Article
Pharmacology & Pharmacy
Xue Zhang, Huiling Su, Haifei Yu, Jialu Ding, Wanyu Deng, Bo Qin, Changlin Zhou, Jie Dou, Min Guo
Summary: This study demonstrates that Eupolyphaga sinensis Walker polysaccharide (ESPS) has potential anti-hepatitis B virus (HBV) activity by inhibiting HBV replication and infection in vitro and in vivo. The anti-HBV effect of ESPS is achieved by activating the Toll-like receptor 4 (TLR4) pathway and enhancing innate immunity function.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Rahul Unnikrishnan, Jabbar Gardy, Ben F. Spencer, Robin Kurinjimala, Avishek Dey, Vahid Nekouie, Sandeep Irukuvarghula, Ali Hassanpour, Christoph Eisenmenger-Sittner, John A. Francis, Michael Preuss
Summary: The oxidation state and surface properties of powder particles have a significant impact on the properties of powder manufactured components. In this study, a protective coating of chromium was applied to a non-stainless low alloy steel powder to prevent progressive oxidation and improve powder flowability. The effects of the coating on oxidation resistance, electrical charging, and flowability were investigated. The results showed that the chromium coating reduced oxidation and improved the flowability of the powder.
MATERIALS & DESIGN
(2022)
Article
Engineering, Biomedical
Jinsheng Huang, Zecong Xiao, Yongcheng An, Shisong Han, Wei Wu, Yong Wang, Yu Guo, Xintao Shuai
Summary: A novel nanocarrier was developed for tumor-targeted delivery in melanoma to activate anti-tumor immunity and reduce adverse effects. Additionally, combining sonodynamic therapy with immunotherapy effectively promotes anti-cancer immunity and suppresses melanoma growth.
Review
Oncology
Isabel Britsch, Anne Paulien van Wijngaarden, Wijnand Helfrich
Summary: This review presents multiple strategies for utilizing anti-cytomegalovirus (CMV) T cells for cancer (immuno)therapy, including immunogenic CMV peptide-loading onto cancer cells and the use of tumor-directed fusion proteins containing CMV peptide/HLA-I complex. Furthermore, the challenges and advantages of using anti-CMV CD8(pos) T cells for CAR T cell therapy and targeting CMV peptide-expressing glioblastomas are discussed. Finally, the review evaluates the strategies and suggests ways to improve the efficacy of anti-CMV T cell therapies.
Article
Immunology
Aritania Sousa Santos, Edecio Cunha-Neto, Nelson Vinicius Gonfinetti, Fernanda Bernardi Bertonha, Pauline Brochet, Aurelie Bergon, Carlos Alberto Moreira-Filho, Christophe Chevillard, Maria Elizabeth Rossi da Silva
Summary: Our study investigated the global gene expression in PBMC of recent-onset T1D patients from a highly admixed Brazilian population, revealing 474 differentially expressed genes between groups. The most expressed genes in T1D patients favored host defense, inflammatory and cell cycle progression, while immune-regulatory pathways were downregulated. These findings suggest immune activation and differential genetic profiles in recent-onset T1D patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Suzanne I. Sitnikova, Jennifer A. Walker, Laura B. Prickett, Michelle Morrow, Viia E. Valge-Archer, Matthew J. Robinson, Robert W. Wilkinson, Simon J. Dovedi
Summary: This study investigates the impact of aging on tumor growth and immune composition using aged mice. The results show significant differences in immune cell composition between aged and young mice, which may contribute to impaired anti-cancer immune responses in aged mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Jin Won Park, Kyung-Ho Jung, Jin Hee Lee, Seung Hwan Moon, Young Seok Cho, Kyung-Han Lee
Summary: This study utilized an antibody that cross-reacts with both human and mouse CD44 isoforms to demonstrate high-specific binding to colon cancer cells and monocytic cells. The research revealed that high splenic uptake of CD44 was attributable to myeloid cells and that CD44 immuno-PET has the potential to monitor CD44 regulation on splenic myeloid cells and be useful for imaging colon tumors.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
William L. Redmond, Melissa J. Kasiewicz, Emmanuel T. Akporiaye
Summary: Cancer immunotherapy, specifically anti-PD-1/anti-PD-L1 immune checkpoint blockade (ICB), is effective in treating advanced malignancies. However, tumor progression eventually occurs in most patients, necessitating additional therapeutic options. Researchers have developed a new agent, a-TEA-LS, which selectively induces tumor cell death and activates tumor-reactive T cells, leading to tumor regression. The combination of a-TEA-LS and ICB shows promise in reducing tumor growth and prolonging survival. These findings support the potential clinical translation of this novel approach.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kai Luo, Xinxin Li, Liu Wang, Wanxiu Rao, Yang Wu, Yue Liu, Mingzhu Pan, Dong Huang, Wenbing Zhang, Kangsen Mai
Summary: The present study revealed that dietary ascorbic acid plays a positive role in regulating immunity, anti-oxidation, and apoptosis in abalone.
