Article
Chemistry, Multidisciplinary
Peter T. Cardew
Summary: In 1897, Ostwald proposed the Rule of Stages (ORS), which suggests that a system proceeds sequentially through metastable states. However, this paper examines the crystallization process of a polymorphic compound using classical nucleation theory and finds that ORS is not applicable in this specific case. The observed process is not sequential, but rather a parallel development of all metastable phases.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Psychology, Multidisciplinary
Maria Alekseeva, Andriy Myachykov, Yury Shtyrov
Summary: Knowledge of language is important, but linguistic theories often do not consider the neurocognitive mechanisms underlying language function. This article discusses the controversial concept of null constituent and the hypothetical zero morpheme, and advocates for neurobiological research to better understand these constructs in linguistic communication.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Gastroenterology & Hepatology
Zoe S. Gottlieb, Bruce E. Sands
Summary: IL-23 antagonism shows promise in the treatment of IBD, and certain molecular markers may help predict patient response to these medications. No significant clinical predictors of response have been identified yet.
JOURNAL OF CROHNS & COLITIS
(2022)
Article
Engineering, Aerospace
Xiaoqian Sun, Sebastian Wandelt, Anming Zhang
Summary: Aviation industry has been severely affected by COVID-19, leading to stranded passengers, bankrupt airlines, and uncertain future demand. Travel bubbles, where countries with successful control over COVID-19 gradually resume international flights, are proposed as a solution. This study investigates the existence of travel bubbles in 2020 flight data and provides insights for policy-making and challenges associated with travel bubbles.
Article
Health Care Sciences & Services
Mihaela Catalina Luca, Isabela Ioana Loghin, Ioana Florina Mihai, Radu Popa, Andrei Vata, Carmen Manciuc
Summary: While COVID-19 primarily affects the lungs, the widespread presence of ACE2 suggests systemic involvement of other organs such as the heart, kidneys, and liver. This retrospective study examined SARS-CoV-2 infected patients in a hospital in Romania and found that liver injury, indicated by increased transaminase levels, was secondary to the viral infection. The study also revealed that high AST and ALT levels at hospital admission were associated with a higher risk of mortality in COVID-19 patients, indicating the prognostic significance of abnormal liver test results.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Medicine, Research & Experimental
Zuzana Strizova, Iva Benesova, Robin Bartolini, Rene Novysedlak, Eva Cecrdlova, Lily Koumbas Foley, Ilja Striz
Summary: Macrophages are a heterogeneous cell population with various roles in defense mechanisms and tissue homeostasis. They can adopt different activation states depending on the microenvironment and natural signals they receive.
Review
Clinical Neurology
Bernard Le Foll
Summary: There is growing evidence that cannabinoids may have an opioid-sparing effect, with preclinical studies supporting this idea. However, clinical studies have mostly yielded negative results, indicating the need for further high-quality research to validate this potential benefit in humans.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Business, Finance
Raheel Asif, Michael Frommel, Alexander Mende
Summary: The study finds that commodity trading advisors (CTAs) provide diversification benefits for investors during crises. This is due to the CTAs' diversification across multiple futures markets and their ability to quickly reduce exposure in crisis markets, resulting in stable performance and crisis alpha.
INTERNATIONAL REVIEW OF FINANCIAL ANALYSIS
(2022)
Article
Social Sciences, Interdisciplinary
Hitoshi Mikami, Tadashi Shiozawa
Summary: This study examines whether the use of problematic strategies poses a threat to the effectiveness of extensive reading. Extensive reading is a widely recognized approach for second language learning, particularly in developing reading skills. However, concerns arise when it is implemented in language courses and learner performance impacts grades. The study conducted interviews and questionnaires at a Japanese university and found that the use of problematic strategies is indeed a threat to the effectiveness of extensive reading. Recommendations for promoting positive engagement with extensive reading are also proposed.
