, Taro Kawai
Summary: The lungs have an immune defense mechanism that uses various cells to eliminate harmful pathogens and activate T cell immune response. In addition to immune cells, other lung cells also participate in antigen presentation and T cell activation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jie Zhang, Biao Fan, Guoliang Cao, Wenping Huang, Fuhao Jia, Guangjun Nie, Hai Wang
Summary: This study developed a personalized DC-mimicking nanovaccine for stimulating TAAs-specific T cell populations. By inducing BMDCs maturation and delivering TAAs through nanostructures, the nanoDCs efficiently generated potent antigen-specific T cell responses, leading to inhibition of tumor growth and metastases formation.
ADVANCED MATERIALS
(2022)
Review
Immunology
Christian Moebs, Martin Salheiser, Fabian Bleise, Marie Witt, Johannes U. Mayer
Summary: This review aims to highlight the role of basophils in antigen presentation and T cell priming, as well as resolving the debate on whether basophils influence antigen presentation through direct or indirect mechanisms. Tissue-specific differences in basophil phenotypes and their interactions with other antigen-presenting cells will be discussed, along with their implications on immunological and clinical outcomes of disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Furong Zeng, Zhizhao Chen, Rao Chen, William J. Shufesky, Mohna Bandyopadhyay, Geoffrey Camirand, Martin H. Oberbarnscheidt, Mara L. G. Sullivan, Catherine J. Baty, Mu-Qing Yang, Michel Calderon, Donna Beer Stolz, Geza Erdos, Roberta Pelanda, Todd Brennan, Sergio D. Catz, Simon C. Watkins, Adriana T. Larregina, Adrian E. Morelli
Summary: It has been found that donor MHC antigens are released from skin or cardiac allografts via extracellular vesicles (EVs) and captured by macrophages in lymph nodes or spleen, triggering B cell activation and DSA production. This unexpected role of graft-derived EVs opens up possibilities to interfere with EV biogenesis, trafficking, or function to restrict alloreactive B cell priming.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mats Van Delen, Ibo Janssens, Amber Dams, Laurence Roosens, Benson Ogunjimi, Zwi N. Berneman, Judith Derdelinckx, Nathalie Cools
Summary: This study aimed to counter the high inflammatory state of COVID-19 by inducing T-cell hyporesponsiveness using tolerogenic dendritic cells (tolDC). The results showed that tolDC could induce SARS-CoV-2-specific T cell hyporesponsiveness, suggesting its clinical potential.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Christophe Macri, Devi Jenika, Cassandra Ouslinis, Justine D. Mintern
Summary: Dendritic cells (DCs) are specialized antigen-presenting cells that play a critical role in adaptive immunity. Targeting antigen directly to DCs is a selective vaccination strategy that takes advantage of the antigen uptake and presentation functions of DC subsets. This review focuses on DC-targeted vaccination strategies aimed at inducing effective cross-presentation for CD8+ T cell immunity. Receptors highly expressed by mouse and human cDCs, such as DEC205, Clec9A, and XCR1, are explored. The outcomes of DC-targeted vaccination in mouse models and human clinical trials are discussed, highlighting its potential for the prevention and treatment of tumors and infectious diseases.
SEMINARS IN IMMUNOLOGY
(2023)
Article
Oncology
Gao-Na Shi, Min Hu, Chengjuan Chen, Junmin Fu, Shuai Shao, Yu Zhou, Lei Wu, Tiantai Zhang
Summary: The combination of MTX and TCL enhances DC maturation, cytokine release, CD8(+) T cell activation, and proliferation. This effect is partly modulated by NLRP3 inflammasome activation. Immunisation with MTX and TCL-pulsed DCs delays tumor onset and growth by priming IFN-gamma releasing CD8(+) T cells and enhancing cytotoxic T lymphocyte killing of tumor cells.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2021)
Article
Immunology
Nitya Mohan, Kathrin Wellach, Ceren Oezerdem, Nisha Veits, Jonas D. Foerster, Sophia Foehr, Maria Bonsack, Angelika B. Riemer
Summary: This study investigates the effect of hypoxia on antigen presentation and T cell cytotoxicity in cervical cancer cells. The results show downregulation of E6 and E7 expression under hypoxic conditions, but intact antigen processing and presentation machinery. The cytotoxicity of T cells towards cervical cancer cells is affected by both epitope-specific and donor-specific factors.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Haochen Yao, Na Shen, Guofeng Ji, Juanjuan Huang, Jiali Sun, Guoqing Wang, Zhaohui Tang, Xuesi Chen
Summary: The study demonstrates the strong antitumor immune response of cisplatin-based nanoparticles in a tumor-bearing mouse model. The sustained retention of nanoparticles leads to persistent tumor MHC-I overexpression, promoting the formation of pMHC-I and enhancing the interaction with T cell receptors. Additionally, the nanoparticles upregulate OX40 on intratumoral CD8+ T cells and synergize with an agonistic OX40 antibody to suppress tumor growth by 89.2%.