Article
Biochemistry & Molecular Biology
Agnese Gugliandolo, Francesca Diomede, Jacopo Pizzicannella, Luigi Chiricosta, Oriana Trubiani, Emanuela Mazzon
Summary: This study evaluates the anti-inflammatory potential of a new lyophilized formulation of conditioned medium derived from human periodontal ligament stem cells (hPDLSCs). The lyophilized formulation was found to downregulate the expression of inflammatory genes and increase cell migration. These results suggest that lyophilization is an effective method for producing stable formulations of MSCs' secretome.
Article
Energy & Fuels
K. Timmo, M. Dolcet Sadurni, M. Pilvet, K. Muska, M. Altosaar, V. Mikli, F. Atlan, M. Guc, V. Izquierdo-Roca, M. Grossberg-Kuusk, M. Kauk-Kuusik
Summary: The efficiency of CZTS monograin layer solar cells is limited by recombination losses, which can be reduced by post-treating the surfaces of monograin powder crystals. This study optimized two sequential post-treatment steps and found that secondary phases were formed on the crystals' surfaces in the thermal annealing process. The study also showed that adjusting the annealing temperature can modify the Cu/Zn+Sn ratio in the CZTS crystals and improve the performance of monograin layer solar cells.
SOLAR ENERGY MATERIALS AND SOLAR CELLS
(2023)
Article
Energy & Fuels
Venkatraman Bansode, Madhuresh Dwivedi, Rama Chandra Pradhan, Tarak Chandra Panda, Samuel Jaddu, Kadavakollu Subrahmanyam, Sibasish Sahoo
Summary: The impact of plasma activated water (PAW) on the properties, polyphenols, antioxidant activities, and anti-nutrients of sweet orange peel powder was investigated. The results showed that PAW treatment significantly increased the total phenols, total flavonoids, and antioxidant activities. The physicochemical properties of PAW treated samples differed significantly from the control samples. The reduction in anti-nutrients in PAW treated samples may be attributed to the action of reactive nitrogen species (RNS) and reactive oxygen species (ROS) generated in PAW.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Review
Immunology
Fenyao Li, Xinxin Wang, Jin Shi, Shuting Wu, Wenbo Xing, Yan He
Summary: Dental pulp stem cells have strong immunomodulatory capabilities and can be used to treat inflammation-related diseases and autoimmune disorders. The mechanism of action is complex and may involve the regulation of immune cells through inflammatory immune-related signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Tamara Davenne, Pauline Percier, Lionel Larbanoix, Muriel Moser, Oberdan Leo, Etienne Meylan, Stanislas Goriely, Pierre Gerard, Nathalie Wauthoz, Sophie Laurent, Karim Amighi, Remi Rosiere
Summary: Despite advances in targeted therapies and immunotherapy in lung cancer, chemotherapy remains a necessary component of treatment. Inhaled chemotherapy, specifically CIS-DPI, has shown promise in delivering cisplatin directly to lung tumors with minimal systemic toxicities. Combining CIS-DPI with anti-PD1 has demonstrated improved outcomes, including reduced tumor size and prolonged survival, along with an enhanced immune response.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Physiology
Meiyao Wang, Jiachun Ge, Xingkong Ma, Shengyan Su, Can Tian, Jianlin Li, Fan Yu, Hongxia Li, Changyou Song, Jiancao Gao, Pao Xu, Yongkai Tang, Gangchun Xu
Summary: This study investigated the regulatory mechanisms of heart development in Eriocheir sinensis after molting using comparative transcriptome analysis. The results showed that many regulatory pathways and genes involved in regeneration, antioxidation, anti-aging, and the immune response were significantly upregulated after molting. Additionally, differentially expressed genes were related to myocardial movement, neuronal signal transduction, glutathione homeostasis, biological rhythms, immune cell development, and immune response.
FRONTIERS IN PHYSIOLOGY
(2022)