Review
Medicine, General & Internal
Roberta Naddei, Ana Rebollo-Gimenez, Marco Burrone, Valentina Natoli, Silvia Rosina, Alessandro Consolaro, Angelo Ravelli
Summary: Juvenile psoriatic arthritis (JPsA) is a controversial subset of juvenile idiopathic arthritis (JIA), accounting for 1-7% of cases. There has been debate about whether JPsA should be classified as a distinct category within JIA. Studies have shown that children with JPsA can be divided into two subgroups based on their clinical features and genetic determinants. The ongoing discussion has prompted the revision of the current classification of JPsA.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Alireza Tojjari, Hassan Abushukair, Anwaar Saeed
Summary: This article discusses the association between the gut microbiota and cancer immunology and immunotherapy, including the impact on immunotherapy outcomes, regulating factors, and the role of microbial interventions.
Review
Biochemistry & Molecular Biology
Quintino Giorgio D'Alessandris, Grazia Menna, Alessandro Izzo, Manuela D'Ercole, Giuseppe Maria Della Pepa, Liverana Lauretti, Roberto Pallini, Alessandro Olivi, Nicola Montano
Summary: In recent years, research on brain cancers has focused on understanding the interactions between the tumor and the normal brain. The influence of neuronal activity on brain tumor development, especially gliomas, has been discovered, including direct electrochemical synapses between neurons and glioma cells. This new field of research, known as cancer neuroscience, has opened up new approaches for the treatment of brain cancers. This review explores the latest findings and therapeutic perspectives in cancer neuroscience, including traditional oncologic approaches and cutting-edge electric stimulation proposals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Cinzia Forni, Massimiliano Rossi, Ilaria Borromeo, Giordana Feriotto, Giovambattista Platamone, Claudio Tabolacci, Carlo Mischiati, Simone Beninati
Summary: Plant metabolites like flavonoids have significant effects on human health, preventing diseases and exhibiting bioactivities such as anticancer and anti-inflammatory properties. Research shows that dietary intake of flavonoids can reduce the risk of cancer.
Article
Medical Laboratory Technology
G. Priyadarshini, Sreejith Parameswaran, Jayaprakash Sahoo, Sandhiya Selvarajan, Medha Rajappa
Summary: The study found that 75% of CKD patients in South India had normal levels of vitamin D, with 15% being deficient and 10% severely deficient. Most patients had a history of taking vitamin D and calcium supplements before coming to the institute, which may explain this paradoxical finding.
CLINICA CHIMICA ACTA
(2021)
Article
Neurosciences
Ruth Feldman
Summary: This article initiates a discussion on women in science, exploring different perspectives and discussing their potential risks. It highlights the importance of recognizing the challenges women face in accessing opportunities in the field and the potential advantages women may bring to the pursuit of knowledge.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Orthopedics
Mattia Alessio-Mazzola, Chiara Stambazzi, Chiara Ursino, Alberto Tagliafico, Roberto Trentini, Matteo Formica
Summary: This study compared the clinical outcomes of chronic plantar fasciitis treated with ultrasound-guided platelet-rich plasma (PRP) and focal ultrasound-guided extracorporeal shockwave therapy (ESW). The results showed that both PRP and ESW were effective in treating plantar fasciitis, but PRP had lower recurrence rate and faster recovery time for athletes.
JOURNAL OF FOOT & ANKLE SURGERY
(2023)
Article
Medicine, General & Internal
Elisa Russo, Alberto Stefano Tagliafico, Lorenzo Derchi, Bianca Bignotti, Simona Tosto, Carlo Martinoli, Alessio Signori, Francesca Brigati, Francesca Viazzi
Summary: The study aimed to investigate the role of opportunistic kidney assessment on non-enhanced chest CT in COVID-19 patients. The results showed that low RPA values and the presence of PFS independently predicted the occurrence of AKI and increased risk for mortality, respectively.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Nicole Brunetti, Massimo Calabrese, Carlo Martinoli, Alberto Stefano Tagliafico
Summary: This study assessed the current development of ultrasound-based artificial intelligence in breast cancer. The results showed that AI has excellent performance in the diagnosis, prognosis, and treatment strategy of breast cancer. However, more prospective and multicenter studies are needed to evaluate the potential impact of AI in breast ultrasound.