Article
Biochemistry & Molecular Biology
Takuya Sakamoto, Terutsugu Koya, Misa Togi, Kenichi Yoshida, Tomohisa Kato, Yasuhito Ishigaki, Shigetaka Shimodaira
Summary: This study evaluated the function and preclinical validation of human dendritic cell (DC) dexosomes, small DC-secreted vesicles that contain immune signals, for cancer vaccination. The researchers characterized a potential dexosome model using immature and mature DCs derived from a cell line called MUTZ3, and found that one type of MUTZ3-derived DC dexosomes exhibited potential immunogenicity and higher antigen presentation potency, making them potential resources for cancer immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Hejin Jiang, Rui Liu, Lu Wang, Xinyue Wang, Mengmeng Zhang, Sisi Lin, Zhenping Cao, Feng Wu, Yingbin Liu, Jinyao Liu
Summary: Chirality plays a critical role in biological systems, and this study demonstrates the potential of using supramolecular chiral polymer micelles (SCPMs) to activate the immune system for disease prevention and treatment.
ADVANCED MATERIALS
(2023)
Article
Immunology
Moah Sohn, Hye Young Na, Hyun Soo Shin, Seul Hye Ryu, Sejung Park, Hyunju In, Wanho Choi, Ji Soo Park, Soomin Hwang, Min Kyung Chu, Chae Gyu Park
Summary: The study found that classical DC subsets in the peritoneal cavity regulate T cell responses differently, with cDC1s being superior in activating CD8 T cells and cDC2s prominently expressing homing receptors for CD4 T cells. The study also revealed that soluble factors from CD8 T cells stimulated by cDC1s, particularly IL-2, play a crucial role in controlling the overall gene expression of T cells. Overall, the different peritoneal cDC subsets effectively diversify T cell responses by altering the level of cytokines, such as IL-2, in the environment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Jawid Nazir Ahmad, Ondrej Cerny, Irena Linhartova, Jiri Masin, Radim Osicka, Peter Sebo
CELLULAR MICROBIOLOGY
(2016)
Article
Cell Biology
Martina Svedova, Jiri Masin, Radovan Fiser, Ondrej Cerny, Jakub Tomala, Marina Freudenberg, Ludmila Tuckova, Marek Kovar, Gilles Dadaglio, Irena Adkins, Peter Sebo
IMMUNOLOGY AND CELL BIOLOGY
(2016)
Article
Immunology
Ondrej Cerny, Jana Kamanova, Jiri Masin, Ilona Bibova, Karolina Skopova, Peter Sebo
JOURNAL OF IMMUNOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Ilona Bibova, David Hot, Kristina Keidel, Fabian Amman, Stephanie Slupek, Ondrej Cerny, Roy Gross, Branislav Vecerek
Article
Microbiology
Ethel Bayer-Santos, Charlotte H. Durkin, Luciano A. Rigano, Andreas Kupz, Eric Alix, Ondrej Cerny, Elliott Jennings, Mei Liu, Aindrias S. Ryan, Nicolas Lapaque, Stefan H. E. Kaufmann, David W. Holden
CELL HOST & MICROBE
(2016)
Article
Immunology
Ondrej Cerny, Karen E. Anderson, Len R. Stephens, Phillip T. Hawkins, Peter Sebo
JOURNAL OF IMMUNOLOGY
(2017)
Article
Multidisciplinary Sciences
Jakub Novak, Ivo Fabrik, Irena Linhartova, Marek Link, Ondrej Cerny, Jiri Stulik, Peter Sebo
SCIENTIFIC REPORTS
(2017)
Review
Food Science & Technology
Jakub Novak, Ondrej Cerny, Adriana Osickova, Irena Linhartova, Jiri Masin, Ladislav Bumba, Peter Sebo, Radim Osicka
Correction
Immunology
Ilona Bibova, Karolina Skopova, Jiri Masin, Ondrej Cerny, David Hot, Peter Sebo, Branislav Vecerek
INFECTION AND IMMUNITY
(2014)
Article
Microbiology
Camilla Godlee, Ondrej Cerny, Charlotte H. Durkin, David W. Holden
Article
Microbiology
Eric Alix, Camilla Godlee, Ondrej Cerny, Samkeliso Blundell, Romina Tocci, Sophie Matthews, Mei Liu, Jonathan N. Pruneda, Kirby N. Swatek, David Komander, Tabitha Sleap, David W. Holden
CELL HOST & MICROBE
(2020)
Review
Cell Biology
Alison Heggie, Ondrej Cerny, David W. Holden
Summary: This passage explores how Salmonella enterica manipulates the F-actin meshwork within host cells to create SCVs through invasion and replication. The study reveals that the Salmonella pathogenicity island 2 encoded effector protein, SteC, plays a crucial role in this process.
CELLULAR MICROBIOLOGY
(2021)
Article
Microbiology
Ondrej Cerny, Camilla Godlee, Romina Tocci, Nancy E. Cross, Haoran Shi, James C. Williamson, Eric Alix, Paul J. Lehner, David W. Holden
Summary: The bacterium Salmonella enterica inhibits T cell immune response by affecting T cell activation, mainly through degradation of the CD97 protein to reduce contacts between antigen-presenting cells and T cells. Additionally, Salmonella effector SteD depletes mature MHCII molecules by enhancing ubiquitination of CD97, which affects dendritic cell-T cell interactions independent of its effect on MHCII.
Article
Microbiology
Camilla Godlee, Ondrej E. Cerny, Mei Liu, Samkeliso W. Blundell, Alanna M. Gallagher, Meriam M. Shahin, David M. Holden
Summary: This study explores the targeting, membrane integration, and trafficking mechanisms of the Salmonella effector SteD. SteD integrates into the early secretory pathway membranes through two steps and hijacks a vesicular trafficking pathway to reach MHCII compartments. This research highlights the intricate interaction between bacterial pathogens and host cell biology at the molecular level.