Editorial Material
Oncology
Alberto Stefano Tagliafico, Nehmat Houssami
Review
Oncology
Martina Dameri, Gabriella Cirmena, Francesco Ravera, Lorenzo Ferrando, Paola Cuccarolo, Mario Stabile, Giuseppe Nicolo Fanelli, Pier Vitale Nuzzo, Massimo Calabrese, Alberto Tagliafico, Alberto Ballestrero, Gabriele Zoppoli
Summary: Liquid biopsy has the potential to revolutionize clinical practice by offering a non-invasive approach for cancer diagnosis and treatment. However, the lack of standardized protocols for sample handling has hindered its implementation in clinical settings. This study provides a critical review of available standard operating procedures (SOPs) for liquid biopsy management and presents SOPs developed and utilized in a clinical trial. The aim is to address common issues and promote the adoption of interlaboratory shared protocols for optimized preanalytical handling of blood and urine samples.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Micaela Berni, Alice Maria Brancato, Camilla Torriani, Valentina Bina, Salvatore Annunziata, Elena Cornella, Michelangelo Trucchi, Eugenio Jannelli, Mario Mosconi, Giulia Gastaldi, Laura Caliogna, Federico Alberto Grassi, Gianluigi Pasta
Summary: Low-level laser therapy (LLLT) is increasingly used in orthopedics practices to promote angiogenesis, fracture healing, and osteogenic differentiation of stem cells. However, the cellular mechanisms during bone formation remain largely unknown. Factors such as wavelength, energy density, irradiation, and frequency of LLLT influence the cellular mechanisms, and the effects of LLLT vary according to cell types treated. This review aims to summarize the current knowledge of the molecular pathways activated by LLLT and its effects on the bone healing process to improve its clinical application.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Sport Sciences
Alberto S. Tagliafico, Lorenzo Torri, Roberta Righetto
Summary: This study aimed to investigate the occurrence of padel tennis injuries in Liguria, Italy. A questionnaire was sent to members of the Italian Federation of Tennis who participated in official tournaments of padel tennis. The results showed that lower limb injuries were more common, with the knee being highly affected, and the elbow was the most affected area in the upper limb.
JOURNAL OF SPORTS MEDICINE AND PHYSICAL FITNESS
(2023)
Editorial Material
Medicine, General & Internal
Giancarlo Castaman, Flora Peyvandi, Raimondo De Cristofaro, Berardino Pollio, Dario M. N. Di Minno
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Daniel Alvarez Sanchez-Bayuela, Navid Ghavami, Cristina Romero Castellano, Alessandra Bigotti, Mario Badia, Lorenzo Papini, Giovanni Raspa, Gianmarco Palomba, Mohammad Ghavami, Riccardo Loretoni, Massimo Calabrese, Alberto Tagliafico, Gianluigi Tiberi
Summary: In this study, the effectiveness of the MammoWave microwave imaging device for breast cancer detection is investigated through a multicentric European clinical trial. The device uses a Huygens-principle-based radar algorithm for image reconstruction and dedicated image analysis software. Conductivity weighted microwave images are created for each breast, and various image parameters are used to quantify their non-homogenous behavior. Welch's t-test is used to verify the statistical significance between the selected image features and the gold standard radiological study review.
Article
Medicine, General & Internal
Alberto Stefano Tagliafico, Massimo Calabrese, Nicole Brunetti, Alessandro Garlaschi, Simona Tosto, Giuseppe Rescinito, Gabriele Zoppoli, Michele Piana, Cristina Campi
Summary: This study aimed to evaluate the advantages of using radiomics in the assessment of breast lesions amenable to MR-VABB. The results showed that a radiomics logistic regression model applied to DCE-MRI images increased the diagnostic accuracy compared to the standard radiological evaluation. This suggests that radiomics has the potential to reduce the number of biopsies required in suspicious breast lesions, benefiting both patients and healthcare resources.
Article
Multidisciplinary Sciences
Daniel alvarez Sanchez-Bayuela, Navid Ghavami, Gianluigi Tiberi, Lorenzo Sani, Alessandro Vispa, Alessandra Bigotti, Giovanni Raspa, Mario Badia, Lorenzo Papini, Mohammad Ghavami, Cristina Romero Castellano, Daniela Bernardi, Massimo Calabrese, Alberto Stefano Tagliafico
Summary: Microwave imaging is a safe and promising technology for breast radiology that avoids discomfort and radiation exposure. This study used a prospective clinical trial to investigate the effectiveness of a microwave imaging device in distinguishing between breasts with and without radiological findings. The results showed potential for identifying breast lesions in asymptomatic women.
Article
Radiology, Nuclear Medicine & Medical Imaging
Federico Zaottini, Riccardo Picasso, Federico Pistoia, Michelle Pansecchi, Luca Tovt, Marta Maccio, Sara Sanguinetti, Carlo Martinoli
Summary: Wrist and hand anatomy can have various clinically relevant variants affecting bones, muscles, tendons, and nerves. Understanding these abnormalities and their appearance in imaging studies is important for proper management. This review discusses the most common anatomical variants encountered in clinical practice, their embryogenesis, related syndromes, and the imaging techniques used to visualize them.
SEMINARS IN MUSCULOSKELETAL RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Federica Rossi, Matteo Lambertini, Nicole Brunetti, Sara De Giorgis, Maria Grazia Razeti, Massimo Calabrese, Alberto Stefano Tagliafico
Summary: The purpose of this study was to evaluate pectoralis muscle area (PMA) depletion in breast cancer patients aged 45 years or younger undergoing neoadjuvant chemotherapy (NAC) and its correlation with clinical and histopathological data. The results showed a decrease in PMA before and after NAC. However, there were no significant associations between PMA changes and other clinical and histopathological data. Therefore, assessing PMA variation on breast MRI during NAC could be a potential tool for monitoring body composition and improving outcomes in young breast cancer patients.
Article
Radiology, Nuclear Medicine & Medical Imaging
Simone Caprioli, Alberto Tagliafico, Martina Fiannacca, Fabio Borda, Riccardo Picasso, Cristina Conforti, Alessandro Casaleggio, Giuseppe Cittadini
Summary: Despite the use of antibiotics, deep neck infections remain a clinical problem with potential life-threatening complications. Imaging, particularly computed tomography, plays a crucial role in identifying the source, extent, and complications of these infections. Knowledge of neck anatomy allows radiologists to evaluate the spread of infections and communicate important information to surgeons. This review focuses on the imaging of deep neck infections, highlighting relevant anatomy and clinical scenarios to aid in prompt diagnosis and early recognition of complications.
Article
Radiology, Nuclear Medicine & Medical Imaging
Alberto Bazzocchi, Amanda Isaac, Danoob Dalili, Anastasia Fotiadou, Eleni P. Kariki, Jan S. Kirschke, Christian R. Krestan, Carmelo Messina, Edwin H. G. Oei, Catherine M. Phan, Mahesh Prakash, Nuran Sabir, Alberto Tagliafico, Francisco Aparisi, Thomas Baum, Thomas M. Link, Giuseppe Guglielmi, Maria Pilar Aparisi Gomez
Summary: This article discusses the latest techniques and methods in imaging of metabolic bone diseases in the spine, including diagnosis, characterization, and monitoring. Different imaging techniques are used to guide the treatment of metabolic bone diseases.
SEMINARS IN MUSCULOSKELETAL RADIOLOGY
(2022)
